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Results for "

Cdkn1a

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

1

Natural
Products

8

Recombinant Proteins

6

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10587
    BIX-01294
    25+ Cited Publications

    		 Histone Methyltransferase Autophagy Cancer
    BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells [1] .
    BIX-01294
  • HY-161138
    WK369

    		BCL6 Apoptosis Cancer
    WK369 is a novel BCL6 small molecule inhibitor, which exhibits excellent anti-ovarian cancer bioactivity, induces cell cycle arrest and causes apoptosis. WK369 can directly bind to the BCL6-BTB domain and block the interaction between BCL6 and SMRT, leading to the reactivation of p53, ATR and CDKN1A [1].
    WK369
  • HY-108239
    BIX-01294 trihydrochloride
    25+ Cited Publications

    		 Histone Methyltransferase Autophagy Cancer
    BIX-01294 trihydrochloride is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 trihydrochloride inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294 trihydrochloride, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 trihydrochloride has antitumor activity in recurrent tumor cells [1] .
    BIX-01294 trihydrochloride
  • HY-RS02410
    CDKN1A Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CDKN1A Human Pre-designed siRNA Set A contains three designed siRNAs for CDKN1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDKN1A Human Pre-designed siRNA Set A
    CDKN1A Human Pre-designed siRNA Set A
  • HY-161024
    AC1Q3QWB

    AQB

    		 Histone Methyltransferase Cancer
    AC1Q3QWB upregulates CDKN1A and SOX17 by interrupting the HOTAIR-EZH2 interaction and enhances the efficacy of Tazemetostat in endometrial cancer [1].
    AC1Q3QWB
  • HY-162384
    EPIC-0628

    		Histone Methyltransferase Cancer
    EPIC-0628 is an inhibitor of the HOTAIR-EZH2 interaction and promotes ATF3 expression. The long noncoding RNA HOTAIR has been found to regulate glioblastoma (GBM) progression and mediate DNA damage repair (DDR) by interacting with the catalytic subunit EZH2 of PRC2. EPIC-0628 also inhibits the ATF3-p38-E2F1 DDR pathway to inhibit the HR pathway and upregulates CDKN1A (p21) expression, causing cell cycle arrest. EPIC-0628 also synergizes with Temozolomide (TMZ) (HY-17364) to enhance its in vivo potency [1].
    EPIC-0628
  • HY-148408
    SIRT2-IN-11

    		Sirtuin Cancer
    SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers [1].
    SIRT2-IN-11
  • HY-RS02411
    Cdkn1a Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cdkn1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdkn1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cdkn1a Rat Pre-designed siRNA Set A
    Cdkn1a Rat Pre-designed siRNA Set A
  • HY-RS16696
    Cdkn1a Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cdkn1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdkn1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cdkn1a Mouse Pre-designed siRNA Set A
    Cdkn1a Mouse Pre-designed siRNA Set A
  • HY-180183
    DLG-41

    		Epigenetic Reader Domain Cancer
    DLG-41 is a GAS41 YEATS domain inhibitor (IC50: 600 nM in AlphaLISA). DLG-41 potently disrupts the association of GAS41 YEATS with chromatin in cells. DLG-41 strongly enhances levels of CDKN1A. DLG-41 has anticancer activity against NSCLC [1].
    DLG-41
  • HY-123994
    Tenovin-D3 hydrochloride

    		Sirtuin Cancer
    Tenovin-D3 hydrochloride is a sirtuin SirT2 inhibitor that increases p21 (CDKN1A) expression in a p53 independent manner [1].
    Tenovin-D3 hydrochloride
  • HY-N7175
    5,8-Epidioxyergosta-6,9(11),22-trien-3-ol

    9,11-Dehydroergosterol peroxide; 9(11)-DHEP

    		 Apoptosis Endogenous Metabolite Cancer
    5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis [1] .
    5,8-Epidioxyergosta-6,9(11),22-trien-3-ol
  • HY-182744
    LLQ-45

    		MDM-2/p53 Cancer
    LLQ-45 is a covalent p53 Y220C mutant protein agonist with an EC50 of 24.97 μM. LLQ-45 activates the anti-tumor function of p53 Y220C through covalent modification, restores its DNA-binding ability and enhances its thermal stability. LLQ-45 selectively inhibits the proliferation of p53 Y220C mutant tumor cells, suppresses cell growth and upregulates the expression of CDKN1A. LLQ-45 can be used in studies related to p53 Y220C mutant cancers [1].
    LLQ-45
  • HY-180886
    ZD-1-186

    		Molecular Glues c-Myc Cancer
    ZD-1-186 is a nondegradative molecular glue that potently suppresses MYC and robustly induces CDKN1A (p21) in diffuse large B-cell lymphoma cells. ZD-1-186 brings together BCL6 with BRD9, a noncanonical BAF complex bromodomain protein implicated in maintaining MYC transcriptional output in specific lymphoma contexts. ZD-1-186 can be used for targeted transcriptional rewiring research [1].
    ZD-1-186
  • HY-108239R
    BIX-01294 trihydrochloride (Standard)

    		Reference Standards Histone Methyltransferase Autophagy Cancer
    BIX-01294 trihydrochloride (Standard) is the analytical standard of BIX-01294 (trihydrochloride) (HY-108239). This product is intended for research and analytical applications. BIX-01294 trihydrochloride is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 trihydrochloride inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294 trihydrochloride, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 trihydrochloride has antitumor activity in recurrent tumor cells [1] .
    BIX-01294 trihydrochloride (Standard)
  • HY-10587R
    BIX-01294 (Standard)

    		Reference Standards Histone Methyltransferase Autophagy Cancer
    BIX-01294 (Standard) is the analytical standard of BIX-01294 (HY-10587). This product is intended for research and analytical applications. BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells [1] .
    BIX-01294 (Standard)

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