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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
855 Results for "
E3 Ligase Ligand-linker Conjugate
" in MedChemExpress (MCE) Product Catalog:
Products (855)
855 Results for "E3 Ligase Ligand-linker Conjugate" in MCE Product Catalog:
5
5 Cited Publications
MT-802 is a BTK PROTAC degrader. MT-802 degrades wild-type BTK (DC50 = 14.6 nM) and BTK mutants including E41K, C481S (DC50 = 14.9 nM), C481R, C481Y, C481T, C481F, L528W, and inhibits their Y223 phosphorylation. BI-4732 can be used for the study of Ibrutinib (HY-10997)-resistant chronic lymphocytic leukemia (CLL). (Pink: BTK ligand (HY-150885), Blue: CRBN Ligand (HY-14658), Black: Linker (HY-141371), E3 ligase ligand-linker conjugate (HY-176340)) .
2
2 Cited Publications
Synonyms: VH032-PEG4-NH2 hydrochloride; VHL Ligand-linker Conjugates 4 hydrochloride; E3 Ligase Ligand-linker Conjugates 7
Research Areas:
(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
2
2 Cited Publications
Synonyms: VH032-PEG4-NH2; VHL Ligand-linker Conjugates 4 ; E3 Ligase Ligand-linker Conjugates 7 Free Base
Research Areas:
(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
2
2 Cited Publications
Synonyms: VH032-PEG4-N3; VHL Ligand-linker Conjugates 5; E3 Ligase Ligand-linker Conjugates 4
Research Areas:
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
1
1 Cited Publications
Cat. No.: HY-128832
Purity: 99.19%
Synonyms: MDM2 Ligand-linker Conjugates 1; E3 Ligase Ligand-linker Conjugates 48
Research Areas:
Nutlin-C1-amido-PEG4-C2-N3 (MDM2 Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 48) is an E3 ligase ligand-linker conjugate that can be used for the synthesis of PROTACs .
1
1 Cited Publications
Synonyms: Cereblon Ligand -linker Conjugates 2 TFA; E3 Ligase Ligand-linker Conjugates 20 TFA
Research Areas:
Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
1
1 Cited Publications
Synonyms: Cereblon Ligand-linker Conjugates 4; E3 Ligase Ligand-linker Conjugates 18
Research Areas:
Thalidomide-O-amido-C4-N3 is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker .
1
1 Cited Publications
Synonyms: VH032-PEG2-N3; VHL Ligand-linker Conjugates 6; E3 Ligase Ligand-linker Conjugates 13
Research Areas:
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-N3 can be used for the synthesis of PROTACs .
1
1 Cited Publications
Research Areas:
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-W1006706
CAS No.: 2502189-47-9
Research Areas:
E3 Ligase Ligand-linker Conjugate 157 is the conjugate composed of the E3 ligase ligand and the linker. E3 Ligase Ligand-linker Conjugate 157 can be used for synthesis of PROTAC degrader KT-253 (HY-170451) .
Cat. No.: HY-179244
CAS No.: 2139329-71-6
Research Areas:
E3 Ligase Ligand-linker Conjugate 215 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 215 can be used to synthesize STAT3 PROTAC Degrader S3D5 (HY-179243) .
Cat. No.: HY-159466
CAS No.: 2378054-01-2
Research Areas:
E3 Ligase Ligand-linker Conjugate 113 is an E3 ligase ligand-linker conjugate.
Cat. No.: HY-163931
Research Areas:
E3 Ligase Ligand-linker Conjugate 111 is an E3 ligase ligand-linker conjugate.
Cat. No.: HY-172593
E3 Ligase Ligand-linker Conjugate 182 is a E3 Ligase Ligand-Linker Conjugates. E3 Ligase Ligand-linker Conjugate 182 consists of a CRBN ligand and a PROTAC linker. E3 Ligase Ligand-linker Conjugate 182 can be used to design PROTACs (such as LZ-07 (HY-172590)) .
Cat. No.: HY-168701
Research Areas:
E3 Ligase Ligand-linker Conjugate 149 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 149 can be used to synthesize Setidegrasib (HY-148273) .
Cat. No.: HY-168659
Research Areas:
E3 Ligase Ligand-linker Conjugate 130 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 130 can be used to synthesize YJ1206 (HY-16855) .
Cat. No.: HY-168866
Research Areas:
E3 Ligase Ligand-linker Conjugate 160 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 160 can be used to synthesize FF2049 (HY-168863) .
Cat. No.: HY-173415
Research Areas:
E3 Ligase Ligand-linker Conjugate 177 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 177 can be used to synthesize STING PROTAC degrader ST9 .
Cat. No.: HY-173424
CAS No.: 2768514-43-6
Research Areas:
E3 Ligase Ligand-linker Conjugate 178 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 178 can be used to synthesize MS2133 (HY-173422) .
Cat. No.: HY-173563
CAS No.: 2850354-06-0
Research Areas:
E3 Ligase Ligand-linker Conjugate 181 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 185 can be used to synthesize MS115 (HY-173561) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
