207 Results for "

EC 2.6.1.1, Human liver

" in MedChemExpress (MCE) Product Catalog:
Products (207)

207 Results for "EC 2.6.1.1, Human liver" in MCE Product Catalog:

9
9 Publications Verification
Cat. No.: HY-N2334
CAS No.: 640-79-9
Synonyms: Chenodeoxycholylglycine
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .
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9
9 Publications Verification
Cat. No.: HY-N2334A
CAS No.: 16564-43-5
Synonyms: Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate
Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .
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4
4 Cited Publications
Cat. No.: HY-13077
CAS No.: 1415559-41-9
Purity:  98.45%
Research Areas:  

Metabolic Disease

MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
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2
2 Cited Publications
Cat. No.: HY-P7880
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ALPL; Alkaline Phosphatase, liver/Bone/Kidney; Prev. HOPS; TNS-ALP; TNSALP; liver/Bone/Kidney-Type Alkaline Phosphatase; Alkaline Phosphatase, Tissue-Nonspecific Isozyme; Tissue-Nonspecific ALP; Alkaline Phosphatase liver/Bone/Kidney Isozyme; Alkaline Pho
Species:  
Human
Source:  
HEK293
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2
2 Cited Publications
Cat. No.: HY-P70275
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FBP1; liver FBPase; Prev. FBP; Growth-Inhibiting Protein 17; Fructose-1,6-Bisphosphatase 1; Fructose-Bisphosphatase; D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase 1; Fructose-Bisphosphatase 1; FBPase 1
Species:  
Human
Source:  
HEK293
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2
2 Cited Publications
Cat. No.: HY-P70178
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT3; CD135 Antigen; Fms Related Receptor Tyrosine Kinase 3; FLK-2; CD135; Growth Factor Receptor Tyrosine Kinase Type III; STK1; Receptor Protein-Tyrosine Kinase; FLK2; Fms-Related Tyrosine Kinase 3; Fms-Like Tyrosine Kinase 3; Fetal liver Kinase 2; Rece
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-W010981
CAS No.: 77-90-7
Synonyms: Tributyl O-acetylcitrate; ATBC
Acetyl tributyl citrate (Tributyl O-acetylcitrate) is a pharmaceutical excipient and biodegradable hydrophobic plasticizer. Acetyl tributyl citrate can be used in cosmetics, food packaging, and as a flavoring substance for food .
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1
1 Cited Publications
Cat. No.: HY-P5645
CAS No.: 1683582-94-6
Synonyms: Human liver expressed antimicrobial peptide-2
LEAP-2 (Human liver expressed antimicrobial peptide-2) is a GHS-R1a antagonist, with an IC50 of 6.0 nM. LEAP-2 suppresses the orexigenic effect of ghrelin. LEAP-2 attenuates ghrelin-induced growth hormone (GH) release and reduces basal food intake. LEAP-2 exhibits antimicrobial activity against microbial model organisms. LEAP-2 can be used for the study of obesity and infection .
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1
1 Cited Publications
Cat. No.: HY-112690A
CAS No.: 625095-61-6
Purity:  99.53%
Synonyms: Remofovir mesylate
Target:  

Cytochrome P450

Research Areas:  

Infection Metabolic Disease

Pradefovir mesylate is a good substrate for liver CYP3A4. Pradefovir is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with a Km of 60 μM.
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1
1 Cited Publications
Cat. No.: HY-P7541A
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ARG1; Type I Arginase; Arginase 1; Arginase, liver; Arginase-1; Arginase; liver-Type Arginase
Species:  
Human
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-P70953
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GFER; Growth Factor, Erv1 (S. Cerevisiae)-Like (Augmenter Of liver Regeneration); Growth Factor, Augmenter Of liver Regeneration; Augmenter Of liver Regeneration; HERV1; ERV1 Homolog (S. Cerevisiae); ALR; Erv1-Like Growth Factor; FAD-Linked Sulfhydryl Oxi
Species:  
Human
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-P70400
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HAMP; liver-Expressed Antimicrobial Peptide 1; Hepcidin Antimicrobial Peptide; Putative liver Tumor Regressor; LEAP1; Hepcidin; HEPC; PLTR; LEAP-1; Hepcidin Preproprotein; HFE2B
Species:  
Human
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-120868
CAS No.: 1454299-21-8
Purity:  99.17%
Target:  

