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Cat. No.: HY-132862

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ZXH-4-137

ZXH-4-137 is a potent and selective CRBN degrader (PROTAC).
(Pink: Cereblon ligand (HY-103596); Blue: VHL ligand (HY-112078); Black: linker (HY-132859)).

For research use only. We do not sell to patients.

CAS No.: 2711006-74-3
Formula: C₄₇H₆₀N₆O₉S
Molecular Weight:885.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ZXH-4-137 Chemical Structure

CAS No.: 2711006-74-3

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

ZXH-4-137 is a potent and selective CRBN degrader (PROTAC). (Pink: Cereblon ligand (HY-103596); Blue: VHL ligand (HY-112078); Black: linker (HY-132859)).

All PROTACs Isoforms :

Chemical Information

CAS No. 2711006-74-3
Molecular Weight 885.08
Formula C₄₇H₆₀N₆O₉S
SMILES

O=C1C2=C(OCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O)C=CC=C2C(N1C6C(NC(CC6)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Powell CE, et al. Selective degradation-inducing probes for studying cereblon (CRBN) biology. RSC Med Chem. 2021 Jul 6;12(8):1381-1390. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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