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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
201 Results for "
DOTAP/DOPE
" in MedChemExpress (MCE) Product Catalog:
Products (201)
201 Results for "DOTAP/DOPE" in MCE Product Catalog:
20
20 Publications Verification
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane chloride
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .
20
20 Publications Verification
Cat. No.: HY-W127378
CAS No.: 144189-73-1
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .
14
14 Cited Publications
Synonyms: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Target:
Liposome Endogenous Metabolite ACSL Family Amino acid Transporter Ferroptosis Glutathione Peroxidase
Research Areas:
DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease .
4
4 Cited Publications
Cat. No.: HY-P2336A
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-W127426
CAS No.: 252769-92-9
1
1 Cited Publications
Cat. No.: HY-W440827
DOPE-PEG2000-COOH is a PEG polymer containing unsaturated DOPE phospholipids and carboxylic acids. DOPE-PEG2000-COOH can be used to prepare liposomes or other nanoparticles for drug delivery .
Research Areas:
DOPE-NHS is a linker. DOPE-NHS can be used for peptides to be conjugated to exosomes and possibly other membrane-based nanoparticles. DOPE-NHS can be used for drug delivery .
Synonyms: NBD-DOTAP
Target:
Research Areas:
Fluorescent DOTAP (NBD-DOTAP) is a cationic lipid which can be used for nucleic acid and protein delivery. Fluorescent DOTAP is labeled with a fluorophore NBD (maximum excitation/emission wavelength ∼463/536 nm). Fluorescent DOTAP can be used for gene delivery systems, drug delivery, as well as cell imaging and nanocarrier tracking. Fluorescent DOTAP is an ideal candidate for both biological and pharmaceutical formulation (e.g. co-delivery of vaccines) research .
Cat. No.: HY-143950S
Cat. No.: HY-112754AGL
CAS No.: 132172-61-3
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)
Cat. No.: HY-N16025
CAS No.: 2342575-85-1
Synonyms: DOPE-PEG2000-NH2 ammonium
Target:
Research Areas:
DOPE-PEG2000-Amine (DOPE-PEG2000-NH2) ammonium is a polyethylene glycol-derivatized phospholipid that can be used to construct liposomes and lipid nanoparticles. DOPE-PEG-Amine ammonium is used for non-covalent functionalization of single-walled carbon nanotubes (SWCNTs) to enhance their water dispersibility and biocompatibility. DOPE-PEG-Amine ammonium can be applied in research related to photothermal applications .
Cat. No.: HY-W440988
DOPE-mPEG2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner .
Cat. No.: HY-W800805
CAS No.: 2295813-15-7
DOPE-Mal is an N-maleimide-derived phosphatidylethanolamine. DOPE-Mal does not interfere with fatty acyl chains or alter lipid bilayer permeability; it increases lipid bilayer order, reduces fluidity, induces conformational changes in phospholipid polar heads and enhances their hydration. DOPE-Mal can be used as a component to prepare maleimide-displaying liposomes, enabling peptide conjugation via maleimide-thiol coupling. DOPE-Mal can be used to prepare Liposomes for delivering Doxorubicin (HY-15142A) to hepatocytes. DOPE-Mal is applicable to research related to hepatocellular carcinoma and lung cancer .
Cat. No.: HY-164035
Target:
Research Areas:
DOPE-PEG2000-DBCO is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .
Cat. No.: HY-W440987
DOPE-mPEG1000 is a phospholipid. Phospholipids have good biocompatibility and significant amphiphilic characteristics, making them the main and suitable dosage form or excipient in drug formulations to achieve better therapeutic effects. DOPE-mPEG1000 can be used in drug delivery research .
Cat. No.: HY-160272
Target:
Research Areas:
DOPE-PEG2000-Fluor 488 is a PEG lipid, composed of a DOPE phospholipid and a Fluor 488 fluorophore. DOPE is an unsaturated phospholipid. Fluor 488 has excitation and emission maxima at 499 nm and 520 nm .
Cat. No.: HY-160280
Target:
Research Areas:
DOPE-PEG2000-Fluor 647 is a PEG-lipid-dye conjugate. composed of a DOPE phospholipid and a Fluor 647 dye .
Cat. No.: HY-N15995
CAS No.: 2342575-87-3
Target:
Research Areas:
DOPE-PEG(2000) Carboxylic acid sodium is a stabilizer. DOPE-PEG(2000) Carboxylic acid sodium produce a coating around the ferrofluid droplet chains which are dispersed in 5CB. DOPE-PEG(2000) Carboxylic acid sodium tends to fold, effectively shielding the surrounding LC molecules from the homeotropic anchoring at the droplet interface and leading to smaller deformations and thus also creating a more stable interface .
Cat. No.: HY-160273
Target:
Research Areas:
DOPE-PEG5000-Fluor 488 is a PEG lipid, composed of a DOPE phospholipid and a Fluor 488 dye .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
