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DT

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52

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-130604
    DT2216
    2 Publications Verification

    Bcl-2 Family PROTACs Apoptosis Cancer
    DT2216 is a potent and selective BCL-XL (Bcl-2 family member) degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax-piperazine (HY-44432), a linker, and a VHL E3 ubiquitin ligase (Pink: Navitoclax-piperazine; Blue: VHL ligand; Black: linker) .
    DT2216
  • HY-132591
    Inclisiran
    Maximum Cited Publications
    7 Publications Verification

    ALN-PCSsc

    PCSK9 Small Interfering RNA (siRNA) Pyroptosis PPAR NOD-like Receptor (NLR) Caspase Interleukin Related Cardiovascular Disease Metabolic Disease
    Inclisiran is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran inhibits the transcription of PCSK9. Inclisiran inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran can be used in researches of hyperlipidemia and cardiovascular disease (CVD) .
    Inclisiran
  • HY-132609
    Patisiran sodium
    1 Publications Verification

    Small Interfering RNA (siRNA) Transthyretin (TTR) Neurological Disease
    Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis .
    Patisiran sodium
  • HY-147080

    ARC1905

    Complement System Others
    Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .
    Avacincaptad pegol sodium
  • HY-112929
    DT-061
    Maximum Cited Publications
    19 Publications Verification

    Phosphatase Cancer
    DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis .
    DT-061
  • HY-20140

    5'-O-(4,4'-Dimethoxytrityl)thymidine

    Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Others
    5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides .
    5'-O-DMT-dT
  • HY-W013068

    Phosphoramidites DNA/RNA Synthesis Others
    DMT-dT Phosphoramidite is typically used in the synthesis of DNA .
    DMT-dT Phosphoramidite
  • HY-44432

    ABT-263-piperazine

    Ligands for Target Protein for PROTAC Bcl-2 Family Cancer
    Navitoclax-piperazine (ABT-263-piperazine) is a Navitoclax (HY-10087) analog and BCL-XL inhibitor. Navitoclax-piperazine is the ligand for target protein of PROTAC DT2216 (HY-130604). Navitodax-pperaie and E3 ubiquitin ligase VHL ligand can be used to synthesize PROTAC DT2216 (HY-130604) .
    Navitoclax-piperazine
  • HY-P99245

    RG 7155; RO 5509554

    c-Fms Cancer
    Emactuzumab(RG 7155) is a specific monoclonal antibody that inhibits colonystimulating factor 1 receptor (CSF1R) activation. Emactuzumab has high affinity for CSF-1R with Ki value of 0.2 nM to blocks CSF-1R dimerization. Emactuzumab can be used for the research of several diseases, such as diffuse-type tenosynovial giant cell tumour (dt-GCT) .
    Emactuzumab
  • HY-120272
    SMAP-2
    1 Publications Verification

    DT-1154

    Phosphatase Cancer
    SMAP-2 (DT-1154) is an orally active protein phosphatase 2A (PP2A) activator, with anti-cancer activity .
    SMAP-2
  • HY-145720

    ALN-CC5

    Complement System Small Interfering RNA (siRNA) Metabolic Disease
    Cemdisiran (ALN-CC5) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases .
    Cemdisiran
  • HY-132581
    Tadnersen
    1 Publications Verification

    BIIB078; IONIS-C9Rx

    Ras Others Neurological Disease
    Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
    Tadnersen
  • HY-148457

    Izervay

    Complement System Infection Neurological Disease Inflammation/Immunology
    Avacincaptad pegol (Izervay) is a selective inhibitor targeting complement component C5, and is a pegylated ribonucleic acid aptamer. Avacincaptad pegol inhibits the cleavage of C5 into pro-inflammatory C5a and C5b, which forms the membrane attack complex (C5b-9), thereby reducing inflammatory cell recruitment and retinal cell damage. Avacincaptad pegol can slow the growth of geographic atrophy (GA) lesions and reduce the risk of persistent vision loss. Avacincaptad pegol can be used in research of geographic atrophy associated with age-related macular degeneration (AMD) and has been approved by the FDA .
    Avacincaptad pegol
  • HY-A0152

