Search Result

Results for "

α1 adrenoceptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (20) Adrenergic Receptor (149) Akt (3) Chloride Channel (1) Cholinesterase (ChE) (3) Dopamine Receptor (13) Drug Derivative (1) Drug Metabolite (3) Endogenous Metabolite (6) Epigenetic Reader Domain (1) FOXO (1) GABA Receptor (3) GHSR (1) Histamine Receptor (1) Isotope-Labeled Compounds (16) mAChR (3) Parasite (3) Phosphodiesterase (PDE) (1) Reference Standards (29) Ribosomal S6 Kinase (RSK) (1) Serotonin Transporter (1) STAT (6)
By Research Areas:	Cancer (29) Cardiovascular Disease (74) Endocrinology (79) Infection (2) Inflammation/Immunology (6) Metabolic Disease (24) Neurological Disease (43)

By Targets:

5-HT Receptor (20)

Adrenergic Receptor (149)

Akt (3)

Chloride Channel (1)

Cholinesterase (ChE) (3)

Dopamine Receptor (13)

Drug Derivative (1)

Drug Metabolite (3)

Endogenous Metabolite (6)

Epigenetic Reader Domain (1)

FOXO (1)

GABA Receptor (3)

GHSR (1)

Histamine Receptor (1)

Isotope-Labeled Compounds (16)

mAChR (3)

Parasite (3)

Phosphodiesterase (PDE) (1)

Reference Standards (29)

Ribosomal S6 Kinase (RSK) (1)

Serotonin Transporter (1)

STAT (6)

By Research Areas:

Cancer (29)

Cardiovascular Disease (74)

Endocrinology (79)

Infection (2)

Inflammation/Immunology (6)

Metabolic Disease (24)

Neurological Disease (43)

161

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0769

Phenylephrine Maximum Cited Publications 34 Publications Verification (R)-(-)-Phenylephrine; L-Phenylephrine	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
(R)-(-)-Phenylephrine is a selective *α₁-adrenoceptor* agonist primarily used as a decongestant.

HY-B0471

Phenylephrine hydrochloride Maximum Cited Publications 34 Publications Verification (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
(R)-(-)-Phenylephrine hydrochloride is a selective *α₁-adrenoceptor* agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-17034A

Dexmedetomidine hydrochloride 25+ Cited Publications (+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride	Adrenergic Receptor	Infection Cancer
Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of *α2-adrenoceptor, with a K_i* of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects .

HY-12719

Dexmedetomidine 25+ Cited Publications (+)-Medetomidine; (S)-Medetomidine	Adrenergic Receptor	Neurological Disease Cancer
Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of *α2-adrenoceptor, with a K_i* of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects .

HY-12987

Pimozide 5+ Cited Publications R6238	Dopamine Receptor Adrenergic Receptor STAT Parasite	Neurological Disease Endocrinology Cancer
Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at *α1-adrenoceptor, with a K_i* of 39 nM; Pimozide also inhibits STAT3 and STAT5.

HY-15746

Dobutamine hydrochloride 5 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Dobutamine hydrochloride is a synthetic catecholamine that acts on **α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors)*. Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR* and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .

HY-N1919

Ajmalicine 2 Publications Verification Raubasine	Adrenergic Receptor Cholinesterase (ChE)	Neurological Disease Endocrinology
Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks *α₁-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor* full inhibitor, with an IC₅₀ of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity .

HY-B0371F

Terazosin hydrochloride 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease Endocrinology
Terazosin hydrochloride is a quinazoline derivative and a competitive and orally active *α1-adrenoceptor* antagonist. Terazosin hydrochloride works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-100672

SR59230A 10+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC₅₀s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively .

HY-B0192

Alfuzosin 1 Publications Verification SL 77499	Adrenergic Receptor	Endocrinology
Alfuzosin (SL 77499-10) is an orally active, selective and competitive *α1-adrenoceptor* antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH) .

HY-103200

SR59230A hydrochloride 10+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC₅₀s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively .

HY-15746A

Dobutamine 5 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Dobutamine is a synthetic catecholamine that acts on **α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors)*. Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR* and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion .

