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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
B1a
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "B1a" in MCE Product Catalog:
5
5 Cited Publications
Synonyms: Abamectin; Avermectin B1a-Avermectin B1b mixt.
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Emamectin Benzoate (MK-244) is an orally active nervoussystem toxicant by binding g-aminobutyric (GABA) receptor in insects. Emamectin Benzoate is one of semi-synthetic derivative of Avermectin (HY-15311) with a broadspectrum of insecticidal and acaricidal activity. Emamectin Benzoate induces ROS-mediated DNA damage and cell apoptosis. Emamectin Benzoate, a mixture of the natural Emamectin B1a benzoate and Emamectin B1b benzoate, has the main component of Emamectin B1a benzoate [1] .
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Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.
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1 Cited Publications
Ivermectin B1a, a derivative of Avermectin B1a (HY-15308), is a main component of Ivermectin (HY-15310) [1]. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .
Cat. No.: HY-P99976
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Cat. No.: HY-W765152
CAS No.: 2962875-16-5
Synonyms: 22,23-Dihydro avermectin B1a; epi-Dihydro avermectin B1a
epi-Ivermectin B1a is a key related substance of Ivermectin (HY-15310), primarily existing as a process-related impurity or potential degradation product in ivermectin-based antiparasitic formulations. epi-Ivermectin B1a can be used for the study of internal/external parasites in cattle [1].
Cat. No.: HY-177552
CAS No.: 122831-73-6
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4''-Oxoavermectin B1a is a potentiator targeting GABA (γ-aminobutyric acid) and glutamate-gated chloride channels with insecticidal and acaricidal activities. 4''-Oxoavermectin B1a is promising for research of agricultural pests [1].
Cat. No.: HY-137252
CAS No.: 73162-95-5
Synonyms: Ivermectin Impurity G
22,23-Dihydroavermectin B1a aglycon is an acid degradation product produced by hydrolysis of the disaccharide unit of ivermectin. It can inhibit nematode larval development, but does not cause paralytic activity.
Cat. No.: HY-15308R
CAS No.: 65195-55-3
Synonyms: Abamectin B1a (Standard)
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Avermectin B1a (Standard) is the analytical standard of Avermectin B1a. This product is intended for research and analytical applications. Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.
Cat. No.: HY-W783297
CAS No.: 102190-68-1
8a-OH-Avermectin B1a is a key primary monooxygenated degradate generated during the photodegradation of Avermectin B1a (HY-15308). 8a-OH-Avermectin B1a can be used for the study of antiparasitic infection [1].
Cat. No.: HY-138149
CAS No.: 106434-14-4
Synonyms: epi-Avermectin B1a
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2-epi-Abamectin is a degradation product of Abamectin. It is toxic to the two-spotted spider mite in a contact assay with an LC50 value of 4 ppm, which is approximately 100-fold less potent than abamectin.
Cat. No.: HY-123686
CAS No.: 71837-27-9
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Cat. No.: HY-N8483
CAS No.: 133305-88-1
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Eprinomectin B1a is a Eprinomectin (HY-12643) metabolite (an antiparasitic compound) [1].
Cat. No.: HY-137968
CAS No.: 71828-14-3
Avermectin B1a aglycon is an aglycone derivative of Avermectin B1a (HY-15308), an antiparasitic agent that paralyzes nematodes. Avermectin B1a aglycon hyperpolarizes P. crassipes muscle fibers, with a minimum effective concentration of 0.1 μM [1].
Cat. No.: HY-W1004917
CAS No.: 113665-89-7
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8,9-Z-Abamectin B1a is the 8,9-Z-isomer of Abamectin B1a (HY-15308). Avermectin B1a is an antiparasitic agent that paralyzes nematodes [1] .
Cat. No.: HY-137229
CAS No.: 71831-09-9
Avermectin B1a monosaccharide is a macrolide anthelmintic that can inhibit Caenorhabditis elegans [1].
Cat. No.: HY-130349
CAS No.: 121124-29-6
Synonyms: L-656,748
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Emamectin B1a (L-656,748) is a semisynthetic derivative of avermectin B1a that binds to GABA receptors (Ki=17.6 nM in rat brain membranes) and enhances GABA responses. Emamectin B1a acitivates GABAA receptors α1β1γ2, α1β2γ2, and α1β3γ2 with IC50s of 57, 210, and 49.8 nM, respectively. Emamectin B1a also binds to glycine receptors, inhibiting glycine receptors with an IC50=218 nM in rat spinal cord. Emamectin B1a (1.067 ng/mL) caused 90% mortality of S. exigua larvae in foliar spray bioassays and topical application, making it more toxic than avermectin B1.
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5-O-Demethyl-28-hydroxy-Avermectin A1a is a degradation product of Avermectin B1a (HY-15308).
Cat. No.: HY-W765261
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
