Search Result
Results for "
DIO.
" in MedChemExpress (MCE) Product Catalog:
3
Biochemical Assay Reagents
5
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D0969
-
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DiOC18(3); 3,3'-Dioctadecyloxacarbocyanine perchlorate
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Fluorescent Dye
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Others
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DiO is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins .
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- HY-18341
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- HY-B0346
-
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6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU
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Environmental Pollutants
Thyroid Hormone Receptor
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Endocrinology
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Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research .
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- HY-18341B
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- HY-P10745
-
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ZP8396
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Amylin Receptor
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Metabolic Disease
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Petrelintide (ZP8396) is a dual amylin and calcitonin receptor agonist (DACRA) Petrelintide elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide can be utilized in diabetes research .
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- HY-P10745A
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ZP8396 acetate
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Amylin Receptor
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Metabolic Disease
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Perelintide (ZP8396) acetate is a dual amylin and calcitonin receptor agonist (DACRA). Perelintide acetate elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Perelintide acetate can be utilized in diabetes research .
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- HY-12443
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Casein Kinase
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Neurological Disease
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PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner . PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity .
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- HY-151500
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Amine N-methyltransferase
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Metabolic Disease
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JBSNF-00002 free base is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 free base can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 free base exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 free base can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease .
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- HY-18341A
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- HY-13467
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AM-1638
3 Publications Verification
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Free Fatty Acid Receptor
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Metabolic Disease
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AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 μM). AM-1638 increases the expression of antioxidant molecules (HO-1 and NQO-1). AM1638 blocks Palmitate (HY-N0830)-mediated superoxide production and ER stress. AM-1638 has antidiabetic activity and improves glycemic control in BDF mice with diet-induced obesity (DIO). AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%) .
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- HY-160912
-
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ELOVL
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Metabolic Disease
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ELOVL6-IN-5 is an orally active and selective elongase enzyme of long-chain fatty acid family 6 (ELOVL6) inhibitor with IC50 values of 85 nM and 38 nM for human and mouse ELOVL6, respectively. ELOVL6-IN-5 shows >60-fold selectivity over other ELOVL family enzymes (ELOVL1, 2, 3, 5) and no effect on other lipid synthesis enzymes like ACC1, ACC2. ELOVL6-IN-5 reduces hepatic fatty acid composition ratio of C18 to C16 in diet-induced obesity (DIO) and KKAy mice. ELOVL6 inhibition by ELOVL6-IN-5 does not improve insulin resistance. ELOVL6-IN-5 can be used for the research of metabolic disease .
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- HY-18341R
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Levothyroxine (Standard); T4 (Standard)
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Reference Standards
Thyroid Hormone Receptor
Endogenous Metabolite
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Endocrinology
Cancer
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L-Thyroxine (Standard) is the analytical standard of L-Thyroxine. This product is intended for research and analytical applications. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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- HY-14342
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MK-5046
2 Publications Verification
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Bombesin Receptor
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Metabolic Disease
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MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity .
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- HY-114557
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3,5-Diiodo-L-thyronine
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JNK
NF-κB
Sirtuin
PGC-1α
COX
TGF-β Receptor
Collagen
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Metabolic Disease
Inflammation/Immunology
Endocrinology
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NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity .
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- HY-147318
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Apoptosis
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Cancer
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PBENZ-DBRMD is a potent iodothyronine deiodinase type 3 (DIO3) inhibitor. PBENZ-DBRMD has anti-proliferative activity and induces apoptosis. PBENZ-DBRMD can be used for cancer research .
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- HY-18341S2
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Thyroid Hormone Receptor
Endogenous Metabolite
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Endocrinology
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L-Thyroxine- 13C6 is the 13C labeled L-Thyroxine . L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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- HY-151500B
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Amine N-methyltransferase
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Metabolic Disease
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JBSNF-00002 hydrochloride is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 hydrochloride can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 hydrochloride exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 hydrochloride can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease .
