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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
122 Results for "
Factor Xa
" in MedChemExpress (MCE) Product Catalog:
Products (122)
122 Results for "Factor Xa" in MCE Product Catalog:
Cat. No.: HY-100655R
CAS No.: 503612-76-8
Target:
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O-Desmethyl apixaban (Standard) is the analytical standard of O-Desmethyl apixaban. This product is intended for research and analytical applications. O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01) . Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively .
Cat. No.: HY-10779
CAS No.: 288079-93-6
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BMS-344577 (Compound 22) is a potent and orally active factor Xa inhibitor (IC50 = 4 nM, EC2xPT = 7 μM). BMS-344577 shows potent CYP3A4 inhibition activity (IC50 = 0.3 μM). BMS-344577 can be used for the research of cardiovascular disease .
Cat. No.: HY-10281
CAS No.: 209187-02-0
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YM-60828 methanesulfonate is an orally active, selective and competitive factor Xa inhibitor with a Ki of 1.3 nM and an IC50 of 2.3 nM. YM-60828 methanesulfonate inhibits thrombus formation and platelet aggregation. YM-60828 methanesulfonate can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders .
Cat. No.: HY-10722A
CAS No.: 150612-55-8
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DX-9065a free base is a selective, nonpeptidic, and orally active factor Xa (FXa) inhibitor with a Ki of 41 nM for human FXa. DX-9065a free base has low activity against other serine proteases. DX-9065a free base has strong anticoagulant actions .
Cat. No.: HY-76948R
CAS No.: 865479-71-6
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5-R-Rivaroxaban (Standard) is the analytical standard of 5-R-Rivaroxaban. This product is intended for research and analytical applications. 5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM).
Cat. No.: HY-10264C
CAS No.: 480448-29-1
Synonyms: DU-176 hydrochloride
Research Areas:
Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research .
Cat. No.: HY-125505
CAS No.: 1622159-00-5
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BI-11634 is an orally active factor Xa inhibitor and a CYP3A4 substrate. The apparent Km values for BI-11634 metabolism are 23 μM in human liver microsomes (HLMs) and 7.6 μM with recombinant CYP3A4. BI-11634 can be used for thromboembolic disease and CYP3A4-mediated drug metabolism research .
Cat. No.: HY-10780
CAS No.: 247131-79-9
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JTV-803 mesylate is a human factor Xa inhibitor with oral anticoagulant activity. JTV-803 exhibits competitive inhibition of human factor Xa, with a Ki value of 0.019μM and IC50Value is 0.081μM. JTV-803 is 100 times more selective at inhibiting human factor Xa than its comparator. JTV-803 is an effective oral anticoagulant for the prevention of thrombosis .
Cat. No.: HY-165180
CAS No.: 70005-46-8
Synonyms: Psychosine 3′-O-sulfate sodium; Psychosine 3′-sulfate sodium
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Lyso-sulfatide (bovine) sodium is a phospholipid component derived from sphingolipid catabolism and a potent factor Xa inhibitor and anticoagulant. Lyso-sulfatide (bovine) sodium binds directly to factor Xa and inhibits prothrombin activation mediated by the prothrombinase complex, thereby prolonging factor Xa-induced plasma clotting time and suppressing thrombin generation. Lyso-sulfatide (bovine) sodium serves as a reliable lipid membrane mimic for studying cell membrane structure, function, and molecular interactions .
Cat. No.: HY-184102
CAS No.: 1333126-80-9
Synonyms: TediXabanum
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Tedixaban (Tedixabanum) is a Factor Xa inhibitor and anticoagulant with an IC50 of 0.50 nM. Tedixaban is applicable to research on thrombosis-related complications.
Cat. No.: HY-17682
CAS No.: 209285-84-7
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RPR-208707 is a selective factor Xa inhibitor with a Ki of 18 nM. RPR-208707 can be used for research of thrombosis-related diseases .
Cat. No.: HY-E70544C
CAS No.: 9001-29-0
Research Areas:
Rabbit Factor X is a vitamin K-dependent plasma serine protease that is activated to generate Factor Xa. Rabbit Factor X mediates the common coagulation pathway and catalyzes the conversion of prothrombin to thrombin . Rabbit Factor X is the first enzyme to act in the common pathway of thrombosis in the coagulation cascade. Rabbit Factor X can be used in studies related to Factor X deficiency .
Cat. No.: HY-10762
CAS No.: 209285-82-5
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FXa-IN-3 (compound 1a) is a potent coagulation factor Xa (FXa) inhibitor with a Ki of 43 nM. FXa-IN-3 can be used in the research of thromboembolic diseases .
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Target:
Cat. No.: HY-137070
CAS No.: 1160170-00-2
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Rivaroxaban diol is a metabolite of Rivaroxaban (HY-50903). Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM) .
Cat. No.: HY-10268S2
Synonyms: PRT054021-13C6
Cat. No.: HY-10279
CAS No.: 179755-65-8
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Research Areas:
YM-60828 hydrochloride is an orally active, selective and competitive factor Xa inhibitor with a Ki of 1.3 nM and an IC50 of 2.3 nM. YM-60828 hydrochloride inhibits thrombus formation and platelet aggregation. YM-60828 hydrochloride can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
