Results for "

Integrin β2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Integrin (9) DNA Methyltransferase (1) ERK (2) JNK (1) Ras (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Inflammation/Immunology (7)

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Targets Recommended: Integrin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125792

Nexinhib20 1 Publications Verification	Reactive Oxygen Species (ROS) Ras Integrin	Cardiovascular Disease Inflammation/Immunology
Nexinhib20 is an inhibitor that targets the interactions of Rab27a-JFC1 (IC₅₀: 2.6 μM) and Rac-1-GTP. Nexinhib20 can inhibit neutrophil exocytosis, adhesion, and β2 integrin activation, and has anti-inflammatory activity. Nexinhib20 can be used in the research of diseases such as systemic inflammation and myocardial ischemia-reperfusion injury ^[2].

HY-B0665

Fibrin	Integrin	Cardiovascular Disease
Fibrin is an insoluble protein isolated from bovine blood that is produced in response to bleeding. As the main component of blood clots, fibrin functions in blood coagulation. Fibrin binds to the integrins ICAM-1, VE-cadherin, αIIbβ3, αMβ2, αvβ3 and α5β1. Fibrin is used in research related to chronic wounds .

HY-175288

*αMβ2 integrin* agonist-1**	Integrin JNK ERK	Inflammation/Immunology Cancer
αMβ2 integrin agonist-1 (Compound 8) is a highly selective αMβ2 integrin agonist with anti-inflammatory activity (EC₅₀=1.4 nM). αMβ2 integrin agonist-1 activates integrin-mediated cell adhesion and JNK/ERK signaling. αMβ2 integrin agonist-1 induces tumor-associated macrophage repolarization and enhances antitumor T-cell immune responses. αMβ2 integrin agonist-1 is promising for research of cancers and chronic inflammatory diseases (e.g., pancreatic cancer, rheumatoid arthritis) .

HY-175286

α4β1 antagonist-1	Integrin ERK	Inflammation/Immunology Cancer
α₄β₁ antagonist-1 (Compound 4) is a highly selective α₄β₁ integrin antagonist (IC₅₀=15 nM). α4β1 antagonist-1 inhibits integrin-mediated cell adhesion and ERK1/2 signaling activation. α₄β₁ antagonist-1 also exhibits partial agonism toward α_Mβ₂ integrin (EC₅₀=23 nM). α₄β₁ antagonist-1 is promising for research of chronic inflammatory diseases (e.g., rheumatoid arthritis, multiple sclerosis) and cancers .

HY-177318

*αLβ2 integrin-IN-1*	Integrin	Inflammation/Immunology
αLβ2 integrin-IN-1 (example 1) is an αLβ2 integrin mediated cell adhesion inhibitor that can be used for the study of αLβ2 integrin mediated inflammatory conditions .

HY-123277

IMB-10	Integrin	Inflammation/Immunology
IMB-10 is an α_Mβ₂ integrin ligand. IMB-10 inhibits α_Mβ₂-dependent migration and inflammation-induced neutrophil emigration .

HY-P991604

MLN2201 YFC51.1; LDP-01	Integrin	Inflammation/Immunology
MLN2201 is a humanized monoclonal antibody inhibitor, targeting Integrin β2. MLN2201 inhibits the reperfusion injury after stroke and can be used for inflammatory diseases like ischemic stroke research ^[2].

HY-139137

N-Acetyl-S-geranylgeranyl-L-cysteine AGGC	DNA Methyltransferase Integrin	Cancer
N-Acetyl-S-geranylgeranyl-L-cysteine is a Methyltransferase inhibitor. N-Acetyl-S-geranylgeranyl-L-cysteine inhibits beta 2 integrin-induced actin polymerization with an IC₅₀ of 45 nM .

HY-P991825

Anti-Mouse CD18 Antibody (C71/16)	Integrin	Inflammation/Immunology
Anti-Mouse CD18 Antibody (C71/16) reacts with an epitope on mouse CD18. CD18 is the Integrin β2 chain. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991604

MLN2201 YFC51.1; LDP-01	Integrin	Inflammation/Immunology
MLN2201 is a humanized monoclonal antibody inhibitor, targeting Integrin β2. MLN2201 inhibits the reperfusion injury after stroke and can be used for inflammatory diseases like ischemic stroke research ^[2].

HY-P991825

Anti-Mouse CD18 Antibody (C71/16)	Integrin	Inflammation/Immunology
Anti-Mouse CD18 Antibody (C71/16) reacts with an epitope on mouse CD18. CD18 is the Integrin β2 chain. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0665

Fibrin	Cardiovascular Disease Natural Products Animals Disease Research Fields Source Classification Cancer	Integrin
Fibrin is an insoluble protein isolated from bovine blood that is produced in response to bleeding. As the main component of blood clots, fibrin functions in blood coagulation. Fibrin binds to the integrins ICAM-1, VE-cadherin, αIIbβ3, αMβ2, αvβ3 and α5β1. Fibrin is used in research related to chronic wounds .

