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CRBN protein

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (1046) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (14) Metabolic Disease (1) Neurological Disease (9)
Click Chemistry:	PROTAC Synthesis (1) Azide (7) Tetrazine (1) Alkynes (3)

1076

Inhibitors & Agonists

Bibliotecas de Screening

Fluorescent Dyes

Recombinant Proteins

Antibodies

Click Chemistry

Thalidomide-O-COOH 2 Publications Verification Cereblon ligand 3; E3 ligase Ligand 3	Ligands for E3 Ligase	Cancer
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs .

MRT-3486	Molecular Glues Ligands for E3 Ligase NEKs	Inflammation/Immunology
MRT-3486 is a molecular glue degrader.MRT-3486 induces ternary complex formation between *CRBN* and predicted β-hairpin G-loop proteins.MRT-3486 is selected from an internal compound library for proximity-ligation experiments .

CRBN ligand-880	Ligands for E3 Ligase	Cancer
CRBN ligand-880 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-880 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-798	Ligands for E3 Ligase	Cancer
CRBN ligand-798 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-798 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-881	Ligands for E3 Ligase	Cancer
CRBN ligand-881 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-881 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-885	Ligands for E3 Ligase	Cancer
CRBN ligand-885 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-885 can be linked to a target protein ligand via a linker to form a PROTAC.

Thalidomide-5-O-C2-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-5-O-C2-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .

CRBN ligand-891	Ligands for E3 Ligase	Cancer
CRBN ligand-891 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-891 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-547	Ligands for E3 Ligase	Cancer
CRBN ligand-547 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-547 can be linked to a target protein ligand via a linker to form a PROTAC.

Thalidomide-NH-C9-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-NH-C9-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-C9-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .

CRBN ligand-224	Ligands for E3 Ligase	Cancer
CRBN ligand-224 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-224 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-660	Ligands for E3 Ligase	Cancer
CRBN ligand-660 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-660 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-788	Ligands for E3 Ligase	Cancer
CRBN ligand-788 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-788 can be linked to a target protein ligand via a linker to form a PROTAC.

Pomalidomide-PEG7-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG7-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-PEG7-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

Pomalidomide-5-C9-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-5-C9-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-5-C9-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

Pomalidomide-5-C7-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-5-C7-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C7-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

Pomalidomide-PEG5-C2-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG5-C2-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-PEG5-C2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

Thalidomide-5-O-C5-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-5-O-C5-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .

Thalidomide-5-O-C6-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-5-O-C6-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .

CRBN ligand-661	Ligands for E3 Ligase	Cancer
CRBN ligand-661 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-661 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-882	Ligands for E3 Ligase	Cancer
CRBN ligand-882 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-882 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-890	Ligands for E3 Ligase	Cancer
CRBN ligand-890 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-890 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-704	Ligands for E3 Ligase	Cancer
CRBN ligand-704 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-704 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-395	Ligands for E3 Ligase	Cancer
CRBN ligand-395 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-395 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-869	Ligands for E3 Ligase	Cancer
CRBN ligand-869 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-869 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-531	Ligands for E3 Ligase	Cancer
CRBN ligand-531 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-531 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-613	Ligands for E3 Ligase	Cancer
CRBN ligand-613 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-613 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-236	Ligands for E3 Ligase	Cancer
CRBN ligand-236 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-236 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-228	Ligands for E3 Ligase	Cancer
CRBN ligand-228 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-228 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-393	Ligands for E3 Ligase	Cancer
CRBN ligand-393 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-393 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-231	Ligands for E3 Ligase	Cancer
CRBN ligand-231 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-231 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-286	Ligands for E3 Ligase	Cancer
CRBN ligand-286 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-286 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-411	Ligands for E3 Ligase	Cancer
CRBN ligand-411 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-411 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-684	Ligands for E3 Ligase	Cancer
CRBN ligand-684 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-684 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-202	Ligands for E3 Ligase	Cancer
CRBN ligand-202 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-202 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-686	Ligands for E3 Ligase	Cancer
CRBN ligand-686 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-686 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-193	Ligands for E3 Ligase	Cancer
CRBN ligand-193 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-193 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-685	Ligands for E3 Ligase	Cancer
CRBN ligand-685 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-685 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-196	Ligands for E3 Ligase	Cancer
CRBN ligand-196 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-196 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-619	Ligands for E3 Ligase	Cancer
CRBN ligand-619 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-619 can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-408	Ligands for E3 Ligase	Cancer
CRBN ligand-408 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-408 can be linked to a target protein ligand via a linker to form a PROTAC.

Pomalidomide-C11-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

Pomalidomide-5-C10-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-5-C10-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-5-C10-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

Pomalidomide-5-C11-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-5-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-5-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

Pomalidomide-5-C12-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-5-C12-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-5-C12-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

Pomalidomide-5-C14-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-5-C14-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C14-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

Cat. No.	Nombre del producto

HY-L934

CRBN Ligand Library

121 compounds

CRBN, namely cereblon, is the substrate recognition subunit of the E3 ubiquitin ligase complex in the ubiquitin-proteasome system. A CRBN ligand library refers to a collection of numerous fragments that can specifically bind to the CRBN protein.

