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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
CIC
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "CIC" in MCE Product Catalog:
16
16 Publications Verification
PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment .
16
16 Publications Verification
PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment .
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Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .
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1 Cited Publications
Synonyms: A 3309; AZD 7806
Research Areas:
Elobixibat (A 3309; AZD 7806) is an orally active, bile acid transporter (IBAT) inhibitor with IC50 values ??of 0.53 nM (human IBAT), 0.13 nM (mouse IBAT), and 5.8 nM (canine IBAT). Elobixibat can lower LDL cholesterol, increase serum GLP-1, promote colonic motility, and has the potential to study metabolic syndrome. Elobixibat can be used in the study of chronic functional constipation (CIC), dyslipidemia, non-alcoholic hepatitis, and liver tumors in the elderly .
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1 Cited Publications
Synonyms: CIC-AP; CIClesonide active principle
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Research Areas:
Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor.
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1 Cited Publications
Synonyms: A 3309 hydrate; AZD 7806 hydrate
Research Areas:
Elobixibat (A 3309; AZD 7806) hydrate is an orally active, bile acid transporter (IBAT) inhibitor with IC50 values ??of 0.53 nM (human IBAT), 0.13 nM (mouse IBAT), and 5.8 nM (canine IBAT). Elobixibat hydrate can lower LDL cholesterol, increase serum GLP-1, promote colonic motility, and has the potential to study metabolic syndrome. Elobixibat hydrate can be used in the study of chronic functional constipation (CIC), dyslipidemia, non-alcoholic hepatitis, and liver tumors in the elderly .
Cat. No.: HY-174866
CAS No.: 3055107-34-8
Research Areas:
BT-O2C is a highly selective p300 PROTAC degrader. BT-O2C can significantly degrade the level of p300 in HAP1 cells. BT-O2C has significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines (IC50 ranges from 152 to 221 nM) and significantly reduces the expression of CDS target genes (ETV1, ETV4, ETV5). BT-O2C can be used for research on cancer .
Cat. No.: HY-RS13089
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SLC25A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC25A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-164532
CAS No.: 265646-94-4
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NS3736 is an orally effective chloride channel inhibitor that can be used for the research of osteoporosis. NS3736 targets the CIC-7 channel in osteocytes, blocks osteoclast acidification and resorption in vitro, with IC50=30 μM. In a rat model of ovariectomy-induced osteoporosis, NS3736 can enhance bone strength and bone density .
Cat. No.: HY-168423
CAS No.: 2749504-71-8
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4-CIC hydrochloride is a drug derivative.
Cat. No.: HY-RS02710
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CIC Human Pre-designed siRNA Set A contains three designed siRNAs for CIC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24137
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Cic Rat Pre-designed siRNA Set A contains three designed siRNAs for Cic gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-125551
CAS No.: 132565-33-4
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L-687908 is a HIV-1 protease inhibitor (CIC95: 12 nM) .
Cat. No.: HY-B0679R
CAS No.: 136790-76-6
Synonyms: RU-0211 (Standard); SPI-0211 (Standard)
Research Areas:
Lubiprostone (Standard) is the analytical standard of Lubiprostone. This product is intended for research and analytical applications. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .
Cat. No.: HY-B0679S
CAS No.: 1217675-13-2
Synonyms: RU-0211-d7; SPI-0211-d7
Cat. No.: HY-111490R
CAS No.: 161115-59-9
Synonyms: CIC-AP(Standard); CIClesonide active principle (Standard)
Research Areas:
Desisobutyryl-ciclesonide (Standard) is the analytical standard of Desisobutyryl-ciclesonide. This product is intended for research and analytical applications. Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor.
Cat. No.: HY-16905
CAS No.: 1351926-90-3
T338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C(IC50=111 nM) relative to WT c-Src (10-fold increase).
Cat. No.: HY-15790S
Synonyms: A 3309-d5; AZD 7806-d5
Cat. No.: HY-15790R
CAS No.: 439087-18-0
Synonyms: A 3309 (Standard); AZD 7806 (Standard)
Research Areas:
Elobixibat (Standard) is the analytical standard of Elobixibat (HY-15790). This product is intended for research and analytical applications. Elobixibat (A 3309; AZD 7806) is orally active, bile acid transporter (IBAT) inhibitor with IC50 values ??of 0.53 nM (human IBAT), 0.13 nM (mouse IBAT), and 5.8 nM (canine IBAT). Elobixibat can lower LDL cholesterol, increase serum GLP-1, promote colonic motility, and has the potential to treat metabolic syndrome. Elobixibat can be used in the study of chronic functional constipation (CIC), dyslipidemia, non-alcoholic hepatitis, and liver tumors in the elderly .
Cat. No.: HY-RS17676
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Research Areas:
Cic Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cic gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