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- HY-W010669
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Sodium levothyroxine
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Thyroid Hormone Receptor
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Endocrinology
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L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
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- HY-P10032
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- HY-114340
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Histone Methyltransferase
Apoptosis
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Cancer
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LEM-14 is a potent and selective NSD2 inhibitor with an IC50 of 132 µM. LEM-14 has very weak activitv
against NSD1 and has no activity against NSD3. LEM-14 inhibits fibrotic gene expression in ND but not DIO BMDMs. LEM-14 combined with ionizing radiation (IR) enhances the apoptosis rate and reduces the colony-formation ability of CRC cells. LEM-14 exhibits enhanced anti-tumor efficacy in Balb/c nude mice bearing LoVo cell xenografts when combined with ionizing radiation. LEM-14 has the potential for the research of multiple myeloma and colorectal cancer .
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- HY-18341F
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Thyroid Hormone Receptor
Endogenous Metabolite
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Endocrinology
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Biotin-(L-Thyroxine) is the biotinylated L-Thyroxine (HY-18341). L-Thyroxine is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from Biotin-(L-Thyroxine) (T4) .
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- HY-133876
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DiA
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Fluorescent Dye
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Others
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4-Di-16-ASP is a green fluorescent membrane dye. 4-Di-16-ASP is a lipophilic aminostyryl probe with a broad emission spectrum (can be detected with green, orange or even red filters). It is commonly used for neuronal membrane tracing (it diffuses faster than DiO) .
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- HY-151959
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FXR
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Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
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FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD) .
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- HY-151500A
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Amine N-methyltransferase
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Metabolic Disease
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JBSNF-00002 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 TFA can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 TFA exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 TFA can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease .
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- HY-172661
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Thyroid Hormone Receptor
Interleukin Related
LDLR
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Infection
Metabolic Disease
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KYLO-0603 is an orally active, selective THR-β agonist (EC50 : 31.07 nM). KYLO-0603 has significant activity in lowering serum cholesterol and low-density lipoprotein cholesterol. KYLO-0603 upregulates the expression of THR-regulated genes (including iodothyronine deiodinase 1 (Dio1), malic enzyme 1 (Me1), and thyroid hormone response (Thrsp) gene) and inhibits the expression of inflammatory and fibrotic genes (low-density lipoprotein receptor (LDL-R) gene) by activating THR-β receptors. KYLO-0603 can be used to treat metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis research .
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- HY-DY1010
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Fluorescent Dye
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Others
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DiO (solution) is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins . Solvent and concentration: DMSO: 5 mM
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- HY-138007
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ROR
PPAR
LXR
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Metabolic Disease
Inflammation/Immunology
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SR-1903 is an inverse agonist of RORγ and PPARγ (IC50 of ∼100 nM and 209 nM for RORγ and PPARγ, respectively) and a LXR agonist. SR-1903 exhibits anti-inflammatory and anti-diabetic efficacy in collagen-induced arthritis and diet-induced obesity mouse models .
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- HY-144287
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Glucokinase
Sodium Channel
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Metabolic Disease
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Glucokinase activator 3 is an orally active Glucokinase (GK) activator with an AC50 of 38 nM. Glucokinase activator 3 inhibits hERG channel and sodium channel in patch clamp assays. Glucokinase activator 3 exhibits high efficacy in reducing blood glucose in diet-induced obese (DIO) mice. Glucokinase activator 3 has the potential for the research of type 2 diabetes .
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- HY-P11321A
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acyl-GIP hydrochloride
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Insulin Receptor
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Metabolic Disease
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IUB0271 (acyl-GIP) hydrochloride is a fatty acylated and long-acting glucose-dependent insulinotropic polypeptide (GIP). IUB0271 hydrochloride increases cFos neuronal activity in hypothalamic feeding centers and decreases body weight, food intake and glycemia in DIO mouse models, and these effects depend on CNS-GIPR signaling. IUB0271 hydrochloride can be used for type 2 diabetes mellitus (T2DM) and obesity research .
