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Results for "

E3 ligase Ligand 2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E3 Ligase Ligand-Linker Conjugates (5) Ligands for E3 Ligase (8) Target Protein Ligand-Linker Conjugates (3) Apoptosis (2) ATM/ATR (2) Autophagy (2) Bcl-2 Family (1) BCL6 (1) DNA/RNA Synthesis (1) Epigenetic Reader Domain (2) Glutathione Peroxidase (1) Histone Acetyltransferase (1) HIV (1) Ligands for Target Protein for PROTAC (6) MDM-2/p53 (1) PROTACs (6) Reference Standards (1) SARS-CoV (1) Virus Protease (1) WDR5 (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (1)

By Targets:

E3 Ligase Ligand-Linker Conjugates (5)

Ligands for E3 Ligase (8)

Target Protein Ligand-Linker Conjugates (3)

Apoptosis (2)

ATM/ATR (2)

Autophagy (2)

Bcl-2 Family (1)

BCL6 (1)

DNA/RNA Synthesis (1)

Epigenetic Reader Domain (2)

Glutathione Peroxidase (1)

Histone Acetyltransferase (1)

HIV (1)

Ligands for Target Protein for PROTAC (6)

MDM-2/p53 (1)

PROTACs (6)

Reference Standards (1)

SARS-CoV (1)

Virus Protease (1)

WDR5 (1)

By Research Areas:

Cancer (21)

Cardiovascular Disease (1)

Infection (2)

Inflammation/Immunology (1)

Targets Recommended: E3 Ligase Ligand-Linker Conjugates Ligands for E3 Ligase E1/E2/E3 Enzyme Target Protein Ligand-Linker Conjugates PD-1/PD-L1 ByeTAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112078

(S,R,S)-AHPC-Me VHL Ligand 2; E3 ligase Ligand 1A	Ligands for E3 Ligase	Cancer
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC₅₀ <1 nM .

HY-42424

(S,R,S)-AHPC-Me hydrochloride VHL Ligand 2 hydrochloride; E3 ligase Ligand 1	Ligands for E3 Ligase	Cancer
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC₅₀ <1 nM .

HY-103596

Thalidomide-4-OH Cereblon Ligand 2; E3 ligase Ligand 2	Ligands for E3 Ligase Autophagy Apoptosis	Cancer
Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs .

HY-139218

(S,R,S)-AHPC-Me-C6-NH2	E3 Ligase Ligand-Linker Conjugates	Others
(S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 (HY-112078). (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTACs .

HY-42424A

(S,R,S)-AHPC-Me dihydrochloride VHL Ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride	Ligands for E3 Ligase	Cancer
(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC₅₀ <1 nM .

HY-128809

cIAP1 ligand 2 E3 ligase Ligand 11	Ligands for E3 Ligase	Cancer
cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER.

HY-128840

PROTAC MDM2 Degrader-1	PROTACs MDM-2/p53	Cancer
PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand 2 (HY-128836); Black: Linker (HY-128844); Blue: E3 ligase Ligand 15 (HY-128836))

HY-161989

DZ-837	PROTACs BCL6	Cancer
DZ-837 (compound 3d) is a PROTAC targeting BCL6 with a DC50 of approximately 600 nM. DZ-837 can induce cell cycle arrest and exert synergistic anticancer effects with Ibrutinib (HY-10997). DZ-837 is composed of PROTAC target protein ligand BCL6 ligand-2 (HY-161990) (red part), E3 ubiquitin ligase ligand Thalidomide-4-OH (HY-103596) (blue part), and PROTAC Linker (HY-W245803) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-hydroxyethoxy)ethyl)amino)isoindoline-1,3-dione (HY-W924949) ^{[1] ^.}

HY-171862

Nef ligand-2	HIV Ligands for Target Protein for PROTAC	Infection
Nef ligand-2 is a binder of Nef. Nef ligand-2 is **Ligands for E3 Ligase*. Nef ligand-2* is the Nef Binder portion of FC-14369 (HY-171860) .

