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Results for "

ARNT

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

2

Fluorescent Dye

1

Recombinant Proteins

1

Isotope-Labeled Compounds

9

Antibodies

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19621
    THS-044

    		HIF/HIF Prolyl-Hydroxylase Cancer
    THS-044 is a modulator of the formation of the HIF2α/ARNT heterodimer. THS-044 binding stabilizes the HIF2α PAS-B folded state (KD = 2 μM), for regulating HIF2 activity in endogenous and pathological settings, and does not bind to HIF1α or ARNT PAS-B. THS-044 can be used for the study of diseases related to hypoxia .
    THS-044
  • HY-159644
    Casdatifan

    AB521

    		 HIF/HIF Prolyl-Hydroxylase VEGFR Cancer
    Casdatifan (AB521) is an orally active and selective allosteric small-molecule inhibitor of hypoxia-inducible factor 2α (HIF-2α). Casdatifan inhibits pro-tumor gene transcription by blocking the heterodimerization of HIF-2α with ARNT, and significantly suppresses tumor growth in clear cell renal cell carcinoma (ccRCC) models either as a monotherapy or in combination with agents such as Zimberelimab (HY-P99109). Casdatifan is applicable for the research of ccRCC .
    Casdatifan
  • HY-120087
    KG-548

    		MOFs HIF/HIF Prolyl-Hydroxylase Cancer
    KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β .
    KG-548
  • HY-D0932
    Sudan IV

    Solvent Red 24; C.I. 26105

    		 Environmental Pollutants Biochemical Assay Reagents Cytochrome P450 Aryl Hydrocarbon Receptor Metabolic Disease
    Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections .
    Sudan IV
  • HY-112374
    NPAS3-IN-1

    		HIF/HIF Prolyl-Hydroxylase Neurological Disease
    NPAS3-IN-1 is a potent inhibitor of NPAS3-ARNT heterodimerization and regulates NPAS3 transcription by disrupting the heterodimerization of NPAS3 with ARNT at the cellular level .
    NPAS3-IN-1
  • HY-D0932R
    Sudan IV (Standard)

    Solvent Red 24 (Standard); C.I. 26105 (Standard)

    		 Biochemical Assay Reagents Aryl Hydrocarbon Receptor Cytochrome P450 Reference Standards Metabolic Disease
    Sudan IV (Standard) (Solvent Red 24 (Standard)) is the analytical standard of Sudan IV (HY-D0932). This product is intended for research and analytical applications. Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.
    Sudan IV (Standard)
  • HY-W012248
    KG-655

    		Aryl Hydrocarbon Receptor Others
    KG-655 is a small molecule compound that binds to the β-folded surface and internal cavity of ARNT PAS-B and interferes with its binding to the transcriptional coactivator TACC3. KG-655 can promote the homodimerization of ARNT PAS-B and has the potential to regulate multiple ARNT-mediated signaling pathways .
    KG-655
  • HY-RS25399
    Arnt Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Arnt Rat Pre-designed siRNA Set A contains three designed siRNAs for Arnt gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Arnt Rat Pre-designed siRNA Set A
    Arnt Rat Pre-designed siRNA Set A
  • HY-RS01011
    ARNT Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ARNT Human Pre-designed siRNA Set A contains three designed siRNAs for ARNT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ARNT Human Pre-designed siRNA Set A
    ARNT Human Pre-designed siRNA Set A
  • HY-RS01012
    ARNT2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ARNT2 Human Pre-designed siRNA Set A contains three designed siRNAs for ARNT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ARNT2 Human Pre-designed siRNA Set A
    ARNT2 Human Pre-designed siRNA Set A
  • HY-RS08421
    MIA3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MIA3 Human Pre-designed siRNA Set A contains three designed siRNAs for MIA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MIA3 Human Pre-designed siRNA Set A
    MIA3 Human Pre-designed siRNA Set A
  • HY-D0932S
    Sudan IV-d6

    Solvent Red 24-d6; C.I. 26105-d6

    		 Isotope-Labeled Compounds Biochemical Assay Reagents Aryl Hydrocarbon Receptor Cytochrome P450 Metabolic Disease
    Sudan IV-d6 (Solvent Red 24-d6) is the deuterium labeled Sudan IV(HY-D0932). Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections .
    Sudan IV-d6
  • HY-RS18908
    Arnt Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Arnt Mouse Pre-designed siRNA Set A contains three designed siRNAs for Arnt gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Arnt Mouse Pre-designed siRNA Set A
    Arnt Mouse Pre-designed siRNA Set A
  • HY-183117
    NEO-811

    		Molecular Glues HIF/HIF Prolyl-Hydroxylase Cancer
    NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader. NEO-811 is mediated by CRL4-CRBN E3 ligase for ARNT degradation. NEO-811 can be used for the study of clear cell renal cell carcinoma (ccRCC) .
    NEO-811
  • HY-183583
    HIF-2α-IN-18

    		HIF/HIF Prolyl-Hydroxylase Cancer
    HIF-2α-IN-18 is a selective HIF-2α inhibitor with a human IC50 of 8.1 nM. HIF-2α-IN-18 binds to the HIF-2α PAS-B domain, induces conformational perturbations at the HIF-2α/ARNT dimerization interface, destabilizes the HIF-2α/ARNT heterodimer, and blocks HIF-2α-mediated transcriptional activity. HIF-2α-IN-18 inhibits hypoxia-induced expression of HIF-2α target genes EPO and SERPINE1, without inhibiting HIF-1α target genes PGK1 and PDK1. HIF-2α-IN-18 can be used for the research of clear cell renal cell carcinoma, hepatocellular carcinoma[1].
    HIF-2α-IN-18
  • HY-186020
    L-4-Aminoarabinose-bactoprenyl phosphate

    L-4-Aminoarabinose-BP

    		 Endogenous Metabolite Infection
    L-4-Aminoarabinose-bactoprenyl phosphate (L-4-Aminoarabinose-BP) is a substrate of the ArnT enzyme and participates in lipid A modification through covalent bonding. L-4-Aminoarabinose-bactoprenyl phosphate transfers L-4-aminoarabinose (Ara4N) to the lipid A portion of lipopolysaccharide (LPS), mediating cationic modification of lipid A, thereby conferring resistance to cationic antimicrobial peptides (CAMPs) in Gram-negative bacteria. L-4-Aminoarabinose-bactoprenyl phosphate is an endogenous intermediate synthesized in vivo by a series of enzymes such as ArnC and ArnD encoded by the arn operon in Gram-negative bacteria such as Escherichia coli .
    L-4-Aminoarabinose-bactoprenyl phosphate
  • HY-16031A
    AFP464

    NSC710464

    		 Aryl Hydrocarbon Receptor Integrin Drug Intermediate DNA/RNA Synthesis Cancer
    AFP464 (NSC710464) is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 is applicable to research related to breast cancer .
    AFP464

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