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- HY-P11321
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acyl-GIP
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Insulin Receptor
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Metabolic Disease
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IUB0271 (acyl-GIP) is a fatty acylated and long-acting glucose-dependent insulinotropic polypeptide (GIP). IUB0271 increases cFos neuronal activity in hypothalamic feeding centers and decreases body weight, food intake and glycemia in DIO mouse models, and these effects depend on CNS-GIPR signaling. IUB0271 can be used for type 2 diabetes mellitus (T2DM) and obesity research .
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- HY-14342A
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Bombesin Receptor
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Metabolic Disease
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(R)-MK-5046 is the isomer of MK-5046 (HY-14342), and can be used as an experimental control. MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity .
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- HY-151500C
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Amine N-methyltransferase
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Metabolic Disease
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JBSNF-00002 is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease .
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- HY-129990
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Liposome
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Cancer
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Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport .
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- HY-177297
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NVP-LCZ960
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Glucokinase
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Metabolic Disease
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LCZ960 is an orally active glucokinase (GK) activator. LCZ960 stimulates GK activity in hepatocytes in vitro and stimulates glucose uptake in vivo through hepatic GK activation. LCZ960 lowers blood glucose in mice with diet-induced obesity (DIO). LCZ960 maintains normoglycemia and improves glucose tolerance in DIO mice and rats. LCZ960 stimulates glycogen synthase flux and increases hepatic glycogen turnover in rats. LCZ960 induces increased hepatic glycogen recycling. LCZ960 can be used to study high-fat diet-induced obesity and type 2 diabetes .
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- HY-101699A
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MCHR1 (GPR24)
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Metabolic Disease
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AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice .
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- HY-B0346R
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6-n-Propylthiouracil (Standard); 6-Propyl-2-thiouracil (Standard); PTU (Standard)
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Thyroid Hormone Receptor
Reference Standards
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Endocrinology
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Propylthiouracil (Standard) is the analytical standard of Propylthiouracil. This product is intended for research and analytical applications. Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research .
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- HY-18341BR
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Levothyroxine sodium (Standard); T4 sodium (Standard)
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Reference Standards
Thyroid Hormone Receptor
Endogenous Metabolite
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Endocrinology
Cancer
|
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L-Thyroxine (sodium) (Standard) is the analytical standard of L-Thyroxine (sodium). This product is intended for research and analytical applications. L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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- HY-18341S1
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- HY-101699
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MCHR1 (GPR24)
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Metabolic Disease
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AMG-076 free base is an orally bioavailable and selective MCHR1 antagonist. AMG-076 free base results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice .
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- HY-W010669R
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Sodium levothyroxine (Standard)
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Reference Standards
Thyroid Hormone Receptor
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Endocrinology
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L-Thyroxine sodium xhydrate (Standard) is the analytical standard of L-Thyroxine sodium xhydrate. This product is intended for research and analytical applications. L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
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- HY-178857
-
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Cannabinoid Receptor
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Metabolic Disease
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CB1 antagonist 6 (Compound 11jE2) is an orally active CB1R antagonist, with an IC50 value of 23 nM. CB1 antagonist 6 significantly reduces food intake and body weight, improves glucose tolerance and insulin resistance, and decreases serum ALT and AST levels in diet-induced obese (DIO) mice, demonstrating hepatoprotective effects. CB1 antagonist 6 can be used for the study of metabolic syndrome (obesity, diabetes) .
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- HY-18341S4
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-
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- HY-P11262
-
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GLP Receptor
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Metabolic Disease
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GUB021794 is a potent and highly selective glucagon-like peptide-1 receptor (GLP-1R) agonist developed using the streaMLine platform with an EC50 value of 18 pM. GUB021794 has a very weak activity against SCTR, with an EC50 value of 190 nM. GUB021794 can significantly reduce the body weight, food intake, and total fat mass of mice in a diet-induced obesity (DIO) model. GUB021794 can be used for research on obesity/diabetes .
