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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

Huh7 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (4) AMPK (1) Apoptosis (29) Atg8/LC3 (2) AUTACs (1) Autophagy (8) Bacterial (1) Branched Chain Amino Acid Transaminase (BCAT) (1) Calcium Channel (1) Caspase (3) CCR (1) CHIKV (1) CMV (1) Connective Peptide (1) Cyclin G-associated Kinase (GAK) (1) Cyclophilin (1) Dengue Virus (4) Dihydroceramide Desaturase 1 (DES1) (1) DNA Methyltransferase (2) DNA/RNA Synthesis (4) Drug Derivative (3) E1/E2/E3 Enzyme (1) Enterovirus (2) Ephrin Receptor (2) Epigenetic Reader Domain (1) ERK (1) Ferroptosis (1) FGFR (5) Flavivirus (6) FLT3 (1) Fungal (2) GLUT (1) GSK-3 (1) HBV (6) HCV (8) HDAC (3) Histamine Receptor (6) Histone Demethylase (1) Histone Methyltransferase (1) HIV (5) HIV Protease (3) IFNAR (3) IKZF Family (1) Influenza Virus (1) Insulin Receptor (1) Interleukin Related (2) IRE1 (1) JNK (3) MAGL (1) MAPKAPK2 (MK2) (1) MDM-2/p53 (2) MicroRNA (1) Microtubule/Tubulin (4) Mitochondrial Metabolism (1) MMP (3) mTOR (2) NEKs (2) Neurotensin Receptor (1) NF-κB (2) OGT (1) p38 MAPK (1) p62 (1) p97 (1) PAK (1) PARP (1) PD-1/PD-L1 (2) PDGFR (1) PERK (2) PI3K (3) Polo-like Kinase (PLK) (1) PPAR (1) PROTACs (6) PTEN (1) Pyruvate Kinase (1) RAD51 (1) Reactive Oxygen Species (ROS) (7) Reference Standards (5) RIG-I-like receptor (RLR) (1) SARS-CoV (10) Sec61 (1) SHP2 (2) Sirtuin (1) Small Interfering RNA (siRNA) (1) STAT (1) Telomerase (1) TGF-β Receptor (1) Topoisomerase (3) VDAC (1) Virus Protease (4) YAP (5)
By Research Areas:	Cancer (62) Cardiovascular Disease (2) Endocrinology (6) Infection (32) Inflammation/Immunology (9) Metabolic Disease (4) Neurological Disease (8)
Click Chemistry:	Azide (1)
Oligonucleotides:	siRNA drugs (1) siRNAs (1)

Inhibitors & Agonists

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Isotope-Labeled Compounds

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Oligonucleotides

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1030

Lanatoside C 5+ Cited Publications	Flavivirus Dengue Virus Autophagy Enterovirus	Cardiovascular Disease Cancer
Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-B0689

Indinavir 5+ Cited Publications MK-639 free base; L-735524 free base	HIV HIV Protease Apoptosis MMP SARS-CoV	Inflammation/Immunology Cancer
Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL ^pro inhibitor .

HY-B0338

Rimantadine 1-Rimantadine	Influenza Virus Autophagy	Infection
Rimantadine (1-Rimantadine) is an orally active inhibitor for M2 protein, which blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity. Rimantadine significantly inhibits hepatitis A virus (HAV) replication at the post-entry stage in Huh7 cells. Rimantadine enhances autophagy. Rimantadine has a significant protective effect against H3N2 virus in mouse model .

HY-120356A

T-1101 tosylate 1 Publications Verification TAI-95 tosylate	NEKs Apoptosis	Cancer
T-1101 tosylate (TAI-95 tosylate) is the tosylate salt form of T-1101 (HY-120356). T-1101 tosylate is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 tosylate blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI₅₀ of 15-70 nM. T-1101 tosylate induces apoptosis in Huh-7. T-1101 tosylate exhibits antitumor efficacy in mouse models .

HY-12794

Vps34-PIK-III Maximum Cited Publications 12 Publications Verification	PI3K Autophagy	Neurological Disease Cancer
Vps34-PIK-III is an orally active and selective VPS34 inhibitor (IC₅₀=18 nM). Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a PI3K inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs) .