    D-T4

    Endogenous Metabolite Metabolic Disease
    D-Thyroxine (D-T4) is an orally active thyroid hormone that inhibits the secretion of TSH. D-Thyroxine can inhibit goiter, promote metamorphosis of tadpoles and influence cholesterol metabolism. D-Thyroxine can be used for the study of hypercholesterolemia .
    D-Thyroxine
  • HY-109561

    EYE001; NX1838

    VEGFR Metabolic Disease Inflammation/Immunology
    Pegaptanib sodium is an RNA aptamer with polyethylene glycol modifications, which is directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .
    Pegaptanib sodium
  • HY-124801
    ABMA
    1 Publications Verification

    Flavivirus Dengue Virus Bacterial Parasite Infection
    ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity .
    ABMA
  • HY-B1991

    Environmental Pollutants Herbicide Others
    Terbutryn is a photosystem II inhibitor and aquatic toxicant. Terbutryn interferes with photosynthesis by inhibiting photosystem II. Terbutryn reduces the production of periphyton by acting directly on periphytic algae in artificial indoor streams. Terbutryn reduces the population growth of Lumbriculus variegatus in artificial indoor streams through indirect effects associated with the reduction of food sources for periphyton. The overall 50% dissipation time (DT50) of Terbutryn in the water of artificial indoor streams is 28 d .
    Terbutryn
  • HY-P2692B
    DT-2 acetate
    1 Publications Verification

    PKG Cancer
    DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG). DT-2 inhibits PKG catalyzed phosphorylation (Ki: 12.5 nM) .
    DT-2 acetate
  • HY-P0142A

    PKG Cardiovascular Disease
    DT-3 acetate is a membrane-permeable protein kinase G Iα (PKG Iα) inhibitory peptide and shows pharmacological blockade of the cGMP-PKG signalling .
    DT-3 acetate
  • HY-138646

    Poly(dA:DT) sodium

    Cyclic GMP-AMP Synthase STING Inflammation/Immunology
    Poly(deoxyadenylic-thymidylic) acid (Poly(dA:dT)) sodium is a double-stranded DNA stimulant. Poly(deoxyadenylic-thymidylic) acid sodium is recognized by the intracellular DNA sensor DDX41 and activates the innate immune pathway via the adaptor protein STING, inducing the production of cytokines such as type I interferons. Poly(deoxyadenylic-thymidylic) acid sodium also serves as an in vitro transcription template for free RNA polymerase .
    Poly(deoxyadenylic-thymidylic) acid sodium
  • HY-156512

    TGF-beta/Smad Cancer
    DT-6 is an effective TGF-β1 inhibitor. DT-6 inhibits M2 macrophage induced epithelial to mesenchymal transition and invasive migration of cancer cells. DT-6 can be used for cancer diseases research .
    DT-6
  • HY-W048513

    DNA/RNA Synthesis Cancer
    7-Deaza-2'-deoxyadenosine is an isosteric dATP analog of 2'-deoxyadenosine. 7-Deaza-2'-deoxyadenosine is recognized by various DNA polymerases and incorporated into DNA strands as a substrate. 7-Deaza-2'-deoxyadenosine undergoes a bioorthogonal inverse electron demand Diels-Alder reaction with tetrazine-modified molecules, enabling site-specific labeling of DNA, surface antibody immobilization and intracellular fluorescent labeling. 7-Deaza-2'-deoxyadenosine reduces the DNA curvature of d(A6)·d(T6) fragments and the stability of DNA/RNA double helices, and leads to decreased antisense activity against SV40 T Antigen. 7-Deaza-2'-deoxyadenosine finds application in the research field of SV40 T Antigen-related cancers .
    7-Deaza-2'-deoxyadenosine
  • HY-132598

    SPC-3649

    MicroRNA HCV Infection Inflammation/Immunology
    Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection .
    Miravirsen
  • HY-130849

    E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604) .
    (S,R,S)-AHPC-Me-C5-COOH
  • HY-W419589

    COX NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Inflammation/Immunology Cancer
    Xanthomicrol is extracted from the resin of the plant called Chinese bellflower (a member of the Scrophulariaceae family) and is a monoamine oxidase (MAOs) inhibitor. Xanthomicrol has anti-tumor and anti-inflammatory properties, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells. Xanthomicrol's the main metabolite of 5DT in mouse colon, and it can reduce levels of iNOS protein and mRNA, as well as COX-2 protein levels. Additionally, Xanthomicrol decreases the production of the pro-inflammatory cytokine IL-1β and induces the expression of the antioxidant enzyme HO-1 .
    Xanthomicrol
  • HY-P0142

