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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
AHPs
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "AHPs" in MCE Product Catalog:
41
Category:
Alkaloids Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae
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5
5 Cited Publications
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(-)-Bicuculline methobromide is a potent GABAA blocker. (-)-Bicuculline methobromide alters membrane properties and firing pattern. (-)-Bicuculline methobromide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca 2+ -activated K + channels. (-)-Bicuculline methobromide facilitates burst firing via blocking apamin-sensitive Ca 2+ -activated K + current .
1
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Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran can be used for the research of acute hepatic porphyria (AHP) .
1
1 Cited Publications
Synonyms: ALN-AS1 sodium
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Givosiran (ALN-AS1) sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran sodium demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran sodium can be used for the research of acute hepatic porphyria (AHP) .
Cat. No.: HY-W997836
CAS No.: 74923-08-3
Synonyms: 4-AHP
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4-Amino-3-hydroxyphenylalanine dihydrochloride (4-AHP) is a photodegradation product of eumelanin. 4-Amino-3-hydroxyphenylalanine dihydrochloride can be used to investigate the development of cutaneous melanoma and age-related macular degeneration .
Cat. No.: HY-121914
CAS No.: 66774-02-5
Synonyms: o-Chlorotriphenylmethanol
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(2-Chlorophenyl)diphenylmethanol (UCL 1880) is an analog of the metabolite 2-chlorophen-diphenyl-methanol (CBM) of 2-chlorophenyl, The IC50 for sI(AHP) inhibition is 1-2 μM. (2-chlorophenyl)diphenylmethanol is a weak Ca 2+ channel blocker .
Category:
Alkaloids Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae
Target:
Cat. No.: HY-100783A
CAS No.: 53552-05-9
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Research Areas:
(+)-Bicuculline methobromide is a potent GABAA blocker. (+)-Bicuculline methobromide alters membrane properties and firing pattern. (+)-Bicuculline methobromide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca 2+ -activated K + channels. (+)-Bicuculline methobromide facilitates burst firing via blocking apamin-sensitive Ca 2+ -activated K + current .
Cat. No.: HY-P2033
CAS No.: 185980-89-6
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Cat. No.: HY-121914R
CAS No.: 66774-02-5
Synonyms: o-Chlorotriphenylmethanol (Standard)
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Research Areas:
(2-Chlorophenyl)diphenylmethanol (Standard) is the analytical standard of (2-Chlorophenyl)diphenylmethanol. This product is intended for research and analytical applications. (2-Chlorophenyl)diphenylmethanol (UCL 1880) is an analog of the metabolite 2-chlorophen-diphenyl-methanol (CBM) of 2-chlorophenyl, The IC50 for sI(AHP) inhibition is 1-2 μM. (2-chlorophenyl)diphenylmethanol is a weak Ca2+ channel blocker .
Cat. No.: HY-N13115
CAS No.: 35931-54-5
Synonyms: (Z)-Protoescigenin 21-tiglate
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Cat. No.: HY-N13115A
CAS No.: 7047-43-0
Synonyms: (E)-21-Angeloyl-protoaescigenin
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