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- HY-RS03769
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Small Interfering RNA (siRNA)
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Others
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DIO1 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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DIO1 Human Pre-designed siRNA Set A
DIO1 Human Pre-designed siRNA Set A
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- HY-RS22137
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Small Interfering RNA (siRNA)
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Others
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Dio3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dio3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Dio3 Mouse Pre-designed siRNA Set A
Dio3 Mouse Pre-designed siRNA Set A
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- HY-RS28658
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Small Interfering RNA (siRNA)
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Others
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Dio3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dio3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Dio3 Rat Pre-designed siRNA Set A
Dio3 Rat Pre-designed siRNA Set A
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- HY-RS03771
-
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Small Interfering RNA (siRNA)
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Others
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DIO3 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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DIO3 Human Pre-designed siRNA Set A
DIO3 Human Pre-designed siRNA Set A
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- HY-RS03770
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Small Interfering RNA (siRNA)
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Others
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DIO2 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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DIO2 Human Pre-designed siRNA Set A
DIO2 Human Pre-designed siRNA Set A
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- HY-165660S
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2,3-Dio-6-ketoPGF1α-d9sodium salt
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Isotope-Labeled Compounds
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Others
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2,3-Dinor-6-ketoProstaglandinF1α-d9 (2,3-Dio-6-ketoPGF1α-d9) sodium saltis deuterium labeled 2,3-Dinor-6-ketoProstaglandinF1α(sodium salt) .
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- HY-N3795
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Echinoynethiophene A; Thiophene A dio
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Others
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Others
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Thiophene E (Echinoynethiophene A) is a natural product .
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- HY-157718
-
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Biochemical Assay Reagents
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1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine is a surfactant that has the activity of promoting liposome formation. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine can effectively study the biological effects of ceramide and ceramide phosphate. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine shows important application in the determination of phospholipase A activity of lecithin-cholesterol acyltransferase in ether matrix.
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- HY-111131
-
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Melanocortin Receptor
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Metabolic Disease
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RY746 is a selective MC4R agonist, with an EC50 of 10 nM. RY764 effectively inhibits food intake and reduces body weight gain in diet-induced obese (DIO) rat models. RY764 can be used for the study of obesity .
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- HY-P10032A
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- HY-D3372
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Dilinoleyl DiO
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Fluorescent Dye
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Neurological Disease
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RAPID DiO (Dilinoleyl DiO) is a cyanine dye with green fluorescence (EX≈490 nm; Em≈505 nm). RAPID DiO is a lipophilic dye that labels cell membranes by inserting its two long hydrocarbon (C18 carbon) chains into the lipid bilayer. RAPID DiO is weakly fluorescent until incorporated into membranes. RAPID DiO diffuses laterally to stain the entire cell, allowing it to be used as an anterograde and retrograde tracer of neurons.
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- HY-18341AR
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Sodium levothyroxine pentahydrate (Standard)
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Thyroid Hormone Receptor
Endogenous Metabolite
Reference Standards
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Endocrinology
Cancer
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L-Thyroxine (sodium salt pentahydrate) (Standard) is the analytical standard of L-Thyroxine (sodium salt pentahydrate). This product is intended for research and analytical applications. L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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- HY-147927
-
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Enteropeptidase
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Metabolic Disease
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Human enteropeptidase-IN-1 (compound 6b) is a highly potent, orally active and low systemic exposure enteropeptidase inhibitor. Human enteropeptidase-IN-1 boosts the increase in fecal protein output, and exhibits potent body weight loss in diet-induced obese (DIO) rat model. Human enteropeptidase-IN-1 can be used for anti-obesity research .
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- HY-147927A
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Enteropeptidase
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Metabolic Disease
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(S)-Human enteropeptidase-IN-1 (Compound 6c) is an orally active enteropeptidase inhibitor with low systemic exposure (IC50 (initial): 26 nM; IC50 (app): 1.8 nM). (S)-Human enteropeptidase-IN-1 promotes increased fecal protein output and effectively reduces body weight in a diet-induced obese (DIO) rat model. (S)-Human enteropeptidase-IN-1 inhibits enteropeptidase via a reversible covalent mechanism and prolongs the enzyme inactivation time. (S)-Human enteropeptidase-IN-1 can be used in anti-obesity research .
