38 Results for "

F8

" in MedChemExpress (MCE) Product Catalog:
Products (38)

38 Results for "F8" in MCE Product Catalog:

Cat. No.: HY-P9964
CAS No.: 906805-06-9
Synonyms: 11F8; IMC-11F8; LY3012211

Target:  

EGFR

Research Areas:  

Cancer

Necitumumab (11F8; IMC-11F8; LY3012211) is a human IgG monoclonal antibody directed against EGFR. Necitumumab binds to the EGF binding site of EGFR, blocks ligand binding, neutralizes ligand-induced EGFR phosphorylation and downstream signaling, induces EGFR internalization and degradation, and mediates antibody-dependent cellular cytotoxicity (ADCC) in EGFR-expressing cells. Necitumumab enhances antitumour activity in combination with Gemcitabine (HY-17026) and Cisplatin (HY-17394) in murine non-small-cell lung cancer xenograft models. Necitumumab can be used in research on cancers such as non-small cell lung cancer and colorectal cancer .
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Cat. No.: HY-P99206
CAS No.: 1879925-92-4
Synonyms: Naxitamab-gqgk; Humanized 3F8; Hu3F8

Target:  

Inhibitory Antibodies

Research Areas:  

Neurological Disease Cancer

Naxitamab (Hu3F8) is a humanized monoclonal antibody targeting the disialoganglioside GD2. Naxitamab can be used in research of neuroblastoma, osteosarcoma and other GD2-positive cancers .
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Cat. No.: HY-P99155
CAS No.: 667901-13-5
Synonyms: 2F8; HUMAX-EGFR

Target:  

EGFR

Research Areas:  

Cancer

Zalutumumab is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab can be used for the research of cancer .
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Cat. No.: HY-P99757
CAS No.: 2278244-14-5
Synonyms: Hu3F8-BsAb

Target:  

CD3

Research Areas:  

Cancer

Nivatrotamab (Hu3F8-BsAb) is a bispecific antibody targeting GD2 and CD3, with KD values of 5.8 nM and 194 nM, respectively. Nivatrotamab redirects T cells to tumor sites and activates immune synapses, thereby mediating antibody-dependent T cell-mediated cytotoxicity. Nivatrotamab induces specific tumor cytotoxicity, stimulates the release of Th1 cytokines and promotes immune cell infiltration into tumors. In addition, its Fc segment deglycosylation design effectively prevents complement activation and cytokine storm. Nivatrotamab can be widely used in research related to various solid tumors, including melanoma, neuroblastoma, osteosarcoma, small cell lung cancer, breast cancer, Ewing's sarcoma, colon cancer, ovarian cancer and rhabdomyosarcoma .
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Cat. No.: HY-171036
CAS No.: 252212-58-1
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD +, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine .
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Cat. No.: HY-D2377
F8 is a small molecule GPR84 fluorescent probe that can visualize and detect GPR84 protein levels at the cellular and tissue levels .
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Cat. No.: HY-157252
CAS No.: 2766493-12-1
Purity:  99.80%
CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .
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Cat. No.: HY-RS04646
Research Areas:  

Others

F8 Human Pre-designed siRNA Set A contains three designed siRNAs for F8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P990221

Target:  

Interleukin Related

Research Areas:  

Infection Neurological Disease Cancer

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse IL-17F. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) can neutralize IL-17. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) can be used for the researches of cancer, infection and neurological disease, such as Alzheimer’s disease (AD) and pancreatic cancer .
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Cat. No.: HY-W440913
DSPE-PEG5000-Cy5 is a fluorescently labeled PEGylated phospholipid. After intravenous injection, DSPE-PEG5000-Cy5 shows only extremely low fluorescence accumulation at tumor sites in orthotopic tumor-bearing mice, and can be used as a negative control for evaluating tumor accumulation of nanoparticles. DSPE-PEG5000-Cy5 can serve as a fluorescent marker to prepare Cy5-labeled NPs-DPPA and NPs-DPPA (C3F8) for pharmacokinetic and biodistribution studies in mice. DSPE-PEG5000-Cy5 is widely applicable to research in fields related to triple-negative breast cancer, hepatocellular carcinoma and so on .
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Cat. No.: HY-RS17355
Research Areas:  

Others

F8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for F8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23809
Research Areas:  

Others

F8 Rat Pre-designed siRNA Set A contains three designed siRNAs for F8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-147845
CAS No.: 301347-96-6
Target:  

SARS-CoV

Research Areas:  

Infection

F8-S40 is an inhibitor of SARS-CoV-2 main protease, with an IC50 of 10.88 μM .
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Cat. No.: HY-147844
CAS No.: 1632320-78-5
Target:  

SARS-CoV

Research Areas:  

Infection

F8-S43-S3 is an inhibitor of SARS-CoV-2 main protease, with an IC50 of 9.69 μM .
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Cat. No.: HY-W391641
CAS No.: 210347-52-7
F8BT is a polymer material with excellent photoelectric properties. F8BT is widely used in organic light-emitting diodes (OLEDs) and organic solar cells (PLEDs), and can effectively improve the luminous efficiency and energy conversion efficiency of the devices. The structure of F8BT makes it perform well in photoelectric conversion and electron transport, making it an important object of modern electronic material research.
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Cat. No.: HY-P992000

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

F8-IL-4 is an immune cytokine targeting IL-4. F8-IL-4 specifically delivers IL-4 to inflammatory sites via binding to targets expressed on neovascular vessels. F8-IL-4 alleviates collagen-induced arthritis in mice by regulating T cell subsets and macrophage polarization. When combined with Dexamethasone (HY-14648), F8-IL-4 produces a synergistic and long-lasting therapeutic effect, and prevents arthritis recurrence after drug withdrawal by maintaining anti-inflammatory cell phenotypes and cytokine profiles. F8-IL-4 can be used in the research of collagen-induced arthritis .
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Cat. No.: HY-P990412

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Anti-F8/Factor VIII Antibody is a CHO-expressed human antibody that targets F8/Factor VIII. Anti-F8/Factor VIII Antibody has a huIgG4 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-F8/Factor VIII Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P99206A
CAS No.: 1879925-92-4

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Naxitamab (Hu3F8) (Mouse IgG1) is a mouse-derived IgG1 monoclonal antibody targeting the diazoglycoside GD2 (hu3F8). Naxitamab can be used in the research of neuroblastoma, osteosarcoma, and other GD2-positive cancers .
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Cat. No.: HY-157125
CAS No.: 3026856-46-9
Target:  

PI3K Apoptosis

Research Areas:  

Cancer

PI3Kα-IN-14 (compound F8) is a selective PI3Kα inhibitor with an IC50 of 0.14 nM. PI3Kα-IN-14 induces a great decrease in mitochondrial membrane which caused cell cycle arrest at G1 phase and apoptosis in U87-MG cells. PI3Kα-IN-14 shows significant anti-proliferative activities against three tumor-derived cell lines (PC-3: IC50 of 0.28 μM; HCT-116: IC50 of 0.57 μM; and U87-MG: IC50 of 1.37 μM) .
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Cat. No.: HY-P990214
Anti-Mouse IL-3 Antibody (MP2-8F8) is an anti-mouse IL-3 IgG1 monoclonal antibody. Anti-Mouse IL-3 Antibody (MP2-8F8) relieves joint inflammation by reducing synovial leukocyte infiltration and cytokine levels. Anti-Mouse IL-3 Antibody (MP2-8F8) can reduce the accumulation of basophils. Anti-Mouse IL-3 Antibody (MP2-8F8) can be used for researches on inflammation or infection conditions such as arthritis and parasitic infections .
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