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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
DVL
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "DVL" in MCE Product Catalog:
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KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases .
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4 Cited Publications
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NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 μM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction .
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells .
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KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .
Cat. No.: HY-102067
CAS No.: 294891-81-9
3289-8625 is an inhibitor of the PDZ domain of Dishevelled (Dvl) protein (Kd=10.6 μM) and has an inhibitory effect on Wnt signaling. In addition, 3289-8625 can slow the growth of prostate cancer PC-3 cells (IC50=12.5 μM). 3289-8625 can be used in the study of embryonic development and cancer .
Cat. No.: HY-P11112
CAS No.: 1609454-11-6
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Cat. No.: HY-178227
CAS No.: 2319609-67-9
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Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
KY19334 is a CXXC5-DVL inhibitor. KY19334 can activate the Wnt/β-catenin pathway by inhibiting CXXC5-Dvl interaction. KY19334 can inhibit cancer cells proliferation, migration, invasion and transformation by inhibiting CDK1. KY19334 can accelerate wound healing and exert regenerative effects. KY19334 can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as cutaneous squamous cell carcinoma and diabetes .
Cat. No.: HY-124156
CAS No.: 2093407-25-9
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KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .
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A3051 is a potent and orally active inhibtor of CXXC5-DVL extracted from patent WO2020079569, has an IC50 of 63.06 nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet (MCD)-induced phenotypes such as obesity, diabetes, and NASH .
Cat. No.: HY-RS04076
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DVL1 Human Pre-designed siRNA Set A contains three designed siRNAs for DVL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04077
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DVL2 Human Pre-designed siRNA Set A contains three designed siRNAs for DVL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04078
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DVL3 Human Pre-designed siRNA Set A contains three designed siRNAs for DVL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20721
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Dvl3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dvl3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27232
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Dvl1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dvl1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27233
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Dvl3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dvl3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20720
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Dvl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dvl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184469
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DVL1/P-gp-IN-1 is a DVL1 inhibitor (lC50 of 0.97 μM) and a P-glycoprptein (P-gp) inhibitor. DVL1/P-gp-IN-1 specific binds to the PDZ domain of the DVL1 protein of the Wnt/β-catenin pathway and inhibition of the P-gp. DVL1/P-gp-IN-1 reduces β-catenin expression, suppresses colon cancer cells proliferation, and induces apoptosis both in vitro and in xenograft models. DVL1/P-gp-IN-1 can be used in colorectal cancer research .
Cat. No.: HY-P810385
Synonyms: Dishevelled 2 (homologous to Drosophila dsh), Dishevelled dsh homolog 2, dishevelled segment polarity protein 2, Dishevelled-2, Dishevelled2, DSH homolog 2, DVL 2, DVL2, DVL2_HUMAN, Segment polarity protein dishevelled homolog DVL 2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
