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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
124 Results for "
Proton pump
" in MedChemExpress (MCE) Product Catalog:
Products (124)
124 Results for "Proton pump" in MCE Product Catalog:
Cat. No.: HY-109079AS
Synonyms: DWP14012-d3 hydrochloride; Fexuprazan-d3 hydrochloride
Target:
Research Areas:
Abeprazan-d3 (DWP14012-d3) hydrochloride is the deuterated-labeled Abeprazan hydrochloride (HY-109079A). Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H +, K +- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.
Cat. No.: HY-P76159A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ATP6V1F; Vacuolar Proton pump Subunit F; ATPase H+ Transporting V1 Subunit F; V-ATPase 14 KDa Subunit; ATP6S14; H(+)-Transporting Two-Sector ATPase, 14kD Subunit; VATF; Adenosinetriphosphatase 14k Chain; V-Type Proton ATPase Subunit F; Vacuolar ATP Syntha
Species:
Human
Source:
E. coli
Cat. No.: HY-P76159
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP6V1F; Vacuolar Proton pump Subunit F; ATPase H+ Transporting V1 Subunit F; V-ATPase 14 KDa Subunit; ATP6S14; H(+)-Transporting Two-Sector ATPase, 14kD Subunit; VATF; Adenosinetriphosphatase 14k Chain; V-Type Proton ATPase Subunit F; Vacuolar ATP Syntha
Species:
Human
Source:
E. coli
Cat. No.: HY-W723158
CAS No.: 100992-60-7
Research Areas:
Epibestatin hydrochloride is an epimer of Bestatin (HY-B0134), a DPP4 inhibitor and protease inhibitor, with an IC50 of 17 μM against DPP4. As a stabilizer, Epibestatin hydrochloride binds to the cleft between 14-3-3 protein and plant proton pump PMA2, selectively stabilizing their interaction without affecting other 14-3-3 client proteins. Epibestatin hydrochloride triggers stomatal opening in leaf epidermis of Commelina communis. Epibestatin hydrochloride can be used in studies related to type 2 diabetes .
Cat. No.: HY-W739793
Synonyms: BY1023-d8 sodium; SKF96022-d8 sodium
Cat. No.: HY-100007R
CAS No.: 881681-00-1
Synonyms: TAK-438 free base (Standard)
Target:
Research Areas:
Vonoprazan (Standard) is the analytical standard of Vonoprazan. This product is intended for research and analytical applications. Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H +,K +-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori .
Cat. No.: HY-P812033
Synonyms: ATP6V1E1; ATPase H+ Transporting V1 Subunit E1; ATP6E2; P31; ATP6E; Vma4; ATPase, H+ Transporting, Lysosomal 31kDa, V1 Subunit E1; V-Type Proton ATPase Subunit E 1; Vacuolar Proton pump Subunit E 1; V-ATPase 31 KDa Subunit; V-ATPase Subunit E 1; ATP6V1E; ATPase, H+ Transporting, Lysosomal 31kDa, V1 Subunit E Isoform 1; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton pump) 31kD; H(+)-Transporting Two-Sector ATPase, 31kDa Subunit; H+-Transporting ATP Synthase Chain E, Vacuolar; V-ATPase Subunit E1; V-ATPase, Subunit E; ARCL2C
Cat. No.: HY-P812033A
Synonyms: ATP6V1E1; ATPase H+ Transporting V1 Subunit E1; ATP6E2; P31; ATP6E; Vma4; ATPase, H+ Transporting, Lysosomal 31kDa, V1 Subunit E1; V-Type Proton ATPase Subunit E 1; Vacuolar Proton pump Subunit E 1; V-ATPase 31 KDa Subunit; V-ATPase Subunit E 1; ATP6V1E; ATPase, H+ Transporting, Lysosomal 31kDa, V1 Subunit E Isoform 1; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton pump) 31kD; H(+)-Transporting Two-Sector ATPase, 31kDa Subunit; H+-Transporting ATP Synthase Chain E, Vacuolar; V-ATPase Subunit E1; V-ATPase, Subunit E; ARCL2C
Cat. No.: HY-100560R
CAS No.: 21293-29-8
Synonyms: (S)-(+)-Abscisic acid (Standard); ABA (Standard)
Cat. No.: HY-126751
CAS No.: 331686-58-9
Target:
Research Areas:
DBM-819 is a reversible inhibitor of H⁺/K⁺-ATPase (H +/K +-ATPase), with an IC50 value of 5 μM. DBM-819 can reversibly block gastric acid secretion by inhibiting the proton pump in the gastric mucosa. It shows significant protective effects against duodenal ulcers induced by Cysteamine (HY-77591), gastric ulcers induced by Indomethacin (HY-14397), and gastric ulcers induced by Aspirin (HY-14654), with EC50 values of 6, 3.1, and 4 mg/kg respectively. DBM-819 can be used in ulcer prevention research .
Cat. No.: HY-135111S
CAS No.: 1794759-05-9
4-Desmethoxy Omeprazole-d3 is the deuterated-labeled 4-Desmethoxy Omeprazole (HY-135111). 4-Desmethoxy Omeprazole is a metabolite of Omeprazole (HY-B0113) and an impurity in its preparation process. Omeprazole is an orally active H+,K+-ATPase inhibitor and also a proton pump inhibitor. Omeprazole competitively inhibits the activity of CYP2C19, CYP3A4, and CYP2C9. Omeprazole inhibits gastric acid secretion and can be used for the treatment of acid-related gastrointestinal disorders. Omeprazole also has neuroprotective and antibacterial effects .
