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Results for "

ITIM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (2) CD28 (2) Fc Receptor (FcR) (1) SHP2 (2) Transmembrane Glycoprotein (3)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (6) Metabolic Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9986

Tiragolumab MTIG-7192A; RG-6058	CD28	Cancer
Tiragolumab is an immune checkpoint inhibitor binding to the T-cell immunoglobulin and ITIM domain (TIGIT). Tiragolumab in combination with Atezolizumab (HY-P9904) and Bevacizumab (HY-P9906) has benefit in unresectable hepatocellular carcinoma. Tiragolumab can be used to study non-small cell lung cancer (NSCLC) and melanoma .

HY-P99202

Vibostolimab	Transmembrane Glycoprotein	Cancer
Vibostolimab is an anti-TIGIT (*T cell immunoglobulin and ITIM* domain**) monoclonal antibody. Vibostolimab shows antitumor activity, and can be used in non-small cell lung cancer (NSCLC) and melanoma research .

HY-P990079

Renvistobart BMS-986207; ONO-4686	CD28	Inflammation/Immunology
Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody .

HY-P3444

CD31 PECAM-1	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P990030

Ralzapastotug AB-308	Transmembrane Glycoprotein	Infection Inflammation/Immunology
Ralzapastotug (AB-308) is an anti-*TIGIT (T cell immunoreceptor with Ig and ITIM* domains)** IgG1 monoclonal antibody .

HY-P990031

Dargistotug M-6223	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .

HY-P3444A

CD31 TFA PECAM-1 TFA	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P991996

SM201	Fc Receptor (FcR)	Inflammation/Immunology
SM201 is a monoclonal antibody that targets FcγRIIB. SM201 specifically binds to FcγRIIB, enhances ITIM phosphorylation of FcγRIIB in an immune complex-dependent manner, and acts synergistically with immune complexes to amplify inhibitory signals. SM201 does not induce apoptosis, activate NK cells, or deplete B cells. SM201 can be used for the research of autoimmune diseases .

Cat. No.	Product Name	Target	Research Area

HY-P3444

CD31 PECAM-1	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P3444A

CD31 TFA PECAM-1 TFA	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9986

Tiragolumab MTIG-7192A; RG-6058	CD28	Cancer
Tiragolumab is an immune checkpoint inhibitor binding to the T-cell immunoglobulin and ITIM domain (TIGIT). Tiragolumab in combination with Atezolizumab (HY-P9904) and Bevacizumab (HY-P9906) has benefit in unresectable hepatocellular carcinoma. Tiragolumab can be used to study non-small cell lung cancer (NSCLC) and melanoma .

HY-P99202

Vibostolimab	Transmembrane Glycoprotein	Cancer
Vibostolimab is an anti-TIGIT (*T cell immunoglobulin and ITIM* domain**) monoclonal antibody. Vibostolimab shows antitumor activity, and can be used in non-small cell lung cancer (NSCLC) and melanoma research .

HY-P990079

Renvistobart BMS-986207; ONO-4686	CD28	Inflammation/Immunology
Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody .

HY-P990030

Ralzapastotug AB-308	Transmembrane Glycoprotein	Infection Inflammation/Immunology
Ralzapastotug (AB-308) is an anti-*TIGIT (T cell immunoreceptor with Ig and ITIM* domains)** IgG1 monoclonal antibody .

HY-P990031

Dargistotug M-6223	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .

HY-P99508

Tamgiblimab IBI939	Inhibitory Antibodies	Cancer
Tamgiblimab (IBI939) is a fully human monoclonal antibody targeting *T-cell immunoreceptor with immunoglobulin and ITIM* domains (TIGIT)**. Tamgiblimab has anticancer effects .

HY-P991996

SM201	Fc Receptor (FcR)	Inflammation/Immunology
SM201 is a monoclonal antibody that targets FcγRIIB. SM201 specifically binds to FcγRIIB, enhances ITIM phosphorylation of FcγRIIB in an immune complex-dependent manner, and acts synergistically with immune complexes to amplify inhibitory signals. SM201 does not induce apoptosis, activate NK cells, or deplete B cells. SM201 can be used for the research of autoimmune diseases .