HY-B0689A

Indinavir sulfate 5+ Cited Publications MK-639; L735524	HIV HIV Protease SARS-CoV Apoptosis MMP	Infection Cancer
Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CL ^pro inhibitor .

HY-15897

LDN-212854 1 Publications Verification	TGF-β Receptor	Cancer
LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC₅₀: 1.3 nM). LDN-212854 also inhibits ALK1 (IC₅₀: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC) .

HY-W014395

Dithiodipropionic acid	Reactive Oxygen Species (ROS) Apoptosis	Cancer
Dithiodipropionic acid can interact with CPUL1 (HY-151802) (a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells .

HY-168016

PROTAC YAP degrader-1	PROTACs YAP	Cancer
PROTAC YAP degrader-1 is a VHL-recruiting PROTAC degrader (DC₅₀=8.2 μM) and antiproliferative agent that targets YAP. PROTAC YAP degrader-1 recruits the E3 ligase VHL and binds to VHL to form a ternary complex containing YAP. PROTAC YAP degrader-1 inhibits the nuclear localization of YAP in cancer cells, reduces YAP/TEAD-mediated transcription, and induces TAZ protein degradation. PROTAC YAP degrader-1 reduces the oncogenic activity of YAP and exerts antiproliferative effects in the Huh7 xenograft mouse model. PROTAC YAP degrader-1 can be used for the research of hepatocellular carcinoma and mesothelioma .

HY-B1067

Antazoline hydrochloride Phenazoline hydrochloride	Histamine Receptor HBV	Neurological Disease Endocrinology
Antazoline hydrochloride is a histamine H1 receptor antagonist with anticholinergic and antiviral properties. Antazoline hydrochloride can prevent histamine from acting on target cells through a reversible competition effect on histamine receptor sites of these cells. Antazoline hydrochloride can exert an antiallegic effect and prevent the occurrence of physiological reactions from the effect of blocking as well as inhibiting H1 receptor. Antazoline hydrochloride can effectively reduce HBV DNA in the extracellular supernatant in a dose-dependent manner, with EC₅₀ of 2.910 μmol/L in HepAD38 cells. Antazoline hydrochloride also has a significant inhibitory effect on HBV DNA in the extracellular supernatant of Huh7 cells (EC₅₀ = 2.349 μmol/L). Antazoline hydrochloride has anti-arrhythmic effect in acute myocardial infarctions. Antazoline hydrochloride can be studied in research for cardiovascular diseases, and HBV .

HY-173011

RJS308	PROTACs Cyclophilin HIV HCV	Infection
RJS308 is a selective Cyclophilin A (CypA) PROTAC degrader. RJS308 induces ubiquitin-dependent CypA degradation by recruiting the VHL E3 ligase complex, and forms a ternary complex with CypA and VHL/elongin C/elongin B. RJS308 exhibits anti-HIV-1 and anti-HCV activities. RJS308 can be used in studies related to viral infections .

HY-N3519

Platycodin D3 1 Publications Verification	HCV Branched Chain Amino Acid Transaminase (BCAT) Interleukin Related NF-κB ERK p38 MAPK JNK	Infection Inflammation/Immunology
Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC₅₀ value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases .

HY-13337

BMS-986094 INX-08189	HCV	Infection
BMS-986094 (INX-08189) is a potent inhibitor of hepatitis C virus (HCV) replication, with an EC₅₀ of 35 nM at 24 h in Huh-7 cells. BMS-986094 is a phosphoramidate proagent of 6-O-methyl-2’-C-methyl guanosine. BMS-986094 can be used for the research of chronic HCV infection .

HY-160093

SQLE-IN-1	PTEN Akt PI3K	Metabolic Disease
SQLE-IN-1 (compound 19) is a squalene epoxidase (SQLE) inhibitor. SQLE-IN-1 inhibits the proliferation and migration of Huh7 cells. SQLE-IN-1 inhibits the cell cholesterol generation. SQLE-IN-1 increases the expression of PTEN and inhibits PI3K and AKT .

HY-112659

Lin28-let-7 antagonist 1	MicroRNA	Neurological Disease Cancer
Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC₅₀ of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells .

