Iba1

By Targets:	Amyloid-β (1) Apoptosis (1) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (1) COX (3) Environmental Pollutants (1) ERK (1) Glycosidase (1) GSK-3 (1) Hemoglobin (1) Interleukin Related (5) JNK (1) nAChR (1) NF-κB (4) NO Synthase (2) p38 MAPK (1) PARP (1) PERK (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (3) SOD (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) β-catenin (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Endocrinology (1) Infection (1) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (6)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148013

K284-6111 1 Publications Verification	Glycosidase Amyloid-β NF-κB COX ERK NO Synthase Interleukin Related	Neurological Disease Inflammation/Immunology
K284-6111 is a high-affinity and orally active *CHI3L1* inhibitor, and inhibits CHI3L1 expression. K284-6111 inhibits ERK and NF-κB pathway. K284-6111 suppresses nuclear translocation of p50 and p65, and phosphorylation of IκB. K284-6111 improves memory dysfunction by alleviating amyloidogenesis and neuroinflammation, with the reduction of inflammatory proteins (eg: iNOS, COX-2, GFAP, and *Iba-1*). K284-6111 reduces atopic-like skin inflammation and inhibits LPS (HY-D1056) -induced liver injury. K284-6111 can be used for the study of Alzheimer's diseases and sepsis like hepatic injury ^[1] .

HY-172371

Hypoxystat	Hemoglobin	Neurological Disease Metabolic Disease Inflammation/Immunology
Hypoxystat is an orally active hypoxia mimetic. HypoxyStat increases Hemoglobin’s oxygen affinity, limiting oxygen offloading to the tissues and inducing local tissue hypoxia. Hypoxystat reduces *Iba1* ⁺ cells. HypoxyStat causes systemic hypoxia. Hypoxystat effectively rescues hyperglycemia in mouse models of type 1 and type 2 diabetes. HypoxyStat not only extends lifespan but also rescues key neuropathological and behavioral deficits in the premier mouse model of Leigh syndrome ^[1] .

HY-108775A

Sodium thiosulfate (99%, water≤1.0%) Sodium hyposulfite (99%, water≤1.0%)	Environmental Pollutants Biochemical Assay Reagents COX Interleukin Related NF-κB β-catenin GSK-3	Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology Cancer
Sodium thiosulfate is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces *IL-1β, COX-2, and Iba-1, and inhibits NFκB* activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease ^[1] .

HY-123789

T5342126 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC₅₀=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC₅₀s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

HY-N6908

Continentalic acid	Bacterial p38 MAPK Apoptosis PARP Bcl-2 Family Caspase Interleukin Related COX PERK JNK NF-κB NO Synthase SOD	Infection Neurological Disease Inflammation/Immunology Cancer
Continentalic acid is a diterpenoid organic acid. Continentalic acid exhibits multiple activities including anti-inflammatory, antioxidant, neuroprotective, antibacterial and antitumor effects. Continentalic acid alleviates oxidative stress, reduces pro-inflammatory cytokine production, inhibits MAPK phosphorylation and neutrophil infiltration, and induces growth inhibition and apoptosis of cancer cells. Continentalic acid can be used in research related to traumatic brain injury, cancer, inflammation and infections ^[1] .

HY-167153

PNA5	Interleukin Related Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
PNA5 is a novel, blood-brain barrier permeable glycosylated angiotensin-(1-7) peptide and MasR agonist. PNA5 inhibits IL-7, increases IL-10. PNA5 inhibits ROS generation, decreases *Iba-1* expression. PNA5 exhibits sustained cognitive protective effects. PNA5 rescues blunted cerebral functional hyperemia. PNA5 can be used in the research of inflammation-related brain diseases ^[1].

HY-RS00490

AIF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AIF1 Human Pre-designed siRNA Set A contains three designed siRNAs for AIF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AIF1 Human Pre-designed siRNA Set A AIF1 Human Pre-designed siRNA Set A

HY-182707

JWX-A0108	nAChR Interleukin Related TNF Receptor NF-κB	Neurological Disease
JWX-A0108 is a selective human α7 nAChR positive allosteric modulator with an EC₅₀ of 4.35 μM. JWX-A0108 potentiates α7 nAChR currents only in the presence of acetylcholine, with no direct activating effect or alteration of desensitization. JWX-A0108 enhances hippocampal GABAergic synaptic transmission by increasing spontaneous inhibitory postsynaptic currents. JWX-A0108 reduces the brain expression levels of *IL-1β, TNF-α, and IL-6* by blocking the NF-κB signaling pathway, and reduces microglial activation by downregulating *Iba1*. JWX-A0108 effectively improves cognitive deficits, neuroinflammation, and hippocampal neuronal damage in mouse models of schizophrenia and Alzheimer's disease. JWX-A0108 can be used for research related to schizophrenia and Alzheimer's disease ^[1] .