HY-174878

BCL-xL ligand 2	Ligands for Target Protein for PROTAC Bcl-2 Family	Cancer
BCL-xL ligand 2 is a ligand for BCL-xL. BCL-xL ligand 2 can be conjugated with E3 ligase Ligand (HY-138793) and linker to synthesize Bcl-xL PROTAC degrader PZ671 (HY-174876) .

HY-174410

PDE4 ligand 2	Ligands for Target Protein for PROTAC	Inflammation/Immunology
PDE4 ligand 2 is a CRBN E3 ligase ligand. PDE4 ligand 2 can be used to synthesize PROTAC such as PDE4 degrader-1 (HY-174405). PDE4 ligand 2 can be studied in research for autoimmune and anti-inflammatory diseases .

HY-161958

dCE-2	PROTACs Histone Acetyltransferase	Cancer
dCE-2 (compound 5) is a PROTAC targeting CREB binding protein (CBP) and E1A-associated protein (EP300), which was developed based on the crystal structure of bromodomain (BRD) inhibitors. dCE-2 is composed of E3 ubiquitin ligase ligand Thalidomide-4-OH (HY-103596) (blue part), PROTAC Linker tert-Butyl 11-aminoundecanoate (HY-130715) (black part) and PROTAC target protein ligand EP300/CBP ligand 2 (HY-161960) (red part), of which the target protein ligand activity control is EP300/CBP ligand 1 (HY-161959), and the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-NH-C10-Boc (HY-161961) ^{[1] ^.}

HY-176124

CDK2 ligand-2	Ligands for Target Protein for PROTAC	Cancer
CDK2 ligand-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). CDK2 ligand-2 combined with E3 Ligase Ligand-linker Conjugate 184 (HY-176125) can be used to synthesize PROTAC degrader (CDK2 degrader 2 (HY-163815)) .

HY-168487

PROTAC WDR5 degrader 1	DNA/RNA Synthesis PROTACs WDR5	Others
PROTAC WDR5 degrader 1 (compound 8g) is a PROTAC degrader targeting WDR5. PROTAC WDR5 degrader 1 is composed of a target protein ligand (red part) WDR5 ligand 2 (HY-168488), a VHL-type E3 ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and a PROTAC linker (balck part) 5-Aminovaleric acid (HY-W015878), in which the VHL ligand and the PROTAC linker form a conjugate (HY-114176A) .

HY-103596R

Thalidomide-4-OH (Standard) Cereblon Ligand 2 (Standard); E3 ligase Ligand 2 (Standard)	Ligands for E3 Ligase Autophagy Apoptosis Reference Standards	Cancer
Thalidomide-4-OH (Standard) is the analytical standard of Thalidomide-4-OH (HY-103596). This product is intended for research and analytical applications. Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs .

HY-176045

LC3B ligand 2	Ligands for E3 Ligase	Cardiovascular Disease Cancer
LC3B ligand 2 is a **ligand for E3 ubiquitin ligase*. LC3B ligand 2* can be connected to the ligand for protein by a linker to form PROTAC PCSK9 autophagic degrader 2 (HY-176043). PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

HY-161960

EP300/CBP ligand 2	Ligands for Target Protein for PROTAC Epigenetic Reader Domain	Cancer
EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958) .

HY-176125

*E3 Ligase* Ligand-linker Conjugate 184**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 184 is a *E3 Ligase* Ligand-Linker Conjugates*, consisting of CDK2 ligand-2* (HY-176124) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 184 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete CDK2 degrader 2 (HY-163815) .

