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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
CES2
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "CES2" in MCE Product Catalog:
3
Cat. No.: HY-E70599
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Human CES2 Enzyme is a carboxylesterase involved in drug metabolism and lipid homeostasis. Human CES2 Enzyme hydrolyzes triglycerides, cholesteryl esters and retinyl esters to regulate lipid metabolism and energy homeostasis. Human CES2 Enzyme improves glucose tolerance and insulin sensitivity, reduces hepatic lipid accumulation, alleviates white adipose tissue steatitis, decreases plasma cholesterol levels, and reduces body weight and white adipose tissue weight. Human CES2 Enzyme can be used in the research of metabolic syndrome .
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CES2-IN-1 (Compound 24) is a reversible and selective CES2 inhibitor (IC50: 6.72 μM for human CES2). CES2-IN-1 reduces the level of CES2 in living cells. CES2-IN-1 is effective against Irinotecan (HY-16562)-induced delayed diarrhea and DSS-induced ulcerative colitis .
Cat. No.: HY-RS02544
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CES2 Human Pre-designed siRNA Set A contains three designed siRNAs for CES2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N1951R
CAS No.: 27210-57-7
Synonyms: Rosmariquinone (Standard)
Cat. No.: HY-168516
CAS No.: 3004676-87-0
FXR/CES2 modulator 1 (compound LE-77) is a doul modulator that activates FXR and inhibits CES2. FXR/CES2 modulator 1 effectively mitigates the intestinal toxicity of irinotecan .
Cat. No.: HY-RS24502
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Ces2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ces2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-D2285
CAS No.: 2956672-93-6
Cat. No.: HY-184061
CAS No.: 2590661-64-4
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Carboxylesterase 2-IN-1 is a potent carboxylesterase CES2 inhibitor with an IC50 of 0.13 μM. Carboxylesterase 2-IN-1 blocks the hydrolysis of fluorescein diacetate by CES2 via non-competitive inhibition. Carboxylesterase 2-IN-1 also effectively inhibits adipogenesis induced in mouse preadipocytes .
Cat. No.: HY-155755
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CES2A-IN-1 (compound 20w) is a potent CES2A inhibitor with an IC50 value of 1.6 nM for human CES2A. CES2A-IN-1, a bysspectin A derivative, shows an approximately 1000-fold improvement over the lead compound bysspectin A .
Cat. No.: HY-173267
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CES2A-IN-2 (compound 14n) is an orally active, highly specific, irreversible and covalent CES2A inhibitor with an IC50 of 0.04 nM for human CES2A. CES2A-IN-2 covalently binds to CES2A by specifically targeting the catalytic serine residue (Ser-228). CES2A-IN-2 can significantly ameliorate Irinotecan-triggered gut toxicity (ITGT) without diminishing the anti-tumor effects of Irinotecan (HY-16562) in tumor-bearing mice .
Cat. No.: HY-176465
CAS No.: 3037959-47-7
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CES2A-IN-3 (Compound 9d) is a potent serine-targeting covalent human carboxylesterase 2A (hCES2A) inhibitor with an IC50 value of 0.12 nM. CES2A-IN-3 is promising for research of diarrhea and ulcerative colitis .
Cat. No.: HY-P76192A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Cocaine esterase; Carboxylesterase 2; CE-2; CES2; ICE
Cat. No.: HY-177196
CAS No.: 1582753-53-4
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5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-adenosine is a nucleotide analogue used in nucleic acid synthesis.
Cat. No.: HY-177197
CAS No.: 1582753-54-5
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5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-cytidine is a nucleotide analogue used in nucleic acid synthesis.
Cat. No.: HY-177198
CAS No.: 1582753-55-6
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5'-DMT-3'-CE-2'-TBDMS 2-cyanoethoxycarbonyl, 2-(4-nitrophenyl)ethyl-guanosine is a nucleotide analogue used in nucleic acid synthesis.
Cat. No.: HY-RS02543
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CES1 Human Pre-designed siRNA Set A contains three designed siRNAs for CES1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-126182
CAS No.: 42399-40-6
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Deacetyldiltiazem is a metabolite with coronary vasodilator activity. Deacetyldiltiazem is present in the plasma of individuals taking Diltiazem. The deacetylase activity of deacetyldiltiazem is mainly catalyzed by the rat Ces2a enzyme. In vitro experiments of deacetyldiltiazem showed that its Km value was similar to that of rat liver microsomes, showing efficient deacetylase activity. The study of deacetyldiltiazem helps to understand the differences in the metabolic kinetics of compounds between different species .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