HY-RS24038

Aif1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Aif1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Aif1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aif1 Rat Pre-designed siRNA Set A Aif1 Rat Pre-designed siRNA Set A

HY-RS17578

Aif1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Aif1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aif1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aif1 Mouse Pre-designed siRNA Set A Aif1 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-108775A

Sodium thiosulfate (99%, water≤1.0%) Sodium hyposulfite (99%, water≤1.0%)	Biochemical Assay Reagents
Sodium thiosulfate is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces *IL-1β, COX-2, and Iba-1, and inhibits NFκB* activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease ^[1] .

Sodium thiosulfate (99%, water≤1.0%)

Sodium hyposulfite (99%, water≤1.0%)

Biochemical Assay Reagents

Sodium thiosulfate is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-167153

PNA5	Interleukin Related Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
PNA5 is a novel, blood-brain barrier permeable glycosylated angiotensin-(1-7) peptide and MasR agonist. PNA5 inhibits IL-7, increases IL-10. PNA5 inhibits ROS generation, decreases *Iba-1* expression. PNA5 exhibits sustained cognitive protective effects. PNA5 rescues blunted cerebral functional hyperemia. PNA5 can be used in the research of inflammation-related brain diseases ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6908

Continentalic acid	Infection Structural Classification Classification of Application Fields Terpenoids Aralia continentalis Kitagawa Diterpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Bacterial p38 MAPK Apoptosis PARP Bcl-2 Family Caspase Interleukin Related COX PERK JNK NF-κB NO Synthase SOD
Continentalic acid is a diterpenoid organic acid. Continentalic acid exhibits multiple activities including anti-inflammatory, antioxidant, neuroprotective, antibacterial and antitumor effects. Continentalic acid alleviates oxidative stress, reduces pro-inflammatory cytokine production, inhibits MAPK phosphorylation and neutrophil infiltration, and induces growth inhibition and apoptosis of cancer cells. Continentalic acid can be used in research related to traumatic brain injury, cancer, inflammation and infections ^[1] .

Species:	Human (1) Mouse (1) Bovine (1)
Tag:	His (3) Myc (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700529

	AIF1 Protein, Bovine (N-His, C-Myc) allograft inflammatory factor 1; Iba1; IRT1; AIF-1; IRT-1; protein G1	Bovine	E. coli
	AIF1 protein influences macrophage activation, modulating immune response and cellular activities. Its involvement implies broader influence on immune regulation and inflammation. Studying AIF1's mechanisms in macrophage activation can provide insights into its role in immune homeostasis and signaling pathways governing macrophage functions. AIF1 Protein, Bovine (N-His, C-Myc) is the recombinant bovine-derived AIF1 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

HY-P7488

	AIF1 Protein, Human (C-His) rHuAllograft inflammatory factor 1, His; AIF-1; Allograft inflammatory factor 1	Human	E. coli
	AIF1 Protein, Human (C-His), the recombinant human allograft inflammatory factor 1, has a His tag at the C-terminus. Allograft inflammatory factor-1 (AIF1) is an inflammatory cytokine produced mainly by macrophages within human white adipose tissue.

HY-P72075

	AIF1 Protein, Mouse (His) Aif1; Iba1Allograft inflammatory factor 1; AIF-1; Ionized calcium-binding adapter molecule 1	Mouse	E. coli
	AIF1 Protein, Mouse (His) is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration.

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Source
Tag
Accession
Gene ID
Molecular Weight
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (1) Rabbit (5)
Reactivity:	Human (3) Rat (3) Mouse (6)
Application:	IHC-P (3) ICC/IF (3) mIHC (1) IP (2) WB (5) FC (1) ELISA (2)
Isotype:	IgG (5) IgG1 (1)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (5) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80501

	Iba1 Antibody (YA353) 3 Publications Verification	WB, IHC-P, FC, IP, ICC/IF	Human, Mouse, Rat
	Iba1 Antibody (YA353) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Iba1.

