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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
KCC2
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "KCC2" in MCE Product Catalog:
2
2 Cited Publications
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CLP290 is an orally available activator of the neuron-specific K +-Cl - cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ (HY-13753) rats [2].
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2 Cited Publications
Cat. No.: HY-P80445
Synonyms: Alpha CaMKII; Calcium calmodulin dependent protein kinase II; Calcium/calmodulin dependent protein kinase II alpha B subunit; Calcium/calmodulin dependent protein kinase type II alpha chain; Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; Calcium/calmodulin-dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase II-alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type IIA; CaM kinase II alpha chain; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaMK II alpha subunit; CaMK-II subunit alpha; Camk2a; CAMKA; CaMKII; CaMKIINalpha; EC2.7.11.17; KCC2A_HUMAN; KIAA0968; MGC123320; MGC139375; MGC155201; mKIAA0968; PK2CDD; PKCCD; R74975; zgc:112538; zgc:123320;
1
1 Cited Publications
Cat. No.: HY-16689
CAS No.: 893990-34-6
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VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca 2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission [2].
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1 Cited Publications
Cat. No.: HY-P84930
Synonyms: Calcium/calmodulin dependent protein kinase II alpha antibody;
Calcium/calmodulin dependent protein kinase II beta antibody;
Calcium/calmodulin dependent protein kinase II delta antibody;
Calcium/calmodulin dependent protein kinase II gamma antibody;
Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody;
CaM kinase II alpha antibody;
CaM kinase II antibody;
CaM kinase II beta antibody;
CaM kinase II delta antibody;
CaM kinase II gamma antibody;
CaM kinase II subunit alpha antibody;
CaMK-II subunit alpha antibody;
CAMK2 antibody;
Camk2a antibody;
CAMK2B antibody;
CAMK2D antibody;
CAMK2G antibody;
CAMKA antibody;
KCC2A_HUMAN antibody;
CaMKⅡ
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VU0463271 is a selective KCC2 antagonist, with an IC50 of 61 nM.
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CLP257 is a selective K +-Cl cotransporter KCC2 activator with an EC50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally [2].
Cat. No.: HY-169929
CAS No.: 3058906-46-7
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KCC2 potentiators-1 is a KCC2 potentiator with an EC50 of less than 0.1 μM in NG-108 cells. KCC2 potentiators-1 exhibits potentiating activity in neuronal cells via fluorescence-based assays. KCC2 potentiators-1 can be used for the research of neurological disorders .
Cat. No.: HY-18172
CAS No.: 1228439-36-8
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KCC2 blocker 1 is an orally active and selective K +-Cl - cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate .
Cat. No.: HY-160083
CAS No.: 2704531-38-2
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KCC2 Modulator-3 (example 54) is a KCC2 modulator. KCC2 Modulator-3 is used for the research of neurological disorders .
Cat. No.: HY-18172A
CAS No.: 1228439-71-1
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(+)-KCC2 blocker 1 is a selective K +-Cl - cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1 .
Cat. No.: HY-160081
CAS No.: 2704531-36-0
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KCC2 Modulator-1 (example 52) is a KCC2 modulator. KCC2 Modulator-1 is used for the research of neurological disorders .
Cat. No.: HY-160082
CAS No.: 2704531-37-1
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KCC2 Modulator-2 (example 53) is a KCC2 modulator with an EC50 of 0.215 μM. KCC2 Modulator-2 can be used in the study of neurological disorders .
Cat. No.: HY-110110A
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VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC50 of 61 nM .
Cat. No.: HY-115606
CAS No.: 1135304-61-8
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ML007 is a selective antagonist targeting the neuron-specific potassium-chloride co-transporter 2 (KCC2) with an IC50 for KCC2 is 537 nM, while its inhibitory activity on KCC1 is extremely weak (IC50 > 50 μM). ML077 inhibits the chloride ion excretion function of KCC2, increasing the intracellular chloride ion concentration, thereby enhancing the depolarization mediated by chloride ion channels. ML007 can promote glucose-stimulated insulin secretion (GSIS) without relying on KATP channels. ML007 can be used to study the functions related to pain, epilepsy, and insulin secretion [2].
Cat. No.: HY-18172B
CAS No.: 1228439-73-3
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(-)-KCC2 blocker 1 is an enantiomer of KCC2 blocker 1 (HY-18172). KCC2 blocker 1 (compound 13) is an orally active and selective K +-Cl - cotransporter KCC2 blocker with an IC50 of 1 μM .
Cat. No.: HY-178362
CAS No.: 3085155-69-4
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CAII/VII-IN-1 is an orally active hCA II (KI = 12.3 nM), and hCA VII (KI = 22.6 nM) inhibitor, showing no significant activity against hCA I. CAII/VII-IN-1 shows excellent neuroprotective activity in vivo Pilocarpine (HY-B0726A)-induced seizure model. CAII/VII-IN-1 can upregulate KCC2 and inhibit mTOR, exerting neuroprotective effects. CAII/VII-IN-1 does not show any significant neurotoxic effects or alterations in liver and kidney function. CAII/VII-IN-1 can be used for the study of epilepsy .
Cat. No.: HY-172816
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Carbonic anhydrase inhibitor 32 (compound 5B) is an orally active and selective hCA (Carbonic anhydrase ) II/VII inhibitor with the Ki values of 6.3 nM, 10.1 nM and 681 nM for hCA II, hCA VII and hCA I,respectively. Carbonic anhydrase inhibitor 32 shows neuroprotective and anticonvulsant potential by reducing mTOR activation, and raising hippocampus KCC2 levels .
Cat. No.: HY-RS13000
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SLC12A5 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC12A5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-103023R
CAS No.: 1181083-81-7
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CLP290 (Standard) is the analytical standard of CLP290 (HY-103023). This product is intended for research and analytical applications. CLP290 is an orally available activator of the neuron-specific K+-Cl- cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ (HY-13753) rats [2].
Cat. No.: HY-180056
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CAII-IN-12 (compound 6c) is a potent and selective carbonic anhydrase (CA) II and VII inhibitor (hCA II Ki = 47.8 nM, hCA VII Ki = 3.6 nM) with anti-epilepitic activity. CAII-IN-12 displays selectivity over hCA I (Ki = 370 nM). CAII-IN-12 exhibits potent anticonvulsant activity in both Pentylenetetrazol- and Pilocarpine (HY-B0726A)-induced seizure mouse models. CAII-IN-12 increases expression of KCC2 in the hippocampus, maintains neuronal integrity, and reduces mTOR activity. CAII-IN-12 can be used for epilepsy research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