HY-B0354A

Urapidil hydrochloride	5-HT Receptor Adrenergic Receptor	Cardiovascular Disease Infection Neurological Disease Metabolic Disease
Urapidil hydrochloride is an orally active and blood-brain barrier permeability *α1-adrenoceptor* antagonist and 5-HT_1A receptor agonist with a pIC₅₀ of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect .

HY-114794

Desglymidodrine ST 1059	Adrenergic Receptor Drug Metabolite	Cardiovascular Disease
Desglymidodrine (ST 1059), the active metabolite of Midodrine(HY-12749), is a selective *α₁-adrenoceptor* agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure .

HY-B0371

Terazosin 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease Endocrinology
Terazosin is a quinazoline derivative and a competitive and orally active *α1-adrenoceptor* antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-B0371A

Terazosin hydrochloride dihydrate 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease Endocrinology
Terazosin hydrochloride dihydrate is a quinazoline derivative and a competitive and orally active *α1-adrenoceptor* antagonist. Terazosin hydrochloride dihydrate works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride dihydrate has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-B1658A

Frovatriptan succinate hydrate (R)-Frovatriptan succinate hydrate; SB 209509 succinate hydrate; VML 251 succinate hydrate	5-HT Receptor	Neurological Disease
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate) is a potent, high affinity, selective and orally active 5-HT_1B (pK₅₀ of 8.2) and 5-HT_1D receptor agonist. Frovatriptan succinate hydrate exhibits >10-fold selectivity for 5-HT_1B and 5-HT_1D over 5-HT_1A, 5-HT_1F, and 5-HT₇ and >1000-fold selectivity over other 5-HT, dopamine, histamine H₁, and α1-adrenoceptor. Frovatriptan succinate hydrate has the potential for migraine research .

HY-B0192A

Alfuzosin hydrochloride 1 Publications Verification SL 77499-10	Adrenergic Receptor	Endocrinology
Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive *α1-adrenoceptor* antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH) .

HY-14903

Ulimorelin TZP-101	GHSR Adrenergic Receptor	Metabolic Disease
Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC₅₀ of 29 nM and a K_i of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at *α1-adrenoceptors*. Ulimorelin stimulates intestinal motility and is used for malnutrition .

HY-100991

FG 7142 ZK 39106; LSU-65	GABA Receptor	Neurological Disease
FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (K_i=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC₅₀= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex .

HY-203894

Carpipramine Defekton	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Carpipramine (Defekton) is an antipsychotic agent that belongs to the iminodibenzyl class. Carpipramine is a potent dopamine antagonist which blocks *alpha 1-* and alpha 2-adrenoceptors. Carpipramine also has antagonist properties with respect to serotonin (5-ΗΤ2) receptors. Carpipramine exhibits antipsychotic and anti-depressant effects. Carpipramine can be used for the research of neurological disease, such as post-traumatic stress disorder (PTSD) and depression .

HY-N6969

Dicentrine	Adrenergic Receptor	Endocrinology
Dicentrine is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an *α₁-adrenoceptor* antagonist which has effective against human hyperplastic prostates .

HY-D1606

BODIPY FL prazosin	Adrenergic Receptor	Metabolic Disease
BODIPY FL prazosin is a fluorescent *α1-adrenergic* antagonist with K_i values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes .

HY-B0769R

Phenylephrine (Standard) (R)-(-)-Phenylephrine (Standard); L-Phenylephrine (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Phenylephrine (Standard) is the analytical standard of Phenylephrine. This product is intended for research and analytical applications. (R)-(-)-Phenylephrine is a selective *α₁-adrenoceptor* agonist primarily used as a decongestant.

HY-106612

Abanoquil U-K52046; Albanoquil	Adrenergic Receptor	Cardiovascular Disease
Abanoquil (U-K52046), an potent and selective **α-1 adrenoceptor** antagonist, is an anti-arrhythmic agent. Abanoquil can be used for erectile dysfunction research .

HY-17034AR

Dexmedetomidine hydrochloride (Standard) (+)-Medetomidine hydrochloride (Standard); (S)-Medetomidine hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Dexmedetomidine (hydrochloride) (Standard) is the analytical standard of Dexmedetomidine (hydrochloride). This product is intended for research and analytical applications. Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of *α2-adrenoceptor, with a K_i* of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects .

HY-12719R

Dexmedetomidine (Standard) (+)-Medetomidine (Standard); (S)-Medetomidine (Standard)	Reference Standards Adrenergic Receptor	Neurological Disease Cancer
Dexmedetomidine (Standard) is the analytical standard of Dexmedetomidine. This product is intended for research and analytical applications. Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of *α2-adrenoceptor, with a K_i* of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects .

HY-106954

Upidosin Rec 15/2739; Recordati 15/2739; SB 216469	Adrenergic Receptor	Inflammation/Immunology
Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a K_b value of 2-3 nM higher than in ear artery and aorta with a K_b value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction .

HY-U00399A

Fiduxosin hydrochloride ABT 980	Adrenergic Receptor	Endocrinology
Fiduxosin hydrochloride (ABT 980) is a potent *α1-adrenoceptor* antagonist, with K_i of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively .

HY-B0371B

(R)-Terazosin	Adrenergic Receptor	Endocrinology
(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent *α1-adrenoceptor* antagonist with K_i values of 6.51 nM, 1.01 nM and 1.97 nM for *α1a, α1b* and *α1d-adrenoceptor*, respectively .

HY-135552

Benoxathian hydrochloride	Adrenergic Receptor	Endocrinology
Benoxathian hydrochloride is a potent α1 adrenoceptor antagonist, can be used for researching anorexia .

HY-B0471R

Phenylephrine hydrochloride (Standard) (R)-(-)-Phenylephrine hydrochloride (Standard); L-Phenylephrine hydrochloride (Standard)	Reference Standards Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Phenylephrine (hydrochloride) (Standard) is the analytical standard of Phenylephrine (hydrochloride). This product is intended for research and analytical applications. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-118335

Prazobind SZL 49	Adrenergic Receptor	Cardiovascular Disease
Prazobind (SZL 49), a prazosin analog, is an irreversible *α1-adrenoceptor* antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC₅₀ of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure .

HY-12987R

Pimozide (Standard) R6238 (Standard)	Reference Standards Dopamine Receptor Adrenergic Receptor STAT Parasite	Neurological Disease Endocrinology Cancer
Pimozide (Standard) is the analytical standard of Pimozide. This product is intended for research and analytical applications. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at *α1-adrenoceptor, with a K_i* of 39 nM; Pimozide also inhibits STAT3 and STAT5.

HY-100672B

(2R)-SR59230A	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
(2R)-SR59230A is the isomer of SR59230A (HY-100672), and can be used as an experimental control. SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC₅₀s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively .

HY-B0354AR

Urapidil hydrochloride (Standard)	Reference Standards 5-HT Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
Urapidil (hydrochloride) (Standard) is the analytical standard of Urapidil (hydrochloride). This product is intended for research and analytical applications. Urapidil hydrochloride is an orally active *α1-adrenoceptor* antagonist and 5-HT_1A receptor agonist with a pIC₅₀ of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect .

HY-U00399

Fiduxosin	Adrenergic Receptor	Endocrinology
Fiduxosin is a potent *α1-adrenoceptor* antagonist, with K_i of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively.

HY-136935

Alloyohimbine	Adrenergic Receptor	Endocrinology
Alloyohimbine, an alkaloid, is a selective *α2-adrenoceptor* antagonist with K_Dα1, K_Dα2 of 0.28 μM and 0.006 μM, respectively .

HY-U00365

5-HT2 antagonist 1	5-HT Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity.

HY-B0371S

Terazosin-d8	Isotope-Labeled Compounds Adrenergic Receptor	Metabolic Disease Endocrinology
Terazosin-d₈ is deuterium labeled Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-19268

GG-818 GW 1818	Adrenergic Receptor	Metabolic Disease
GG-818 (GW 1818) is a potent and selective α1 adrenoceptor antagonist, with pK_i values of 9.7 for *α1_a, 7.8 for α1_b, and 7.6 for α1_d*. GG-818 (GW 1818) can be used for benign prostatic hyperplasia research .