HY-147255

Canocapavir ZM-H1505R	HBV	Infection
Canocapavir (ZM-H1505R) is an orally active HBV core protein-targeting antiviral agent. Canocapavir binds to the hydrophobic pocket at the dimer-dimer interface of HBV core protein (HBc), stimulating intracellular accumulation of nonfunctional HBV capsids, disrupting viral replication. Canocapavir interferes with the interaction between HBc and HBV large surface protein, resulting in diminished production of empty virionsis. Canocapavir can be used for the research of hepatitis B virus (HBV) infection .

HY-N3677

Dammarenediol II	OGT Akt mTOR GSK-3 Reactive Oxygen Species (ROS) Apoptosis PARP MDM-2/p53	Inflammation/Immunology Cancer
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy .

HY-W013403

2'-Deoxy-2'-fluorouridine	IFNAR	Infection
2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .

HY-146178

IMP2-IN-1	Insulin Receptor	Cancer
IMP2-IN-1 (compound 4) is a potent IMP2 inhibitor with IC₅₀ value of 81.3~127.5 for IMP2 RNA sequence. IMP2-IN-1 reduces IMP2 in SW480 cells. IMP2-IN-1 significantly reduces the viability of both differentiated and non-differentiated Huh7 cells .

HY-133178

Urolithin D 3,4,8,9-Tetrahydroxy urolithin	Ephrin Receptor PPAR AMPK	Metabolic Disease Inflammation/Immunology Cancer
Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC₅₀ of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases .

HY-156202

Geranylgeranoic acid	Histone Demethylase PD-1/PD-L1 Apoptosis	Cancer
Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC₅₀ value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis .

HY-121204

Iberverin 3-Methylthiopropyl isothiocyanate	Apoptosis Reactive Oxygen Species (ROS)	Cancer
Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species .

HY-153492A

Olpasiran sodium AMG 890 sodium; ARC-LPA sodium	Small Interfering RNA (siRNA)	Inflammation/Immunology
Olpasiran (AMG 890, ARC-LPA) sodium is an N-acetyl galactosamine (GalNAc)-conjugated, hepatocyte-targeted siRNA. Olpasiran sodium directly inhibits LPA messenger RNA translation in hepatocytes and potently reduce Lp(a) concentration. Olpasiran sodium can be used for the research of cardiovascular disease, such as atherosclerosis .

HY-168574

SZU-B6	PROTACs Sirtuin Apoptosis	Cancer
SZU-B6 is a PROTAC degrader for SIRT6 with DC₅₀ of 45 nM and 154 nM in cell SK-HEP-1 and Huh-7. SZU-B6 inhibits the proliferation of cell SK-HEP-1 with an IC₅₀ of 1.51 μM, inhibits the colony formation of SK-HEP-1 and Huh-7, induces apoptosis and arrests the cell cycle at G2/M phase in SK-HEP-1. SZU-B6 exhibits antitumor efficacy in mouse model. (Pink: ligand for target protein (HY-16605); Black: linker (HY-W012935); BLue: ligand for E3 ligase (HY-W453548)

HY-169120

FKB04	Telomerase	Cancer
FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanism in liver cancer cells, leading to T-loop defects, telomere shortening, and cellular senescence. Additionally, FKB04 can inhibit tumor growth in a human liver cancer xenograft mouse model (with Huh-7 cells implanted in BALB/c mice). FKB04 can be used in liver cancer research .

HY-123805

KIN1400	RIG-I-like receptor (RLR) HCV IFNAR	Infection
KIN1400 is a potent IRF3 activator. KIN1400 triggers IRF3-dependent innate immune antiviral genes (RIG-I, MDA5, IFIT1, and Mx1) and IFN-β expression. KIN1400 inhibits WNV and DV, two mosquito-borne members of the Flaviviridae and the genus Flavivirus. KIN1400 also inhibits HCV replication. KIN1400 induces innate antiviral immunity through a MAVS-IRF3 axis .

HY-N8389

Globulol	Bacterial Fungal PAK Akt STAT PD-1/PD-L1 Apoptosis CCR	Infection Cancer
Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma .

