518-67-2
Chemical Structure
Dimidium bromide
- CAS No.: 518-67-2
- Formula:C20H18BrN3
- Molecular Weight:380.28
IUPAC Name: 3,8-diamino-5-methyl-6-phenylphenanthridin-5-ium bromide
InChIKey: MQOKYEROIFEEBH-UHFFFAOYSA-N
SMILES: NC1=CC2=[N+](C(C3=CC=CC=C3)=C4C=C(N)C=CC4=C2C=C1)C.[Br-]
Biological Activity: Dimidium bromide is a phenanthridine cationic fluorescent dye with trypanocidal activity and antibacterial activity. Dimidium bromide is a nucleic acid intercalating binding molecule that can bind both DNA and RNA, and its fluorescence signal is significantly enhanced upon binding; it can inhibit the biosynthesis of DNA and RNA. Dimidium bromide can stain the nucleoplasm and nucleoli of various living plant leaf cells, with a fluorescence emission peak at 600 nm under an excitation wavelength of 525 nm. Dimidium bromide can be used in fluorescence imaging-related research[1][2][3][4].
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Dimidium bromide | 98.64% | Dimidium bromide is a phenanthridine cationic fluorescent dye with trypanocidal activity and antibacterial activity. Dimidium bromide is a nucleic acid intercalating binding molecule that can bind both DNA and RNA, and its fluorescence signal is significantly enhanced upon binding; it can inhibit the biosynthesis of DNA and RNA. Dimidium bromide can stain the nucleoplasm and nucleoli of various living plant leaf cells, with a fluorescence emission peak at 600 nm under an excitation wavelength of 525 nm. Dimidium bromide can be used in fluorescence imaging-related research. | ||||||||||||||||||||
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Dimidium bromide (Standard) | ≥98% | Dimidium bromide (Standard) is the analytical standard of Dimidium bromide (HY-D0788). This product is intended for research and analytical applications. Dimidium bromide is a phenanthridine cationic fluorescent dye with trypanocidal activity and antibacterial activity. Dimidium bromide is a nucleic acid intercalating binding molecule that can bind both DNA and RNA, and its fluorescence signal is significantly enhanced upon binding; it can inhibit the biosynthesis of DNA and RNA. Dimidium bromide can stain the nucleoplasm and nucleoli of various living plant leaf cells, with a fluorescence emission peak at 600 nm under an excitation wavelength of 525 nm. Dimidium bromide can be used in fluorescence imaging-related research. | ||||||||||||||||||||
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References
- [1]. Hawkins SE, et al. Nuclear transplantation studies of the action of dimidium bromide on amoebae. Nature. 1969 Apr 5;222(5188):86-7.
- [2]. Watkins TI, et al. Effect of changing the quaternizing group on the trypanocidal activity of dimidium bromide. Nature. 1952 Mar 22;169(4299):506-.
- [3]. Ichikawa S, et al. Fluorescence staining of the nucleus in living plant cells using dimidium bromide. Plant biotechnology (Tokyo, Japan). 2025 Dec 25;42(4):441-448.
- [4]. Seaman A, et al. The therapeutic index of chemotherapeutic agents: the effect of nucleic acid on dimidium bromide. Journal of Applied Bacteriology. 1955 Dec;18(3):397-400.
