38 Results for "

IL6R

" in MedChemExpress (MCE) Product Catalog:
Products (38)

38 Results for "IL6R" in MCE Product Catalog:

45
45 Publications Verification
Cat. No.: HY-P9917
CAS No.: 375823-41-9
Synonyms: Anti-Human IL6R, Humanized Antibody; RG-1569; rhPM-1
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis . Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P7223
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuIL-6R; IL-6RA; IL-6R 1; CD126; Membrane glycoprotein 80
Species:  
Source:  
CHO
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P990211

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse IL-6R Antibody (15A7) is a rat-derived anti-mouse IL-6R IgG2b κ type antibody inhibitor. Anti-Mouse IL-6R Antibody (15A7) blocks IL-6 binding to IL-6Rα and inhibits both IL-6 classic and trans-signaling. Anti-Mouse IL-6R Antibody (15A7) can be used for the researches of cancer and inflammation, such as triple-negative breast cancer .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P10284
CAS No.: 853248-13-2
S7 is an inhibitory polypeptide targeting IL-6R, which specifically binds to IL-6R and its A chain (gp80/IL-6RA) to block its signal transduction. S7 inhibits IL-6-mediated anti-apoptosis (apoptosis), angiogenesis and the expression of VEGF-A, blocks related survival signaling pathways, and enhances the sensitivity of cancer cells to chemotherapeutic drugs. S7 can be applied to the research of related diseases such as cervical cancer, multiple myeloma, Kaposi's sarcoma, prostate cancer and basal cell carcinoma .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P76370
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; gp130; CD130
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P99112
CAS No.: 1535963-91-7
Synonyms: RG-6168; SA-237

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Satralizumab is a humanized monoclonal antibody that targets IL-6R. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research .
loading...
    loading...
Cat. No.: HY-P9916
CAS No.: 1189541-98-7
Synonyms: Anti-Human IL6Rα, Human Antibody
Sarilumab is a monoclonal antibody targeting IL6 that binds to IL6R and blocks the binding of IL6, thereby inhibiting the activation of the downstream STAT3 phosphorylation signaling pathway. In tumor cells with active IL6/STAT3 signaling pathways, Sarilumab induces Apoptosis and inhibits cell growth. Sarilumab is applicable to research related to prostate cancer, lung cancer and rheumatoid arthritis .
loading...
    loading...
Cat. No.: HY-P0317
Target:  

Interleukin Related

Research Areas:  

Others

IL-6R (352-363) is a peptide fragment of IL-6R with the amino acid sequence TSLPVQDSSSVP .
loading...
    loading...
Cat. No.: HY-P99385
CAS No.: 1628814-88-9
Synonyms: ALX-0061

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Vobarilizumab (ALX-0061) is a humanized bispecific anti-IL-6R and anti-human serum albumin (ALB) monoclonal antibody (mAb) (Kd: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-human serum albumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis .
loading...
    loading...
Cat. No.: HY-P990012
CAS No.: 2744320-12-3
Synonyms: EBI-031

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Vamikibart (EBI-031) is a humanized IgG2κ monoclonal antibody targeting IL-6, with high binding affinity for IL-6 and the IL-6/IL-6R complex. Vamikibart reduces central retinal thickness, resolves intraretinal and subretinal foveal fluid, and decreases the levels of intraocular inflammatory markers. Vamikibart can be used in studies of uveitic macular edema (UME) secondary to non-infectious uveitis .
loading...
    loading...
Cat. No.: HY-177063
CAS No.: 296790-70-0
Target:  

Interleukin Related

Research Areas:  

Infection Inflammation/Immunology

IL-6-IN-2 is an interleukin-6 (IL-6) inhibitor. IL-6-IN-2 binds to IL-6 at Lys66, Phe74, Gln175, Ser176, and Arg179 via π-π, π-alkyl, hydrogen bond, and hydrophobic interactions to block IL-6/IL-6R heterocomplex formation. IL-6-IN-2 exhibits low gastrointestinal absorption rate. IL-6-IN-2 can be used for the research of cytokine release syndrome, covid-19 .
loading...
    loading...
Cat. No.: HY-P99702
CAS No.: 2035008-70-7
Synonyms: BCD-089

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Levilimab (BCD-089) is a fully humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody. Levilimab is an inflammation-alleviating antibody. Levilimab can be used for the research of rheumatoid .
loading...
    loading...
Cat. No.: HY-RS06777
Research Areas:  

Others

IL6R Human Pre-designed siRNA Set A contains three designed siRNAs for IL6R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS23587
Research Areas:  

Others

Il6r Rat Pre-designed siRNA Set A contains three designed siRNAs for Il6r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-174599
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human IL6R mRNA encodes the human interleukin 6 receptor (IL6R) protein, a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response.
loading...
    loading...
Cat. No.: HY-P991602
Synonyms: TZLS-501

Target:  

Interleukin Related

Research Areas:  

Cancer

NI-1201 is a monoclonal antibody that targets, in the human IL-6R sequence, the epitope recognized by 25F10 for mice. NI-1201 inhibits both IL-6 cis- and trans-signaling. NI-1201 targets site IIb of hIL-6R. NI-1201 inhibits gp130 binding to IL-6R .
loading...
    loading...
Cat. No.: HY-P78472
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; IL6R; CD126; IL6RQ; gp80
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P78852
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL6R; CD126; IL-6R-1; IL-6RA; IL6RA; IL-6R-alpha; IL6RQ; gp80
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P70515
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6R 1; Membrane glycoprotein 80; gp80; CD126
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P72388
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6R 1; Membrane glycoprotein 80; gp80; CD126
Species:  
Source:  
loading...
    loading...