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Isoforms Recommended:	KDM4

Results for "

KDM4A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Apoptosis (4) Bacterial (3) Histone Demethylase (14) Isotope-Labeled Compounds (1) PROTACs (2) Reference Standards (2) Small Interfering RNA (siRNA) (3) β-catenin (3)
By Research Areas:	Cancer (15) Infection (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148807

Zavondemstat QC8222 free base; TACH 101 free base	Histone Demethylase Apoptosis	Cancer
Zavondemstat (QC8222 free base; TACH 101 free base) is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-104048

QC6352 Maximum Cited Publications 11 Publications Verification	Histone Demethylase	Cancer
QC6352 is an orally active *KDM4* inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits *KDM4* different isoforms with IC₅₀s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against *KDM5* with an IC₅₀ of 750 nM (KDM5B) .

HY-100760

Toxoflavin 5+ Cited Publications Xanthothricin; Toxoflavine; PKF-118-310	β-catenin Bacterial Antibiotic Histone Demethylase	Infection Cancer
Toxoflavin (Xanthothricin) is an antagonist of *transcription factor 4 (TCF4)/β-catenin* complex, also acts as an inhibitor of KDM4A**, with antitumor and antibiotic activity .

HY-107573

KDM2/7-IN-1 1 Publications Verification	Histone Demethylase	Cancer
KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase *KDM2/7* subfamily inhibitor (IC₅₀ values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro .

HY-110154

NSC636819	Histone Demethylase	Cancer
NSC636819 is a competitive and selective inhibitor of *KDM4A/KDM4B. KDM4A/KDM4B* are potential progression factors for prostate cancer. NSC636819 has the potential for the research of cancer diseases, especially prostate cancer .

HY-RS07213

KDM4A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KDM4A Human Pre-designed siRNA Set A contains three designed siRNAs for KDM4A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KDM4A Human Pre-designed siRNA Set A KDM4A Human Pre-designed siRNA Set A

HY-RS17467

Kdm4a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kdm4a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm4a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm4a Mouse Pre-designed siRNA Set A Kdm4a Mouse Pre-designed siRNA Set A

HY-RS23925

Kdm4a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kdm4a Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm4a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm4a Rat Pre-designed siRNA Set A Kdm4a Rat Pre-designed siRNA Set A

HY-128343

KDM4-IN-2	Histone Demethylase	Cancer
KDM4-IN-2 (Compound 19a) is a potent and selective *KDM4/KDM5* dual inhibitor with K_is of 4 and 7 nM for KDM4A and KDM5B, respectively .

HY-150619

KDM4-IN-4	Histone Demethylase	Cancer
KDM4-IN-4 (compound 47) is a potent histone lysine demethylase 4 (KDM4) inhibitor with a modest affinity binding to ~80 μM for KDM4A-Tudor domain. KDM4-IN-4 can inhibit H3K4Me3 binding to the Tudor domain in cells with an EC₅₀ value of 105 μM. KDM4-IN-4 can be used for researching anticancer .

HY-120766

NCDM-32B	Histone Demethylase	Cancer
NCDM-32B is a potent and selective *KDM4* inhibitor, with IC₅₀ values of 3.0 μM for *KDM4A* and 1.0 μM for *KDM4C* in in vitro enzyme assays. NCDM-32B specifically increases global H3K9me3/me2 levels in basal breast cancer cells. NCDM-32B impairs the viability of *KDM4C*-amplified basal breast cancer cell lines (HCC1954 and Colo824). NCDM-32B can be used for the study of breast cancer .

HY-173135

*PROTAC KDM4* degrader-1**	PROTACs Histone Demethylase Apoptosis	Cancer
PROTAC KDM4 degrader-1 is a *KDM4* PROTAC degrader that degrades *KDM4A-C* with DC₅₀ values of 37.53, 39.93, and 49.41 nM, respectively, while sparing KDM4D. PROTAC KDM4 degrader-1 induces cell cycle arrest, apoptosis and antiproliferative activity in esophageal cancer cells. PROTAC KDM4 degrader-1 can be used for the research of esophageal cancer .