    PKG Cardiovascular Disease
    DT-3 is a membrane-permeable protein kinase G Iα (PKG Iα) inhibitory peptide and shows pharmacological blockade of the cGMP-PKG signalling .
    DT-3
  • HY-138597

    DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Infection Cancer
    5'-O-TBDMS-dT is a nucleoside with protective and modification effects.
    5'-O-TBDMS-dT
  • HY-164181

    DNA/RNA Synthesis Phosphoramidites Cancer
    Fmoc-protected DMT-Dt PEG2 NH2 amidite is a phosphoramidite monomer.
    Fmoc-protected DMT-Dt PEG2 NH2 amidite
  • HY-147079

    ARC 1779

    Integrin Cardiovascular Disease
    Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.
    Egaptivon pegol
  • HY-132600

    Temavirsen

    MicroRNA HCV Infection
    RG-101 is a hepatocyte targeted N-acetylgalactosamine conjugated oligonucleotide that antagonises miR-122. miR-122 is an important host factor for hepatitis C virus (HCV) replication .
    RG-101
  • HY-W700549

    Phosphoramidites Nucleoside Antimetabolite/Analog Others
    DMT-dT is a nucleotide derivative .
    DMT-dT
  • HY-177023

    Nucleoside Antimetabolite/Analog Cancer
    Ap5dT is a cytosolic thymidine kinase and mitochondrial enzyme inhibitor with Kis of 0.12 μM and 0.50 μM, respectively. Ap5dT can be used for the study of acute myelocytic leukemia .
    Ap5dT
  • HY-177631

    DT01; coDbait

    Poly(ADP-ribose) Glycohydrolase (PARG) Cancer
    Etidaligide, an AsiDNA, a first-in-class DNA repair inhibitor designed to prevent the repair of DNA damage in tumour cells. It also activates DNA-dependent protein kinase (DNA-PK) and poly (ADP-ribose) polymerase enzymes that induce phosphorylation of H2A
    Etidaligide
  • HY-177631A

    DT01 sodium; coDbait sodium

    Poly(ADP-ribose) Glycohydrolase (PARG) Cancer
    Etidaligide sodium, an AsiDNA, a first-in-class DNA repair inhibitor designed to prevent the repair of DNA damage in tumour cells. It also activates DNA-dependent protein kinase (DNA-PK) and poly (ADP-ribose) polymerase enzymes that induce phosphorylation
    Etidaligide sodium
  • HY-173452

    Fungal Infection
    DT-23 is a potent antifungal agent with an MIC50 of 15 μg/mL. DT-23 inhibits recombinant Arg1 and Kcs1 with IC50s of 0.6 and 0.68 μM, respectively .
    DT-23
  • HY-W013068S3

    Isotope-Labeled Compounds DNA/RNA Synthesis Others
    DMT-dT Phosphoramidite-d11 is deuterium labeled DMT-dT Phosphoramidite (HY-W013068). DMT-dT Phosphoramidite is typically used in the synthesis of DNA.
    DMT-dT Phosphoramidite-d11
  • HY-W013068S2

    Isotope-Labeled Compounds DNA/RNA Synthesis Others
    DMT-dT Phosphoramidite- 13C is 13C-labeled DMT-dT Phosphoramidite (HY-W013068). DMT-dT Phosphoramidite is typically used in the synthesis of DNA.
    DMT-dT Phosphoramidite-13C
  • HY-W013068S1

    Isotope-Labeled Compounds DNA/RNA Synthesis Others
    DMT-dT Phosphoramidite- 15N2 is the 15N labeled DMT-dT Phosphoramidite . DMT-dT Phosphoramidite is typically used in the synthesis of DNA .
    DMT-dT Phosphoramidite-15N2
  • HY-161436

    Small Interfering RNA (siRNA) Others
    TPA-dT is a thymidine analog with a tris[(2-pyridyl)methyl]amine (TPA) group. TPA-dT can be used to modify siRNAs. The TPA-modified siRNAs remain functionally inactive and is incapable of silencing gene expression until the TPA moiety is removed upon exposure to Cu(I) .
    TPA-dT
  • HY-112929B
    (1S,2S,3R)-DT-061
    1 Publications Verification

