Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
174 Results for "
beta-sheet backbone
" in MedChemExpress (MCE) Product Catalog:
Products (174)
174 Results for "beta-sheet backbone" in MCE Product Catalog:
Cat. No.: HY-50936S
Synonyms: Ecteinascidin 743-d3; ET-743-d3
Target:
Research Areas:
Pyridin-3-ylboronic acid is a synthetic building block belonging to the pyridine boronic acid class. Pyridin-3-ylboronic acid serves as a substrate for the Suzuki-Miyaura coupling reaction to construct oligopyridine backbones. Pyridin-3-ylboronic acid also acts as a heteroaryl boronic acid in the phosphine-free Suzuki-Miyaura coupling reaction of 2-iodogalactal. Pyridin-3-ylboronic acid is applicable to research related to organic synthesis .
Synonyms: C24:1 Deoxy dihydroceramide; C24:1 DeoxyDHceramide; Cer(m18:0/24:1)
Target:
Research Areas:
C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) (C24:1 Deoxy dihydroceramide) is a lipid molecule, which is composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under the conditions of obesity and type 2 diabetes (T2D). Deoxyceramide is unable to be further metabolized to more complex sphingolipid, and is toxic when accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro .
Cat. No.: HY-154970A
Purity: 99.40%
Target:
Research Areas:
BMPR2-IN-1 TFA is a selective BMPR2 inhibitor with a human BMPR2 IC50 of 506 nM and a Kd of 83.5 nM. BMPR2-IN-1 TFA functions as an ATP mimetic, forming hydrogen bonds with the BMPR2 kinase domain backbone and hydrophobic interactions with specific residues, and demonstrates high selectivity for BMPR2 over other kinases.BMPR2-IN-1 TFA can be used for the researches of cancer, pulmonary arterial hypertension and Alzheimer’s disease .
Cat. No.: HY-177966
CAS No.: 250159-76-3
Research Areas:
ETM-305 is a degradation product of the anticancer agent ET-743 (HY-50936). ET-743 (Ecteinascidin 743; Trabectedin) is a tetrahydroisoquinoline alkaloid that binds to the minor groove of DNA, blocks the transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cell apoptosis, and increases ROS production in MCF-7 and MDA-MB-453 cells. Trabectedin is used in the research of soft tissue sarcoma and ovarian cancer .
Cat. No.: HY-P1889A
Target:
Research Areas:
Bim BH3, Peptide IV TFA is an Aβ42-binding peptide and the pro-apoptotic BH3 domain of the BIM protein. Bim BH3, Peptide IV TFA binds Aβ42 with a Kd of 7.1 μM. Bim BH3, Peptide IV TFA modulates Aβ42 structure, fibrillization pathways, aggregate morphology, and membrane interactions, inhibiting fibril formation while enhancing protofibril assembly. Bim BH3, Peptide IV TFA promotes Aβ42 β-sheet formation and accelerates aggregation. Bim BH3, Peptide IV TFA enhances Aβ42 membrane internalization and bilayer stiffening. Bim BH3, Peptide IV TFA induces neuronal cell death by enhancing BH3-induced membrane interactions of Aβ42 prefibrillar species. Bim BH3, Peptide IV TFA can be used for research on Alzheimer's disease .
Target:
Research Areas:
Glycidyl methacrylate is a bifunctional monomer containing both a polymerizable methacrylate double bond and a reactive epoxy group. Glycidyl methacrylate can be introduced into polymer backbones via free radical polymerization, and its epoxy group undergoes ring-opening reactions with nucleophilic groups such as amines, carboxylic acids and thiols, thus being used for the preparation of functional polymers, surface-grafted materials and crosslinkable biomaterials. Glycidyl methacrylate is applicable to research related to polymer chemistry, biomaterials, surface modification and drug delivery materials .
Cat. No.: HY-123558
CAS No.: 74141-69-8
Synonyms: Y 14556
Target:
Research Areas:
Bactobolin C is an antibiotic produced by Pseudomonas sp. BMG13A7, which has strong antimicrobial and antitumor activities, can also inhibit antibody production and treat autoimmune encephalomyelitis. However, its undesirable toxicity limits its medicinal application. The unique chemical structure and promising biological activities of Bactobolin C have attracted people's interest in its total synthesis and new active analogs. So far, the structural modification of Bactobolin C has mainly focused on the hydroxyl groups on the amino acid side chains and backbone.
Synonyms: 2'-Deoxy-2'-fluoro-5-Methyluridine
Target:
Research Areas:
2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine) is a nucleoside analog and hCNT inhibitor, with an IC50 of 1.1 μM against hCNT1 and an IC50 of 9.7 μM against hCNT3. 2'-Fluorothymidine undergoes phosphorylation by cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2). 2'-Fluorothymidine acts as a backbone stabilizer in oligonucleotide synthesis and can also form radiolabeled candidates. 2'-Fluorothymidine is applicable in tumor-related research .
Cat. No.: HY-139283
CAS No.: 1246298-58-7
Synonyms: C24:1(15Z) 1-Deoxyceramide; C24:1 Ceramide (m18:1/24:1(15Z)); Cer(m18:1/24:1(15Z))
Target:
Research Areas:
C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) (C24:1(15Z) 1-Deoxyceramide) is a lipid molecule, which is composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under the conditions of obesity and type 2 diabetes (T2D). Deoxyceramide is unable to be further metabolized to more complex sphingolipid, and is toxic when accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro .
