62 Results for "

ANP

" in MedChemExpress (MCE) Product Catalog:
Products (62)

62 Results for "ANP" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-P1235A
CAS No.: 1366000-58-9
Synonyms: Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate
Target:  

Endothelin Receptor

Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.
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2
2 Cited Publications
Cat. No.: HY-21065
CAS No.: 40180-04-9
Synonyms: Ticrynafen; ANP 3624
Target:  

Cytochrome P450

Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro .
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1
1 Cited Publications
Cat. No.: HY-113469A
CAS No.: 40732-48-7
Purity:  99.89%
Cyclic GMP (cGMP) sodium, an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP sodium occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .
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1
1 Cited Publications
Cat. No.: HY-P703074
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ANP-A; ANPa; Atrionatriuretic peptide receptor A; Guanylate cyclase A; Guanylate cyclase; GUC2A; NPRA
Species:  
Source:  
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Cat. No.: HY-125079
CAS No.: 1233231-30-5
Purity:  98.33%
Synonyms: ANP-230
DSP-2230 is the orally active inhibitor for voltage-gated sodium channel that inhibits Nav1.7-, Nav1.8-, and Nav1.9-derived sodium currents with IC50s of 7.1 μM, 11.4 μM and 6.7 μM, respectively. DSP-2230 can be used to improve neuropathic pain .
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Cat. No.: HY-P1236
CAS No.: 88898-17-3
Synonyms: Atrial natriuretic factor (1-28) (rat, mouse)
Target:  

Endothelin Receptor

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
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Cat. No.: HY-P1419
CAS No.: 124833-45-0
AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation .
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Cat. No.: HY-P990951
CAS No.: 2845128-05-2
Synonyms: REGN-5381
Vixticibart (REGN-5381) is a fully human IgG4 monoclonal antibody and NPR1 agonist that targets NPR1. Vixticibart stabilizes the receptor in an activated conformation by binding to the N-terminal domain of NPR1, and enhances the activity of endogenous ligands ANP and BNP without blocking ligand binding when these ligands are present. Vixticibart exerts vasodilatory and hypotensive effects by inducing cGMP production, preferentially dilating venous vessels to reduce systolic and venous pressure, but does not induce diuresis and may trigger a compensatory increase in heart rate. Vixticibart produces a synergistic hypotensive effect when combined with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and is currently mainly used in research related to heart failure and hypertension .
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Cat. No.: HY-P1526
CAS No.: 111863-73-1
ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds NPR-C .
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Cat. No.: HY-P1236A
Synonyms: Atrial natriuretic factor (1-28) (rat, mouse) TFA
Target:  

Endothelin Receptor

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
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Cat. No.: HY-P2026
CAS No.: 132956-87-7
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [ 125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells .
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Cat. No.: HY-149453
CAS No.: 2747162-85-0
Purity:  99.85%
Target:  

Guanylate Cyclase

Research Areas:  

Cardiovascular Disease

MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy .
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Cat. No.: HY-P5792
CAS No.: 102686-43-1
Synonyms: ANP (3-28) (human)
Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)) is a peptide hormone that is synthesized and secreted by the atrial myocardium. Atrial natriuretic peptide (3-28) (human) is involved in the regulation of blood pressure, fluid balance, and electrolyte homeostasis .
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Cat. No.: HY-P4127A
M65 TFA is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches .
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Cat. No.: HY-B0950A
CAS No.: 3413-64-7
Synonyms: ANP-297 hydrochloride
Target:  

Dopamine Receptor

Research Areas:  

Neurological Disease

Mefexamide (ANP-297) hydrochloride is a psychostimulant psychopharmaceutical and aryloxyacetic acid derivative antidepressant with dopaminergic activity. Mefexamide hydrochloride can be used for the research of depression .
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Cat. No.: HY-P1235
CAS No.: 89213-87-6
Synonyms: Atrial Natriuretic Peptide (ANP) (1-28), human, porcine
Target:  

Endothelin Receptor

Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.
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Cat. No.: HY-P4127
CAS No.: 1872440-65-7
Target:  

Peptides

Research Areas:  

Neurological Disease

M65 is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches .
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Cat. No.: HY-P3762
CAS No.: 309245-16-7
Target:  

Endothelin Receptor

ANP (1-30), frog is a peptide fragment of atrial natriuretic peptide derived from frog. ANP (1-30), frog has natriuretic, diuretic, and vasorelaxant effects.
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Cat. No.: HY-P3772
CAS No.: 112926-01-9
[Mpr7, DAla9] ANP (7-28), amide, rat is an atrial peptide .
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Cat. No.: HY-P1556
CAS No.: 141676-35-9
Target:  

PKG

Research Areas:  

Cardiovascular Disease

Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
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