Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1103 Results for "
biosynthesis
" in MedChemExpress (MCE) Product Catalog:
Products (1103)
1103 Results for "biosynthesis" in MCE Product Catalog:
Cat. No.: HY-107420R
CAS No.: 366-93-8
Research Areas:
AY 9944 (Standard) is the analytical standard of AY 9944 (HY-107420). This product is intended for research and analytical applications. AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol .
Target:
Cat. No.: HY-115736B
CAS No.: 3056945-74-2
Synonyms: 5'-XTP lithium
Target:
Research Areas:
Xanthosine-5'-triphosphate (5'-XTP) lithium is a purine nucleotide that stimulates Adenylate Cyclase to induce Cyclic AMP (cAMP) (HY-B1511) biosynthesis, binds to the AL1 allosteric site of the D137N-SAMHD1 mutant to activate dNTP triphosphohydrolase activity, and stimulates P2Y/P2U purinergic receptor-coupled phosphoinositide-specific phospholipase C with Michaelis-Menten kinetics. Xanthosine-5'-triphosphate lithium can be used for HIV-1 research .
Cat. No.: HY-117358
CAS No.: 113302-01-5
Target:
Research Areas:
KW-5805 is an orally effective anti-ulcer agent that potently inhibits gastric injury induced by various necrotizing agents. KW-5805 enhances the activity of gastric mucosal glucosamine synthetase, increases the levels of gastric adherent mucus and mucosal glycoproteins, and promotes the biosynthesis, storage and secretion of gastric mucus. KW-5805 inhibits the reduction of gastric mucosal blood volume and oxygen supply caused by hemorrhagic shock. KW-5805 suppresses the development of experimental gastric and duodenal ulcers, necrotizing agent-induced gastric mucosal injury, and induced gastric acid secretion. KW-5805 can be used in ulcer-related research .
Cat. No.: HY-125818S3
Purity: 99.0%
Synonyms: Cytidine triphosphate-13C9 dilithium; 5'-CTP-13C9 dilithium
Cat. No.: HY-125818S6
Purity: ≥97.0%
Synonyms: Cytidine triphosphate-15N3 dilithium; 5'-CTP-15N3 dilithium
Synonyms: LRCL 3794
Target:
Research Areas:
Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms .
Cat. No.: HY-160109A
CAS No.: 1334320-77-2
Target:
Research Areas:
Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research .
Cat. No.: HY-161844
CAS No.: 1794091-10-3
Target:
Research Areas:
Virapinib is a macropinocytosis inhibitor with antiviral activity. Virapinib exhibits broad-spectrum antiviral activity against SARS-CoV-2, monkeypox virus, tick-borne encephalitis virus, and Ebola pseudotyped vesicular stomatitis virus, and it enhances Dengue Virus infection. Virapinib blocks viral entry by inhibiting macropinocytosis, reduces syncytium formation in SARS-CoV-2-infected cells, and impairs cellular entry of SARS-CoV-2 variants. Virapinib upregulates the expression of genes related to sterol biosynthesis. Virapinib can be used in studies related to COVID-19, monkeypox, tick-borne encephalitis, and Ebola virus infection .
Cat. No.: HY-189346
Myosin I-IN-1 is an Antifungal agent and Myosin I inhibitor with a Kd of 0.14 μM for FgMyoI. Myosin I-IN-1 inhibits mycelial growth, sporulation, spore germination, and Deoxynivalenol (HY-N6684) biosynthesis. Myosin I-IN-1 disrupts cell wall and cell membrane integrity and induces hyphal morphological changes. Myosin I-IN-1 exhibits broad-spectrum antifungal activity against plant pathogenic fungi. Myosin I-IN-1 shows protective efficacy against Fusarium head blight in wheat and maize. Myosin I-IN-1 can be used for research on Fusarium head blight .
