37 Results for "

CD70

" in MedChemExpress (MCE) Product Catalog:
Products (37)

37 Results for "CD70" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99014
CAS No.: 1864871-20-4
Synonyms: ARGX-110

Research Areas:  

Inflammation/Immunology Cancer

Cusatuzumab (ARGX-110) is a selective competitive blocker targeting CD70 (with an equilibrium dissociation constant of 17 pM for binding to human CD70). Cusatuzumab also possesses enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. It is a humanized IgG1 monoclonal antibody, artificially synthesized through humanization and genetic engineering modifications (CH2 region mutation to enhance effector function). Cusatuzumab has a dual mechanism of action: firstly, it competitively blocks the interaction between CD70 and CD27, inhibiting the CD27-NF-κB signaling pathway, reducing regulatory T cell (Treg) activation and tumor cell proliferation; secondly, by enhancing binding to FcγRIIIa, it mediates ADCC and antibody-dependent cellular phagocytosis (ADCP), directly lysing CD70-positive tumor cells. Cusatuzumab can efficiently eliminate leukemia stem cells (LSCs), induce tumor cell differentiation and apoptosis, restore immune surveillance, and target CD70-positive tumors. Cusatuzumab is used in the study of acute myeloid leukemia (AML) .
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Cat. No.: HY-P99273
CAS No.: 1165740-62-4

Target:  

TNF Receptor

Research Areas:  

Cancer

Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a human anti-CD70 antibody. Vorsetuzumab enhances macrophage-related phagocytosis of renal carcinoma cells, shows inhibitory efficacy against Burkitt’s lymphoma .
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Cat. No.: HY-P99334
CAS No.: 1165741-01-4
Synonyms: Anti-Human CD70 Recombinant Antibody; SGN-75
Vorsetuzumab mafodotin (SGN-75) is an Auristatin-based anti-CD70 antibody-drug conjugate (ADC). Vorsetuzumab mafodotin consists of a humanized monoclonal antibody, Vorsetuzumab and an ADC cytotoxin MMAF. Vorsetuzumab mafodotin has antineoplastic activity .
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Cat. No.: HY-P990264

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD70 Antibody (FR70) is a rat-derived ant-mouse CD70 IgG2b κ type antibody inhibitor. Anti-Mouse CD70 Antibody (FR70) decreases CD4 +, CD8 + T cells and eosinophils. Anti-Mouse CD70 Antibody (FR70) shows potent anti-inflammatory and anti-immune effects on allergic lung inflammation and cardiac transplant mice models .
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Cat. No.: HY-174736
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human CD70 mRNA encodes the human CD70 molecule (CD70) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. It is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
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Cat. No.: HY-P991645
Synonyms: MDX-1203 antibody; BMS-936561 antibody

Research Areas:  

Cancer

MDX-1115 (MDX-1203 antibody; BMS-936561 antibody) is a humanized IgG1 monoclonal antibody targeting CD70. MDX-1115 can be used for synthesis of ADC BMS-936561 .
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Cat. No.: HY-178257
CAS No.: 2901788-27-8
Target:  

ADC Payloads

Research Areas:  

Cancer

Fmoc-Val-Lys-PAB-Exatecan is a derivative of Exatecan (DX-8951) (HY-13631). Fmoc-Val-Lys-PAB-Exatecan can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. Fmoc-Val-Lys-PAB-Exatecan is often combined with CD70 mAb to form ADC drugs for the study of tumors with high CD70 expression .
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Cat. No.: HY-RS02264
Research Areas:  

Others

CD70 Human Pre-designed siRNA Set A contains three designed siRNAs for CD70 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS16751
Research Areas:  

Others

Cd70 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd70 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23190
Research Areas:  

Others

Cd70 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd70 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-160649
CAS No.: 1599439-52-7
Research Areas:  

Cancer

MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo .
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Cat. No.: HY-P991809

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD70 Antibody (TAN 1-7) reacts with the mouse CD70. Anti-Mouse CD70 Antibody (TAN 1-7) is a non-depleting antibody which blocks the CD70-CD27 interaction. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).
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Cat. No.: HY-P991562
CAS No.: 2101467-47-2

Research Areas:  

Cancer

MDX-1411 is a fully human monoclonal antibody targeting CD70. MDX-1411 is capable of inducing antibody-dependent cellular cytotoxicity (ADCC). MDX-1411 can be used in the research of B-cell malignancies .
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Cat. No.: HY-P991120
CAS No.: 3010940-29-8
Synonyms: PF-08046040; SGN-CD70

Target:  

TNF Receptor

Research Areas:  

Cancer

Balertatug is a human IgG1K antibody targeting CD70. The corresponding isotype control is: Human lgG1 kappa, lsotype Control (HY-P99001) .
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Cat. No.: HY-P990261
Anti-Mouse CD83 Antibody (Michel-17) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse CD83. Anti-Mouse CD83 Antibody (Michel-17) can block CD83 and inhibit T cells proliferation. Anti-Mouse CD83 Antibody (Michel-17) can be used for the researches of cancer and immunology, such as solid tumor .
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Cat. No.: HY-178271
CAS No.: 147597-66-8
Target:  

Drug Intermediate

Research Areas:  

Cancer

P-SCN-Bn-NOTA is a metal chelator and molecular imaging probe precursor that allows radiolabeling with Ga-68. P-SCN-Bn-NOTA can be conjugated to CD70-specific molecules B3, B6, ABDB3 and ABDB6 to form NOTA-labeled derivatives. P-SCN-Bn-NOTA is applicable for preclinical PET/CT imaging of CD70-expressing tumors in NCG mouse PDX models. P-SCN-Bn-NOTA can be used in studies related to CD70-positive tumors .
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Cat. No.: HY-P704279
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CD70 antigen; CD70; CD27 ligand; CD27LG; TNFSF7; CD27L
Species:  
Source:  
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Cat. No.: HY-P704364
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD70 antigen; CD70; CD27 ligand; CD27LG; TNFSF7; CD27L
Species:  
Source:  
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Cat. No.: HY-P85005
Synonyms: CD70; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD antigen CD70; CD70 nanobody;

Host:  

Mouse

Application:  

ELISA, FC

Reactivity:  

Human

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Cat. No.: HY-P72741
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD70 antigen; CD70; CD27 ligand; CD27LG; TNFSF7; CD27L
Species:  
Source:  
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