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Results for "

CD70

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

11

Inhibitory Antibodies

15

Recombinant Proteins

2

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99014
    Cusatuzumab
    1 Publications Verification

    ARGX-110

    Fc Receptor (FcR) NF-κB Inflammation/Immunology Cancer
    Cusatuzumab (ARGX-110) is a selective competitive blocker targeting CD70 (with an equilibrium dissociation constant of 17 pM for binding to human CD70). Cusatuzumab also possesses enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. It is a humanized IgG1 monoclonal antibody, artificially synthesized through humanization and genetic engineering modifications (CH2 region mutation to enhance effector function). Cusatuzumab has a dual mechanism of action: firstly, it competitively blocks the interaction between CD70 and CD27, inhibiting the CD27-NF-κB signaling pathway, reducing regulatory T cell (Treg) activation and tumor cell proliferation; secondly, by enhancing binding to FcγRIIIa, it mediates ADCC and antibody-dependent cellular phagocytosis (ADCP), directly lysing CD70-positive tumor cells. Cusatuzumab can efficiently eliminate leukemia stem cells (LSCs), induce tumor cell differentiation and apoptosis, restore immune surveillance, and target CD70-positive tumors. Cusatuzumab is used in the study of acute myeloid leukemia (AML) .
    Cusatuzumab
  • HY-P99273

    TNF Receptor Cancer
    Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a human anti-CD70 antibody. Vorsetuzumab enhances macrophage-related phagocytosis of renal carcinoma cells, shows inhibitory efficacy against Burkitt’s lymphoma .
    Vorsetuzumab
  • HY-P99334

    Anti-Human CD70 Recombinant Antibody; SGN-75

    Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin Cancer
    Vorsetuzumab mafodotin (SGN-75) is an Auristatin-based anti-CD70 antibody-drug conjugate (ADC). Vorsetuzumab mafodotin consists of a humanized monoclonal antibody, Vorsetuzumab and an ADC cytotoxin MMAF. Vorsetuzumab mafodotin has antineoplastic activity .
    Vorsetuzumab mafodotin
  • HY-P990264

    Transmembrane Glycoprotein Inflammation/Immunology
    Anti-Mouse CD70 Antibody (FR70) is a rat-derived ant-mouse CD70 IgG2b κ type antibody inhibitor. Anti-Mouse CD70 Antibody (FR70) decreases CD4 +, CD8 + T cells and eosinophils. Anti-Mouse CD70 Antibody (FR70) shows potent anti-inflammatory and anti-immune effects on allergic lung inflammation and cardiac transplant mice models .
    Anti-Mouse CD70 Antibody (FR70)
  • HY-174736

    mRNA Inflammation/Immunology
    Human CD70 mRNA encodes the human CD70 molecule (CD70) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. It is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
    Human CD70 mRNA
  • HY-P991645

    MDX-1203 antibody; BMS-936561 antibody

    TNF Receptor ADC Antibody Cancer
    MDX-1115 is a humanized IgG1 monoclonal antibody targeting CD70. MDX-1115 can be used for synthesis of ADC BMS-936561 .
    MDX-1115
  • HY-178257

    ADC Payload Cancer
    Fmoc-Val-Lys-PAB-Exatecan is a derivative of Exatecan (DX-8951) (HY-13631). Fmoc-Val-Lys-PAB-Exatecan can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. Fmoc-Val-Lys-PAB-Exatecan is often combined with CD70 mAb to form ADC drugs for the study of tumors with high CD70 expression .
    Fmoc-Val-Lys-PAB-Exatecan
  • HY-RS02264

    Small Interfering RNA (siRNA) Others

    CD70 Human Pre-designed siRNA Set A contains three designed siRNAs for CD70 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CD70 Human Pre-designed siRNA Set A
    CD70 Human Pre-designed siRNA Set A
  • HY-RS16751