Research Areas:
Dimidium bromide (Standard) is the analytical standard of Dimidium bromide (HY-D0788). This product is intended for research and analytical applications. Dimidium bromide is a phenanthridine cationic fluorescent dye with trypanocidal activity and antibacterial activity. Dimidium bromide is a nucleic acid intercalating binding molecule that can bind both DNA and RNA, and its fluorescence signal is significantly enhanced upon binding; it can inhibit the biosynthesis of DNA and RNA. Dimidium bromide can stain the nucleoplasm and nucleoli of various living plant leaf cells, with a fluorescence emission peak at 600 nm under an excitation wavelength of 525 nm. Dimidium bromide can be used in fluorescence imaging-related research .
Cat. No.: HY-N6715S
Cat. No.: HY-N7101
CAS No.: 87239-81-4
Synonyms: U-76,252; CS-807
Research Areas:
Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .
Cat. No.: HY-W015940
CAS No.: 1455-77-2
Target:
Guanazole is a ribonucleotide reductase (RNR) inhibitor that blocks replicative DNA synthesis by inhibiting deoxyribonucleotide biosynthesis. Guanazole selectively inhibits DNA synthesis in rapidly proliferating tissues, induces replication stress and G2/M phase arrest in Schizosaccharomyces pombe, and exhibits myelosuppressive, immunosuppressive, and anti-L1210 leukemia activities. Guanazole does not induce DNA repair and only shows slight mutagenicity towards Salmonella typhimurium TA102. Guanazole serves as an alternative tool to Hydroxyurea (HY-B0313) for replication checkpoint studies in Schizosaccharomyces pombe. Guanazole can be applied in research related to leukemia and solid tumors .
Cat. No.: HY-W051612
CAS No.: 16900-57-5
DL-Propargylglycine hydrochloride is an irreversible and selective CSE inhibitor that blocks the biosynthesis of endogenous hydrogen sulfide. DL-Propargylglycine hydrochloride induces ROS and TGF-β1 expression. DL-Propargylglycine hydrochloride downregulates carotid ACE2 and Ang-(1-7), and elevates Ang II. DL-Propargylglycine hydrochloride upregulates ICAM-1/LFA-1, exacerbating Aspirin (HY-14654)-induced gastric mucosal injury. DL-Propargylglycine hydrochloride is used in research on diabetes-induced liver injury, diabetic nephropathy, atherosclerosis, gastric mucosal injury, hemorrhagic shock, and Streptococcus agalactiae infection .
Cat. No.: HY-W264185
CAS No.: 375394-74-4
ADSS2-IN-1 is a ADSS2 inhibitor. ADSS2-IN-1 inhibits de novo AMP biosynthesis by targeting ADSS2, downregulates AMPK activity and promotes mitophagy in drug-resistant cells. ADSS2-IN-1 alone induces mild apoptosis in acute myeloid leukemia cells, and acts synergistically with BH3 mimetics to enhance the apoptotic effect. ADSS2-IN-1 restores the sensitivity of drug-resistant acute myeloid leukemia cells and reduces disease burden in immunocompetent mouse models. ADSS2 antagonist-1 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-W653921
CAS No.: 2714417-30-6
Cat. No.: HY-113359AS2
Purity: 99.5%
Synonyms: UDP-13C9,15N2 dilithium
Synonyms: 5'-XTP trisodium solution (100 mM)
Target:
Research Areas:
Xanthosine-5'-triphosphate (5'-XTP) trisodium solution (100 mM) is a purine nucleotide that stimulates Adenylate Cyclase to induce Cyclic AMP (cAMP) (HY-B1511) biosynthesis, binds to the AL1 allosteric site of the D137N-SAMHD1 mutant to activate dNTP triphosphohydrolase activity, and stimulates P2Y/P2U purinergic receptor-coupled phosphoinositide-specific phospholipase C with Michaelis-Menten kinetics. Xanthosine-5'-triphosphate trisodium solution (100 mM) can be used for HIV-1 research .
Cat. No.: HY-12040R
CAS No.: 488832-69-5
Synonyms: STA-4783 (Standard)
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Elesclomol (Standard) is the analytical standard of Elesclomol (HY-12040). This product is intended for research and analytical applications. Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