Target:
Research Areas:
Lactosylceramide (bovine buttermilk) (LacCer (bovine buttermilk)) is a natural lactosylceramide (LacCer) mixture derived from bovine buttermilk, belonging to neutral glycosphingolipids, and composed of a lactose polar head group and a ceramide backbone. LacCer is an important component of cell membrane glycosphingolipids and is associated with processes such as signal transduction, cell recognition, cell adhesion, and cell growth. LacCer derived from bovine buttermilk contains multiple molecular species composed of different long-chain bases and fatty acyl groups. Lactosylceramide (bovine buttermilk) can be used for research related to lactosylceramide and glycosphingolipids .
Cat. No.: HY-135629
CAS No.: 1383376-93-9
Target:
Research Areas:
PF-5236216 is a brain-penetrant CK1δ/CK1ε inhibitor with IC50 values of 8 and 36 nM. PF-5236216 inhibits CK1δ and CK1ε-mediated PER3 nuclear translocation. PF-5236216 forms an H-bond with the backbone NH of Leu85, hydrophobic stacking with Met82, and a water-mediated H-bond with Lys38 of CK1δ. PF-5236216 can be used as a tool ligand for CNS PET studies .
Cat. No.: HY-149545
CAS No.: 214038-32-1
Synonyms: 1,3-Dipalmitoyl-2-docosahexaenoyl glycerol
Research Areas:
1,3-Palmitin-2-docosahexaenoin (1,3-Dipalmitoyl-2-docosahexaenoyl glycerol) is the isomer of triacylglycerol (TAG), in which docosahexaenoic acid (DHA) is located at the β position (sn-2) of the glycerol backbone. 1,3-Palmitin-2-docosahexaenoin inhibits fatty acid synthase and cholesterol metabolism enzymes, activates carnitine palmitoyltransferase (CPT) in liver mitochondria and promotes β-oxidation of fatty acids. 1,3-Palmitin-2-docosahexaenoin exhibits lipid metabolism regulating activity .
Cat. No.: HY-188138
Target:
Research Areas:
BP1002 is an antisense oligonucleotide targeting BCL-2. BP1002 silences BCL-2 expression by targeting the translation initiation site of Bcl-2 mRNA. Its backbone carries ethoxy modifications, which confer nuclease resistance, reduce off-target effects, and lower toxicity. BP1002 prolongs survival in non-Hodgkin's lymphoma xenograft models. BP1002 can be used in studies of acute myeloid leukemia, aggressive non-Hodgkin's lymphoma, and Venetoclax (HY-15531)-resistant hematological malignancies .
Cat. No.: HY-W1061685
Target:
Research Areas:
Dithiol Serinol Phosphoramidite is a phosphoramidite reagent for dithiol modification of oligonucleotides. Dithiol Serinol Phosphoramidite contains a serinol linker arm, which keeps the dithiol groups away from the phosphate backbone and allows the sequential introduction of multiple Dithiol Serinol units without the need for additional spacer arm phosphoramidites. Dithiol Serinol Phosphoramidite can be incorporated into oligonucleotides via standard oligonucleotide synthesis and deprotection procedures, and can be introduced sequentially multiple times without adding intermediate spacer arms. Dithiol Serinol Phosphoramidite can be used to prepare multi-dithiol modified oligonucleotides and for surface functionalization studies of gold nanoparticles (AuNPs) .
Cat. No.: HY-128710R
CAS No.: 122799-38-6
Synonyms: 2'-Deoxy-2'-fluoro-5-Methyluridine (Standard)
Research Areas:
2'-Fluorothymidine (Standard) is the analytical standard of 2'-Fluorothymidine. This product is intended for research and analytical applications. 2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine) is a nucleoside analog and hCNT inhibitor, with an IC50 of 1.1 μM against hCNT1 and an IC50 of 9.7 μM against hCNT3. 2'-Fluorothymidine undergoes phosphorylation by cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2). 2'-Fluorothymidine acts as a backbone stabilizer in oligonucleotide synthesis and can also form radiolabeled candidates. 2'-Fluorothymidine is applicable in tumor-related research.
Cat. No.: HY-140661
Purity: ≥95.0%
Target:
Research Areas:
Azide-PEG2000-amine is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. Azide-PEG2000-amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems. Azide-PEG2000-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-140662
Target:
Research Areas:
Azide-PEG3500-amine is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. Azide-PEG3500-amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems. Azide-PEG3500-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-140663
Purity: ≥95.0%
Target:
Research Areas:
Azide-PEG5000-amine is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. Azide-PEG5000-amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems. Azide-PEG5000-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-D3099
CAS No.: 3078752-74-3
Target:
Research Areas:
CSMPP is a ratiometric lysosomal pH fluorescent probe with aggregation-induced emission (AIE) properties, which is used for real-time quantitative detection of lysosomal pH changes in living cells and in vivo. CSMPP has a cyanodistyrene backbone, and contains N-methylpiperazine and pyridine groups (pH-responsive); protonation of the pyridine group significantly enhances intramolecular charge transfer (ICT), leading to green fluorescence emission (Ex/Em = 405/503 nm) under neutral/basic conditions and red fluorescence emission (Ex/Em = 405/615 nm) under acidic conditions. CSMPP exhibits high selectivity, reversibility, good biocompatibility and excellent photostability .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