    Small Interfering RNA (siRNA) Others

    Cd70 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd70 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cd70 Mouse Pre-designed siRNA Set A
    Cd70 Mouse Pre-designed siRNA Set A
  • HY-RS23190

    Small Interfering RNA (siRNA) Others

    Cd70 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd70 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cd70 Rat Pre-designed siRNA Set A
    Cd70 Rat Pre-designed siRNA Set A
  • HY-160649

    Drug-Linker Conjugates for ADC Topoisomerase Cancer
    MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo .
    MC-Gly-Gly-Phe-Gly-GABA-Exatecan
  • HY-P991809

    TNF Receptor Inflammation/Immunology
    Anti-Mouse CD70 Antibody (TAN 1-7) reacts with the mouse CD70. Anti-Mouse CD70 Antibody (TAN 1-7) is a non-depleting antibody which blocks the CD70-CD27 interaction. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).
    Anti-Mouse CD70 Antibody (TAN 1-7)
  • HY-P991562

    Transmembrane Glycoprotein Cancer
    MDX-1411 is a fully human monoclonal antibody targeting CD70. MDX-1411 is capable of inducing antibody-dependent cellular cytotoxicity (ADCC). MDX-1411 can be used in the research of B-cell malignancies .
    MDX-1411
  • HY-P991120

    PF-08046040; SGN-CD70

    TNF Receptor Cancer
    Balertatug is a human IgG1K antibody targeting CD70. The corresponding isotype control is: Human lgG1 kappa, lsotype Control (HY-P99001) .
    Balertatug
  • HY-P990261

    Transmembrane Glycoprotein Inflammation/Immunology Cancer
    Anti-Mouse CD83 Antibody (Michel-17) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse CD83. Anti-Mouse CD83 Antibody (Michel-17) can block CD83 and inhibit T cells proliferation. Anti-Mouse CD83 Antibody (Michel-17) can be used for the researches of cancer and immunology, such as solid tumor .
    Anti-Mouse CD83 Antibody (Michel-17)
  • HY-178271

    Drug Intermediate Cancer
    P-SCN-Bn-NOTA is a metal chelator and molecular imaging probe precursor that allows radiolabeling with Ga-68. P-SCN-Bn-NOTA can be conjugated to CD70-specific molecules B3, B6, ABDB3 and ABDB6 to form NOTA-labeled derivatives. P-SCN-Bn-NOTA is applicable for preclinical PET/CT imaging of CD70-expressing tumors in NCG mouse PDX models. P-SCN-Bn-NOTA can be used in studies related to CD70-positive tumors .
    P-SCN-Bn-NOTA
  • HY-185484

    BMS-936561

    Antibody-Drug Conjugates (ADCs) Transmembrane Glycoprotein Cancer
    MDX-1203 (BMS-936561) is an antibody-drug conjugate targeting CD70. MDX-1203 binds to CD70 and mediates the specific delivery of its conjugated cytotoxic payload to tumors. MDX-1203 delivers a DNA alkylating payload into cells. MDX-1203 can be used in research related to advanced clear cell renal cell carcinoma and relapsed/refractory B-cell non-Hodgkin lymphoma .
    MDX-1203
  • HY-P99014A

    Transmembrane Glycoprotein Cancer
    Cusatuzumab (FUT8-KO) is an anti-CD70 monoclonal antibody that prepared by knocking out the fucosyltransferase 8 gene (FUT8) to remove fucose and thereby enhance the ADCC activity of the antibody .
    Cusatuzumab (FUT8-KO)
  • HY-P991930

    ADC Antibody TNF Receptor Cancer
    ARX305 Antibody is an anti-human CD70 antibody. ARX305 Antibody can generate antibody drug conjugate (ADC) (ARX305) with a potent microtubule inhibitor PEG4-aminooxy-MMAF (AS269) (HY-128968). ARX305 Antibody can be used for the study of multiple solid and hematological cancers .
    ARX305 Antibody

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