87 Results for "

Capsaicin

" in MedChemExpress (MCE) Product Catalog:
Products (87)

87 Results for "Capsaicin" in MCE Product Catalog:

81
Capsaicin
Capsaicin
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81 Publications Verification
Cat. No.: HY-10448
CAS No.: 404-86-4
Purity:  99.79%
Synonyms: (E)-Capsaicin
Category:  

Capsicum annuum L. Monophenols Phenols Plants Solanaceae Disease Research Fields Biological Pesticide Research Cancer Agricultural Research

Target:  

Environmental Pollutants TRP Channel Autophagy Endogenous Metabolite Apoptosis

Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .
81
Capsaicin (Standard)
Capsaicin (Standard)
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81 Publications Verification
Cat. No.: HY-10448R
CAS No.: 404-86-4
Purity:  99.38%
Synonyms: (E)-Capsaicin (Standard)
Category:  

Capsicum annuum L. Phenols Plants Solanaceae Disease Research Fields Biological Pesticide Research Cancer Agricultural Research

Target:  

Reference Standards TRP Channel Autophagy Apoptosis Endogenous Metabolite

Capsaicin (Standard) is the analytical standard of Capsaicin. This product is intended for research and analytical applications. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .
21
Capsaicin (Purity 65%)
Capsaicin (Purity 65%)
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21 Cited Publications
Cat. No.: HY-10448A
CAS No.: 404-86-4
Purity:  99.20%
Category:  

Capsicum annuum L. Monophenols Neurological Disease Phenols Plants Solanaceae Disease Research Fields Inflammation/Immunology

Target:  

TRP Channel Autophagy Apoptosis Endogenous Metabolite

Capsaicin (Purity 65%) is a mixture of Capsaicin and Dihydrocapsaicin (Ratio >2:1). Capsaicin (Purity 65%) is an orally active capsaicin receptor (TRPV1) agonist .
5
MK-3207
MK-3207
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5 Cited Publications
Cat. No.: HY-10301
CAS No.: 957118-49-9
Purity:  99.60%
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

MK-3207 is an orally active, highly selective and species-specific CGRP receptor antagonist (for human CGRP receptor: IC50=0.12 nM; Ki=0.024 nM). MK-3207 can be used for migraine studies .
4
Dihydrocapsaicin
Dihydrocapsaicin
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4 Cited Publications
Cat. No.: HY-N0361
CAS No.: 19408-84-5
Category:  

Alkaloids Capsicum annuum L. Monophenols Other Alkaloids Metabolic Disease Phenols Plants Solanaceae Disease Research Fields

Target:  

Environmental Pollutants Caspase Akt Apoptosis Reactive Oxygen Species (ROS) TRP Channel Bcl-2 Family PI3K

Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .
4
Capsiate
Capsiate
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4 Cited Publications
Cat. No.: HY-N8377
CAS No.: 205687-01-0
Category:  

Capsicum annuum L. Monophenols Phenols Plants Solanaceae Disease Research Fields Inflammation/Immunology

Target:  

TRP Channel

Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1 .
3
4',5-Dihydroxyflavone
4',5-Dihydroxyflavone
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3 Cited Publications
Cat. No.: HY-N1881
CAS No.: 6665-67-4
Category:  

Flavonoids Leguminosae Glycine max (L.) merr Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Lipoxygenase Glycosidase

4',5-Dihydroxyflavone (Compound 2c; Compound B3) is a type of flavonoid compound. 4',5-Dihydroxyflavone can inhibit various oxidases and its IC50 values for collagenase A (ColA) and α-glucosidase are less than 1 μM and 66 μM respectively; for soybean lipoxygenase-1 (LOX-1), its Ki value is 102.6 μM. 4',5-Dihydroxyflavone can be used in studies on anti-toxicity and anti-diabetes .
3
S1RA hydrochloride
S1RA hydrochloride
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3 Cited Publications
Cat. No.: HY-18099A
CAS No.: 1265917-14-3
Synonyms: E-52862 hydrochloride
Target:  

Sigma Receptor 5-HT Receptor

Research Areas:  

Neurological Disease

S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization .
2
HCGRP-(8-37)
HCGRP-(8-37)
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2 Cited Publications
Cat. No.: HY-P1014
CAS No.: 119911-68-1
Synonyms: Human α-CGRP (8-37)
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

