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AK

" in MedChemExpress (MCE) Product Catalog:

127

Inhibitors & Agonists

1

Peptides

22

Inhibitory Antibodies

2

Natural
Products

12

Recombinant Proteins

31

Antibodies

1

Click Chemistry

43

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169179

    PROTACs STAT Cancer
    AK-1690 is a selective PROTAC degrader targeting STAT6 (DC50=1 nM) with a Ki of 6 nM against human STAT6. AK-1690 degrades STAT6 via the interaction of STAT6 with cereblon and a ubiquitin-like process. AK-1690 effectively depletes STAT6 protein in mouse liver and lung tissues, and is applicable to research related to leukemia, Hodgkin's lymphoma, follicular lymphoma, etc. .
    AK-1690
  • HY-P99675
    Ivonescimab
    1 Publications Verification

    AK112

    PD-1/PD-L1 VEGFR Cancer
    Ivonescimab (AK112) is a PD-1/VEGF bispecific antibody. Ivonescimab competitively inhibiting PD-1/PD-L1 interaction, reversing the immunosuppression mediated by it, and blocks the binding of VEGF-A to VEGFR2, inhibiting tumour angiogenesis in the tumour microenvironment. Ivonescimab also has significantly anticancer activity against EGFR-mutated locally advanced or metastatic non-squamous non-small cell lung cancer (NSCL) .
    Ivonescimab
  • HY-114258
    LY3295668
    3 Publications Verification

    AK-01

    Aurora Kinase Apoptosis Cancer
    LY3295668 (AK-01) is a highly specific and orally active inhibitor of Aurora-A kinase with a Ki values for AurA and AurB of 0.8 nM and 1038 nM respectively. LY3295668 can effectively inhibit the autophosphorylation of AurA, induce mitotic arrest and apoptosis. LY3295668 avoids the formation of polyploids related to AurB inhibition. LY3295668 can be used for the study of small cell lung cancer .
    LY3295668
  • HY-119240
    CCT020312
    Maximum Cited Publications
    39 Publications Verification

    PERK Autophagy Neurological Disease Cancer
    CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells.
    CCT020312
  • HY-P99117
    Cadonilimab
    1 Publications Verification

    AK104

    PD-1/PD-L1 CTLA-4 Inflammation/Immunology Cancer
    Cadonilimab (AK104) is a humanized tetravalent IgG1 bispecific antibody targeting PD1/CTLA4. Cadonilimab blocks both PD-1 and CTLA-4 pathways, thereby relieving their corresponding immunosuppressive effects and reversing tumor specific T cell exhaustion. Cadonilimab significantly downregulates Fc-mediated effector functions, including antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement dependent cytotoxicity (CDC). Cadonilimab can be used for research of metastatic cervical cancer, as well as other malignancies such as gastric cancer, GEJ adenocarcinoma and non-small cell lung cancer (NSCLC) .
    Cadonilimab
  • HY-148813
    AK-2292
    2 Publications Verification

    PROTACs STAT Cancer
    AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC50 of 0.10 μM. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models . AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    AK-2292
  • HY-P99706
    Ligufalimab
    1 Publications Verification

    AK 117

    CD47 Interleukin Related Cancer
    Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity .
    Ligufalimab
  • HY-109142
    Ziresovir
    5 Publications Verification

    AK0529; RO-0529

    RSV Infection
    Ziresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC50=3 nM) and highlights pharmacokinetics in animal species .
    Ziresovir
  • HY-169182

    Ligands for Target Protein for PROTAC STAT Cancer
    AK-068 is a high-affinity and selective STAT6 ligand, with a Ki of 6 nM. AK-068 demonstrates at least >150- and >85-fold binding selectivity over STAT5A (Ki >1 μM) and STAT5B (Ki >500 μM) proteins, respectively. AK-068 is a ligand for target protein for PROTAC, can be used for synthesis of PROTACs .
    AK-068
  • HY-16691
    AK-7
    5+ Cited Publications

    Sirtuin Neurological Disease
    AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor, with an IC50 of 15.5 μM.
    AK-7
  • HY-P991636

    Transmembrane Glycoprotein Inflammation/Immunology
    AK006 is a humanized IgG1 monoclonal antibody agonist targeting Sialic acid-binding immunoglobulin-like lectin6 (Siglec-6). AK006 potently inhibits IgE-mediated human mast cell activation. AK006 can be used for inflammatory diseases like chronic urticaria (CU) and asthma research .
    AK006
  • HY-P99371

    AK002; Antolimab

    Apoptosis Inflammation/Immunology
    Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .
    Lirentelimab
  • HY-17450A

    AK602 hydrochloride; GSK-873140 hydrochloride; GW-873140 hydrochloride

    CCR HIV Infection
    Aplaviroc (AK 602) hydrochloride, a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
    Aplaviroc hydrochloride
  • HY-101465

    Sirtuin Neurological Disease
    AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.
    AK-1
  • HY-162563

