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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
165 Results for "
FP
" in MedChemExpress (MCE) Product Catalog:
Products (165)
165 Results for "FP" in MCE Product Catalog:
Cat. No.: HY-125837
CAS No.: 2366264-12-0
Target:
Research Areas:
MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells .
Cat. No.: HY-126911
CAS No.: 62145-07-7
Synonyms: Fluprostenol Prostaglandin D2
Target:
Research Areas:
11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.
Cat. No.: HY-126115R
CAS No.: 145773-22-4
Synonyms: 15-epi Latanoprost (Standard)
Research Areas:
15(S)-Latanoprost (Standard) is the analytical standard of 15(S)-Latanoprost. This product is intended for research and analytical applications. 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.
Cat. No.: HY-146578
CAS No.: 2769963-54-2
Target:
Research Areas:
Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with IC50s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1 .
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) (Pink: ligand for target protein (HY-138834); black: linker (HY-Y1760); Blue: E3 ligase ligand (HY-112078)) .
Cat. No.: HY-182473
CAS No.: 170552-18-8
Target:
Research Areas:
AL-6556 is a full agonist of the DP receptor and a partial agonist of the EP2 receptor. AL-6556 has an EC50 of 799 nM for bovine DP, a Ki of 3200 nM for human DP, and an EC50 of 1180 nM for human EP2, with selectivity over EP3, FP, IP, TP and 19 non-prostaglandin receptors. AL-6556 stimulates cAMP production via receptor activation and reduces intraocular pressure through aqueous humor inflow and outflow mechanisms. AL-6556 can be used in research related to ocular hypertension and glaucoma .
Cat. No.: HY-186119
Research Areas:
E3 Ligase Ligand-linker Conjugate 228 is an E3 ligase CRBN ligand-linker conjugate composed of 2-(4-(2,4-Dioxotetrahydropyrimidin-1 (2H)-yl)-3-methylphenoxy) acetic acid (HY-W733199) and a linker. E3 ligase ligand-linker conjugates can be used to synthesize degraders of PROTAC TEAD, such as KG-FP-003 (HY-186117). E3 Ligase Ligand-linker Conjugate 228 can be applied to glioblastoma research .
Cat. No.: HY-N7857
CAS No.: 64625-53-2
Synonyms: 19(R)-Hydroxy PGF2α
Category:
Target:
Research Areas:
U7D-1 is a USP7 PROTAC degrader that induces selective proteasomal degradation of USP7. U7D-1 destabilizes and downregulates the expression of variant PRC1 complex subunits PCGF1, RING1A and PCGF6, and also slightly reduces the protein level of KDM2B. U7D-1 decreases cell viability, arrests neuroblastoma cells at the G0/G1 cell cycle phase, and downregulates the expression of target genes of PAX3::FOXO1 in FP-RMS cells. U7D-1 increases the level of cleaved PARP in FP-RMS cells, induces cell apoptosis, and upregulates the expression of muscle differentiation markers MYH1 and MYF5. U7D-1 inhibits the growth and proliferation of p53 wild-type and mutant cancer cells, and regulates the apoptosis pathway and E2F pathway. U7D-1 is applicable to studies on neuroblastoma, fusion-positive rhabdomyosarcoma, p53-mutant cancers and cancer-related research .
Cat. No.: HY-19518
CAS No.: 860005-21-6
Synonyms: NCX116; LBN
Target:
Research Areas:
Latanoprostene bunod (NCX116; LBN) is a nitric oxide-releasing prostaglandin F2α analog. Latanoprostene bunod is a prodrug that, upon instillation into the eye, is hydrolyzed by corneal esterases into two active metabolites: Latanoprost (HY-B0577) and NO. Latanoprost activates the prostaglandin FP receptor to increase the outflow of aqueous humor through the uveoscleral pathway. NO increases aqueous humor drainage through the trabecular meshwork pathway, achieving synergistic enhancement targeting the dual pathways of aqueous humor outflow. Latanoprostene bunod can be used in research related to open-angle glaucoma and ocular hypertension .