Species:	Human (5) Mouse (1)
Tag:	His (5) Flag (1)
Source:	HEK293 (4) CHO (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704217

	Integrin alpha L beta 2 Protein, Human (CHO, His) Integrin alpha L beta 2; LITGAL&ITGB2	Human	CHO

HY-P73863

	Integrin alpha X beta 2 Protein, Human (HEK293, His) Integrin alpha X beta 2; CD11c; ITGAX; CD18; ITGB2	Human	HEK293
	Integrin α-X/β-2 is a receptor for fibrinogen that recognizes GPR sequences. It plays a key role in inflammatory responses, particularly in monocyte adhesion and chemotaxis. Integrin alpha X beta 2 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha X beta 2 Protein, Human (HEK293, His), has molecular weight of 130-150 kDa (ITGAX) & 85-96 kDa (ITGB2), respectively.

HY-P705545

	Integrin alpha D beta 2 Protein, Human (CHO, His)	Human	CHO

HY-P73864

	Integrin alpha X beta 2 Protein, Human (HEK293, Flag, His) Integrin alpha X beta 2; CD11c; ITGAX; CD18; ITGB2	Human	HEK293
	Integrin α-X/β-2 is a receptor for fibrinogen that recognizes GPR sequences. It plays a key role in inflammatory responses, particularly in monocyte adhesion and chemotaxis. Integrin alpha X beta 2 Protein, Human (HEK293, Flag, His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein, expressed by HEK293 , with C-His, C-Flag labeled tag.

HY-P700758

	Integrin alpha L beta 2 Protein, Mouse (HEK293, His) αLβ2; ITGAL&ITGB2; ITGAL; ITGB2	Mouse	HEK293
	The integrin alpha L beta 2 protein is a receptor for ICAM1, ICAM2, ICAM3, ICAM4, and F11R and is involved in immune phenomena, including leukocyte-endothelial cell interactions, cytotoxic T cell killing, and antibody-dependent killing. It contributes to natural killer cell cytotoxicity and leukocyte adhesion and migration. Integrin alpha L beta 2 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha L beta 2 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha L beta 2 Protein, Mouse (HEK293, His), has molecular weight of 160-180 kDa (ITGAL) & 90-105 kDa (ITGB2), respectively.

HY-P700759

	Integrin alpha M beta 2 Protein, Human (HEK293, His) αMβ2; ITGAM&ITGB2; ITGAM; ITGB2; Mac-1; complement receptor-3 (CR3)	Human	HEK293
	Integrin α M β 2 (ITGAM/ITGB2) mediates adhesion of monocytes and granulocytes and promotes uptake of complement-coated particles and pathogens. As a receptor for iC3b and fibrinogen, it regulates neutrophil migration, contributes to CD177-PRTN3-mediated activation, and may influence phagocytosis-induced apoptosis. Integrin alpha M beta 2 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha M beta 2 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha M beta 2 Protein, Human (HEK293, His), has molecular weight of 140-160 kDa (ITGAM) & 90-100 kDa (ITGB2), respectively.

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Host:	Mouse (1) Rat (1) Rabbit (2)
Reactivity:	Human (3) mouse (1) Rat (2) Mouse (3)
Application:	ICC/IF (1) IP (3) WB (3) ELISA (1)
Isotype:	IgG (2) IgG2a (1)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Phosphorylated (1) Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810219

	Integrin β2/ITGB2/CD18 Antibody (YA9563)	WB, IP	mouse
	Integrin β2/ITGB2/CD18 Antibody (YA9563) is a Rat-derived and non-conjugated IgG2a monoclonal antibody, targeting to Integrin β2/ITGB2/CD18.

HY-P85085

	CD18 Antibody (YA4777) ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18	ICC/IF, ELISA	Human, Mouse
	CD18 Antibody (YA4777) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD18.

HY-P80795

	Phospho-CD18 (Ser745) Antibody (YA220) ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18	WB, IP	Human, Mouse, Rat
	Phospho-CD18 (Ser745) Antibody (YA220) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CD18 (Ser745).

HY-P80795A

	Phospho-CD18 (Ser745) Antibody (YA220)(PBS only) ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18	WB, IP	Human, Mouse, Rat
	Phospho-CD18 (Ser745) Antibody (YA220) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CD18 (Ser745).

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Integrin β2

Inhibitors & Agonists

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