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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
66 Results for "
H-N systerm
" in MedChemExpress (MCE) Product Catalog:
Products (66)
66 Results for "H-N systerm" in MCE Product Catalog:
575
575 Publications Verification
Synonyms: (1S,3R)-RSL3
Research Areas:
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
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Futibatinib (TAS-120) is an orally bioavailable, highly selective, and irreversible FGFR inhibitor, with IC50s of 3.9, 1.3, 1.6, and 8.3 nM for FGFR 1-4, respectively. Futibatinib inhibits mutant and wild-type FGFR2 with similar IC50s (wild-type FGFR2=0.9 nM; V5651=1-3 nM; N550H=3.6 nM; E566G=2.4 nM) .
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3 Cited Publications
Target:
Research Areas:
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
1
1 Cited Publications
Synonyms: 1,3,6,8-THN; T4HN
Target:
Research Areas:
1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an indispensable precursor to DHN (1,8-Dihydroxynaphthalene) melanin and is an unique symmetrical compound of polyketide origin .
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1
1
1 Cited Publications
Cat. No.: HY-P72229
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HNRNPA1; Heterogeneous Nuclear Ribonucleoprotein A1B Protein; Prev. HNRPA1; Nuclear Ribonucleoprotein Particle A1 Protein; HnRNP-A1; Single-Strand DNA-Binding Protein UP1; ALS20; HnRNP Core Protein A1-Like 3; Epididymis Secretory Sperm Binding Protein; Hn
Species:
Human
Source:
E. coli
Target:
Research Areas:
HN37 as a potent and chemically stable antiepileptic agent candidate, with an EC50 of 37 nM for KCNQ2 . HN37 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-N15720
CAS No.: 39524-13-5
Synonyms: Pulsatilla saponin B
Category:
Triterpenes Terpenoids Plants Caprifoliaceae Extract Lonicera macrantha (D. Don) Spreng. Pentacyclic Triterpenoids
Target:
Cat. No.: HY-W012872
CAS No.: 2480-26-4
Target:
Research Areas:
Cat. No.: HY-W130965
CAS No.: 20127-63-3
Category:
Alkaloids Simaroubaceae Extract Pyridine Alkaloids Plants Picrasma quassioides(D．Don)Benn．
Target:
Cat. No.: HY-W004078
CAS No.: 696-60-6
Category:
Monophenols Metabolic Disease Phenols Plants Other Families Extract Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-163529
CAS No.: 2233566-79-3
Target:
Research Areas:
HN0037 is a selective, orally active Helicase-primase inhibitor. HN0037 is mainly metabolized by CYP3A4. HN0037 inhibits HSV replication by targeting the viral helicase-primase complex, which consists of three proteins encoded by UL5 (helicase), UL52 (primase), and UL8 (scaffold protein that promotes primer synthesis) .
Cat. No.: HY-100818R
CAS No.: 1448169-71-8
Synonyms: TAS-120 (Standard)
Target:
Research Areas:
Futibatinib (Standard) is the analytical standard of Futibatinib. This product is intended for research and analytical applications. Futibatinib (TAS-120) is an orally bioavailable, highly selective, and irreversible FGFR inhibitor, with IC50s of 3.9, 1.3, 1.6, and 8.3 nM for FGFR 1-4, respectively. Futibatinib inhibits mutant and wild-type FGFR2 with similar IC50s (wild-type FGFR2=0.9 nM; V5651=1-3 nM; N550H=3.6 nM; E566G=2.4 nM) .
Cat. No.: HY-W015926
CAS No.: 3913-67-5
Target:
Research Areas:
Cat. No.: HY-P4092
CAS No.: 386223-83-2
HN-1 is a tumor-specific internalizing peptide . HN-1 internalizes through receptor-mediated, energy-dependent, Clathrin-mediated endocytosis. HN-1 preferentially binds to invasive head and neck squamous cell carcinoma and is selectively internalized. HN-1 enhances the transfer of liposome-DNA complexes to head and neck squamous cell carcinoma. HN-1 can be used for research on head and neck squamous cell carcinoma .
Cat. No.: HY-149904
CAS No.: 146426-20-2
Synonyms: hn6A
Target:
Research Areas:
N6-Hydroxynorvalylcarbamoyladenosine (hn6A) (compound 1) is a nucleoside discovered in unfractionated tRNA from Thermodesulfobacterium commune . N6-Hydroxynorvalylcarbamoyladenosine is a modified nucleoside .
Cat. No.: HY-P991508
Cat. No.: HY-19214
CAS No.: 149968-26-3
Synonyms: HN 65021
Target:
Research Areas:
Elisartan is an orally active non-peptide pro-agent of angiotensin II AT1 receptor antagonist HN-12206, and shows anti-hypertension activities.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