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- HY-123765
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Acyltransferase
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Metabolic Disease
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JTT-553 is a DGAT1 inhibitor (IC50: 2.38 nM). JTT-553 reduces plasma concentrations of glucose, insulin, non-esterified fatty acids (NEFA), total cholesterol (TC), and hepatic triglycerides (TG). JTT-553 improves insulin-dependent glucose uptake and glucose intolerance in adipose tissue of DIO mice. JTT-553 reduces TNF-α mRNA levels and increases GLUT4 mRNA levels in adipose tissue of KK-Ay mice. JTT-553 improves adipose tissue insulin resistance and systemic glucose metabolism by reducing body weight. JTT-553 can be used in the study of obesity and type 2 diabetes mellitus (T2DM) .
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- HY-P11075
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Neurokinin Receptor
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Metabolic Disease
|
|
[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide (HY-156131)-induced dysfunctional voiding in wild-type mice. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research .
|
-
- HY-114557R
-
|
3,5-Diiodo-L-thyronine (Standard)
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
NSC 90469 (Standard) is the analytical standard of NSC 90469. This product is intended for research and analytical applications. NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity .
|
-
- HY-D3419
-
|
|
Fluorescent Dye
|
Neurological Disease
|
|
Neuro-DiO 4-chlorobenzenesulfonate is a hydrophobic C18 alkyl chain carbocyanine dye with green fluorescence, commonly used as a vascular marker, cell internalizer and deposition agent. Neuro-DiO 4-chlorobenzenesulfonate inserts its alkyl chain into the endothelial plasma membrane via liposome-mediated perfusion to achieve vascular labeling. Neuro-DiO chlorobenzenesulfonate can also stain the cell membrane and cytoplasm of cancer cells to assist in confocal microscopy observations. Neuro-DiO chlorobenzenesulfonate can be released from nanosponges and accumulate on the surface of mouse retina, then internalize into retinal ganglion cells, which is applicable to researches related to glaucoma and other diseases. It should be noted that during liposome-mediated vascular staining in mice, Neuro-DiO 4-chlorobenzenesulfonate may cause leakage of airway lavage fluid .
|
-
- HY-165674S
-
|
11-dehydo-2,3-dio TXB2-d9
|
Isotope-Labeled Compounds
|
Others
|
|
11-dehydro-2,3-dinor Thromboxane B2-d9 (11-dehydo-2,3-dio TXB2-d9) is deuterium labeled 11-dehydro-2,3-dinor Thromboxane B2 .
|
-
- HY-D3379
-
-
- HY-W412313
-
-
- HY-182688
-
|
|
Thyroid Hormone Receptor
|
Neurological Disease
|
|
ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression .
|
-
- HY-P11587
-
|
|
Amylin Receptor
CGRP Receptor
|
Metabolic Disease
|
|
BGM1812 is a dual agonist of amylin (hAMY3R) (EC50 = 0.627 nM) and CGRP Receptor (hCTR) (EC50 = 2.27 nM). BGM1812 achieves weight loss, increases the proportion of lean body mass, and reduces fat mass in diet-induced obese (DIO) rats. BGM1812 is applicable to research related to obesity .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D0969
-
|
DiOC18(3); 3,3'-Dioctadecyloxacarbocyanine perchlorate
|
Fluorescent Dye
|
|
DiO is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins .
|
-
- HY-18341F
-
|
|
Fluorescent Dye
|
|
Biotin-(L-Thyroxine) is the biotinylated L-Thyroxine (HY-18341). L-Thyroxine is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from Biotin-(L-Thyroxine) (T4) .
|
-
- HY-133876
-
|
DiA
|
Fluorescent Dye
|
|
4-Di-16-ASP is a green fluorescent membrane dye. 4-Di-16-ASP is a lipophilic aminostyryl probe with a broad emission spectrum (can be detected with green, orange or even red filters). It is commonly used for neuronal membrane tracing (it diffuses faster than DiO) .