HY-N3741

Didrovaltrate Didrovaltratum	Calcium Channel Reactive Oxygen Species (ROS) Autophagy	Inflammation/Immunology Cancer
Didrovaltrate (Didrovaltratum) is an L-type calcium channel blocker, ROS scavenger, autophagy enhancer, and lipid accumulation inhibitor. Didrovaltrate blocks L-type calcium currents in a concentration-dependent manner, shifts the current-voltage curve upward, modulates steady-state inactivation kinetics, and inhibits the nuclear translocation of glucocorticoid receptors. Didrovaltrate reduces ROS levels, downregulates the expression of muscle atrophy-related genes, enhances autophagy via lipophagy, and decreases Oleic acid-induced lipid accumulation. Didrovaltrate exhibits cytotoxic activity against cancer cells. Didrovaltrate can be used in research related to skeletal muscle atrophy, non-alcoholic fatty liver disease, breast cancer, lung cancer, gastric cancer, and prostate cancer .

HY-B1067A

Antazoline Phenazoline	Histamine Receptor	Neurological Disease Endocrinology
Antazoline (Phenazoline) is a histamine H1 receptor antagonist with anticholinergic and antiviral properties. Antazoline can prevent histamine from acting on target cells through a reversible competition effect on histamine receptor sites of these cells. Antazoline can exert an antiallegic effect and prevent the occurrence of physiological reactions from the effect of blocking as well as inhibiting H1 receptor. Antazoline can effectively reduce HBV DNA in the extracellular supernatant in a dose-dependent manner, with EC₅₀ of 2.910 μmol/L in HepAD38 cells. Antazoline also has a significant inhibitory effect on HBV DNA in the extracellular supernatant of Huh7 cells (EC₅₀ = 2.349 μmol/L). Antazoline has anti-arrhythmic effect in acute myocardial infarctions. Antazoline can be studied in research for cardiovascular diseases, and HBV .

HY-162616

SelSA	HDAC Apoptosis	Cancer
SelSA is a selective, orally active inhibitor for histone deacetylase 6 (HDAC6) with IC₅₀ of 56.9 nM. SelSA inhibits the phosphorylation of ERK1/2. SelSA inhibits the proliferation of breast cancer cells and hepatocellular carcinoma cells with IC₅₀ of 0.58-2.6 μM, inhibits cell migration and invasion of Huh7, and induces apoptosis. SelSA exhibits antitumor activity in mouse model .

HY-158073

ML2006a4	SARS-CoV	Infection
ML2006a4 is an orally active inhibitor for SARS-CoV-2 main protease (M ^pro) with IC₅₀ in picomolare value. ML2006a4 is cell permeable and antiviral active, that inhibits replication in SARS-CoV-2 in cells Huh7.5.1-ACE2-TMPRSS2 (Huh7.5.1++) in picomolare level

HY-178098

TEAD-IN-21	YAP	Cancer
TEAD-IN-21 is a potent and orally active pan-TEAD inhibitor with an IC₅₀ of 3 nM. TEAD-IN-21 effectively inhibited the proliferation of Huh-7 cells. TEAD-IN-21 selectively downregulates TEAD-dependent downstream genes. TEAD-IN-21 achieves tumor regression in a liver cancer-derived tumor xenograft mice model. TEAD-IN-21 can be used in the research of hepatocellular carcinoma (HCC) .

HY-120356

T-1101 TAI-95	Apoptosis NEKs	Cancer
T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI₅₀ of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models .

HY-B1030R

Lanatoside C (Standard)	Dengue Virus Flavivirus Reference Standards CHIKV Autophagy Enterovirus	Cardiovascular Disease Cancer
Lanatoside C (Standard) is the analytical standard of Lanatoside C. This product is intended for research and analytical applications. Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-172880

PLK1-IN-15	Polo-like Kinase (PLK) Apoptosis	Cancer
PLK1-IN-15 (Compound 7n) is a PLK1 inhibitor (IC₅₀: 38.5 nM). PLK1-IN-15 exhibits antiproliferative activity against HepG2, Huh7, H1299 and A549 cells (IC₅₀: 2.03, 2.08, 4.79 and 17.11 μM, respectively). PLK1-IN-15 induces cell cycle arrest at the G2/M phase and apoptosis, and has anticancer activity .

HY-14844

Lagociclovir MIV-210	HBV	Infection
Lagociclovir (FLG) is a nucleoside analogue that inhibits wild-type hepatitis B virus (HBV) replication in a human hepatoma cell line permanently expressing HBV .

