24 Results for "

19S

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "19S" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P1259A
Target:  

Proteasome Bacterial

Research Areas:  

Inflammation/Immunology

PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .
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Cat. No.: HY-B1184A
CAS No.: 70989-04-7
Synonyms: (+)-Mephenytoin
Target:  

Cytochrome P450

Research Areas:  

Neurological Disease

(S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism .
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Cat. No.: HY-B1184AR
CAS No.: 70989-04-7
Synonyms: (+)-Mephenytoin (Standard)
Research Areas:  

Neurological Disease

(S)-Mephenytoin (Standard) is the analytical standard of (S)-Mephenytoin. This product is intended for research and analytical applications. (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism .
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Cat. No.: HY-159808
CAS No.: 875165-39-2
Target:  

Proteasome

Research Areas:  

Cancer

TCL1 is a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit in the 19S regulatory particle (19S RP) of the proteasome with an IC50 value of approximately 26 μM. TCL1 interferes with the recognition and transport of ubiquitinated proteins by Rpn-13, inhibits the degradation of proteins by the proteasome, and thus affects the balance of intracellular protein metabolism. TCL1 is promising for research of hematological malignancies .
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Cat. No.: HY-118332
CAS No.: 115461-39-7
Research Areas:  

Cardiovascular Disease

19(R)-HETE is a vasodilator in renal arteries, whereas 19(S)-HETE was relatively inactive .
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Cat. No.: HY-P1259
CAS No.: 139637-11-9
Target:  

Proteasome Bacterial

Research Areas:  

Inflammation/Immunology

PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .
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Cat. No.: HY-N13334
CAS No.: 85372-70-9
5,19-Epoxy-19S,25-dimethoxycucurbita-6,23-dien-3-ol is a natural product .
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Cat. No.: HY-N13704
CAS No.: 874287-87-3
(19S,23E)-5β,19-Epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol is an active compound.
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Cat. No.: HY-N13530
CAS No.: 1616120-83-2
(19S,23S)-5B,19-Epoxy-19,23-Dimethoxycucurbita-6,24-Dien-3B-Ol is a natural product .
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Cat. No.: HY-N13541
CAS No.: 1474062-47-9
(19S,23R)-5β,19-Epoxy-19,23-dimethoxycucurbita-6,24-dien-3β-ol is a natural product .
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Cat. No.: HY-142972
CAS No.: 115461-40-0
Research Areas:  

Cardiovascular Disease

19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels .
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Cat. No.: HY-157690
CAS No.: 2460392-58-7
Target:  

Drug Metabolite

Research Areas:  

Others

19(S),20(R)-EDP is an epoxidized metabolite of docosahexaenoic acid (HY-B2167) .
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Cat. No.: HY-N1610
CAS No.: 16790-93-5
Synonyms: 20-Hydroxyconopharyngine
Target:  

Others

Research Areas:  

Others

19(S)-Hydroxyconopharyngine (20-Hydroxyconopharyngine) is a natural product that can be isolated from Tabernaemontana bovina .
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Cat. No.: HY-181495
CAS No.: 2375455-53-9
RAJQ14 is a BRD4 PROTAC-like CAP-TAC (Proteasome Cap Targeting Chimeras) degrader. RAJQ14 binds to 19S proteasome cap subunits RPN1, RPN10, RPN13, and USP14 to recruit target proteins to the proteasome for ubiquitination-independent, proteasome-dependent degradation. RAJQ14 can be used for the research of cancer (Pink: BRD4 Ligand (HY-181496); Blue: Proteasome Ligand (HY-128978); Black: Linker).
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Cat. No.: HY-184563S
CAS No.: 3086790-98-6
(2S,10S,19S)-Amine-(CO-CH2-N-Me)9-CO-CH2-CH(NH-CO-CH2-CH2-2-piperidone-tetrahydropyran-pyrimidine-SO2-cyclopentane)-(CO-NH-CH2)2-CO-NH-CH(CH2-benzene)-(CO-NH-CH2)2-O-CH(cyclopropane)-COOH-7-MAD-MDCPT-d2 is the deuterium labeled (2S,10S,19S)-Amine-(CO-CH2-N-Me)9-CO-CH2-CH(NH-CO-CH2-CH2-2-piperidone-tetrahydropyran-pyrimidine-SO2-cyclopentane)-(CO-NH-CH2)2-CO-NH-CH(CH2-benzene)-(CO-NH-CH2)2-O-CH(cyclopropane)-COOH-7-MAD-MDCPT.
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Cat. No.: HY-CE00318
Synonyms: (S)-3-Hydroxy-19-methyleicosanoyl-coenzyme A
Research Areas:  

Metabolic Disease

(S)-3-Hydroxy-19-methyleicosanoyl-CoA ((S)-3-Hydroxy-19-methyleicosanoyl-coenzyme A) is a coenzyme A derivative.
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Cat. No.: HY-P0184
CAS No.: 1002295-95-5
Target:  

NO Synthase

Research Areas:  

Neurological Disease

Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase .
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Cat. No.: HY-P0184A
Target:  

NO Synthase

Research Areas:  

Neurological Disease

Camstatin TFA, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase .
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Cat. No.: HY-157690A
CAS No.: 2242542-60-3
Target:  

Drug Metabolite

Research Areas:  

Others

19(R),20(S)-EDP (compound 19(S),20(R)-2a) is an oxylipin and a metabolite of docosahexaenoic acid (HY-B2167) .
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Cat. No.: HY-181499
CAS No.: 2375455-68-6
Target:  

Proteasome

Research Areas:  

Cancer

RA190-PEG1-NH2 (Compound S16), RA190 (HY-100739) derivative, is a Proteasome ligand. RA190-PEG1-NH2 can be used to synthesis FKBP12 CAP-TAC degrader RAFKBP12 (HY-181498) .
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