CPS

By Targets:	Carbamoyl Phosphate Synthetase (CPS) (2) Bacterial (1) Biochemical Assay Reagents (1) Cadherin (1) CDK (1) Drug Metabolite (1) Ligands for Target Protein for PROTAC (1) NF-κB (1) Nuclear Factor of activated T Cells (NFAT) (1) PAK (3) Potassium Channel (1) PROTACs (3) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (7) Infection (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: Carbamoyl Phosphate Synthetase (CPS)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141680

CPS2 1 Publications Verification	PROTACs CDK	Cancer
CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader (IC₅₀= 24 nM). CPS2 can be used for the research of acute myeloid leukemia .

HY-B0711

Carglumic Acid 2 Publications Verification N-Carbamyl-L-glutamic acid	Carbamoyl Phosphate Synthetase (CPS)	Cancer
Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

HY-136128

H3B-120 1 Publications Verification	Potassium Channel Carbamoyl Phosphate Synthetase (CPS)	Cancer
H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC₅₀ of 1.5 μM and a K_i of 1.4 μM. H3B-120 has anti-cancer activity .

HY-137199

Pro-Phe-Arg-AMC	Biochemical Assay Reagents	Others
Pro-Phe-Arg-AMC is a synthetic peptide substrate of Cysteine peptidases (CPs) .

HY-117987

CPS-11 N-(Hydroxymethyl)thalidomide	Nuclear Factor of activated T Cells (NFAT) NF-κB Reactive Oxygen Species (ROS)	Cancer
CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines .

HY-174247

CPS-021	PROTACs PAK Cadherin	Cancer
CPS-021 is a selective PAK4 PROTAC degrader with a DC₅₀ of 50 nM. CPS-021 has potent antimigratory and invasive activity and significantly suppresses the invasion and metastasis of tumor cells in A549-luc lung metastasis mice model . Pink: PAK4 ligand (HY-174822); Blue: CRBN ligase ligand (HY-10984); Black: linker

HY-U00265

3-CPs 3-Carbethoxypsoralen; 3-Ethoxycarbonylpsoralen	Bacterial	Infection
3-CPs is a monofunctional furanocoumarin and a photoprotective agent targeting Staphylococcus aureus DNA, possessesing anti-UVB lethal activity. 3-CPs competitively intercalates into DNA, forming exclusively 4',5'-furan-side mono-adducts upon UVB irradiation, and irreversibly inhibits the formation of cyclobutane pyrimidine dimers. 3-CPs prevents UVB-induced DNA damage by preferentially binding to strong (AT)_n sites within the DNA, without inducing lethal interstrand DNA cross-links; the limited number of mono-adducts it induces can be efficiently repaired by bacteria. 3-CPs holds potential for use in the development of photoprotective formulations for skin diseases, as well as in studies investigating bacterial DNA photodamage repair mechanisms and the optimization of photochemotherapy safety .

HY-B0711R

Carglumic Acid (Standard) N-Carbamyl-L-glutamic acid (Standard)	Reference Standards Others	Cancer
Carglumic Acid (Standard) is the analytical standard of Carglumic Acid. This product is intended for research and analytical applications. Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

HY-RS23946

Cps1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cps1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cps1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cps1 Rat Pre-designed siRNA Set A Cps1 Rat Pre-designed siRNA Set A

HY-RS17488

Cps1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cps1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cps1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cps1 Mouse Pre-designed siRNA Set A Cps1 Mouse Pre-designed siRNA Set A

HY-174822

PAK4-IN-6	Ligands for Target Protein for PROTAC PAK	Others
PAK4-IN-6 is a selective degrader of PAK4. PAK4-IN-6 can be used to synthesize PROTACs such as CPS-021 (HY-174247) .

HY-RS03115

CPS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CPS1 Human Pre-designed siRNA Set A contains three designed siRNAs for CPS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CPS1 Human Pre-designed siRNA Set A CPS1 Human Pre-designed siRNA Set A

HY-174248

PS21M	PROTACs PAK	Cancer
PS21M is a negative control of CPS-021 (HY-174247). PS21M cannot effectively degrade PAK4 in MDA-MB-231 cells. (Pink: Target Protein Ligand (HY-174822); Black: Linker; Blue: E3 Ligase Ligand (HY-W586822)) .

HY-131275R

Imatinib Impurity E (Standard)	Drug Metabolite Reference Standards	Others
Carglumic Acid (Standard) is the analytical standard of Carglumic Acid. This product is intended for research and analytical applications. Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

Cat. No.	Product Name

HY-L926

Cysteine Protease Focused Covalent Library	2,114 compounds
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (e.g., abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for disease intervention via the development of specific inhibitors. Currently reported CP covalent inhibitors encompass diverse structural types, including epoxides, aziridine, and activated double bonds (vinyl sulphones, α,β-unsaturated ketones), providing clear structural references for the development of novel CP covalent inhibitors. This compound library contains multiple warheads that specifically target cysteine proteases, serving as a powerful tool for the efficient discovery of novel covalent inhibitors against this enzyme family.