    STING Inflammation/Immunology Cancer
    AK59 is a STING degrader that works by leveraging HERC4, a hect domain E3 ligase. AK59 can be used in the study of autoimmune diseases and cancer .
    AK59
  • HY-P99108
    Penpulimab
    1 Publications Verification

    AK-105

    PD-1/PD-L1 Inflammation/Immunology Cancer
    Penpulimab is an IgG1 backbone anti-PD-1 monoclonal antibody with antitumor activities .
    Penpulimab
  • HY-148327

    Adenosine Kinase Cardiovascular Disease Neurological Disease Inflammation/Immunology
    AK-IN-1 (compound 4072-2732) is an adenosine kinase (AK) inhibitor that is competitive for adenosine (Ado) but not for ATP. AK-IN-1 inhibits 86%, 87% and 89% of AK activity at concentrations of 2, 4 and 10 µM, respectively. AK-IN-1 has good potential for research in many disease areas, including ischaemia, inflammation and seizures .
    AK-IN-1
  • HY-144707

    Apoptosis VEGFR MMP PTEN Cancer
    AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. AK-778-XXMU inhibits the ID2-KDR signaling axis, thereby down-regulating the downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), and up-regulating the tumor suppressor factor (PTEN). AK-778-XXMU can be used for the study of glioma .
    AK-778-XXMU
  • HY-P99652

    AK 111

    Interleukin Related Inflammation/Immunology
    Gumokimab (AK 111) is a monoclonal antibody targeting IL-17A, which can be used in the study of psoriasis, ankylosing spondylitis. Gumokimab competitively blocks the binding of human IL-17A to IL-17R.
    Gumokimab
  • HY-160851

    AK3287; AKEX0011

    ASK1 p38 MAPK Inflammation/Immunology
    GDC-3280 (AK3287; AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673)'s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects .
    GDC-3280
  • HY-P99865

    AK-119

    CD73 Others
    Dresbuxelimab (AK-119) is an IgG-κ monoclonal antibody targeting CD73. The expression system is usually CHO (Chinese Hamster Ovary) cells .
    Dresbuxelimab
  • HY-P99724

    AK120

    Interleukin Related Inflammation/Immunology
    Manfidokimab (AK120) is an anti-interleukin 4 receptor alpha (IL-4Rα) IgG4 monoclonal antibody .
    Manfidokimab
  • HY-W004643

    AK-II

    Fungal Herbicide Infection
    Akardite II (AK-II) is a stabilizer for nitrocellulose (NC) propellants as it scavenges NOx. Akardite II helps control a variety of plant pathogens and weeds, which can be used as fungicides and herbicides .
    Akardite II
  • HY-119378

    CX 295

    Proteasome Apoptosis Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
    AK 295 (CX 295) is a selective calpain inhibitor. AK 295 can inhibit apoptosis through a calpain-dependent pathway. AK 295 shows potent neuroprotective effect. AK 295 can inhibit the activity of the cysteine protease calpain and reduce myocardial injury. AK 295 can be used for the researches of infection, inflammation, cardiovascular and neurological disease, such as stroke and viral myocarditis .
    AK 295
  • HY-W459522

    PROTAC Linkers Cancer
    7-Bromohept-1-yne is a PROTAC linker that can be used to synthesize AK-1690 (HY-169179) .
    7-Bromohept-1-yne
  • HY-RS00505

    Small Interfering RNA (siRNA) Others

    AK1 Human Pre-designed siRNA Set A contains three designed siRNAs for AK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AK1 Human Pre-designed siRNA Set A
    AK1 Human Pre-designed siRNA Set A
  • HY-17450

    AK 602; GSK 873140; GW 873140

    CCR HIV Infection Endocrinology
    Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
    Aplaviroc
  • HY-127110

    Phospholipase Others Neurological Disease Inflammation/Immunology
    AK106-001616 is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) (IC50=3.8 nmol/L). AK106-001616 is able to reduce the production of prostaglandins (PG) E2 and leukotrienes (LT) B4 by stimulated cells. AK106-001616 can be used in the study of inflammatory diseases, neuropathic pain and pulmonary fibrosis .
    AK106-001616
  • HY-P991050

    AK-1967

    Dipeptidyl Peptidase Inflammation/Immunology
    Procizumab (AK-1967) is a humanized IgG1 antibody that targets dipeptidyl peptidase 3 (DPP3). Procizumab has the potential for the study of sepsis. The isotype control for Procizumab can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
    Procizumab
  • HY-P99871

    AK102

    PCSK9 Others
    Ebronucimab (AK102) is an IgG1-λ2 antibody targeting PCSK9 and is primarily expressed by CHO DG44 (Chinese Hamster Ovary) cells .
    Ebronucimab
  • HY-17616

    LEO 43204

    Drug Metabolite Others
    Ingenol disoxate (LEO 43204) is a drug metabolite, that exhibits potential in ameliorating actinic keratosis .
    Ingenol disoxate
  • HY-165363