These ligands are mostly designed based on validated CRBN-binding warheads and modified through AI-driven molecular generation optimization systems. They not only include classic lenalidomide-derived structures but also cover novel non-lenalidomide scaffolds. After drug-likeness filtering, these ligands exhibit structural diversity and favorable druggable properties. They can be further optimized and modified to facilitate the development of novel molecular glue degraders, accelerate the discovery of molecular glues that induce interactions between CRBN and new substrate proteins, and enable the exploration of novel CRBN substrates for identifying previously unknown CRBN-binding proteins.

MCE compiles 121 fragments that can specifically bind to the CRBN protein, with molecular weights ranging from 200 to 500. Compounds developed based on the library ligands target multiple disease targets such as cancer and autoimmune diseases, further advancing the development of Molecular Glues and PROTACs therapeutic agents.

HY-L128

E3 Ligase Ligand Library

177 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation.

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 177 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L918

Molecular Glue-like Compound Library

317 compounds

Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms.

Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases.

Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 317 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

Cat. No.	Nombre del producto	Type

HY-D3392

Thalidomide-cyanine 5

Fluorescent Dyes

Thalidomide-cyanine 5 is a fluorescent probe prepared by conjugating the CRBN binder Thalidomide (HY-14658) with the near-infrared fluorescent dye Cy5. Thalidomide-cyanine 5 binds to DDB1-CRBN protein complex with a K_d of 121.6 nM. Thalidomide-cyanine 5 binds to CRBN to form a binary complex, and is mainly used for the visual tracking research of degradants such as PROTAC (Ex/Em = 650/665 nm) .

Species:	Human (9)
Tag:	His (4) Avi (5) Flag (2)
Source:	HEK293 (2) Sf9 insect cells (6) E. coli (1)

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HY-P702820

	CRBN Protein, Human (His) 1 Publications Verification protein cereblon; CRBN; AD-006	Human	E. coli
	CRBN Protein, Human (His) is the recombinant human-derived CRBN, expressed by E. coli , with C-6*His labeled tag.

HY-P702818

	CRBN Protein, Human (HEK293, Flag) protein cereblon; CRBN; AD-006	Human	HEK293
	CRBN Protein, Human (HEK293, Flag) is the recombinant human-derived Cereblon, expressed by HEK293 , with N-3*Flag labeled tag.

HY-P702851

	CRBN-DDB1 Protein, Human (sf9, Avi) protein cereblon; CRBN; AD-006; DNA damage-binding protein 1; DDB p127 subunit; XAP1; UV-damaged DNA-binding factor; HBV X-associated protein 1 (XAP-1); Damage-specific DNA-binding protein 1; DDBa	Human	Sf9 insect cells
	CRBN-DDB1 Protein, Human (sf9, Avi) is the recombinant human-derived CRBN-DDB1, expressed by Sf9 insect cells , with Avi labeled tag. ,

HY-P705555

	CRBN-DDB1 Protein, Human (sf9) protein cereblon; CRBN; AD-006; DNA damage-binding protein 1; DDB p127 subunit; XAP1; UV-damaged DNA-binding factor; HBV X-associated protein 1 (XAP-1); Damage-specific DNA-binding protein 1; DDBa	Human	Sf9 insect cells

HY-P702825

	CRBN-DDB1 Protein, Human (sf9, His, Avi) protein cereblon; CRBN; AD-006; DNA damage-binding protein 1; DDB p127 subunit; XAP1; UV-damaged DNA-binding factor; HBV X-associated protein 1 (XAP-1); Damage-specific DNA-binding protein 1; DDBa	Human	Sf9 insect cells
	CRBN-DDB1, CUL4, and Rbx1 form an E3 ubiquitin ligase complex. CRBN-DDB1 is necessary for lenalidomide (HY-A0003) and pomalidomide (HY-10984) to exert T cell immunomodulatory functions and upregulate IL-2 and TNF-α. CRBN-DDB1 mediates the anti-proliferative and cell cycle arrest effects of both classes of drugs in myeloma cells and regulates p21WAF1 expression. CRBN-DDB1 can serve as a molecular glue platform to recruit novel small molecule degraders and target kinases such as WEE1 and CK1α. CRBN-DDB1 protein, Human (sf9, His, Avi) is a recombinant CRBN-DDB1 protein expressed from Sf9 insect cells with N-His, N-Avi tags.

HY-P702850

	CRBN-DDB1 Protein, Human (Biotinylated, sf9, Avi) protein cereblon; CRBN; AD-006; DNA damage-binding protein 1; DDB p127 subunit; XAP1; UV-damaged DNA-binding factor; HBV X-associated protein 1 (XAP-1); Damage-specific DNA-binding protein 1; DDBa	Human	Sf9 insect cells
	The DDB1-CRBN complex is a crucial component of the E3 ubiquitin ligase system. CRBN-DDB1 is widely used in targeted protein degradation (TPD) and oncology research, it is essential for studying the mechanism of immunomodulatory drugs (IMiDs) and discovering novel PROTACs. CRBN-DDB1 Protein, Human (Biotinylated, sf9, Avi) is a recombinant protein expressed by Sf9 insect cells , with Avi labeled tag.