Cat. No.: HY-P77251
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TMUB2; MGC3123; Transmembrane And Ubiquitin Like Domain Containing 2; Transmembrane And Ubiquitin-Like Domain Containing 2; Transmembrane And Ubiquitin-Like Domain-Containing Protein 2; FP2653
Species:
Human
Source:
HEK293
Cat. No.: HY-P704801
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SDHA; Succinate Dehydrogenase [Ubiquinone] Flavoprotein Subunit; Prev. SDH2; CMD1GG; SDHF; MC2DN1; Succinate Dehydrogenase [Ubiquinone] Flavoprotein Subunit, Mitochondrial; NDAXOA; Flavoprotein Subunit Of Complex II; PPGL5; FP; PGL5; Succinate Dehydrogena
Species:
Human
Source:
E. coli
Cat. No.: HY-184583
CAS No.: 3121876-09-0
Research Areas:
S27-1047 is a brain-penetrant, potent and selective BChE (eqBChE IC50 = 7.16 nM; hBChE IC50 = 296.10 nM) inhibitor and Nrf2 activator. S27-1047 can directly bind Keap1, disrupt Keap1-Nrf2 interaction (FP IC50 = 36.87 nM), enhance antioxidant enzyme expression and activate the GSH-GPX4 axis to inhibit Aβ-induced ferroptosis. S27-1047 can protect against oxidative stress and neuroinflammation. S27-1047 can be used in Alzheimer's disease research .
Cat. No.: HY-19518R
CAS No.: 860005-21-6
Synonyms: NCX116 (Standard); LBN (Standard)
Research Areas:
Latanoprostene bunod (NCX116; LBN) (Standard) is the analytical standard of Latanoprostene bunod. This product is intended for research and analytical applications. Latanoprostene bunod is a nitric oxide-releasing prostaglandin F2α analog. Latanoprostene bunod is a prodrug that, upon instillation into the eye, is hydrolyzed by corneal esterases into two active metabolites: Latanoprost (HY-B0577) and NO. Latanoprost activates the prostaglandin FP receptor to increase the outflow of aqueous humor through the uveoscleral pathway. NO increases aqueous humor drainage through the trabecular meshwork pathway, achieving synergistic enhancement targeting the dual pathways of aqueous humor outflow. Latanoprostene bunod can be used in research related to open-angle glaucoma and ocular hypertension.
Cat. No.: HY-116679
CAS No.: 221246-34-0
Synonyms: 17-Trifluoromethylphenyl trinor PGF2α
Target:
Research Areas:
A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.
Cat. No.: HY-P7662
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BID; Human BID Coding Sequence; BH3 Interacting Domain Death Agonist; Apoptic Death Agonist; BH3-Interacting Domain Death Agonist; Desmocollin Type 4; P22 BID; BID Isoform Si6; BH3 Interacting Domain Death Agonist Si6 Isoform; FP497
Species:
Human
Source:
E. coli
Cat. No.: HY-P701328
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BID; Human BID Coding Sequence; BH3 Interacting Domain Death Agonist; Apoptic Death Agonist; BH3-Interacting Domain Death Agonist; Desmocollin Type 4; P22 BID; BID Isoform Si6; BH3 Interacting Domain Death Agonist Si6 Isoform; FP497
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P72852
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BID; Human BID Coding Sequence; BH3 Interacting Domain Death Agonist; Apoptic Death Agonist; BH3-Interacting Domain Death Agonist; Desmocollin Type 4; P22 BID; BID Isoform Si6; BH3 Interacting Domain Death Agonist Si6 Isoform; FP497
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P76154
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: APCDD1; Adenomatosis Polyposis Coli Down-Regulated 1; APC Down-Regulated 1; Hypoptrichosis Simplex; Protein APCDD1; FP7019; B7323; HYPT1; Adenomatosis Polyposis Coli Down-Regulated 1 Protein; HHS; DRAPC1; HTS
Species:
Human
Source:
HEK293
Cat. No.: HY-P77873
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: APCDD1; Adenomatosis Polyposis Coli Down-Regulated 1; APC Down-Regulated 1; Hypoptrichosis Simplex; Protein APCDD1; FP7019; B7323; HYPT1; Adenomatosis Polyposis Coli Down-Regulated 1 Protein; HHS; DRAPC1; HTS
Species:
Mouse
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