HY-175204

SHP2 protein degrader-3	AUTACs SHP2 Apoptosis Autophagy Atg8/LC3	Cancer
SHP2 protein degrader-3 is a SHP2 AUTAC degrader. SHP2 protein degrader-3 shows dose-dependent SHP2 degradation ability (DC₅₀ = 3.22 μM) and anti-tumor activity (IC₅₀ = 5.59 μM) in HeLa cells. SHP2 protein degrader-3 induces degradation through the LC3-mediated autophagy pathway, which can be inhibited by lysosome inhibitors. SHP2 protein degrader-3 induces apoptosis in various cancer cells (HeLa cells, HepG2 cells, LoVo cells, Huh-7 cells) (SHP2 Ligand : (HY-100388); LC3 Ligand: (HY-10542); Linker : (HY-128834)) .

HY-159174

EPHA2/A4/GAK-IN-1	Ephrin Receptor Cyclin G-associated Kinase (GAK) Dengue Virus	Infection
EPHA2/A4/GAK-IN-1 (compound 55) is a potent inhibitor of EPHA2/EPHA4 and GAK with K_D values of 180.5 nM for EPHA2 and 19.2 nM for GAK, respectively. EPHA2/GAK-IN-1 shows an extrapolated half-life time of 4.6 h in a microsomal stability assay. EPHA2/GAK-IN-1 shows antiviral activity and prevents dengue virus infection of Huh7 liver cells .

HY-W411439

1-O-p-Coumaroyl-β-D-glucose	GLUT	Metabolic Disease
1-O-p-Coumaroyl-β-D-glucose can promote glucose uptake in HuH7 cells, and be be extracted from Luffa cylindrica (L.) Roem (sponge gourds) .

HY-162327

PROTAC PAPD5 degrader 1	PROTACs HBV	Infection
PROTAC PAPD5 degrader 1 (compound 12b) inhibits both hepatitis A (HAV) and hepatitis B virus (HBV) in vitro and in vivo , with IC₅₀ and CC₅₀ of 10.59 μM and ＞ 50 μM, respectively in Huh7 cells .

HY-155759

HMGB1-IN-2	NF-κB Interleukin Related Caspase Apoptosis	Inflammation/Immunology Cancer
HMGB1-IN-2 (compound 15) is an inhibitor of highly conserved nuclear protein (HMGB1), showing NO inhibitory effect with IC₅₀ value of 20.2 μM in RAW264.7 cells. HMGB1-IN-2 (30 μM) decreases the level of IL-1 β, TNF-α, caspase-1 p20, inhibits the phosphorylation of NF-κB p65, exhibits anti-apoptotic activity. HMGB1-IN-2 (15 mg/kg; ip) relives kidney injury in septic acute kidney injury mouse. HMGB1-IN-2 inhibits Huh7 cells and A549 cells with IC₅₀s of 77.0 μM, and 82.0 μM, respectively .

HY-168102

Antiproliferative agent-59	Microtubule/Tubulin Apoptosis	Cancer
Antiproliferative agent-59 (Compound 14u) is an inhibitor for tubulin polymerization. Antiproliferative agent-59 exhibits antiproliferative activities against cancer cells Huh7, SGC-7901, and MCF-7 with IC₅₀ of 0.03, 0.18, and 0.13μM. Antiproliferative agent-59 arrests the cell cycle at G2/M phase and induces apoptosis in Huh7 cell. Antiproliferative agent-59 exhibits antitumor efficacy against liver cancer in Huh7 xenograft mouse models, without significant toxicity .

HY-177299

HCV NS5B polymerase-IN-3	HCV	Infection
HCV NS5B polymerase-IN-3 (Compound 30a) is an inhibitor of the HCV NS5B polymerase. HCV NS5B polymerase-IN-3 exhibits anti-HCV activity in the Huh7 replicon cell line with an EC₅₀ of 0.23 μM and shows no obvious cytotoxicity. HCV NS5B polymerase-IN-3 can be used in research related to the hepatitis C virus .

HY-N12887

Mycothiazole	Mitochondrial Metabolism	Others Cancer
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .

HY-29866

Tubulin polymerization-IN-75	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-75 (Compound 6) is an inhibitor for tubulin polymerization with an IC₅₀ of 30 μM. Tubulin polymerization-IN-75 inhibits the proliferation of cancer cell Huh7 and 293T with IC₅₀ of 14.3 μM and 13.8 μM .