MetAP

Research Areas:  

Metabolic Disease Cancer

TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM against MetAP2. TP-004 is a chemical probe. TP-004 suppresses MetAP2 enzymatic activity, blocks N-terminal methionine cleavage, impairs protein maturation and stability, and thereby inhibits cell proliferation and angiogenesis. TP-004 can be used for the study of tumors and diseases associated with excessive angiogenesis .
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1
1 Cited Publications
Cat. No.: HY-P7196
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL16; Small-Inducible Cytokine A16; Prev. SCYA16; liver-Expressed Chemokine; LCC-1; C-C Motif Chemokine 16; HCC-4; Chemokine LEC; NCC-4; Monotactin-1; LMC; ILINCK; Mtn-1; NCC4; CKb12; liver CC Chemokine-1; SCYL4; C-C Motif Chemokine; LEC; New CC Chemokin
Species:  
Human
Source:  
CHO
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1
1 Cited Publications
Cat. No.: HY-P72965
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CSTB; Cystatin B (Stefin B); Prev. STFB; CPI-B; Prev. EPM1; Epididymis Secretory Sperm Binding Protein; CST6; Epilepsy, Progressive Myoclonic 1; Cystatin-B; Stefin B; PME; EPM1A; liver Thiol Proteinase Inhibitor; ULD; Cystatin B; Stefin-B
Species:  
Human
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-P70552
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KDR; Fetal liver Kinase 1; Kinase Insert Domain Receptor; Vascular Endothelial Growth Factor Receptor 2 Variant; Vascular Endothelial Growth Factor Receptor 2; Tyrosine Kinase Growth Factor Receptor; VEGFR2; Receptor Protein-Tyrosine Kinase; FLK1; Fetal L
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P71145
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX6; PRX; Peroxiredoxin 6; P29; AiPLA2; Red Blood Cells Page Spot 12; NSGPx; Lyso-PC Acyltransferase 5; AOP2; LPC Acyltransferase 5; Acidic Calcium-Independent Phospholipase A2; Antioxidant Protein 2; Lysophosphatidylcholine Acyltransferase 5; liver 2D
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-133668
CAS No.: 2306-33-4
Purity:  96.78%
Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms .
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Cat. No.: HY-124529
CAS No.: 37116-80-6
Lunularin is an inhibitor of 11β-hydroxysteroid dehydrogenase 1, with an IC50 of 45.44 μM and a Ki of 35.8 μM against human 11β-HSD1, and an IC50 of 17.39 μM and a Ki of 10.31 μM against rat 11β-HSD1. Lunularin upregulates the transcription levels of Sirt1 and Hmox1 genes in the liver. Lunularin reduces food intake and body weight gain, and decreases blood glucose levels in mice fed a high-fat diet. Lunularin inhibits LPS-induced TLR4-mediated NF-κB pathway activation and nitric oxide production. Lunularin inhibits the proliferation and colony formation of renal cancer and colon cancer cells, and exhibits cancer cell-specific cytotoxicity. Lunularin binds to the steroid-binding site of human 11β-HSD1 and the steroid/NADPH-binding region of rat 11β-HSD1, but does not inhibit 11β-HSD2 or mouse 11β-HSD1. Lunularin can be used in research related to diet-induced obesity, renal cancer, colorectal cancer, inflammatory diseases and metabolic syndrome .
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Cat. No.: HY-137083
CAS No.: 165602-90-4
Purity:  95.80%
Synonyms: UGT1A4
Target:  

UGT

Research Areas:  

Metabolic Disease

Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .
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