HY-P86692

	AIF1 Antibody (YA6384) AIF 1; AIF1 protein; Iba1; Iba-1; Iba 1; allograft inflammatory factor 1; Allograft inflammatory factor 1 splice variant G; balloon angioplasty responsive transcription; BART 1; G1; G1 putative splice variant of allograft inflamatory factor 1; Iba 1; Iba1; interferon gamma responsive transcript; Ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule; IRT 1; IRT1; Microglia response factor; MRF1; Protein G1.	WB	Mouse
	AIF1 Antibody (YA6384) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AIF1.

HY-P86692A

	AIF1 Antibody (YA6384)(PBS only) AIF 1; AIF1 protein; Iba1; Iba-1; Iba 1; allograft inflammatory factor 1; Allograft inflammatory factor 1 splice variant G; balloon angioplasty responsive transcription; BART 1; G1; G1 putative splice variant of allograft inflamatory factor 1; Iba 1; Iba1; interferon gamma responsive transcript; Ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule; IRT 1; IRT1; Microglia response factor; MRF1; Protein G1.	WB	Mouse
	AIF1 Antibody (YA6384) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AIF1.

HY-P85890

	Iba1 Antibody (YA5582) AIF 1; AIF-1; Aif1; AIF1 protein; AIF1_HUMAN; Allograft inflammatory factor 1; Allograft inflammatory factor 1 splice variant G; allograft inflammatory factor-1 splice variant Hara-1; balloon angioplasty responsive transcription; BART 1; G1; G1 putative splice variant of allograft inflamatory factor 1; Iba 1; Iba1; interferon gamma responsive transcript; Interferon responsive transcript 1; interferon responsive transcript factor 1; Ionized calcium binding adapter molecule 1; Ionized calcium-binding adapter molecule 1; ionized calcium-binding adapter molecule; IRT 1; IRT1; Microglia response factor; MRF1; Protein g1;	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Iba1 Antibody (YA5582) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Iba1.

HY-P86536

	Iba1 Antibody (YA6228) AIF 1; AIF-1; Aif1; AIF1 protein; AIF1_HUMAN; Allograft inflammatory factor 1; Allograft inflammatory factor 1 splice variant G; allograft inflammatory factor-1 splice variant Hara-1; balloon angioplasty responsive transcription; BART 1; G1; G1 putative splice variant of allograft inflamatory factor 1; Iba 1; Iba1; interferon gamma responsive transcript; Interferon responsive transcript 1; interferon responsive transcript factor 1; Ionized calcium binding adapter molecule 1; Ionized calcium-binding adapter molecule 1; ionized calcium-binding adapter molecule; IRT 1; IRT1; Microglia response factor; MRF1; Protein g1;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Iba1 Antibody (YA6228) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Iba1.

HY-P86921

	Iba1 Antibody(YA6614) AIF 1 antibody; AIF-1 antibody; Aif1 antibody; AIF1 protein antibody; AIF1_HUMAN antibody; Allograft inflammatory factor 1 antibody; Allograft inflammatory factor 1 splice variant G antibody; allograft inflammatory factor-1 splice variant Hara-1 antibody; balloon angioplasty responsive transcription antibody; BART 1 antibody; AIF 1 antibody; AIF-1 antibody; Aif1 antibody; AIF1 protein antibody; AIF1_HUMAN antibody; Allograft inflammatory factor 1 antibody; Allograft inflammatory factor 1 splice variant G antibody; allograft inflammatory factor-1 splice variant Hara-1 antibody; balloon angioplasty responsive transcription antibody; BART 1 antibody; G1 antibody; G1 putative splice variant of allograft inflamatory factor 1 antibody; Iba 1 antibody; Iba1 antibody; interferon gamma responsive transcript antibody; Interferon responsive transcript 1 antibody; interferon responsive transcript factor 1 antibody; Ionized calcium binding adapter molecule 1 antibody; Ionized calcium-binding adapter molecule 1 antibody; ionized calcium-binding adapter molecule antibody; IRT 1 antibody; IRT1 antibody; Microglia response factor antibody; MRF1 antibody; Protein g1 antibody;	mIHC	Mouse
	Iba1 Antibody(YA6614) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Iba1.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS00490

AIF1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
AIF1 Human Pre-designed siRNA Set A contains three designed siRNAs for AIF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24038

Aif1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Aif1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Aif1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17578

Aif1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Aif1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aif1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Iba1

Inhibitors & Agonists

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