HY-161648

Anticancer agent 222	Drug Derivative	Cancer
Anticancer agent 222 (Compound 19) is an orally active anticancer agent that exhibits significant anticancer activity against Huh7, FOCUS, SNU475, SNU182, HepG2, and Hep3B cells (IC₅₀ = 2.9–9.3 μM) .

HY-169239

MAGL-IN-20	MAGL	Cancer
MAGL-IN-20 (compound ±34) is a reversible monoacylglycerol lipase (MAGL) inhibitor. MAGL-IN-20 exhibits appreciable antiproliferative activities against several cancer cells, including H460, HT29, CT-26, Huh7 and HCCLM-3. .

HY-163569

FGFR4-IN-20	FGFR	Cancer
FGFR4-IN-20 (comp 11) is an orally active and selective FGFR4 inhibitor with IC₅₀s of 19 and 36 nM against Huh7 cells and FGFR4 enzyme. FGFR4-IN-20 can be used for hepatocellular carcinoma research .

HY-168715

SHP2-IN-33	SHP2 Apoptosis MAPKAPK2 (MK2)	Cancer
SHP2-IN-33 (Compound D13) is an allosteric inhibitor of SHP2 with an IC₅₀ of 1.2 μM. In cellular studies, SHP2-IN-33 demonstrates antiproliferative activity with an IC₅₀ of 38 μM against Huh7 cells by arresting the G0/G1 cell cycle, promoting apoptosis (Apoptosis), and suppressing the MAPK signaling pathway. In an in vivo Huh7 xenograft mouse model, SHP2-IN-33 exhibits significant antitumor activity and favorable pharmacokinetics, including 54% oral bioavailability and a half-life of 10.57 hours. SHP2-IN-33 is a promising compound for studying tumor diseases associated with SHP2 .

HY-113860

Antiviral agent 52	HCV	Infection
Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hepatitic C virus (HCV) with an EC₅₀ of 17 nM. Antiviral agent 52 reveals cytotoxicity in cell Huh7.5.1 with CC₅₀ of 21.3 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1030

Lanatoside C 5+ Cited Publications	other families Classification of Application Fields Cardiacglycosides Plants Disease Research Fields Steroids Source Classification Cancer	Flavivirus Dengue Virus Autophagy Enterovirus
Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-N3519

Platycodin D3 1 Publications Verification	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Source Classification	HCV Branched Chain Amino Acid Transaminase (BCAT) Interleukin Related NF-κB ERK p38 MAPK JNK
Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC₅₀ value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases .

HY-N3677

Dammarenediol II	Triterpenes Structural Classification other families Boswellia freerana Terpenoids Plants Source Classification	OGT Akt mTOR GSK-3 Reactive Oxygen Species (ROS) Apoptosis PARP MDM-2/p53
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy .

HY-133178

Urolithin D 3,4,8,9-Tetrahydroxy urolithin	Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification Cancer	Ephrin Receptor PPAR AMPK
Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC₅₀ of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases .

HY-121204

Iberverin 3-Methylthiopropyl isothiocyanate	Natural Products Cruciferous vegetables Classification of Application Fields Plants Brassicaceae Disease Research Fields Source Classification Cancer	Apoptosis Reactive Oxygen Species (ROS)
Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species .

HY-N8389

Globulol	Structural Classification Terpenoids Sesquiterpenes Myrtaceae Plants Eucalyptus globulus Labill. Source Classification	Bacterial Fungal PAK Akt STAT PD-1/PD-L1 Apoptosis CCR
Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma .

HY-N3741

Didrovaltrate Didrovaltratum	Structural Classification Natural Products Classification of Application Fields Valeriana officinalis Linn. Plants Valerianaceae Disease Research Fields Source Classification Cancer	Calcium Channel Reactive Oxygen Species (ROS) Autophagy
Didrovaltrate (Didrovaltratum) is an L-type calcium channel blocker, ROS scavenger, autophagy enhancer, and lipid accumulation inhibitor. Didrovaltrate blocks L-type calcium currents in a concentration-dependent manner, shifts the current-voltage curve upward, modulates steady-state inactivation kinetics, and inhibits the nuclear translocation of glucocorticoid receptors. Didrovaltrate reduces ROS levels, downregulates the expression of muscle atrophy-related genes, enhances autophagy via lipophagy, and decreases Oleic acid-induced lipid accumulation. Didrovaltrate exhibits cytotoxic activity against cancer cells. Didrovaltrate can be used in research related to skeletal muscle atrophy, non-alcoholic fatty liver disease, breast cancer, lung cancer, gastric cancer, and prostate cancer .

