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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
135 Results for "
ACP
" in MedChemExpress (MCE) Product Catalog:
Products (135)
135 Results for "ACP" in MCE Product Catalog:
36
Target:
Domaines de recherche:
Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL). Acalabrutinib can be used for CLL research . Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
12
Target:
Domaines de recherche:
Pimavanserin is a selective, brain-penetrant, inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
12
12 Cited Publications
Synonyms: ACP-103 hemitartrate
Target:
Domaines de recherche:
Pimavanserin (ACP-103) hemitartrate is a potent and brain-penetrant5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.
6
6 Cited Publications
Target:
Domaines de recherche:
ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively.
2
Domaines de recherche:
Diethyl phthalate is an orally active plasticizer and detergent base. Diethyl phthalate increases the activities of ACP, ALP, SDH, and ALT in liver, muscle, or both tissues. Diethyl phthalate induces dose-dependent mortality and sluggish behavior in freshwater fish. Diethyl phthalate may induce male reproductive toxicity. Diethyl phthalate is added to plastic polymers to help maintain their flexibility .
1
1 Cited Publications
Target:
Domaines de recherche:
ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM .
1
1 Cited Publications
Target:
Domaines de recherche:
APOL1-IN-1 is a natural product antibiotic and selective FabF inhibitor discovered in Streptomyces platensis. Platensimycin exhibits IC50 values of 48 nM and 160 nM against Staphylococcus aureus and Escherichia coli FabF, respectively. Platensimycin preferentially recognizes the acyl-enzyme conformation of FabF, occupies the malonyl-binding subsite, and competes with malonyl-ACP, thereby inhibiting bacterial fatty acid elongation. Platensimycin is useful for research on bacterial fatty acid biosynthesis and Gram-positive bacterial infections .
1
1 Cited Publications
Diazaborine is an inhibitor for enoyl-acyl carrier protein (enoyl ACP) in an NAD+-dependent manner. Diazaborine exhibits antibacterial activity, MIC for E. coli and K. pneumoniae is 25 and 3.12 μg/mL .
1
1 Cited Publications
Cat. No.: HY-P71828
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MCAT; Malonyl-CoA-Acyl Carrier Protein Transacylase, Mitochondrial; Malonyl-CoA-Acyl Carrier Protein Transacylase; Malonyl CoA:ACP Acyltransferase (Mitochondrial); MCT; Mitochondrial Malonyl CoA:ACP Acyltransferase; MT; [Acyl-Carrier-Protein] S-Malonyltra
Species:
Staphylococcus aureus
Source:
P. pastoris
1
Cat. No.: HY-175023A
Target:
Domaines de recherche:
OncoACP3 TFA is a small-molecule ligand of prostatic acid phosphatase (ACP3) with an IC50 of 0.30 nM. OncoACP3 TFA has a modular structure that supports flexible payload delivery. After radiolabeling with Lu-177 it selectively accumulates in ACP3-expressing tumors with a long retention time, enabling targeted radiation delivery. OncoACP3 TFA is applicable to research related to prostate cancer .
Cat. No.: HY-176567
CAS No.: 3084148-32-0
Target:
Domaines de recherche:
ACP3 ligand 1 is a ligand of Acid Phosphatase 3 (ACP3, ACPP). ACP3 ligand 1 interacts with ACP3 expressed on the surface of tumor cells for in vivo pharmaco-delivery applications .
Cat. No.: HY-W040256
CAS No.: 9001-77-8
Synonyms: ACP
Target:
Cat. No.: HY-W008689
CAS No.: 88574-06-5
Synonyms: N-Fmoc-6-Aminohexanoic acid
Cat. No.: HY-P1743
CAS No.: 66851-75-0
Target:
Domaines de recherche:
Cat. No.: HY-175023
CAS No.: 3084147-81-6
Target:
Domaines de recherche:
OncoACP3 is a small-molecule ligand of prostatic acid phosphatase (ACP3) with an IC50 of 0.30 nM. OncoACP3 has a modular structure that supports flexible payload delivery. After radiolabeling with Lu-177 it selectively accumulates in ACP3-expressing tumors with a long retention time, enabling targeted radiation delivery. OncoACP3 is applicable to research related to prostate cancer .
Category:
Metabolic Disease Lipids Plants Myristica fragrans Houtt. Endogenous metabolite Disease Research Fields Myristicaceae Extract
Target:
Cat. No.: HY-P11111
CAS No.: 1501983-51-2
Target:
Domaines de recherche:
Cat. No.: HY-17600S
CAS No.: 2699608-18-7
Synonyms: ACP-196-d4
Cat. No.: HY-P10277
CAS No.: 2222514-07-8
Synonyms: Transcon PTH; ACP-014
Target:
Domaines de recherche:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