    Drug Derivative Lactate Dehydrogenase ATP Synthase Cardiovascular Disease
    AK-135 hydrochloride is a Menadione (HY-B0332) derivative. AK-135 hydrochloride restores the electron flow in defective respiratory chain systems. AK-135 hydrochloride decreases LDH release, increases the amount of ATP. AK-135 hydrochloride has a protective effect against myocardial injury .
    AK-135 hydrochloride
  • HY-119131

    Proteasome Neurological Disease
    AK 275, a calpain inhibitor, exhibits neuroprotection activity. AK 275 can be used in the study for central nervous system trauma and ischemia .
    AK 275
  • HY-118674

    Calcium Channel Cardiovascular Disease
    AK-2-38, a Nifedipine (HY-B0284) analogue, is a calcium channel antagonist. AK-2-38 also has partial agonist effects on isolated guinea pig left atrium .
    AK-2-38
  • HY-169926

    Mitochondrial Metabolism Cancer
    AK-4 is a glucose-lowering agent, acting function as a mitochondrial uncoupler .
    AK-4
  • HY-164374

    PAK Cancer
    AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways .
    AK963/40708899
  • HY-P991071

    Transmembrane Glycoprotein Inflammation/Immunology
    AK-001 is a fully human IgG1 antibody that targets Siglec-8. VRC-01 can be used for the study of chronic rhinosinusitis with nasal polyps. The isotype control for AK-001 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
    AK-001
  • HY-168461

    Bacterial Infection
    AK-968-11563024 is an inhibitor of marine V. vulnificus NAT [ (VIBVN)NAT] with an IC50 of 18.86 µM. NATs (Arylamine N-acetyltransferases) in marine V. vulnificus plays a role in drug metabolism, contributing to the development of drug resistance. Therefore, AK-968-11563024 can be utilized in research related to drug resistance .
    AK-968-11563024
  • HY-169180

    Ligands for Target Protein for PROTAC STAT Cancer
    AK-068-OH (Compound 49) is an active control of ligand for target protein for PROTAC (HY-169179) .
    AK-068-OH
  • HY-167897

    Histamine Receptor Neurological Disease
    UR-AK49 (compound 11) is a human histamine H1 and H2 receptor agonist. UR-AK49 has an EC50 of 23 nM in a GTPase assay with hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 can be used in neuro-related research .
    UR-AK49
  • HY-157389

    Bcr-Abl Cancer
    AK-HW-90 (compound 2B) is a potent panBcr-Abl inhibitor with significant inhibitory activity against Imatinib (HY-15463)-resistant mutants. AK-HW-90 inhibits the resistance mutant Bcr-Abl T315I with an IC50 of 0.65 nM. AK-HW-90 has potential anticancer activity and can be used in the study of chronic myelogenous leukemia (CML) .
    AK-HW-90
  • HY-122191

    Others Infection
    AK-Toxin II is a phytotoxic metabolite that can be isolated from culture broth of alternaria alternata Japanese pear pathotype. AK-Toxin II induces characteristic veinal necrosis and rapid K + loss on susceptible pear leaves .
    AK-Toxin II
  • HY-117249

    AK-2123

    Apoptosis Caspase Cancer
    Sanazole (AK-2123) is a hypoxic cell radiosensitizer. Sanazole enhances radiation-induced DNA strand breaks. In mouse fibroblast tumors, Sanazole increases nuclear condensation and fragmentation, as well as elevates caspase-3 activity, thereby enhancing radiation-induced apoptosis .
    Sanazole
  • HY-174720

    mRNA Inflammation/Immunology
    Human EIF2AK2 mRNA encodes the human eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2) protein, a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. EIF2AK2 plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation.
    Human EIF2AK2 mRNA
  • HY-RS00509

    Small Interfering RNA (siRNA) Others

    AK7 Human Pre-designed siRNA Set A contains three designed siRNAs for AK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AK7 Human Pre-designed siRNA Set A
    AK7 Human Pre-designed siRNA Set A
  • HY-RS28600

    Small Interfering RNA (siRNA) Others
    Ak6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ak6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ak6 Rat Pre-designed siRNA Set A
    Ak6 Rat Pre-designed siRNA Set A
  • HY-RS24927

    Small Interfering RNA (siRNA) Others

    Ak4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ak4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ak4 Rat Pre-designed siRNA Set A
    Ak4 Rat Pre-designed siRNA Set A
  • HY-RS22080

    Small Interfering RNA (siRNA) Others

    Ak6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ak6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ak6 Mouse Pre-designed siRNA Set A
    Ak6 Mouse Pre-designed siRNA Set A
  • HY-RS00506

    Small Interfering RNA (siRNA) Others

    AK2 Human Pre-designed siRNA Set A contains three designed siRNAs for AK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AK2 Human Pre-designed siRNA Set A
    AK2 Human Pre-designed siRNA Set A
  • HY-RS26357

    Small Interfering RNA (siRNA) Others

    Ak3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ak3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ak3 Rat Pre-designed siRNA Set A
    Ak3 Rat Pre-designed siRNA Set A

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