HY-B1030R

Lanatoside C (Standard)	Structural Classification other families Cardiacglycosides Plants Steroids Source Classification	Dengue Virus Flavivirus Reference Standards CHIKV Autophagy Enterovirus
Lanatoside C (Standard) is the analytical standard of Lanatoside C. This product is intended for research and analytical applications. Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-W411439

1-O-p-Coumaroyl-β-D-glucose	Monophenols Simple Phenylpropanols Cucurbitaceae Phenols Phenylpropanoids Plants Luffa aegyptiaca Miller Source Classification	GLUT
1-O-p-Coumaroyl-β-D-glucose can promote glucose uptake in HuH7 cells, and be be extracted from Luffa cylindrica (L.) Roem (sponge gourds) .

HY-N12887

Mycothiazole	Natural Products Marine natural products Sponge Source Classification	Mitochondrial Metabolism
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .

HY-N2858

Alpinumisoflavone acetate	Coumarins Phenylpropanoids Plants Millettia thonningii (Schumach. & Thonn.) Baker Source Classification Fabaceae	Apoptosis
Alpinumisoflavone acetate is a anticancer agent. Alpinumisoflavone acetate shows antiproliferative activity. Alpinumisoflavone acetate decreases the expression of phosphorylation of ERK1/2. Alpinumisoflavone acetate induces mitochondrial dysfunction and mitochondria-mediated Apoptosis. Alpinumisoflavone acetate has the potential for the research of HCC .

HY-121204R

Iberverin (Standard) 3-Methylthiopropyl isothiocyanate (Standard)	Structural Classification Natural Products Cruciferous vegetables Plants Brassicaceae Source Classification	Reference Standards Apoptosis Reactive Oxygen Species (ROS)
Iberverin (Standard) is the analytical standard of Iberverin. This product is intended for research and analytical applications. Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species[1].

HY-N11846

4′-O-Methylglabridin	Structural Classification Natural Products Glycyrrhiza glabra Linn. Leguminosae Plants Source Classification	Apoptosis Caspase
4′-O-Methylglabridin is an apoptosis inducer with antioxidant, cell cycle-disrupting and anticancer cytotoxic activities. 4′-O-Methylglabridin inhibits various cancer cell lines including liver cancer, breast cancer and colorectal cancer cell lines. By reducing the expression levels of phosphorylated Rb (Ser807/811) and p21 proteins, 4′-O-Methylglabridin promotes cell accumulation at the subG1 and G2/M phases, and triggers caspase-dependent apoptosis via cytochrome C release and caspase-9 activation. 4′-O-Methylglabridin also exerts antioxidant effects by inhibiting lipid peroxide levels and reducing β-carotene consumption, thereby blocking LDL oxidation. 4′-O-Methylglabridin can be used in the research of various cancers and atherosclerotic diseases .

HY-N3000A

6-Methoxydihydrosanguinarine hydrochloride	Structural Classification Alkaloids Meconopsis simplicifolia (D. Don) Walp. Quinoline Alkaloids Plants Papaveraceae Source Classification	JNK IRE1 Akt mTOR YAP Reactive Oxygen Species (ROS) Autophagy Apoptosis Ferroptosis Fungal Caspase DNA/RNA Synthesis
6-Methoxydihydrosanguinarine hydrochloride is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine hydrochloride activates IRE1/JNK signaling, blocks Akt/mTOR and PI3K/AKT/mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, GPX4, and EGFR, upregulates IRE1 and DR5, and activates JNK and caspases. 6-Methoxydihydrosanguinarine hydrochloride induces apoptosis, G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis, autophagy, and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine hydrochloride disruptes the biofilm formation of Candida albicans (C. albicans). 6-Methoxydihydrosanguinarine hydrochloride can be used for the research of non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer .

Cat. No.	Product Name	Chemical Structure

HY-W013403S

2'-Deoxy-2'-fluorouridine-d2

2'-Deoxy-2'-fluorouridine-d₂ is the deuterium labeled 2'-Deoxy-2'-fluorouridine . 2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .

Cat. No.	Product Name		Classification