HY-B0471S

Phenylephrine-d3 hydrochloride (R)-(-)-Phenylephrine-d3 hydrochloride; L-Phenylephrine-d3 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-U00333

*α1 adrenoceptor-MO-1*	Adrenergic Receptor	Neurological Disease Endocrinology
α1 adrenoceptor-MO-1, an S enantiomer, has affinity at alpha 1 adrenergic receptor, shows alphalytic activity, and possesses analgesic action; more active than R enantiomer.

HY-B0471S1

Phenylephrine-2,4,6-d3 hydrochloride (R)-(-)-Phenylephrine-2,4,6-d3 hydrochloride; L-Phenylephrine-2,4,6-d3 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-2,4,6-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-17034AS

Dexmedetomidine-13C,d3 hydrochloride (+)-Medetomidine-13C,d3 hydrochloride; (S)-Medetomidine-13C,d3 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Dexmedetomidine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a K_i of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects .

HY-17019

SL-89.0591	Adrenergic Receptor	Inflammation/Immunology
SL-89.0591 is a uroselective *α1-adrenoceptor* antagonist. SL-89.0591 exhibits a more potent blocking effect on urethral receptors than on vascular receptors in anesthetized rabbits, with a lower risk of orthostatic hypotension. SL-89.0591 can be used in research related to benign prostatic hyperplasia .

HY-B0192AR

Alfuzosin hydrochloride (Standard) SL 77499-10 (Standard)	Reference Standards Adrenergic Receptor	Endocrinology
Alfuzosin (hydrochloride) (Standard) is the analytical standard of Alfuzosin (hydrochloride). This product is intended for research and analytical applications. Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH) .

HY-12987S

Pimozide-d4 R6238-d₄	Dopamine Receptor Adrenergic Receptor STAT	Neurological Disease Endocrinology Cancer
Pimozide-d₄ is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits STAT3 and STAT5 .

HY-12987S1

Pimozide-d5 N-Oxide	Isotope-Labeled Compounds Dopamine Receptor Adrenergic Receptor STAT	Neurological Disease Endocrinology Cancer
Pimozide-d₅ N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5 .

HY-N1919R

Ajmalicine (Standard) Raubasine (Standard)	Reference Standards Adrenergic Receptor Cholinesterase (ChE)	Neurological Disease Endocrinology
Ajmalicine (Standard) is the analytical standard of Ajmalicine. This product is intended for research and analytical applications. Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity .

Cat. No.	Product Name	Target	Research Area

HY-P1442

AdTx1	Adrenergic Receptor	Cancer
AdTx1 is a selective *α1A-adrenoceptor* antagonist (K_i: 0.35 nM). AdTx1 can be used for research of benign prostatic hyperplasia .

HY-P5846

Muscarinic toxin 3 MT3	mAChR Adrenergic Receptor	Neurological Disease
Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and *adrenoceptors* antagonist with pIC₅₀s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M₁, M₄, α_1A, α_1B, α_1D,α_2A,α_2B and α_2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0471

Phenylephrine hydrochloride Maximum Cited Publications 34 Publications Verification (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Cardiovascular Disease Alkaloids Monophenols Classification of Application Fields Other Alkaloids Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
(R)-(-)-Phenylephrine hydrochloride is a selective *α₁-adrenoceptor* agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-N1919

Ajmalicine 2 Publications Verification Raubasine	Iridoids Classification of Application Fields Terpenoids Rosaceae Plants Disease Research Fields Endocrinology Source Classification Rosa multifoloraThunb	Adrenergic Receptor Cholinesterase (ChE)
Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks *α₁-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor* full inhibitor, with an IC₅₀ of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity .

HY-B0371

Terazosin 5+ Cited Publications	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Terazosin is a quinazoline derivative and a competitive and orally active *α1-adrenoceptor* antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-N6969

Dicentrine	Alkaloids Structural Classification Classification of Application Fields Stephania epigaea Lo Plants Isoquinoline Alkaloids Menispermaceae Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor
Dicentrine is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an *α₁-adrenoceptor* antagonist which has effective against human hyperplastic prostates .

