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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
124 Results for "
Proton pump
" in MedChemExpress (MCE) Product Catalog:
Products (124)
124 Results for "Proton pump" in MCE Product Catalog:
Cat. No.: HY-19153
CAS No.: 156601-79-5
Synonyms: rel-TY-11345 free base
Target:
Research Areas:
Nepaprazole (rel-TY-11345 free base) is a proton pump inhibitor. Nepaprazole inhibits H +/K +-ATPase activity in isolated rabbit gastric mucosal microsomes with the IC50 values of 5.8 μM and 9.9 μM at pH 6.0 and pH 7.4, respectively. Nepaprazole can be used for study of peptic ulcer diseases .
Cat. No.: HY-B0656AS2
Synonyms: LY307640-d4 potassium
Cat. No.: HY-W719463
Cat. No.: HY-B0656R
CAS No.: 117976-89-3
Synonyms: LY307640 (Standard)
Research Areas:
Rabeprazole (Standard) is the analytical standard of Rabeprazole. This product is intended for research and analytical applications. Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .
Cat. No.: HY-17507S1
CAS No.: 922727-37-5
Synonyms: BY1023-d3; SKF96022-d3
Cat. No.: HY-B0656AS1
CAS No.: 1216494-11-9
Synonyms: LY307640-d3 sodium
Cat. No.: HY-B0656S1
CAS No.: 1261392-48-6
Synonyms: LY307640-13C,d3
Cat. No.: HY-B2145R
CAS No.: 172152-50-0
Synonyms: IY-81149 sodium (Standard)
Target:
Research Areas:
Ilaprazole (sodium) (Standard) is the analytical standard of Ilaprazole (sodium). This product is intended for research and analytical applications. Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium is used for the research of gastric ulcers. Ilaprazole sodium is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor .
Cat. No.: HY-113371R
CAS No.: 6061-96-7
Synonyms: Methylcitric acid (Standard)
Cat. No.: HY-17421R
CAS No.: 113712-98-4
Synonyms: TU-199 (Standard)
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Tenatoprazole (Standard) is the analytical standard of Tenatoprazole. This product is intended for research and analytical applications. Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H+/K+-ATPase activity with an IC50 of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV .
Cat. No.: HY-B0656AS3
Synonyms: LY307640-13C,d3 sodium
Cat. No.: HY-17507S2
CAS No.: 934294-34-5
Synonyms: BY1023-d8; SKF96022-d8
Cat. No.: HY-17507S4
CAS No.: 934294-71-0
Synonyms: BY1023-d4; SKF96022-d4
Cat. No.: HY-P810986
Synonyms: CGI-11, ATP6V1H, V-type Proton ATPase subunit H, V-ATPase subunit H, Nef-binding protein 1, Protein VMA13 homolog, V-ATPase 50/57 kDa subunits, Vacuolar Proton pump subunit H, Vacuolar Proton pump subunit SFD, NBP1
Cat. No.: HY-188169
CAS No.: 99499-40-8
Synonyms: U-69167
Target:
Research Areas:
Disuprazole (U-69167) is an orally active benzimidazole proton pump inhibitor that inhibits gastric H +/K +-ATPase with an IC50 of 2 × 10 -5 M. Disuprazole reduces gastric acid secretion by inhibiting gastric proton pump activity. Disuprazole can be used in research related to gastric acid secretion and peptic ulcer .
Cat. No.: HY-109023A
CAS No.: 955095-50-8
Target:
Research Areas:
Azeloprazole potassium is an orally active proton pump inhibitor. Azeloprazole potassium irreversibly binds to and blocks the proton pump (H +/K +-ATPase) on parietal cells, thereby inhibiting gastric acid secretion. Azeloprazole potassium is primarily metabolized by the CYP3A4 enzyme, and its pharmacokinetics and acid-suppressive effects are independent of CYP2C19 activity. Azeloprazole potassium can be used for research on acid-related diseases such as reflux esophagitis and gastroesophageal reflux disease .
Cat. No.: HY-19153A
CAS No.: 157564-11-9
Synonyms: rel-TY-11345
Target:
Research Areas:
Nepaprazole sodium (rel-TY-11345) is a proton pump H+/K+-ATPase inhibitor. Nepaprazole sodium inhibits H+/K+-ATPase activity in rabbit gastric mucosal microsomes, with IC50 values of 5.8 μM and 9.9 μM at pH 6.0 and pH 7.4, respectively, and its inhibitory activity is enhanced under weakly acidic conditions. Nepaprazole sodium inhibits basal and Tetragastrin (HY-125556)-stimulated gastric acid secretion. Nepaprazole sodium can be used in studies on gastric proton pump function, gastric acid secretion, and mechanisms related to peptic ulcers .
Cat. No.: HY-L011
2,278 compounds
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.
MCE designs a unique collection of 2,278 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.
Cat. No.: HY-109079AR
CAS No.: 1902954-87-3
Synonyms: DWP14012 hydrochloride (Standard); Fexuprazan hydrochloride (Standard)
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Abeprazan hydrochloride (Standard) is the analytical standard of Abeprazan (hydrochloride) (HY-109079A). This product is intended for research and analytical applications. Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases .
Cat. No.: HY-109079R
CAS No.: 1902954-60-2
Synonyms: DWP14012 (Standard); Fexuprazan (Standard)
Target:
Research Areas:
Abeprazan (Standard) is the analytical standard of Abeprazan (HY-109079). This product is intended for research and analytical applications. Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
