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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
ELK1
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "ELK1" in MCE Product Catalog:
2
2 Cited Publications
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TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity [1]. TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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2 Cited Publications
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TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity [1]. TD52 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
1
1 Cited Publications
ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4 has little effect on ERK protein phosphorylation by its upstream activator MEK1/2 [1].
Synonyms: HRX-0215
Darizmetinib (HRX-0215) is an orally active, potent and selective inhibitor of mitogen-activated protein kinase kinase 4 (MKK4). Darizmetinib leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration. Darizmetinib is promising for research of preventing liver failure after extensive oncological liver resections or transplantation of small liver grafts [1] .
Cat. No.: HY-RS04305
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ELK1 Human Pre-designed siRNA Set A contains three designed siRNAs for ELK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17329
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Elk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Elk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23784
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Elk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Elk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-111000
CAS No.: 96335-59-0
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BNC-1 is an Elk-1 activator that can promote phosphorylation and activation of Elk-1 [1].
Cat. No.: HY-P4133
CAS No.: 355367-87-2
Cat. No.: HY-P74176
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ETS domain-containing protein ELK-1; ELK1
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Source:
Cat. No.: HY-W585976
CAS No.: 58917-67-2
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Benzo[a]pyrene diol epoxide is a carcinogen present in tobacco smoke as well as in environmental pollution. Benzo[a]pyrene diol epoxide is a metabolite of benzo[a]pyrene (BaP) , which is polycyclic aromatic hydrocarbon (PAH) . Benzo[a]pyrene diol epoxide induces esophageal carcinogenesis. Benzo[a]pyrene diol epoxide may act to induce activation of ERKs and p38 MAPK marked by an increased level of phosphorylation of both the ERKs and p38 MAPK which corresponds with the increased activation of both kinases as evidenced by increased phsosphorylation of their substrates Elk-1 and ATF-2, respectively.
Cat. No.: HY-RS28129
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Kcnh8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kcnh8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07131
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KCNH8 Human Pre-designed siRNA Set A contains three designed siRNAs for KCNH8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-163323
CAS No.: 891075-67-5
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AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