|
-
- HY-DY1010
-
|
|
Fluorescent Dye
|
DiO (solution) is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins . Solvent and concentration: DMSO: 5 mM
|
-
- HY-D3372
-
|
Dilinoleyl DiO
|
Fluorescent Dye
|
|
RAPID DiO (Dilinoleyl DiO) is a cyanine dye with green fluorescence (EX≈490 nm; Em≈505 nm). RAPID DiO is a lipophilic dye that labels cell membranes by inserting its two long hydrocarbon (C18 carbon) chains into the lipid bilayer. RAPID DiO is weakly fluorescent until incorporated into membranes. RAPID DiO diffuses laterally to stain the entire cell, allowing it to be used as an anterograde and retrograde tracer of neurons.
|
-
- HY-D3419
-
|
|
Fluorescent Dye
|
|
Neuro-DiO 4-chlorobenzenesulfonate is a hydrophobic C18 alkyl chain carbocyanine dye with green fluorescence, commonly used as a vascular marker, cell internalizer and deposition agent. Neuro-DiO 4-chlorobenzenesulfonate inserts its alkyl chain into the endothelial plasma membrane via liposome-mediated perfusion to achieve vascular labeling. Neuro-DiO chlorobenzenesulfonate can also stain the cell membrane and cytoplasm of cancer cells to assist in confocal microscopy observations. Neuro-DiO chlorobenzenesulfonate can be released from nanosponges and accumulate on the surface of mouse retina, then internalize into retinal ganglion cells, which is applicable to researches related to glaucoma and other diseases. It should be noted that during liposome-mediated vascular staining in mice, Neuro-DiO 4-chlorobenzenesulfonate may cause leakage of airway lavage fluid .
|
-
- HY-D3379
-
| Cat. No. |
Product Name |
Type |
-
- HY-W010669
-
|
Sodium levothyroxine
|
Biochemical Assay Reagents
|
|
L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
|
-
- HY-W010669R
-
|
Sodium levothyroxine (Standard)
|
Biochemical Assay Reagents
|
|
L-Thyroxine sodium xhydrate (Standard) is the analytical standard of L-Thyroxine sodium xhydrate. This product is intended for research and analytical applications. L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
|
-
- HY-157718
-
|
|
Biochemical Assay Reagents
|
|
1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine is a surfactant that has the activity of promoting liposome formation. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine can effectively study the biological effects of ceramide and ceramide phosphate. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine shows important application in the determination of phospholipase A activity of lecithin-cholesterol acyltransferase in ether matrix.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10745
-
|
ZP8396
|
Amylin Receptor
|
Metabolic Disease
|
|
Petrelintide (ZP8396) is a dual amylin and calcitonin receptor agonist (DACRA) Petrelintide elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide can be utilized in diabetes research .
|
-
- HY-P10745A
-
|
ZP8396 acetate
|
Amylin Receptor
|
Metabolic Disease
|
|
Perelintide (ZP8396) acetate is a dual amylin and calcitonin receptor agonist (DACRA). Perelintide acetate elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Perelintide acetate can be utilized in diabetes research .
|
-
- HY-P10032
-
-
- HY-P11321A
-
|
acyl-GIP hydrochloride
|
Insulin Receptor
|
Metabolic Disease
|
|
IUB0271 (acyl-GIP) hydrochloride is a fatty acylated and long-acting glucose-dependent insulinotropic polypeptide (GIP). IUB0271 hydrochloride increases cFos neuronal activity in hypothalamic feeding centers and decreases body weight, food intake and glycemia in DIO mouse models, and these effects depend on CNS-GIPR signaling. IUB0271 hydrochloride can be used for type 2 diabetes mellitus (T2DM) and obesity research .
|
-
- HY-P11321
-
|
acyl-GIP
|
Insulin Receptor
|
Metabolic Disease
|
|
IUB0271 (acyl-GIP) is a fatty acylated and long-acting glucose-dependent insulinotropic polypeptide (GIP). IUB0271 increases cFos neuronal activity in hypothalamic feeding centers and decreases body weight, food intake and glycemia in DIO mouse models, and these effects depend on CNS-GIPR signaling. IUB0271 can be used for type 2 diabetes mellitus (T2DM) and obesity research .