    Phosphatase Cancer
    (1S,2S,3R)-DT-061 is an enantiomer of DT-061 (HY-112929). DT-061 is an orally active activator of protein phosphatase 2A (PP2A). (1S,2S,3R)-DT-061 can be used as a negative control in the research of KRAS-mutant and MYC-driven lung cancer tumorigenesis .
    (1S,2S,3R)-DT-061
  • HY-W013068S

    Isotope-Labeled Compounds DNA/RNA Synthesis Others
    DMT-dT Phosphoramidite- 13C10, 15N2 is the 13C and 15N labeled DMT-dT Phosphoramidite . DMT-dT Phosphoramidite is typically used in the synthesis of DNA .
    DMT-dT Phosphoramidite-13C10,15N2
  • HY-D1901

    Fluorescent Dye Others
    FAM-dT phosphoramidite (Compound 21) is a fully protected labelled nucleoside phosphoramidite that can be incorporated into oligonucleotides .
    FAM-dT phosphoramidite
  • HY-179677

    Liposome Others
    DSPE-PEG2000-Mal-Cys-DT7 is a phospholipid-PEG conjugate. DSPE-PEG2000-Mal-Cys-DT7 utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles.
    DSPE-PEG2000-Mal-Cys-DT7
  • HY-179677A

    Liposome Others
    DSPE-PEG3400-Mal-Cys-DT7 is a phospholipid-PEG conjugate. DSPE-PEG3400-Mal-Cys-DT7 utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles.
    DSPE-PEG3400-Mal-Cys-DT7
  • HY-168345A

    DNA/RNA Synthesis Others
    Ap4dT is an inhibitor for human adenylate kinase isozyme 1 (hAK1), that inhibits the ATP and ADP synthesis with IC50s of 42 μM and 38 μM .
    Ap4dT
  • HY-168345

    DNA/RNA Synthesis Others
    Ap4dT is an inhibitor for human adenylate kinase isozyme 1 (hAK1), that inhibits the ATP and ADP synthesis with IC50s of 42 μM and 38 μM .
    Ap4dT tetraammonium
  • HY-147265

    MicroRNA Cancer
    Eldocasiran is a micro-ARN-193a-3p analogue, Eldocasiran has anticancer activity. Eldocasiran can be used for cancer research .
    Eldocasiran
  • HY-E70739

    c-Kit Cancer
    KIT (CD117) is an important cell surface marker used to identify certain types of hematopoietic(blood) progenitors in the bone marrow. KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT V559D/T670I is a mutant of KIT. KIT V559D/T670I Recombinant Human Active Protein Kinase is a recombinant KIT V559D/T670I protein that can be used to study KIT V559D/T670I-related functions .
    KIT V559D/T670I Recombinant Human Active Protein Kinase
  • HY-P11298

    Caspase Apoptosis JNK p38 MAPK Interleukin Related IFNAR Inflammation/Immunology Cancer
    d-T101 peptide, a human hormone-peptide, is a T1/ST2 receptor ligand. d-T101 peptide binds to the T1/ST2 receptor and activates caspases 8, 9 and 3 mediated apoptosis, together with activation of JNKinase and p38 MAPKinase. d-T101 peptide also changes Golgi structural with function loss and downregulation of the endoplasmic reticulum (ER) stress repair mechanism. d-T101 peptide has immunostimulatory and anticancer activity, selectively induces apoptosis in proliferating cancer cells and increases IL-2 and IFN-γ expression as well as the recruitment of NK cells and M1 macrophages to the tumor site .
    d-T101 peptide
  • HY-123400A

    iso-DTTX30; iso-DT-TX 30 SE

    Prostaglandin Receptor Cardiovascular Disease
    Iso-Samixogrel (iso-DTTX30) is a combined thromboxane A2 receptor blocker and thromboxane synthetase inhibitor that exhibits potent antithrombotic activity. Iso-Samixogrel effectively eliminates recurrent arterial thrombus formation and inhibits collagen-induced platelet aggregation ex vivo. Iso-Samixogrel also prolongs sublingual bleeding time, demonstrating its biological efficacy in managing thrombosis.
    iso-Samixogrel

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