Species:	Human (6) Rat (1) Mouse (5) Cynomolgus (6)
Tag:	His (7) Avi (6) Fc (11)
Source:	HEK293 (18)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71009

	TIGIT Protein, Mouse (118a.a, HEK293, Fc) T-cell immunoreceptor with Ig and ITIM domains; Tigit	Mouse	HEK293
	TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (118a.a, HEK293, Fc) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72418

	TIGIT Protein, Human (HEK293, His-Avi) T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3	Human	HEK293
	The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (HEK293, His-Avi) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P74513

	TIGIT Protein, Rat (HEK293, Fc) T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3	Rat	HEK293
	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins, binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation or T cell dependent B cell responses by promoting the generation of mature immunoregulatory dendritic cells. TIGIT Protein, Rat (HEK293, Fc) is the recombinant rat-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77235

	TIGIT Protein, Mouse (HEK293, mFc) T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3	Mouse	HEK293
	TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P76674

	TIGIT Protein, Cynomolgus (HEK293, Fc) T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3	Cynomolgus	HEK293
	TIGIT is a receptor of the Ig superfamily that plays a key role in restricting adaptive and innate immunity. TIGIT can be used as an immune modulator to inhibit the activity of T cells and NK cells, and also regulates the recognition of cancer cells. TIGIT consists of an extracellular immunoglobulin (Ig) variable domain, a type 1 transmembrane domain, and a cytoplasmic tail with two inhibitory motifs. TIGIT Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P7414

	TIGIT Protein, Human (HEK293, Fc) rHuTIGIT, Fc Chimera; VSIG9; VSTM3; T Cell Immunoreceptor with Ig and ITIM Domains	Human	HEK293
	TIGIT Protein, Human (HEK293, Fc) produced in HEK293 cells with the C-termimal human IgG1 Fc fragment. T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3). It belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM).

HY-P705100

	TIGIT Protein, Human (Biotinylated, HEK293, hFc-Avi) T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3	Human	HEK293

HY-P705184

	TIGIT Protein, Cynomolgus (Biotinylated, HEK293, Fc-Avi) T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3	Cynomolgus	HEK293

HY-P705272

	TIGIT Protein, Mouse (Biotinylated, HEK293, Fc-Avi) T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and transmembrane domain-containing protein 3; VSTM3	Mouse	HEK293

HY-P705273

	TIGIT Protein, Mouse (Biotinylated, HEK293, His-Avi) T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and transmembrane domain-containing protein 3; VSTM3	Mouse	HEK293

HY-P72449

	TIGIT Protein, Mouse (110a.a, HEK293, His) T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and transmembrane domain-containing protein 3; VSTM3	Mouse	HEK293
	TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (110a.a, HEK293, His) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70624

	TIGIT Protein, Human (HEK293, His) T-cell immunoreceptor with Ig and ITIM domains; ; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Human	HEK293
	The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (HEK293, His) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70677

	TIGIT Protein, Cynomolgus (HEK293, His) T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Cynomolgus	HEK293
	Ig-like domain-containing protein is a class of proteins that may be involved in protein–protein and protein–ligand interactions, therefore being involved in biological processes such as down-regulation of T cell activation or cardiac and neuronal development. TIGIT Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71363

	TIGIT Protein, Human (HEK293, mFc) T-cell immunoreceptor with Ig and ITIM domains; ; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Human	HEK293
	The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (HEK293, mFc) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P704922

	TIGIT Protein, Cynomolgus (HEK293, mFc) T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Cynomolgus	HEK293

HY-P71007

	TIGIT Protein, Cynomolgus (HEK293, C-hFc) T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Cynomolgus	HEK293
	Ig-like domain-containing protein is a class of proteins that may be involved in protein–protein and protein–ligand interactions, therefore being involved in biological processes such as down-regulation of T cell activation or cardiac and neuronal development. TIGIT Protein, Cynomolgus (HEK293, C-hFc) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P705630

	TIGIT dimer Protein, Human (HEK293, His) T-cell immunoreceptor with Ig and ITIM domains; ; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Human	HEK293
	The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT dimer Protein, Human (HEK293, His) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with N-His labeled tag.

HY-P705185

	TIGIT Protein, Cynomolgus (Biotinylated, HEK293, C-His-Avi) T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Cynomolgus	HEK293

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HY-P810384

	KLRG1 Antibody (YA9701) 2F1 Ag, 2F1, C type lectin domain family 15 member A, C-type lectin domain family 15 member A, CLEC15A, ITIM containing receptor MAFA L, ITIM-containing receptor MAFA-L, Killer cell lectin like receptor G1, Killer cell lectin like receptor subfamily G member 1, Killer cell lectin-like receptor subfamily G member 1	WB	Human, Rat, Mouse
	KLRG1 Antibody (YA9701) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to KLRG1.

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