HY-148807A

Zavondemstat L-lysine QC8222; TACH 101	Apoptosis Histone Demethylase	Cancer
Zavondemstat (QC8222; TACH 101) L-lysine is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat L-lysine induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat L-lysine suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat L-lysine can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-100760S

Toxoflavin-13C4 Xanthothricin-¹³C₄; Toxoflavine-¹³C₄; PKF-118-310-¹³C₄	Isotope-Labeled Compounds β-catenin Bacterial Antibiotic	Infection Cancer
Toxoflavin- ¹³C₄ is the ¹³C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity . Antibiotic properties.

HY-100760R

Toxoflavin (Standard) Xanthothricin (Standard); Toxoflavine (Standard); PKF-118-310 (Standard)	Reference Standards β-catenin Bacterial Antibiotic Histone Demethylase	Infection Cancer
Toxoflavin (Standard) is the analytical standard of Toxoflavin. This product is intended for research and analytical applications. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor and antibiotic activity[1][2].

HY-148807C

Zavondemstat sodium QC8222 sodium; TACH 101 sodium	Apoptosis Histone Demethylase	Cancer
Zavondemstat (QC8222; TACH 101) sodium is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat sodium induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat sodium suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat sodium can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-104048R

QC6352 (Standard)	Reference Standards Histone Demethylase	Cancer
QC6352 (Standard) is the analytical standard of QC6352 (HY-104048). This product is intended for research and analytical applications. QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC₅₀s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC₅₀ of 750 nM (KDM5B) .

HY-183618

DW-229	PROTACs Histone Demethylase	Cancer
DW-229 is a PROTAC degrader derived from Deferiprone (HY-B0568), targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs). DW-229 degrades *KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B* in breast cancer cells. DW-229 shows IC₅₀ < 0.5 μM against MCF‑7 cells and IC₅₀ of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity. DW-229 can be used for the research of breast cancer, liver cancer, prostate cancer, lung cancer .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701618

	JMJD2A Protein, Human KDM4A; Lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A; [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A	Human	E. coli
	The JMJD2A protein is a central histone demethylase in the histone code that specifically targets "Lys-9" and "Lys-36" of histone H3. It excludes demethylation of H3 "Lys-4", "Lys-27" and H4 "Lys-20". JMJD2A Protein, Human is the recombinant human-derived JMJD2A protein, expressed by E. coli , with tag free.

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Toxoflavin-13C4
Toxoflavin- ¹³C₄ is the ¹³C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity . Antibiotic properties.

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (1) Mouse (1)
Application:	IHC-P (1) IF-Tissue (1) IP (3) IHC-F (1) WB (3)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85236

	KDM4A/JHDM3A/JMJD2A Antibody (YA4928) KDM4A; JHDM3A; JMJD2; JMJD2A; KIAA0677; Lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A	WB, IHC-P, IHC-F, IP, IF-Tissue	Human, Mouse, Rat
	KDM4A/JHDM3A/JMJD2A Antibody (YA4928) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to KDM4A/JHDM3A/JMJD2A.

HY-P83586

	KDM4A/JHDM3A/JMJD2A Antibody (YA3331) KDM4A; JHDM3A; JMJD2; JMJD2A; KIAA0677; Lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A	WB, IP	Human
	KDM4A/JHDM3A/JMJD2A Antibody (YA3331) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KDM4A/JHDM3A/JMJD2A.

HY-P83586A

	KDM4A/JHDM3A/JMJD2A Antibody (YA3331)(PBS only) KDM4A; JHDM3A; JMJD2; JMJD2A; KIAA0677; Lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A	WB, IP	Human
	KDM4A/JHDM3A/JMJD2A Antibody (YA3331) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KDM4A/JHDM3A/JMJD2A.

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KDM4A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KDM4A Human Pre-designed siRNA Set A contains three designed siRNAs for KDM4A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm4a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Kdm4a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm4a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm4a Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Kdm4a Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm4a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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