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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
Cdkn1a
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "Cdkn1a" in MCE Product Catalog:
3
1
1 Cited Publications
Cat. No.: HY-P704204
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Cdkn1a; Cdk-Interacting Protein 1; Prev. Cdkn1; MDA-6; CAP20; Melanoma Differentiation Associated Protein 6; CIP1; Melanoma Differentiation-Associated Protein 6; WAF1; Wild-Type P53-Activated Fragment 1; SDI1; CDK-Interaction Protein 1; P21; CDK-Interacti
Species:
Mouse
Source:
E. coli
1
Cat. No.: HY-161138
WK369 is a novel BCL6 small molecule inhibitor, which exhibits excellent anti-ovarian cancer bioactivity, induces cell cycle arrest and causes apoptosis. WK369 can directly bind to the BCL6-BTB domain and block the interaction between BCL6 and SMRT, leading to the reactivation of p53, ATR and CDKN1A [1].
Cat. No.: HY-RS02410
Target:
Research Areas:
CDKN1A Human Pre-designed siRNA Set A contains three designed siRNAs for CDKN1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-161024
CAS No.: 46697-00-1
Synonyms: AQB
Target:
Research Areas:
AC1Q3QWB upregulates CDKN1A and SOX17 by interrupting the HOTAIR-EZH2 interaction and enhances the efficacy of Tazemetostat in endometrial cancer [1].
Cat. No.: HY-162384
CAS No.: 3034959-68-4
Target:
Research Areas:
EPIC-0628 is an inhibitor of the HOTAIR-EZH2 interaction and promotes ATF3 expression. The long noncoding RNA HOTAIR has been found to regulate glioblastoma (GBM) progression and mediate DNA damage repair (DDR) by interacting with the catalytic subunit EZH2 of PRC2. EPIC-0628 also inhibits the ATF3-p38-E2F1 DDR pathway to inhibit the HR pathway and upregulates CDKN1A (p21) expression, causing cell cycle arrest. EPIC-0628 also synergizes with Temozolomide (TMZ) (HY-17364) to enhance its in vivo potency [1].
Cat. No.: HY-161989
CAS No.: 3105664-95-4
DZ-837 is a BCL6 PROTAC degrader with a DC50 of 557.7 nM. DZ-837 induces BCL6 ubiquitination and degradation in a CRBN-dependent manner via the ubiquitin-proteasome system. DZ-837 activates CDKN1A and CDKN1B, the downstream genes of BCL6. DZ-837 upregulates p21 and p27 proteins . DZ-837 inhibits tumor growth in a diffuse large B-cell lymphoma xenograft mouse model. DZ-837 exerts synergistic antiproliferative effects when combined with Ibrutinib (HY-10997). DZ-837 can be used in studies related to diffuse large B-cell lymphoma [1] .
Cat. No.: HY-RS02411
Target:
Research Areas:
Cdkn1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdkn1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers [1].
Cat. No.: HY-RS16696
Target:
Research Areas:
Cdkn1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdkn1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-180183
Target:
Research Areas:
DLG-41 is a GAS41 YEATS domain inhibitor (IC50: 600 nM in AlphaLISA). DLG-41 potently disrupts the association of GAS41 YEATS with chromatin in cells. DLG-41 strongly enhances levels of CDKN1A. DLG-41 has anticancer activity against NSCLC [1].
Cat. No.: HY-123994
CAS No.: 1258283-70-3
Tenovin-D3 hydrochloride is a sirtuin SirT2 inhibitor that increases p21 (CDKN1A) expression in a p53 independent manner [1].
Cat. No.: HY-N7175
CAS No.: 86363-50-0
Synonyms: 9,11-Dehydroergosterol peroxide; 9(11)-DHEP
Category:
Solanum lyratum Thunberg Plants Disease Research Fields Cancer Solanaceae Extract Steroids
Target:
Cat. No.: HY-P700570
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cdkn1a; Cdk-Interacting Protein 1; Prev. Cdkn1; MDA-6; CAP20; Melanoma Differentiation Associated Protein 6; CIP1; Melanoma Differentiation-Associated Protein 6; WAF1; Wild-Type P53-Activated Fragment 1; SDI1; CDK-Interaction Protein 1; P21; CDK-Interacti
Species:
Human
Source:
E. coli
Cat. No.: HY-P76746
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: BCCIP; TOK1; BRCA2 And Cdkn1a Interacting Protein; BRCA2 And Cip1/P21 Interacting Protein; BRCA2 And Cdkn1a-Interacting Protein; Cdk Inhibitor P21 Binding Protein; BCCIPalpha; TOK-1alpha; TOK-1; BCCIPbeta; P21- And CDK-Associated Protein 1; TOK-1beta; Pro
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P76747
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: BCCIP; TOK1; BRCA2 And Cdkn1a Interacting Protein; BRCA2 And Cip1/P21 Interacting Protein; BRCA2 And Cdkn1a-Interacting Protein; Cdk Inhibitor P21 Binding Protein; BCCIPalpha; TOK-1alpha; TOK-1; BCCIPbeta; P21- And CDK-Associated Protein 1; TOK-1beta; Pro
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-180886
Research Areas:
ZD-1-186 is a non-degradative, covalent-dependent molecular glue that targets BCL6 and BRD9. ZD-1-186 inhibits the transcriptional output of MYC, relieves the repression of canonical BCL6 target loci (including CDKN1A (p21)), and mediates the selective recruitment of BRD9 to BCL6. ZD-1-186 can be used for research on diffuse large B-cell lymphoma [1].
Cat. No.: HY-P80773A
Synonyms: Cdkn1a; CAP20; Cdkn1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