HY-B0471R

Phenylephrine hydrochloride (Standard) (R)-(-)-Phenylephrine hydrochloride (Standard); L-Phenylephrine hydrochloride (Standard)	Structural Classification Alkaloids Monophenols Other Alkaloids Phenols Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Endogenous Metabolite
Phenylephrine (hydrochloride) (Standard) is the analytical standard of Phenylephrine (hydrochloride). This product is intended for research and analytical applications. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-136935

Alloyohimbine	Apocynaceae Alkaloids Alstonia scholaris (L.) R. Br. Plants Indole Alkaloids Source Classification	Adrenergic Receptor
Alloyohimbine, an alkaloid, is a selective *α2-adrenoceptor* antagonist with K_Dα1, K_Dα2 of 0.28 μM and 0.006 μM, respectively .

HY-N1919R

Ajmalicine (Standard) Raubasine (Standard)	Structural Classification Iridoids Terpenoids Rosaceae Plants Source Classification Rosa multifoloraThunb	Reference Standards Adrenergic Receptor Cholinesterase (ChE)
Ajmalicine (Standard) is the analytical standard of Ajmalicine. This product is intended for research and analytical applications. Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity .

HY-N1919A

Ajmalicine hydrochloride Raubasine hydrochloride	Alkaloids Rosaceae Plants Source Classification Rosa multifoloraThunb	Adrenergic Receptor Cholinesterase (ChE)
Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks *α₁-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor* full inhibitor, with an IC₅₀ of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity .

Cat. No.	Product Name	Chemical Structure

HY-B0371S

Terazosin-d8
Terazosin-d₈ is deuterium labeled Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-B0471S

Phenylephrine-d3 hydrochloride
Phenylephrine-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S1

Phenylephrine-2,4,6-d3 hydrochloride
Phenylephrine-2,4,6-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-17034AS

Dexmedetomidine-13C,d3 hydrochloride

Dexmedetomidine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a K_i of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects .

HY-12987S

Pimozide-d4
Pimozide-d₄ is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits STAT3 and STAT5 .

HY-12987S1

Pimozide-d5 N-Oxide
Pimozide-d₅ N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5 .

HY-B0471S3

Phenylephrine-d6 hydrochloride
Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S2

(S)-Phenylephrine-d6 hydrochloride
(S)-Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-15746S

(rac)-Dobutamine-d4 hydrochloride

(rac)-Dobutamine-d₄ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .

HY-15746S1

(rac)-Dobutamine-d6 hydrochloride

(rac)-Dobutamine-d₆ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .

HY-B0192S

Alfuzosin-d7
Alfuzosin-d₇ is the deuterium labeled Alfuzosin . Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH) .

HY-118335S

Prazobind-d8

Prazobind-d₈ (SZL 49-d₈) is the deuterium labeled Prazobind (HY-118335). Prazobind, a prazosin analog, is an irreversible α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC₅₀ of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure.

HY-12987S2

Pimozide-d4-1
Pimozide-d₄-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits STAT3 and STAT5 .

HY-B0192S3

Alfuzosin-d6
Alfuzosin-d₆ (SL 77499-d₆) is deuterium labeled Alfuzosin. Alfuzosin (SL 77499-10) is an orally active, selective and competitive *α1-adrenoceptor* antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH) .

HY-B0192S3A

Alfuzosin hydrochloride-d6

Alfuzosin (hydrochloride)-d₆ (SL 77499-10-d₆) is deuterium labeled Alfuzosin (hydrochloride). Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH) .

HY-W704363

Pimozide-d5
Pimozide-d₅ (R6238-d₅) is the deuterium labeled Pimozide (HY-12987). Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.

HY-B1658BS

Frovatriptan-d3 succinate

Frovatriptan-d₃ (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research .

HY-B0391S1

Naftopidil-d5
Naftopidil-d₅ is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia .

HY-B0391S2

Naftopidil-d7
Naftopidil-d₇ (KT-611-d₇ ) is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective *alpha1-adrenoceptor* antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia .

HY-B0702S

Nicergoline-13C,d3
Nicergoline- ¹³C,d₃ is the ¹³C- and deuterium labeled Nicergoline. Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α1A-adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease .

HY-W743952

Nicergoline-d3
Nicergoline-d₃ is the deuterium labeled Nicergoline (HY-B0702). Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α1A-adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks