α4β1 antagonist-1
α4β1 antagonist-1 (Compound 4) is a highly selective α4β1 integrin antagonist (IC50=15 nM). α4β1 antagonist-1 inhibits integrin-mediated cell adhesion and ERK1/2 signaling activation. α4β1 antagonist-1 also exhibits partial agonism toward αMβ2 integrin (EC50=23 nM). α4β1 antagonist-1 is promising for research of chronic inflammatory diseases (e.g., rheumatoid arthritis, multiple sclerosis) and cancers.
For research use only. We do not sell to patients.
- Formula: C15H17F3N2O5
- Molecular Weight:362.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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α4β1 15 nM (IC50) |
ERK1 |
ERK2 |
Chemical Information
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Molecular Weight 362.30
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Formula C15H17F3N2O5
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SMILES
[NH3+]C1=CC=C(C=C1)CC(N2CCC[C@H]2C(O)=O)=O.O=C([O-])C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α4β1 antagonist-1 Related Classifications
HY-175286 Related Classifications
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