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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
150 Results for "
thermosensitive ionic microgels
" in MedChemExpress (MCE) Product Catalog:
Products (150)
150 Results for "thermosensitive ionic microgels" in MCE Product Catalog:
Cat. No.: HY-W099617
CAS No.: 2277-23-8
Synonyms: 1-Decanoyl-rac-glycerol
Research Areas:
2,3-Dihydroxypropyl decanoate (1-Decanoyl-rac-glycerol) is a derivative of Decanoic acid (HY-W015309) and a non-ionic surfactant, with an IC50 > 100 μM against Shp2-PTP, VHR and HePTP. 2,3-Dihydroxypropyl decanoate is found in the roots of Angelica dahurica (Baizhi). 2,3-Dihydroxypropyl decanoate acts as a component of reverse micelle systems for the encapsulation of proteins and nucleic acids .
Cat. No.: HY-W142692
CAS No.: 59122-55-3
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Oleic acid diethanolamide (OADA) is a non-ionic, biodegradable surfactant. Oleic acid diethanolamide reduces the surface tension of water, emulsifies free water in diesel fuel to form a stable emulsion, and can be loaded onto sulfonated polystyrene nanoparticles to enhance oil recovery. Oleic acid diethanolamide is one of the nematicidal secondary metabolites produced by Aspergillus flavus. Oleic acid diethanolamide can be used in studies related to biological control of root-knot nematodes, enhanced oil recovery, and diesel fuel emulsion stabilization .
Cat. No.: HY-157521
CAS No.: 3055162-52-9
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AANAT-IN-1 is an arylalkylamine N-acetyltransferase (AANAT) inhibitor with a sheep AANAT IC50 of 9.9 μM. AANAT-IN-1 binds to the active site of sheep AANAT, interacting with amino acid residues via hydrogen bonds, hydrophobic interactions, ionic interactions, and water bridges, inhibiting the enzyme's catalytic activity. AANAT-IN-1 can be used for the researches of circadian rhythm-associated neuropsychiatric conditions, seasonal affective disorder, and other diseases associated with abnormally elevated melatonin levels .
Cat. No.: HY-B2106DR
CAS No.: 9002-92-0
Synonyms: Decaethylene glycol monododecyl ether (C12E10) (Standard); Polidocanol (10) (Standard)
Cat. No.: HY-W131101
CAS No.: 26658-19-5
Cat. No.: HY-W460471
Cat. No.: HY-W777582
CAS No.: 1173019-48-1
Cat. No.: HY-186083
CAS No.: 36167-80-3
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Propylbenzilylcholine mustard (PrBCM) is an irreversible, covalently binding selective antagonist targeting rat cardiac muscarinic receptors, with a preference for muscarinic receptor subtypes that show low affinity for agonists. Propylbenzilylcholine mustard inactivates such receptors in a dose- and time-dependent manner in vitro, and its receptor selectivity remains stable across different ionic strengths and in GTP-containing buffer systems. Propylbenzilylcholine mustard can be applied to basic pharmacological studies on the structure and function of muscarinic receptors, especially focusing on the heterogeneity of cardiac muscarinic receptors and related cardiovascular pharmacological research .
Cat. No.: HY-K3120
MCE Serum/Plasma Exosome Isolation and Purification Kit (Magnetic Beads) utilizes a magnetic bead-based method for the isolation and purification of exosomes. The underlying principle is based on the charge-dependent interaction between exosomes and functional polymers on the surface of the magnetic beads under an optimized buffer system, enabling selective adsorption of exosomes. Subsequent adjustment of the ionic strength and pH of the buffer promotes the gentle dissociation of exosomes from the magnetic beads, thereby enabling efficient exosome isolation and purification while maintaining high vesicle integrity and low impurity carryover.