Cat. No.: HY-P72099
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP6AP2; ER-Localized Type I Transmembrane Adapter; Prev. ATP6IP2; Prorenin Receptor; Renin Receptor; ELDF10; ATP6M8-9; N14F; ATPase H(+)-Transporting Lysosomal-Interacting Protein 2; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton pump) Membrane Sect
Species:
Human
Source:
E. coli
Cat. No.: HY-P72100
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP6AP2; ER-Localized Type I Transmembrane Adapter; Prev. ATP6IP2; Prorenin Receptor; Renin Receptor; ELDF10; ATP6M8-9; N14F; ATPase H(+)-Transporting Lysosomal-Interacting Protein 2; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton pump) Membrane Sect
Species:
Human
Source:
E. coli
Cat. No.: HY-135111R
CAS No.: 110374-16-8
Research Areas:
4-Desmethoxy Omeprazole Standard is the analytical standard of 4-Desmethoxy Omeprazole (HY-135111). This product is intended for research and analytical applications. 4-Desmethoxy Omeprazole is a metabolite of Omeprazole (HY-B0113) and an impurity in its preparation process. Omeprazole is an orally active H+,K+-ATPase inhibitor and also a proton pump inhibitor. Omeprazole competitively inhibits the activity of CYP2C19, CYP3A4, and CYP2C9. Omeprazole inhibits gastric acid secretion and can be used for the treatment of acid-related gastrointestinal disorders. Omeprazole also has neuroprotective and antibacterial effects .
Cat. No.: HY-109546
CAS No.: 95382-33-5
Target:
Na+/K+ ATPase Interleukin Related Proton Pump Cytochrome P450 Bacterial Apoptosis Autophagy TNF Receptor Atg8/LC3
Research Areas:
Omeprazole (H 16868) magnesium is an orally active H +,K +-ATPase inhibitor and a proton pump inhibitor. Omeprazole magnesium competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole magnesium inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole magnesium inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole magnesium alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole magnesium also has neuroprotective and antibacterial effects .
Cat. No.: HY-183390
CAS No.: 136565-26-9
Cat. No.: HY-B0113AR
CAS No.: 95510-70-6
Synonyms: H 16868 sodium (Standard)
Target:
Reference Standards Na+/K+ ATPase Interleukin Related Proton Pump Cytochrome P450 Bacterial Apoptosis Autophagy TNF Receptor Atg8/LC3
Research Areas:
Omeprazole (sodium) (Standard) is the analytical standard of Omeprazole (sodium). This product is intended for research and analytical applications. Omeprazole sodium (H 16868) is an orally active H +,K +-ATPase inhibitor and a proton pump inhibitor. Omeprazole sodium competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole sodium inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole sodium inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole sodium alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole sodium also has neuroprotective and antibacterial effects .
Cat. No.: HY-B0113R
CAS No.: 73590-58-6
Synonyms: H 16868 (Standard)
Target:
Reference Standards Na+/K+ ATPase Interleukin Related Proton Pump Cytochrome P450 Bacterial Apoptosis Autophagy TNF Receptor Atg8/LC3
Research Areas:
Omeprazole (Standard) is the analytical standard of Omeprazole. This product is intended for research and analytical applications. Omeprazole (H 16868) is an orally active H +,K +-ATPase inhibitor and a proton pump inhibitor. Omeprazole competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole also has neuroprotective and antibacterial effects .
Cat. No.: HY-B0113S4
Synonyms: H 16868-d3 sodium
Target:
Isotope-Labeled Compounds Na+/K+ ATPase Interleukin Related Proton Pump Cytochrome P450 Bacterial Apoptosis Autophagy TNF Receptor Atg8/LC3
Research Areas:
Omeprazole-d3 sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole sodium (H 16868) is an orally active H +,K +-ATPase inhibitor and a proton pump inhibitor. Omeprazole sodium competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole sodium inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole sodium inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole sodium alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole sodium also has neuroprotective and antibacterial effects .
Cat. No.: HY-187719
CAS No.: 318262-42-9
Target:
Research Areas:
NIK-12192 is an orally active inhibitor of vacuolar H +-ATPase. NIK-12192 reduces intracellular pH, decreases lysosomal volume and acidity, and alters the intracellular localization of V-ATPase by inhibiting proton pumps . NIK-12192 induces αvβ5 integrin polarization, cytoskeletal disruption, cell detachment, anoikis-mediated delayed apoptosis and necrosis, a delayed reduction in mitochondrial membrane potential, and lysosomal/phagosomal accumulation. NIK-12192 inhibits tumor cell migration, invasion, and three-dimensional spheroid growth, and enhances the activity of Topotecan (HY-13768). NIK-12192 suppresses spontaneous lung metastasis in vivo. NIK-12192 is used in research related to colon cancer, ovarian cancer, lung cancer, breast cancer, renal cancer, prostate cancer, acute myeloid leukemia, and melanoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
