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Results for "

HuR

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

1

Natural
Products

2

Recombinant Proteins

4

Antibodies

4

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100685
    MS-444
    2 Publications Verification

    BE-34776

    		 HuR Apoptosis COX Neurological Disease Cancer
    MS-444 (BE-34776) is a HuR (ELAVL1) inhibitor that blocks the cytoplasmic translocation of HuR and inhibits its dimerization. MS-444 reduces cytoplasmic HuR levels by preventing the binding of HuR to ARE-mRNA, without altering the total expression of HuR. MS-444 induces apoptosis, inhibits cell growth, angiogenesis and invasion, and also regulates immune function and microbiota. MS-444 effectively alters the number, size and invasiveness of tumors in various cancer models. MS-444 is tolerable to intraperitoneal injection in vivo and can be applied to research related to colorectal cancer, familial adenomatous polyposis, colitis-associated cancer and glioblastoma .
    MS-444
  • HY-134601
    KH-3

    		HuR Cancer
    KH-3 is a potent RNA-binding protein Hu antigen R (HuR) inhibitor with an IC50 value of 0.35 μM. KH-3 has anti-proliferative activity. KH-3 suppresses breast cancer cell invasion as well as delays the initiation of lung colonies by disrupting HuR-FOXQ1 mRNA interaction .
    KH-3
  • HY-153083
    COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)
    1 Publications Verification

    		 mRNA SARS-CoV Infection
    COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) is an mRNA encoding the SARS-CoV-2 spike protein with enhanced performance via chemical modification. COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) replaces natural uridine (UTP) with N1-Me-Pseudo UTP, which effectively reduces immunogenicity and improves stability and translation efficiency. The 3' UTR of COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) optimizes AU-rich elements through HuR anchor sites, exhibiting higher translation efficiency. COVID-19 Spike Protein mRNA is widely used in COVID-19-related scientific research and vaccine development .
    COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)
  • HY-148853
    SRI-42127
    1 Publications Verification

    		 HuR Others
    SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes .
    SRI-42127
  • HY-124828
    CMLD-2
    2 Publications Verification

    		 HuR Cancer
    CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation .
    CMLD-2
  • HY-175324
    MG-HuR2

    		Molecular Glues HuR Cancer
    MG-HuR2 is a molecular glue degrader targeting the oncogenic RNA-binding protein HuR (IC50=0.5 μM). MG-HuR2 is promising for research of HuR-overexpressing malignancies (e.g., breast cancer) .
    MG-HuR2
  • HY-163759
    HuR degrader 2

    		Molecular Glues HuR Cancer
    HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-binding protein Hu antigen R (HuR) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC50≤200 nM. HuR degrader 2 exhibits a high affinity with cereblon, with an HTRF ratio < 0.02 .
    HuR degrader 2
  • HY-160783
    SRI-43265

    		HuR Cancer
    SRI-43265 (compound 40) is an inhibitor of human antigen R protein (HuR) dimerization, and HuR multimers have been implicated in cancer and inflammatory pathogenesis .
    SRI-43265
  • HY-160115
    TDP-43 degrader-1

    		DNA/RNA Synthesis Neurological Disease
    TDP-43 degrader-1 (Compound example 7) is a TDP-43 degrader. TDP-43 degrader-1 reduces the aggregation of TDP-43-positive HuR stress granules in cells and promotes the relocalization of abnormally distributed TDP-43 in the cytoplasm to the nucleus. TDP-43 degrader-1 can be used in the study of amyotrophic lateral sclerosis and Alzheimer's disease .
    TDP-43 degrader-1
  • HY-168539
    TM11

    		HuR Inflammation/Immunology
    TM11, a Tanshinone mimic, is a potent HuR inhibitor that can inhibit HuR-RNA complex formation. TM11 reduces LPS-induced inflammatory response in murine macrophages .
    TM11
  • HY-124844
    Azaphilone-9

    AZA-9

    		 HuR Cancer
    Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression .
    Azaphilone-9
  • HY-101112
    Okicenone

    		HuR Inflammation/Immunology
    Okicenone is a Hu protein R (HuR) inhibitor. Okicenone inhibits HuR oligomerization, interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation .
    Okicenone
  • HY-RS24786
    Elavl1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Elavl1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Elavl1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Elavl1 Rat Pre-designed siRNA Set A
    Elavl1 Rat Pre-designed siRNA Set A
  • HY-RS04294
    ELAVL1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ELAVL1 Human Pre-designed siRNA Set A contains three designed siRNAs for ELAVL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ELAVL1 Human Pre-designed siRNA Set A
    ELAVL1 Human Pre-designed siRNA Set A
  • HY-163760
    ZM-32

    		HuR MMP Cancer
    ZM-32 is an inhibitor for human antigen R (HuR), that downregulates the expression of VEGF-A and MMP9, and thus inhibits breast cancer tumor angiogenesis. ZM-32 exhibits broad-spectrum anti-proliferative effects in a variety of cancer cell lines, and exhibits antitumor efficacy against MDA-MB-231 in mouse models .
    ZM-32
  • HY-RS18308
    Elavl1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Elavl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Elavl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Elavl1 Mouse Pre-designed siRNA Set A
    Elavl1 Mouse Pre-designed siRNA Set A

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