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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
E3 ligase Ligand 2
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "E3 ligase Ligand 2" in MCE Product Catalog:
Synonyms: VHL Ligand 2; E3 ligase Ligand 1A
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(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
Cat. No.: HY-42424
CAS No.: 1948273-03-7
Synonyms: VHL Ligand 2 hydrochloride; E3 ligase Ligand 1
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(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
Synonyms: Cereblon Ligand 2; E3 ligase Ligand 2
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Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs .
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(S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 (HY-112078). (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTACs .
Cat. No.: HY-42424A
CAS No.: 2504950-56-3
Synonyms: VHL Ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride
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(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
Cat. No.: HY-128809
CAS No.: 2357114-70-4
Synonyms: E3 ligase Ligand 11
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cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER.
Cat. No.: HY-171862
CAS No.: 3066896-28-1
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Nef ligand-2 is a binder of Nef. Nef ligand-2 is Ligands for E3 Ligase. Nef ligand-2 is the Nef Binder portion of FC-14369 (HY-171860) .
Cat. No.: HY-174878
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BCL-xL ligand 2 is a ligand for BCL-xL. BCL-xL ligand 2 can be conjugated with E3 ligase Ligand (HY-138793) and linker to synthesize Bcl-xL PROTAC degrader PZ671 (HY-174876) .
Cat. No.: HY-174410
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PDE4 ligand 2 is a CRBN E3 ligase ligand. PDE4 ligand 2 can be used to synthesize PROTAC such as PDE4 degrader-1 (HY-174405). PDE4 ligand 2 can be studied in research for autoimmune and anti-inflammatory diseases .
Cat. No.: HY-176124
CAS No.: 3030281-30-9
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CDK2 ligand-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). CDK2 ligand-2 combined with E3 Ligase Ligand-linker Conjugate 184 (HY-176125) can be used to synthesize PROTAC degrader (CDK2 degrader 2 (HY-163815)) .
Cat. No.: HY-103596R
CAS No.: 5054-59-1
Synonyms: Cereblon Ligand 2 (Standard); E3 ligase Ligand 2 (Standard)
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Thalidomide-4-OH (Standard) is the analytical standard of Thalidomide-4-OH (HY-103596). This product is intended for research and analytical applications. Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs .
Cat. No.: HY-176045
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LC3B ligand 2 is a ligand for E3 ubiquitin ligase. LC3B ligand 2 can be connected to the ligand for protein by a linker to form PROTAC PCSK9 autophagic degrader 2 (HY-176043). PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .
Cat. No.: HY-161960
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EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958) .
Cat. No.: HY-179299
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POI ligand-2-NH-C10H20-NH-Boc is a target protein ligand linker conjugate that contains a GPX4 ligand (HY-179294) and a PROTAC linker (HY-W047688), which can recruit E3 ligases. POI ligand-2-NH-C10H20-NH-Boc can be used for synthesis of PROTAC GPX4 degrader-5 (HY-178925) .
Cat. No.: HY-176125
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E3 Ligase Ligand-linker Conjugate 184 is a E3 Ligase Ligand-Linker Conjugates, consisting of CDK2 ligand-2 (HY-176124) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 184 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete CDK2 degrader 2 (HY-163815) .
Cat. No.: HY-163217
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PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
Cat. No.: HY-175890
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DDB1 ligand-2 is an E3 ligase ligand. DDB1 ligand-2 can be coupled with BRD4 ligand JQ-1 carboxylic acid (HY-78695) via the linker NH2-C5-NH-Boc (HY-W004710) to form PROTAC MM-02-08 (HY-161167) .
Cat. No.: HY-176046
CAS No.: 3081572-35-9
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E3 Ligase Ligand-linker Conjugate 183 is an E3 ligase ligand-linker conjugate of PCSK9 autophagic degrader 2 (HY-176043). E3 Ligase Ligand-linker Conjugate 183 consists of LC3B ligand 2 (HY-176045) and the corresponding linker (HY-141373) .
Cat. No.: HY-182017
CAS No.: 3060178-60-8
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ATR ligand 2 (Compound 26) is a ATR PROTAC ligand. ATR ligand 2 can be conjugated with E3 ligase Ligand (HY-W077589A) and linker to synthesize PROTAC ATR degrader-3 (HY-182016) .
Cat. No.: HY-W288798
CAS No.: 24044-52-8
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DCAF11 ligand 2 is an E3 ligase ligand that can be used in the recruitment of DCAF11. DCAF11 ligand 2 can be connected to the BRD4 ligand (HY-78695) by a linker to synthesis of PROTAC BRD4 degrader LGF308 (HY-181756) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