|
-
- HY-P11262
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
GUB021794 is a potent and highly selective glucagon-like peptide-1 receptor (GLP-1R) agonist developed using the streaMLine platform with an EC50 value of 18 pM. GUB021794 has a very weak activity against SCTR, with an EC50 value of 190 nM. GUB021794 can significantly reduce the body weight, food intake, and total fat mass of mice in a diet-induced obesity (DIO) model. GUB021794 can be used for research on obesity/diabetes .
|
-
- HY-P10032A
-
-
- HY-P11075
-
|
|
Neurokinin Receptor
|
Metabolic Disease
|
|
[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide (HY-156131)-induced dysfunctional voiding in wild-type mice. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research .
|
-
- HY-P11587
-
|
|
Amylin Receptor
CGRP Receptor
|
Metabolic Disease
|
|
BGM1812 is a dual agonist of amylin (hAMY3R) (EC50 = 0.627 nM) and CGRP Receptor (hCTR) (EC50 = 2.27 nM). BGM1812 achieves weight loss, increases the proportion of lean body mass, and reduces fat mass in diet-induced obese (DIO) rats. BGM1812 is applicable to research related to obesity .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-18341
-
-
-
- HY-18341B
-
-
-
- HY-18341A
-
-
-
- HY-18341R
-
-
-
- HY-114557
-
|
3,5-Diiodo-L-thyronine
|
Structural Classification
Monophenols
Classification of Application Fields
Ketones, Aldehydes, Acids
Phenols
Metabolic Disease
Endogenous metabolite
Disease Research Fields
Source Classification
|
JNK
NF-κB
Sirtuin
PGC-1α
COX
TGF-β Receptor
Collagen
|
|
NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity .
|
-
-
- HY-18341F
-
-
-
- HY-18341BR
-
-
-
- HY-N3795
-
-
-
- HY-18341AR
-
-
-
- HY-114557R
-
|
3,5-Diiodo-L-thyronine (Standard)
|
Structural Classification
Monophenols
Ketones, Aldehydes, Acids
Phenols
Endogenous metabolite
Source Classification
|
Reference Standards
Endogenous Metabolite
|
|
NSC 90469 (Standard) is the analytical standard of NSC 90469. This product is intended for research and analytical applications. NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity .
|
-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-18341S2
-
|
|
|
L-Thyroxine- 13C6 is the 13C labeled L-Thyroxine . L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
|
-
-
- HY-18341S1
-
|
|
|
Thyroxine hydrochloride- 13C6 is the 13C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
|
-
-
- HY-18341S4
-
|
|
|
L-Thyroxine- 13C6-1 (Levothyroxine- 13C6-1; T4- 13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
|
-
-
- HY-165660S
-
|
|
|
2,3-Dinor-6-ketoProstaglandinF1α-d9 (2,3-Dio-6-ketoPGF1α-d9) sodium saltis deuterium labeled 2,3-Dinor-6-ketoProstaglandinF1α(sodium salt) .
|
-
-
- HY-165674S
-
|
|
|
11-dehydro-2,3-dinor Thromboxane B2-d9 (11-dehydo-2,3-dio TXB2-d9) is deuterium labeled 11-dehydro-2,3-dinor Thromboxane B2 .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-129990
-
|
|
|
Cationic Lipids
|
|
Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport .
|
-
- HY-RS03769
-
|
|
|
siRNAs
Human Pre-designed siRNA Sets
|
|
DIO1 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
- HY-RS22137
-
|
|
|
siRNAs
Mouse Pre-designed siRNA Sets
|
|
Dio3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dio3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
- HY-RS28658
-
|
|
|
siRNAs
Rat Pre-designed siRNA Sets
|
|
Dio3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dio3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
- HY-RS03771
-
|
|
|
siRNAs
Human Pre-designed siRNA Sets
|
|
DIO3 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
- HY-RS03770
-
|
|
|
siRNAs
Human Pre-designed siRNA Sets
|
|
DIO2 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
- HY-157718
-
|
|
|
Phospholipids
|
|
1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine is a surfactant that has the activity of promoting liposome formation. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine can effectively study the biological effects of ceramide and ceramide phosphate. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine shows important application in the determination of phospholipase A activity of lecithin-cholesterol acyltransferase in ether matrix.
|
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