HY-179299

POI ligand-2-NH-C10H20-NH-Boc	Target Protein Ligand-Linker Conjugates Glutathione Peroxidase	Cancer
POI ligand-2-NH-C10H20-NH-Boc is a *target protein ligand* linker conjugate that contains a GPX4** ligand (HY-179294) and a PROTAC linker (HY-W047688), which can recruit E3 ligases. POI ligand-2-NH-C10H20-NH-Boc can be used for synthesis of PROTAC GPX4 degrader-5 (HY-178925) .

HY-163217

PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc is a *conjugate of E3 ligase* ligand and linker*, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand* that recruits VHL proteins. PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162815

PROTAC SMARCA2/4-degrader-26	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-26 (compound 6) is a PROTAC targeting SMARCA2/4. SMARCA2 and SMARCA4 are genes and cancer targets with complementary functions that catalyze nucleosome movement. PROTAC SMARCA2/4-degrader-25 is composed of PROTAC target protein ligand 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid (HY-46618) (red part), E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248) (blue part), PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140) (black part), and the conjugate composed of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845) ^{[1] ^.}

HY-161789

PROTAC SARS-CoV-2 Mpro degrader-3	PROTACs SARS-CoV Virus Protease	Infection
PROTAC SARS-CoV-2 Mpro degrader-3 (Compound P2) exhibits antiviral activity through the degradation of the main protease (Mpro) of human coronaviruses (HCoVs) (DC₅₀=27 μM). PROTAC SARS-CoV-2 Mpro degrader-3 inhibits the viral replication, with EC₅₀ of 4.6 μM, 4.6 μM, and 0.71 μM, for human coronaviruses HCoV-229E, HCoV-OC43 and SARS-CoV-2, respectively. (Pink: ligand for target protein Mpro ligand 2 (HY-161791); Black: linker (HY-161792); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) .

HY-176046

*E3 Ligase* Ligand-linker Conjugate 183**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 183 is an E3 ligase ligand-linker conjugate of PCSK9 autophagic degrader 2 (HY-176043). E3 Ligase Ligand-linker Conjugate 183 consists of LC3B ligand 2 (HY-176045) and the corresponding linker (HY-141373) .

HY-182017

ATR ligand 2	Ligands for Target Protein for PROTAC ATM/ATR	Others
ATR ligand 2 (Compound 26) is a ATR PROTAC ligand. ATR ligand 2 can be conjugated with E3 ligase Ligand (HY-W077589A) and linker to synthesize PROTAC ATR degrader-3 (HY-182016) .

HY-W288798

DCAF11 ligand 2	Ligands for E3 Ligase	Cancer
DCAF11 ligand 2 is an E3 ligase ligand that can be used in the recruitment of DCAF11. DCAF11 ligand 2 can be connected to the BRD4 ligand (HY-78695) by a linker to synthesis of PROTAC BRD4 degrader LGF308 (HY-181756) .

HY-179515

FAK ligand-2-C6-amine	Target Protein Ligand-Linker Conjugates	Cancer
FAK ligand-2-C6-amine is a *target protein ligand* linker conjugate** that contains a FAK ligand (HY-151010) and a PROTAC linker (HY-W011561), which can recruit E3 ligases. FAK ligand-2-C6-amine can be used for synthesis of BSJ-04-146 (HY-179512) .

HY-182018

ATR ligand 2-CO-Ph-COOH	Target Protein Ligand-Linker Conjugates ATM/ATR	Others
ATR ligand 2-CO-Ph-COOH (Compound 39) is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for ATR (HY-182017) and a PROTAC linker, which recruits E3 ligases. can be used for synthesis of PROTAC ATR degrader-3 (HY-182016) .

HY-W937057

(S,R,S)-AHPC-Me-10-bromodecanoic acid	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Me-10-bromodecanoic acid is an *E3 ligase* ligand-linker conjugate** that incorporates a VHL ligand 2 (HY-112078) and linker 10-bromoheptanoic acid. (S,R,S)-AHPC-Me-10-bromodecanoic acid can be used for synthesis of PROTAC PI3Kδ degrader-1 (HY-176239) .

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