HCGRP-(8-37) (Human α-CGRP (8-37)) is a fragment of human calcitonin gene-related peptide (hCGRP) and an antagonist of the CGRP receptor, with an IC50 of 32.1 pM against the CGRP receptor. HCGRP-(8-37) blocks adenylate cyclase activation induced by CGRP receptor ligands and attenuates vascular responses triggered by CGRP. HCGRP-(8-37) reduces capsaicin-induced vasodilation in porcine nasal mucosa and superficial skin. HCGRP-(8-37) serves as a research tool to distinguish effects mediated by CGRP or calcitonin receptors, and to investigate CGRP-induced vascular effects .
1
ω-Agatoxin IVA
ω-Agatoxin IVA
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1 Cited Publications
Cat. No.: HY-P1080
CAS No.: 145017-83-0
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease Neurological Disease

ω-Agatoxin IVA is a potent, selective P/Q type Ca 2+ (Cav2.1) channel blocker with IC50 values of 2 nM and 90 nM. ω-Agatoxin IVA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA can be used for the research of neurological and cardiovascular disease .
1
ω-Agatoxin IVA TFA
ω-Agatoxin IVA TFA
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1 Cited Publications
Cat. No.: HY-P1080A
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca 2+ (Cav2.1) channel blocker with IC50 values of 2 nM and 90 nM. ω-Agatoxin IVA TFA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA TFA can be used for the research of neurological and cardiovascular disease .
(Z)-Capsaicin
(Z)-Capsaicin
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Cat. No.: HY-B1583
CAS No.: 25775-90-0
Synonyms: ZuCapsaicin; Civamide; cis-Capsaicin
Target:  

TRP Channel HSV

Research Areas:  

Neurological Disease

(Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.
Mavatrep
Mavatrep
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Cat. No.: HY-16935
CAS No.: 956274-94-5
Synonyms: JNJ-39439335
Target:  

TRP Channel

Research Areas:  

Neurological Disease

Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca 2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain .
Dexbrompheniramine
Dexbrompheniramine
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Cat. No.: HY-A0191
CAS No.: 132-21-8
Synonyms: (+)-Brompheniramine; (S)-Brompheniramine
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite Histamine Receptor TRP Channel

Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine can be used in the research of chronic cough and related pathological mechanisms .
A-425619
A-425619
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Cat. No.: HY-110292
CAS No.: 581809-67-8
Target:  

TRP Channel Calcium Channel

Research Areas:  

Inflammation/Immunology

A-425619 is an orally active and selective transient receptor potential type V1 (TRPV1) antagonist. A-425619 blocks Capsaicin (HY-10448)- and N-arachidonoyl-dopamine (NADA)-induced Ca 2+ influx in dorsal root ganglia and trigeminal ganglia. A-425619 relieves pathophysiological pain associated with inflammation and tissue injury in rats. A-425619 can be used for the study of pain related to inflammation and tissue injury .
Pellitorine
Pellitorine
0 Images
Cat. No.: HY-N3097
CAS No.: 18836-52-7
Category:  

Alkaloids Other Alkaloids Piperaceae Plants Disease Research Fields Piper nigrum Linn. Biological Pesticide Research Cancer Agricultural Research

Target:  

TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB ERK Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial

Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria .
Nordihydrocapsaicin
Nordihydrocapsaicin
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Cat. No.: HY-N0449
CAS No.: 28789-35-7
Category:  

Alkaloids Capsicum annuum L. Monophenols Other Alkaloids Other Diseases Phenols Plants Solanaceae Disease Research Fields

Target:  

Environmental Pollutants Keap1-Nrf2 GABA Receptor

Nordihydrocapsaicin, an analog of Capsaicin (HY-10448), is an orally active compound with pungent properties and anti-cancer activities, which is found in fresh and processed peppers. Nordihydrocapsaicin can cause a burning sensation when consumed .
TRPV1 antagonist 3
TRPV1 antagonist 3
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Cat. No.: HY-144372
CAS No.: 2765294-54-8
Purity:  99.30%
Target:  

TRP Channel

Research Areas:  

Neurological Disease

TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC50 of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant .
Capsaicin β-D-glucopyranoside
Capsaicin β-D-glucopyranoside
0 Images
Cat. No.: HY-N9452
CAS No.: 153409-16-6
Category:  

Alkaloids Capsicum annuum L. Other Diseases Plants Solanaceae Disease Research Fields

Target:  

Others

Capsaicin β-D-glucopyranoside is a glucoside converted by Capsaicin. Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent flavor .
Phenylcapsaicin
Phenylcapsaicin
0 Images
Cat. No.: HY-158110
CAS No.: 848127-67-3
Purity:  99.77%
Target:  

TRP Channel

Research Areas:  

Inflammation/Immunology

Phenylcapsaicin is an analogue of Capsaicin (HY-10448). Phenylcapsaicin is a TRPV1 receptor activator. Phenylcapsaicin enhances fat oxidation during aerobic exercise .
Assay Types