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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
107 Results for "
CRL
" in MedChemExpress (MCE) Product Catalog:
Products (107)
107 Results for "CRL" in MCE Product Catalog:
Cat. No.: HY-RS03189
Target:
Research Areas:
CRLS1 Human Pre-designed siRNA Set A contains three designed siRNAs for CRLS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20895
Target:
Research Areas:
Crls1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Crls1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06755
Target:
Research Areas:
IL31RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL31RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-168646
Target:
Research Areas:
SJ46411-Br is one of CRL2 KLHDC2 targeting Ligands for E3 Ligase. SJ46411-Br can bind to KLHDC2 to form a complex to promote cooperative homologous selective ternary complex formation. SJ46411-Br can be coupled to BET ligand JQ1 (HY-13030) through PROTAC linker to synthesize corresponding PROTACs .
Cat. No.: HY-D2336
CAS No.: 3038774-43-2
PROTAC Aster-A degrader-1 is a PROTAC degrader targeting the sterol transporter (Aster-A), with a DC50 of 4.8 μM. PROTAC Aster-A degrader-1 binds to the sterol-binding domain of Aster-A, with a FI-Kd value of 83 nM. PROTAC Aster-A degrader-1 induces CRL- and proteasome-dependent degradation of Aster-A and inhibits autophagy in cancer cells. PROTAC Aster-A degrader-1 serves as a fluorescent probe. PROTAC Aster-A degrader-1 is useful for research related to cervical cancer, breast cancer, and lung adenocarcinoma .
Cat. No.: HY-106361
CAS No.: 82101-10-8
Synonyms: CRL 40827
Target:
Research Areas:
Flerobuterol is a beta-adrenoceptor agonist with antidepressant activity. Flerobuterol enhances serotonergic neurotransmission .
Cat. No.: HY-183117
CAS No.: 3084635-77-5
Research Areas:
NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader. NEO-811 is mediated by CRL4-CRBN E3 ligase for ARNT degradation. NEO-811 can be used for the study of clear cell renal cell carcinoma (ccRCC) .
Cat. No.: HY-111178R
CAS No.: 90280-13-0
Synonyms: BisfluoroModafinil (Standard); CRL-40940 (Standard); NLS-4 (Standard)
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Lauflumide (Standard) is the analytical standard of Lauflumide (HY-111178). This product is intended for research and analytical applications. Lauflumide (BisfluoroModafinil) is the common alternative of modafinil. Modafinil is commonly prescribed for the research narcolepsy. Lauflumide has the potential for cognitive enhancing .
Cat. No.: HY-175599A
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Research Areas:
Z6466608628 hydrochloride is a selective PPIL4 molecular glue degrader with human PPIL4 EC50 values of 0.34 µM. Z6466608628 hydrochloride functionally recruits PPIL4 to CRBN, induces CRL4 CRBN-mediated ubiquitylation and degradation of PPIL4. Z6466608628 hydrochloride can be used for the research of intracranial aneurysms[1].
Cat. No.: HY-P88735A
Synonyms: CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE; GREM3; SP1
Cat. No.: HY-130800R
CAS No.: 1860875-51-9
Synonyms: CC-90009 (Standard)
Research Areas:
Eragidomide (Standard) is the analytical standard of Eragidomide (HY-130800). This product is intended for research and analytical applications. Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4 CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation .
Cat. No.: HY-P70823
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CRLF2; IL-XR; Cytokine Receptor Like Factor 2; Thymic Stromal-Derived Lymphopoietin Receptor; TSLPR; Cytokine Receptor CRL2 Precusor; CRL2; Cytokine Receptor-Like 2; Thymic Stromal Lymphopoietin Protein Receptor; CRLF2Y; Cytokine Receptor-Like Factor 2; P
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P70989
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CRLF2; IL-XR; Cytokine Receptor Like Factor 2; Thymic Stromal-Derived Lymphopoietin Receptor; TSLPR; Cytokine Receptor CRL2 Precusor; CRL2; Cytokine Receptor-Like 2; Thymic Stromal Lymphopoietin Protein Receptor; CRLF2Y; Cytokine Receptor-Like Factor 2; P
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P71389
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CRLF2; IL-XR; Cytokine Receptor Like Factor 2; Thymic Stromal-Derived Lymphopoietin Receptor; TSLPR; Cytokine Receptor CRL2 Precusor; CRL2; Cytokine Receptor-Like 2; Thymic Stromal Lymphopoietin Protein Receptor; CRLF2Y; Cytokine Receptor-Like Factor 2; P
Species:
Human
Source:
HEK293
Cat. No.: HY-P700842
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CRLF2; IL-XR; Cytokine Receptor Like Factor 2; Thymic Stromal-Derived Lymphopoietin Receptor; TSLPR; Cytokine Receptor CRL2 Precusor; CRL2; Cytokine Receptor-Like 2; Thymic Stromal Lymphopoietin Protein Receptor; CRLF2Y; Cytokine Receptor-Like Factor 2; P
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-184151
Target:
Research Areas:
KBD-1 is a muscle-specific BRD4 PROTAC degrader with human KDs of 27.04 nM and 37.36 µM against BRD4 and KLHL4L, respectively. KBD-1 recruits the muscle-specific E3 ligase KLHL41, mediating Cullin-RING ligase (CRL)-dependent ubiquitination and proteasome degradation of BRD4. KBD-1 can be used for the research of myosarcoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
