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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
DKK1 inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "DKK1 inhibitor" in MCE Product Catalog:
13
11
11 Cited Publications
Cat. No.: HY-P7155A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DKK1; Dickkopf 1 Homolog (Xenopus Laevis); Dickkopf Wnt Signaling Pathway inhibitor 1; Dickkopf 1 Homolog; SK; Dickkopf-1 Like; DKK-1; Dickkopf-1; Dickkopf-Related Protein 1; HDKK-1; Dickkopf-Like Protein 1; DKK-1; Dickkopf (Xenopus Laevis) Homolog 1
Species:
Human
Source:
HEK293
6
6 Cited Publications
Cat. No.: HY-P7154
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DKK1; Dickkopf 1 Homolog (Xenopus Laevis); Dickkopf Wnt Signaling Pathway inhibitor 1; Dickkopf 1 Homolog; SK; Dickkopf-1 Like; DKK-1; Dickkopf-1; Dickkopf-Related Protein 1; HDKK-1; Dickkopf-Like Protein 1; DKK-1; Dickkopf (Xenopus Laevis) Homolog 1
Species:
Mouse
Source:
CHO
5
5 Cited Publications
Cat. No.: HY-N5124
CAS No.: 60767-80-8
Synonyms: Isovitexin 2''-O-glucoside; Isovitexin 2''-O-β-D-glucoside
5
5 Cited Publications
Cat. No.: HY-P72968
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DKK1; Dickkopf 1 Homolog (Xenopus Laevis); Dickkopf Wnt Signaling Pathway inhibitor 1; Dickkopf 1 Homolog; SK; Dickkopf-1 Like; DKK-1; Dickkopf-1; Dickkopf-Related Protein 1; HDKK-1; Dickkopf-Like Protein 1; DKK-1; Dickkopf (Xenopus Laevis) Homolog 1
Species:
Human
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P72969
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DKK1; Dickkopf 1 Homolog (Xenopus Laevis); Dickkopf Wnt Signaling Pathway inhibitor 1; Dickkopf 1 Homolog; SK; Dickkopf-1 Like; DKK-1; Dickkopf-1; Dickkopf-Related Protein 1; HDKK-1; Dickkopf-Like Protein 1; DKK-1; Dickkopf (Xenopus Laevis) Homolog 1
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P70513
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DKK1; Dickkopf 1 Homolog (Xenopus Laevis); Dickkopf Wnt Signaling Pathway inhibitor 1; Dickkopf 1 Homolog; SK; Dickkopf-1 Like; DKK-1; Dickkopf-1; Dickkopf-Related Protein 1; HDKK-1; Dickkopf-Like Protein 1; DKK-1; Dickkopf (Xenopus Laevis) Homolog 1
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P73305
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DKK1; Dickkopf 1 Homolog (Xenopus Laevis); Dickkopf Wnt Signaling Pathway inhibitor 1; Dickkopf 1 Homolog; SK; Dickkopf-1 Like; DKK-1; Dickkopf-1; Dickkopf-Related Protein 1; HDKK-1; Dickkopf-Like Protein 1; DKK-1; Dickkopf (Xenopus Laevis) Homolog 1
Species:
Rat
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P73305A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DKK1; Dickkopf 1 Homolog (Xenopus Laevis); Dickkopf Wnt Signaling Pathway inhibitor 1; Dickkopf 1 Homolog; SK; Dickkopf-1 Like; DKK-1; Dickkopf-1; Dickkopf-Related Protein 1; HDKK-1; Dickkopf-Like Protein 1; DKK-1; Dickkopf (Xenopus Laevis) Homolog 1
Species:
Rat
Source:
HEK293
Synonyms: SK3530
Research Areas:
Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .
Synonyms: SK-3530 dihydrochloride
Research Areas:
Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .
Target:
Research Areas:
Gallocyanine chloride is a synthetic blue dyestuff that can be used as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies. Gallocyanine chloride inhibits DKK1/LRP6 interaction (IC50=6.38 μM), activates Wnt signaling pathway, and causes β-catenin accumulation. Gallocyanine chloride exhibits anti-metastasis, anti-inflammatory and anti-fibrosis activities. Gallocyanine chloride can be used as a fluorescent probe for detection of superoxide anion radicals .
Cat. No.: HY-14930R
CAS No.: 862189-95-5
Synonyms: SK3530 (Standard)
Research Areas:
Mirodenafil (Standard) is the analytical standard of Mirodenafil. This product is intended for research and analytical applications. Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .
Cat. No.: HY-175219
Target:
Research Areas:
CA-II/Dkk1-IN-1 (Compound 5d) is a dual-functional inhibitor of CA-II and Dkk1 with a IC50 of 6.90 nM for CA-II. CA-II/Dkk1-IN-1 has significantly antioxidant activity and superior DNA binding capacity. CA-II/Dkk1-IN-1 can be used for cancers research, such as esophageal, renal, and lung cancer .
Cat. No.: HY-P991569
Target:
Research Areas:
Cat. No.: HY-14930AR
CAS No.: 862189-96-6
Synonyms: SK-3530 dihydrochloride (Standard)
Research Areas:
Mirodenafil (dihydrochloride) (Standard) is the analytical standard of Mirodenafil (dihydrochloride). This product is intended for research and analytical applications. Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .
Cat. No.: HY-P992113
CAS No.: 3061142-96-6
Synonyms: AGA2118
Research Areas:
Evabosmig (AGA2118) is a humanized bispecific monoclonal antibody targeting sclerostin (SOST/sclerostin) and DKK1. SOST and DKK1 are two key secreted negative regulators of the intramedullary Wnt/β-catenin pathway. Evabosmig possesses activities to induce bone formation, inhibit bone resorption and increase bone mineral density. Evabosmig is applicable for research related to osteoporosis .
Research Areas:
Gallocyanine (NCI8642) is a DKK/LRP interaction inhibitor and Wnt/β-catenin signaling pathway activator. Gallocyanine binds to the YWTD repeat domains of LRP5/6, competitively blocks the interaction between DKK and LRP5/6, with an IC50 of approximately 3 μM for inhibiting DKK1 binding to LRP5, an IC50 of 6.38 μM for inhibiting DKK1 binding to LRP6, and a Ki of 14 μM for inhibiting the DKK2C/LRP6-E3E4 interaction. Gallocyanine reverses the inhibitory effect of DKK1 on WNT3A signaling, with an EC50 of approximately 5 μM. Gallocyanine can be used in studies related to Alzheimer's disease, bone formation and glucose metabolism .
Cat. No.: HY-P7155B
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DKK1; Dickkopf 1 Homolog (Xenopus Laevis); Dickkopf Wnt Signaling Pathway inhibitor 1; Dickkopf 1 Homolog; SK; Dickkopf-1 Like; DKK-1; Dickkopf-1; Dickkopf-Related Protein 1; HDKK-1; Dickkopf-Like Protein 1; DKK-1; Dickkopf (Xenopus Laevis) Homolog 1
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