HY-P706007

	CRBN-DDB1(ΔBPB) Protein, Human (Biotinylated, sf9, Avi) protein cereblon; CRBN; AD-006; DNA damage-binding protein 1; DDB p127 subunit; XAP1; UV-damaged DNA-binding factor; HBV X-associated protein 1 (XAP-1); Damage-specific DNA-binding protein 1; DDBa	Human	Sf9 insect cells
	CRBN-DDB1(ΔBPB) Protein, Human (Biotinylated, sf9, Avi) is the recombinant human-derived CRBN-DDB1, expressed by Sf9 insect cells , with Avi labeled tag,

HY-P702817

	CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (HEK293, Flag, His) Cereblon-DDB1-Cul4A-Rbx1 Complex	Human	HEK293
	CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (HEK293, Flag, His) is the recombinant human-derived Cereblon, expressed by HEK293 , with N-6*His, N-Flag labeled tag.

HY-P702826

	CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (sf9, His, Avi) Cereblon-DDB1-Cul4A-Rbx1 Complex	Human	Sf9 insect cells
	CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (sf9, His, Avi) is the recombinant human-derived CRBN-DDB1-CUL4A-RBX1 Complex, expressed by Sf9 insect cells , with N-His, N-Avi labeled tag. ,

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HY-P86823

	CRBN Antibody (YA6516) 2610203G15Rik antibody; 2900045O07Rik antibody; AF229032 antibody; AW108261 antibody; Cereblon antibody; CRBN antibody; CRBN_HUMAN antibody; DKFZp781K0715 antibody; MGC27358 antibody; MRT2A antibody; 2610203G15Rik antibody; 2900045O07Rik antibody; AF229032 antibody; AW108261 antibody; Cereblon antibody; CRBN antibody; CRBN_HUMAN antibody; DKFZp781K0715 antibody; MGC27358 antibody; MRT2A antibody; OTTHUMP00000209555 antibody; piL antibody; protein cereblon antibody; protein x 0001 antibody;	WB, IHC-P, IP	Human, Mouse, Rat
	CRBN Antibody (YA6516) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CRBN.

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Cat. No.	Nombre del producto		Classification

HY-115997

PROTAC HSP90 degrader BP3 1 Publications Verification		PROTAC Synthesis
PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a *CRBN*-dependent fashion. PROTAC HSP90 degrader BP3 has a certain degradation effect on HSP90 protein in MCF-7 cells (DC₅₀=0.99 μM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell . PROTAC HSP90 degrader BP3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139339

Pomalidomide 4'-alkylC6-azide		Azide
Pomalidomide 4'-alkylC6-azide is the Pomalidomide (HY-123324)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC6-azide can be connected to the ligand for protein by a linker to form PROTAC .

HY-130296

Palbociclib-propargyl PROTAC CDK6 ligand 1		Alkynes
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC₅₀ of 2.1 nM for CDK6 . Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-126457

Thalidomide-propargyl		Alkynes
Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs . Thalidomide-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101460

Tz-Thalidomide		Tetrazine
Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a CLIP-TAC (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research .

HY-W458035

Desamino lenalidomide-alkynes		Alkynes
Desamino lenalidomide-alkynes is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-alkynes can be linked to a target protein ligand via a linker to form a PROTAC.

HY-139333

Pomalidomide 4'-PEG5-azide		Azide
Pomalidomide 4'-PEG5-azide is the Pomalidomide (HY-123324)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 4'-PEG5-azide can be connected to the ligand for protein by a linker to form PROTAC .

HY-159164

PROTAC CRBN ligand-3		Azide
PROTAC CRBN ligand-3 is a target protein ligand of RGB110 (HY-159087).

HY-161134

Lenalidomide 4'-PEG2-azide		Azide
Lenalidomide 4'-PEG2-azide is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG2-azide can be connected to the ligand for protein by a linker to form PROTAC .

HY-157514

Thalidomide 4'-ether-PEG1-azide		Azide
Thalidomide 4'-ether-PEG1-azide is the Thalidomide (HY-14658)-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4'-ether-PEG1-azide can be connected to the ligand for protein by a linker to form PROTACs .

HY-139332

Pomalidomide 4'-PEG6-azide		Azide
Pomalidomide 4'-PEG6-azide (compound 33e) is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .

HY-159087

RGB110		Azide
RGB110 (Compound 10d) is a PROTAC inhibitor for D-dopachrome tautomerase with an IC₅₀ of 5.9 μM. RGB110 causes no degradation of D-DT. (Pink: ligand for target protein (HY-159164); Black: linker (HY-W125017); Blue: ligand for E3 ligase CRBN (HY-10984))

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