Cysteine Protease Focused Covalent Library

2,114 compounds

Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (e.g., abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for disease intervention via the development of specific inhibitors. Currently reported CP covalent inhibitors encompass diverse structural types, including epoxides, aziridine, and activated double bonds (vinyl sulphones, α,β-unsaturated ketones), providing clear structural references for the development of novel CP covalent inhibitors.

This compound library contains multiple warheads that specifically target cysteine proteases, serving as a powerful tool for the efficient discovery of novel covalent inhibitors against this enzyme family.

HY-L925

Cysteine Protease Focused Library	9,192 compounds
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (such as abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for developing specific inhibitors in disease intervention. Currently reported CP inhibitors primarily achieve their inhibitory function by precisely binding to CP active pockets (e.g., S1-S4 non-primed regions or S1'-S2' primed regions) and forming covalent/non-covalent interactions with the active site cysteine residues, providing clear structural references for the development of novel inhibitors. This compound library, designed based on the core strategy of "similarity-based known active structures", contains over 200 cysteine protease inhibitors. Leveraging AI-driven molecular screening technology, it retains the critical pharmacological and shape features of reported CP inhibitors, serving as a specialized tool for efficiently discovering novel cysteine protease inhibitors.

Cysteine Protease Focused Library

9,192 compounds

Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (such as abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for developing specific inhibitors in disease intervention. Currently reported CP inhibitors primarily achieve their inhibitory function by precisely binding to CP active pockets (e.g., S1-S4 non-primed regions or S1'-S2' primed regions) and forming covalent/non-covalent interactions with the active site cysteine residues, providing clear structural references for the development of novel inhibitors.

This compound library, designed based on the core strategy of "similarity-based known active structures", contains over 200 cysteine protease inhibitors. Leveraging AI-driven molecular screening technology, it retains the critical pharmacological and shape features of reported CP inhibitors, serving as a specialized tool for efficiently discovering novel cysteine protease inhibitors.

Cat. No.	Product Name	Target	Research Area

HY-137199

Pro-Phe-Arg-AMC	Biochemical Assay Reagents	Others
Pro-Phe-Arg-AMC is a synthetic peptide substrate of Cysteine peptidases (CPs) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0711R

Carglumic Acid (Standard) N-Carbamyl-L-glutamic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Others
Carglumic Acid (Standard) is the analytical standard of Carglumic Acid. This product is intended for research and analytical applications. Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

Species:	Human (2)
Tag:	His (2)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71445

	CPS1/CPSase I Protein, Human (sf9, His) Carbamoyl phosphate synthase; Carbamoyl phosphate synthase mitochondrial; Carbamoyl phosphate synthase; Carbamoyl phosphate synthetase 1; Carbamoyl phosphate synthetase 1 mitochondrial; Carbamoyl phosphate synthetase I; Carbamoyl-phosphate synthase [ammonia]; Carbamoyl-phosphate synthetase I; Carbamoylphosphate synthase; Carbamoylphosphate synthetase 1; Carbamoylphosphate synthetase I; CPS 1; CPS1; CPSase 1; CPSase I; CPSASE1; mitochondrial; MS738	Human	Sf9 insect cells
	The CPS1/CPSase I protein is critical in participating in the urea cycle and is essential for the elimination of excess ammonia in urea-bearing animals. This essential enzyme converts toxic ammonia (a byproduct of amino acid catabolism) into urea, promoting safe excretion. CPS1/CPSase I Protein, Human (sf9, His) is the recombinant human-derived CPS1/CPSase I protein, expressed by sf9 insect cells , with His labeled tag.

HY-P72164

	CYP21A2 Protein, Human (His) CYP21; 21 OHase; 21-OHase; CA21H ; CAH1; CP21A_HUMAN; CPS1; CYP21A 2; CYP21A2; CYP21B; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 C21B; Cytochrome P450 XXI; Cytochrome P450; family 21; subfamily A; polypeptide 2; Cytochrome P450; subfamily XXIA steroid 21 hydroxylase;	Human	E. coli
	CYP21A2 Protein, a cytochrome P450 monooxygenase, crucially hydroxylates progesterone and 17alpha-hydroxyprogesterone at C-21, yielding vital intermediates for mineralocorticoid and glucocorticoid biosynthesis in adrenal steroidogenesis. This enzymatic process involves molecular oxygen, with NADPH providing essential electrons via cytochrome P450 reductase (CPR). CYP21A2 plays a pivotal role in regulating adrenal cortex hormone production. CYP21A2 Protein, Human (His) is the recombinant human-derived CYP21A2 protein, expressed by E. coli , with N-6*His labeled tag.

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HY-P81916

	CPS1 Antibody (YA1661) CPS1; CPSase 1; CPSase I; CPSASE1; MS738	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	CPS1 Antibody (YA1661) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CPS1.

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Cat. No.	Product Name		Classification

HY-RS23946

Cps1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cps1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cps1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17488

Cps1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cps1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cps1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03115

CPS1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CPS1 Human Pre-designed siRNA Set A contains three designed siRNAs for CPS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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