29 Results for "

ITIM

" in MedChemExpress (MCE) Product Catalog:
Products (29)

29 Results for "ITIM" in MCE Product Catalog:

Cat. No.: HY-P9986
CAS No.: 1918185-84-8
Synonyms: MTIG-7192A; RG-6058

Target:  

CD28

Research Areas:  

Cancer

Tiragolumab is an immune checkpoint inhibitor binding to the T-cell immunoglobulin and ITIM domain (TIGIT). Tiragolumab in combination with Atezolizumab (HY-P9904) and Bevacizumab (HY-P9906) has benefit in unresectable hepatocellular carcinoma. Tiragolumab can be used to study non-small cell lung cancer (NSCLC) and melanoma .
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Cat. No.: HY-P99202
CAS No.: 2231305-30-7

Research Areas:  

Cancer

Vibostolimab is an anti-TIGIT (T cell immunoglobulin and ITIM domain) monoclonal antibody. Vibostolimab shows antitumor activity, and can be used in non-small cell lung cancer (NSCLC) and melanoma research .
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Cat. No.: HY-P990079
CAS No.: 2725062-35-9
Synonyms: BMS-986207; ONO-4686

Target:  

CD28

Research Areas:  

Inflammation/Immunology

Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody .
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Cat. No.: HY-P3444
CAS No.: 161374-99-8
Synonyms: PECAM-1
Target:  

SHP2 Bacterial

CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation - .
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Cat. No.: HY-P990030
CAS No.: 2581724-89-0
Synonyms: AB-308
Ralzapastotug (AB-308) is an anti-TIGIT (T cell immunoreceptor with Ig and ITIM domains) IgG1 monoclonal antibody .
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Cat. No.: HY-P990031
CAS No.: 2649362-29-6
Synonyms: M-6223
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .
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Cat. No.: HY-P99508
CAS No.: 2411914-36-6
Synonyms: IBI939

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Tamgiblimab (IBI939) is a fully human monoclonal antibody targeting T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT). Tamgiblimab has anticancer effects .
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Cat. No.: HY-P3444A
Synonyms: PECAM-1 TFA
Target:  

SHP2 Bacterial

CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation - .
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Cat. No.: HY-P991996

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

SM201 is a monoclonal antibody that targets FcγRIIB. SM201 specifically binds to FcγRIIB, enhances ITIM phosphorylation of FcγRIIB in an immune complex-dependent manner, and acts synergistically with immune complexes to amplify inhibitory signals. SM201 does not induce apoptosis, activate NK cells, or deplete B cells. SM201 can be used for the research of autoimmune diseases .
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Cat. No.: HY-P71009
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: T-cell immunoreceptor with Ig and ITIM domains; Tigit
Species:  
Source:  
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Cat. No.: HY-P72418
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3
Species:  
Source:  
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Cat. No.: HY-P74513
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3
Species:  
Rat
Source:  
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Cat. No.: HY-P77235
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3
Species:  
Source:  
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Cat. No.: HY-P76674
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3
Species:  
Source:  
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Cat. No.: HY-P7414
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuTIGIT, Fc Chimera; VSIG9; VSTM3; T Cell Immunoreceptor with Ig and ITIM Domains
Species:  
Source:  
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Cat. No.: HY-P705100
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3
Species:  
Source:  
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Cat. No.: HY-P705184
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3
Species:  
Source:  
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Cat. No.: HY-P811359
Synonyms: Vstm3, Tigit, T-cell immunoreceptor with Ig and ITIM domains, V-set and transmembrane domain-containing protein 3

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Mouse

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Cat. No.: HY-P705272
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and transmembrane domain-containing protein 3; VSTM3
Species:  
Source:  
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Cat. No.: HY-P705273
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and transmembrane domain-containing protein 3; VSTM3
Species:  
Source:  
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