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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
GDNF
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "GDNF" in MCE Product Catalog:
5
2
1
1 Cited Publications
Target:
Forschungsgebiete:
BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF) . BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function .
1
Art. -Nr.: HY-136832
CAS. Nr.: 110514-35-7
Forschungsgebiete:
Noribogaine hydrochloride is an orally active, blood-brain barrier permeable SERT inhibitor (IC50=50-300 nM) and hERG channel blocker. Noribogaine hydrochloride enhances serotonergic transmission, activates the κ-opioid receptor (OPRK) G protein signaling pathway and inhibits β-arrestin recruitment. Meanwhile, Noribogaine hydrochloride blocks the μ-opioid receptor (OPRM) signaling pathway as well as ion channels associated with cardiac repolarization. Noribogaine hydrochloride induces neuritogenesis, upregulates GDNF mRNA expression, and modulates opioid tolerance. Noribogaine hydrochloride reduces alcohol-seeking behavior in experimental animals, and is widely used in studies related to depression, addiction, alcoholism, and cardiotoxicity .
Synonyms: XIB4035
Target:
Forschungsgebiete:
(E)-Aminoquinol (XIB4035) is a GFRα-1 agonist. (E)-Aminoquinol has mimic neurotrophic effects of GDNF, and induces Ret autophosphorylation in Neuro-2A cells. (E)-Aminoquinol can be used for research of Parkinson’s disease .
Art. -Nr.: HY-163840
Target:
Forschungsgebiete:
GFRα2/3-IN-1 (Compound 16) is a selective GFRα2/3 inhibitor with IC50 values of 0.1 and 0.2 μM for GFRα2 and GFRα3, respectively. GFRα2 is a glial cell line-derived neurotrophic factor (GDNF) receptor related to GFRα1, GFRα2/3-IN-1 can be used for pain and itch research .
Art. -Nr.: HY-RS05361
Target:
Forschungsgebiete:
GDNF Human Pre-designed siRNA Set A contains three designed siRNAs for GDNF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS16523
Target:
Forschungsgebiete:
Gdnf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gdnf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS22954
Target:
Forschungsgebiete:
Gdnf Rat Pre-designed siRNA Set A contains three designed siRNAs for Gdnf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-W101298S
Synonyms: L-Leucyl-13C6,15N-L-isoleucine TFA
Art. -Nr.: HY-119910A
CAS. Nr.: 10023-54-8
Synonyms: (E/Z)-XIB4035
Target:
Forschungsgebiete:
Aminoquinol is a GFRα-1 agonist. Aminoquinol exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol can be used in research related to Parkinson's disease .
Art. -Nr.: HY-119910B
CAS. Nr.: 7195-12-2
Synonyms: (E/Z)-XIB4035 phosphate
Target:
Forschungsgebiete:
Aminoquinol ((E/Z)-XIB4035) phosphate is a GFRα-1 agonist. Aminoquinol phosphate exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol phosphate can be used in research related to Parkinson's disease .
Art. -Nr.: HY-119910C
CAS. Nr.: 3653-53-0
Synonyms: (E/Z)-XIB4035 triphosphate
Target:
Forschungsgebiete:
Aminoquinol ((E/Z)-XIB4035) phosphate is a GFRα-1 agonist. Aminoquinol phosphate exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol phosphate can be used in research related to Parkinson's disease .
Art. -Nr.: HY-123439
CAS. Nr.: 249289-10-9
Target:
Forschungsgebiete:
FTY720-C2 is a derivative of FTY72 (HY-12005). FTY720-C2 promotes the expression of brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) in multiple system atrophy (MSA) models, without causing immunosuppression. FTY720-C2 improves motor dysfunction and reduces the levels of insoluble alpha-synuclein (αSyn) in MSA mouse models. FTY720-C2 is blood-brain barrier penetrate .
Art. -Nr.: HY-P700084AF
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3
Art. -Nr.: HY-P73075
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3
Species:
Source:
Art. -Nr.: HY-P700179AF
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rMuGDNF; GDNF; ATF
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
