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Results for "

D2R

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

2

Peptides

1

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0807A
    Prochlorperazine dimaleate

    		Dopamine Receptor NADPH Oxidase Dengue Virus Flavivirus Neurological Disease Inflammation/Immunology Cancer
    Prochlorperazine dimaleate is an orally active phenothiazine-type dopamine D2 receptor (D2R) antagonist. Prochlorperazine exhibits anti-cancer activity in vitro against various cancer cell lines. Prochlorperazine dimaleate exhibits IC50 values of 6.4 μM, 4.5 μM and 2.3 μM for NOX1, NOX2 and NOX5, respectively. Prochlorperazine dimaleate has antedesmosidic activity against dengue virus (DENV). Prochlorperazine dimaleate can be used for research on nausea, vomiting, migraine, and schizophrenia [2] .
    Prochlorperazine dimaleate
  • HY-10684
    Pridopidine

    ACR16; ASP2314; FR310826

    		 Dopamine Receptor Neurological Disease
    Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.
    Pridopidine
  • HY-108751
    Aripiprazole Lauroxil
    2 Publications Verification

    		 Dopamine Receptor Neurological Disease
    Aripiprazole lauroxil, an N-acyloxymethyl proagent of Aripiprazole (HY-14546), is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia and a ligand of dopamine receptor D2R/D4R. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.
    Aripiprazole Lauroxil
  • HY-128121
    MLS1547

    		Dopamine Receptor Neurological Disease
    MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (Ki=1.2 μM). MLS1547 stimulates D2R G protein-mediated signaling (EC50=0.37 μM in a calcium mobilization assay). MLS1547 acts as an antagonist for dopamine (DA)-stimulated β-arrestin recruitment to the D2R (IC50=9.9 μM) [2].
    MLS1547
  • HY-111385
    UNC9994 hydrochloride
    2 Publications Verification

    		 Dopamine Receptor 5-HT Receptor Arrestin Neurological Disease
    UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity .
    UNC9994 hydrochloride
  • HY-126068
    Esamisulpride

    (S)-Amisulpride; (S)-Aramisulpride; (S)-DAN 2163

    		 Dopamine Receptor 5-HT Receptor Neurological Disease
    Esamisulpride ((S)-Amisulpride) is the S-isomer of Amisulpride (HY-14545). Esamisulpride is a potent dopamine D2/D3 receptor antagonist with Ki values of 4.43 nM for D2R and 0.72 nM for D3R. Esamisulpride is a 5-HT7 receptor antagonist with a Ki of 900 nM. Esamisulpride can be used in the research of schizophrenia and depression [2] .
    Esamisulpride
  • HY-129946
    Dopamine D2 receptor antagonist-1

    		Dopamine Receptor Neurological Disease
    Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity .
    Dopamine D2 receptor antagonist-1
  • HY-109167
    Aramisulpride

    (R)-Amisulpride; (R)-Esamisulpride; (R)-DAN 2163

    		 Dopamine Receptor 5-HT Receptor Neurological Disease
    Aramisulpride (R-(+)-Amisulpride) is the R-isomer of Amisulpride (HY-14545). Aramisulpride is a 5-HT7 receptor antagonist with a Ki value of 22 nM. Aramisulpride is a D2/D3 receptor antagonist with a Ki value of 140 nM for D2R and a Ki value of 13.9 nM for D3R. Aramisulpride can be used in psychiatric research [2].
    Aramisulpride
  • HY-117829
    UNC9994
    2 Publications Verification

    		 Dopamine Receptor 5-HT Receptor Histamine Receptor Arrestin Neurological Disease
    UNC9994, an analog of Aripiprazole, is a functionally selective β-arrestin-biased dopamine D2 receptor (D2R) agonist with EC50 <10 nM for β-arrestin-2 recruitment to D2 receptors. UNC9994 is simultaneously partial agonists of β-arrestin-2 translocation and antagonists of Gi-regulated cAMP production. Antipsychotic Activity .
    UNC9994
  • HY-12324
    SB269652

    		Dopamine Receptor Neurological Disease
    SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.
    SB269652
  • HY-P3294
    Onzigolide

    BIM-23A760; TBR-760

    		 Dopamine Receptor Somatostatin Receptor Neurological Disease Cancer
    Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors [2].
    Onzigolide
  • HY-P10450
    (Asp)2-Rhodamine 110

    D2R; (D)2-Rhodamine 110

    		 Caspase Others
    (Asp)2-Rhodamine 110 (D2R) is a fluorescent caspase substrate .
    (Asp)2-Rhodamine 110
  • HY-175504
    MLS6357

    		Dopamine Receptor PERK Neurological Disease
    MLS6357 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist. MLS6357 exhibits antagonist activity in the D3R-mediated and the BRET-based β-arrestin recruitment assay with IC50s of 13 and 14 μM, and no activity for other DAR subtypes (D1R/D2R/D4R/D5R) (IC50 > 100 μM). MLS6357 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 17 μM. MLS6357 can be used for the study of neuropsychiatric disorders, including substance use disorder .
    MLS6357
  • HY-129089
    (-)-MDO-NPA

    		Dopamine Receptor Neurological Disease
    (-)-MDO-NPA is an N-propylnorapomorphine analog and a D1R/D2R dual-target ligand. (-)-MDO-NPA has EC50 values of 1949 nM (D1R) and 520 nM (D2R) for β-arrestin. (-)-MDO-NPA has EC50 values of 717.5 nM (D1R) and 7.7 nM (D2R) for cAMP. (-)-MDO-NPA can be used in the research of dopamine-related diseases such as Parkinson’s disease .
    (-)-MDO-NPA
  • HY-W004758
    1-(4-Chlorophenyl)piperazine

    		Drug Intermediate Others
    1-(4-Chlorophenyl)piperazine is a chemical intermediate, and can be used for synthesis of D2R ligand .
    1-(4-Chlorophenyl)piperazine
  • HY-116445
    UNC9975

    		Dopamine Receptor Neurological Disease
    UNC9975 is a D2R agonist that displays signaling bias via β-arrestin–ergic signaling and a simultaneously antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9975 can be utilized in antipsychotic research .
    UNC9975
  • HY-156239
    Dopamine D3 receptor ligand-5

    		Dopamine Receptor 5-HT Receptor Neurological Disease
    Dopamine D3 receptor ligand-5 (13a), a Cariprazine (HY-14763) analogue, is a dopamine D3 receptor ligand, with Ki values of 2.85 nM and 0.14 nM for D2R and D3R, respectively .
    Dopamine D3 receptor ligand-5
  • HY-175532
    M4 mAChR Modulator-2

    		mAChR Neurological Disease
    M4 mAChR Modulator-2 is an orally active, selective, brain-penetrant positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (M4 mAChR) (EC50 = 513 nM). M4 mAChR Modulator-2 exhibits high target selectivity, showing negligible affinity and low inhibition rates for non-target receptors (D1R/D2R/D3R, 5-HT subtypes, κ/δ/μ opioid receptors, H1, M1/M2) while specifically binding to M4 mAChR with a Ki of 377 nM and an inhibition rate of 62.8%. M4 mAChR Modulator-2 reverses Dizocilpine (MK-801) (HY-15084B)-induced hyperlocomotion in mice. M4 mAChR Modulator-2 can be used for the study of schizophrenia
    M4 mAChR Modulator-2
  • HY-124583
    PF-4363467

    		Dopamine Receptor Neurological Disease
    PF-4363467, a dopamine D3/D2 receptor antagonist, attenuates opioid drug-seeking behavior without concomitant D2 side effects. PF-4363467 exhibits Ki values of 3.1 nM and 692 nM for D3R and D2R .
    PF-4363467
  • HY-123788
    BRD5814

    		Dopamine Receptor Neurological Disease
    BRD5814 is a D2R antagonist. BRD5814 can be used in schizophrenia research .
    BRD5814
  • HY-111210
    Pridopidine hydrochloride

    ACR16 hydrochloride; ASP2314 hydrochloride; FR310826 hydrochloride

    		 Dopamine Receptor Neurological Disease
    Pridopidine (ACR16) hydrochloride, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100-fold higher than its affinity toward D2R.
    Pridopidine hydrochloride
  • HY-10684R
    Pridopidine (Standard)

    ACR16 (Standard); ASP2314 (Standard); FR310826 (Standard)

    		 Dopamine Receptor Reference Standards Neurological Disease
    Pridopidine (Standard) is the analytical standard of Pridopidine. This product is intended for research and analytical applications. Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.
    Pridopidine (Standard)
  • HY-112015
    Deschlorohaloperidol

    R-1838

    		 Dopamine Receptor Neurological Disease
    Deschlorohaloperidol (compound 8h) is an analogue of Haloperidol (HY-14538). Haloperidol is a dopamine D2 receptor (D2R) antagonist for schizophrenia .
    Deschlorohaloperidol
  • HY-14793
    Lensiprazine

    		Dopamine Receptor Neurological Disease
    Lensiprazine is a potent dopamine D2 receptor (D2R) antagonist that acts as a serotonin reuptake inhibitor. Lensiprazine can be used to study bipolar disorder and schizophrenia [2] .
    Lensiprazine
  • HY-145308
    Heterobivalent ligand-1

    		Adenosine Receptor Dopamine Receptor Neurological Disease
    Heterobivalent ligand-1 (compound 26) is a heterobivalent ligand for the Adenosine A 2A-dopamine D 2 receptor heteromer (KDB1 A2AR=2.1 nM, KDB1 D2R= 0.13 nM) .
    Heterobivalent ligand-1
  • HY-119768
    (±)-BAK2-66

    		Dopamine Receptor Neurological Disease
    (±)-BAK2-66 is a selectivity dopamine D3 receptor antagonist with theKi values of 1nM and 960 nM for D3R and D2R, respectively. (±)-BAK2-66 can be used for study in animal models of addiction .
    (±)-BAK2-66
  • HY-109167A
    Aramisulpride hydrochloride