Cat. No.: HY-D3144
CAS No.: 2713577-11-6
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RhBIV is a thermosensitive rhodamine B (RhB)-derived fluorescent probe that fluorescently labels cellular mitochondria and detects mitochondrial temperature in vitro and in vivo. RhBIV contains a quaternized rhodamine B core, which confers a positive charge for binding to the negatively charged mitochondrial membrane, and an ortho-substituted electron-donating piperidine group; at lower temperatures, RhBIV forms an unstable ion pair form under kinetic control and exhibits strong fluorescence, whereas elevated temperature disrupts or partially interrupts the ion pair form, favoring formation of the conjugated RhBV form and leading to loss of fluorescence. RhBIV exhibits decreased fluorescence responsiveness with increasing temperature over the range of 20-42°C. RhBIV enables biological imaging of cells and mice, mitochondrial thermogenesis imaging, dynamic observation in mitochondrial thermogenesis imaging experiments, and non-invasive imaging of mitochondrial function in living animals (Ex/Em = 520/592 nm) .
Cat. No.: HY-D1739
Research Areas:
DDAO phosphate diTEA is an amphoteric surfactant derived from DDAO (dimethyldodecylamine oxide). The head group of DDAO in DDAO phosphate diTEA exists in a non-ionic state at pH > 7 and in a cationic state at pH < 5 due to protonation of the oxygen atom. When combined with the anionic surfactant SDS, DDAO can incorporate into mixed micelles, reducing the net micellar charge and attenuating electrostatic repulsion between SDS head groups. DDAO can be used to formulate the ONOO⁻-targeting probe DDAO-PN, which generates significant near-infrared fluorescence at 657 nm .
Cat. No.: HY-148140A
CAS No.: 9041-35-4
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Cross-linked dextran G 25, coarse is a cross-linked dextran gel chromatography coarse (average particle size D50 = 200-250 μm) that possesses multiple separation activities, including molecular sieve effects, weak anion exchange, and aromatic adsorption. Cross-linked dextran G 25, coarse weakly exchanges cations through immobilized terminal carboxyl groups and repels anions at low ionic strength. Cross-linked dextran G 25, coarse is used for the fractionation of low molecular weight solutes, including peptides, amino acids, nucleotide sugar derivatives, and aromatic compounds .
Cat. No.: HY-148140B
CAS No.: 9041-35-4
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Cross-linked dextran G 25, medium is a cross-linked dextran gel chromatography medium (average particle size D50 = 120-140 μm) that possesses multiple separation activities, including molecular sieve effects, weak anion exchange, and aromatic adsorption. Cross-linked dextran G 25, medium weakly exchanges cations through immobilized terminal carboxyl groups and repels anions at low ionic strength. Cross-linked dextran G 25, medium is used for the fractionation of low molecular weight solutes, including peptides, amino acids, nucleotide sugar derivatives, and aromatic compounds .
Cat. No.: HY-148140C
CAS No.: 9041-35-4
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Cross-linked dextran G 25, fine is a cross-linked dextran gel chromatography fine (average particle size D50 = 70-90 μm) that possesses multiple separation activities, including molecular sieve effects, weak anion exchange, and aromatic adsorption. Cross-linked dextran G 25, fine weakly exchanges cations through immobilized terminal carboxyl groups and repels anions at low ionic strength. Cross-linked dextran G 25, fine is used for the fractionation of low molecular weight solutes, including peptides, amino acids, nucleotide sugar derivatives, and aromatic compounds .
Cat. No.: HY-W037619
CAS No.: 487-21-8
Target:
Cat. No.: HY-W010361
CAS No.: 10581-12-1
Cat. No.: HY-W016638
CAS No.: 479500-35-1
Synonyms: 1-Butyl-1-methylpyrrolidin-1-ium chloride
Synonyms: β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin
Target:
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6A-Azido-6A-deoxy-β-cyclodextrin (β-CDN3) is a site-specifically modified β-cyclodextrin with a single azido group replacing the hydroxyl group at the C6 position. 6A-Azido-6A-deoxy-β-cyclodextrin forms a host-guest inclusion complex with Dexamethasone (HY-14648), localizing the drug within its hydrophobic cavity, which restricts the rotational mobility of the drug and places Dexamethasone in a less polar environment. 6A-Azido-6A-deoxy-β-cyclodextrin acts as a coupling agent to graft β-cyclodextrin onto thermosensitive nanogels via strain-promoted alkyne-azide cycloaddition (SPAAC). 6A-Azido-6A-deoxy-β-cyclodextrin also serves as a click chemistry reagent. It contains an azide group and undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules bearing an alkyne group. It also undergoes strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