    (R)-Amisulpride hydrochloride; (R)-Esamisulpride hydrochloride; (R)-DAN 2163 hydrochloride

    		 Dopamine Receptor 5-HT Receptor Neurological Disease
    Aramisulpride hydrochloride is a 5-HT7 receptor antagonist with a Ki value of 22 nM. Aramisulpride hydrochloride is a D2/D3 receptor antagonist with a Ki value of 140 nM for D2R and a Ki value of 13.9 nM for D3R. Aramisulpride hydrochloride can be used in psychiatric research [2].
    Aramisulpride hydrochloride
  • HY-14545B
    SEP-4199

    		5-HT Receptor Dopamine Receptor Neurological Disease
    SEP4199 is an orally active 5-HT7 receptor ligand, with a Ki value of 66 nM for human 5-HT7R and 16 nM for human D2R. SEP4199 mediates antidepressant effects. SEP4199 is applicable for the research of bipolar depression .
    SEP-4199
  • HY-108751R
    Aripiprazole Lauroxil (Standard)

    		Others Reference Standards Neurological Disease
    Aripiprazole Lauroxil (Standard) is the analytical standard of Aripiprazole Lauroxil. This product is intended for research and analytical applications. Aripiprazole lauroxil, an N-acyloxymethyl proagent of Aripiprazole (HY-14546), is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia and a ligand of dopamine receptor D2R/D4R. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.
    Aripiprazole Lauroxil (Standard)
  • HY-47412
    Cariprazine impurity 1

    		Dopamine Receptor Neurological Disease
    Cariprazine impurity 1 is a dopamine D2 receptor (D2R) agonist. Cariprazine impurity 1 modulates D2R-mediated Gi/o signaling pathway to inhibit cAMP production, and regulates D2R-mediated β-arrestin2 recruitment pathway .
    Cariprazine impurity 1
  • HY-179713
    D2R/D3R/5-HT1AR agonist 1

    		Dopamine Receptor 5-HT Receptor Neurological Disease
    D2R/D3R/5-HT1AR agonist 1 (compound 22b) is an orally active triple-target D2R/D3R/5-HT1AR agonist with EC50 values of 1.29, 1.05 and 153.5 nM. D2R/D3R/5-HT1AR agonist 1 can improve the behavioral disorders induced by MPTP (HY-W114750) and exerts anti-depression effect. D2R/D3R/5-HT1AR agonist 1 can be used for the research of Parkinson's disease and depression .
    D2R/D3R/5-HT1AR agonist 1
  • HY-173044
    5-HT1AR/5-HT6R ligand-1

    		5-HT Receptor Dopamine Receptor Neurological Disease
    5-HT1AR/5-HT6R ligand-1 (Compound PP13) is the ligand for 5-HT receptor that exhibits good affinity to 5-HT1AR, 5-HT6R and 5-HT7R (Ki of 19, 69 and 198 nM, respectively), thereby inhibiting the cAMP production in HEK293 cell with EC50 of 1535, 488 and 53 nM, respectively. 5-HT1AR/5-HT6R ligand-1 exhibits anti-proliferative activity against a variety of cancer cells (IC50 for 1321N1, U87MG, MCF7, and AsPC-1 is 9.6, 13.6, 19.3 and 14.6 μM, respectively). 5-HT1AR/5-HT6R ligand-1 also exhibits antagonist activity for dopamine receptor D2R with Ki of 1903 nM .
    5-HT1AR/5-HT6R ligand-1
  • HY-RS03998
    Drd2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Drd2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Drd2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Drd2 Mouse Pre-designed siRNA Set A
    Drd2 Mouse Pre-designed siRNA Set A
  • HY-RS03997
    DRD2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DRD2 Human Pre-designed siRNA Set A contains three designed siRNAs for DRD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DRD2 Human Pre-designed siRNA Set A
    DRD2 Human Pre-designed siRNA Set A
  • HY-181049
    FMJ-01-054

    		Dopamine Receptor Neurological Disease
    FMJ-01-054 is a selective dopamine D4 Receptor (D4R) antagonist with a Ki od 77.7 nM. FMJ-01-054 shows subtype selectivity over D2R and D3R. FMJ-01-054 inhibits D4R-mediated β-arrestin recruitment and cAMP production with IC50 values of 3800 nM and 134 nM, respectively. FMJ-01-054 has desirable plasma half-life and brain exposure in rats. FMJ-01-054 can be used for the research of neurological disorders .
    FMJ-01-054
  • HY-181047
    FMJ-01-042

    		Dopamine Receptor Neurological Disease
    FMJ-01-042 is a blood-brain barrier-permeable, low-efficacy partial agonist with high affinity (Kᵢ = 4.33 nM) and exceptional subtype selectivity for the dopamine D4 receptor. FMJ-01-042 exhibits good metabolic stability and is suitable for research on neurological and psychiatric disorders .
    FMJ-01-042

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