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Results for "

KLF4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	KLF (2) Apoptosis (2) Bcl-2 Family (1) c-Myc (3) CDK (1) GSK-3 (1) Histone Methyltransferase (1) mRNA (1) Notch (1) PAK (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Inflammation/Immunology (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Transcription Factors (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Screening Libraries

Peptides

Antibodies

Oligonucleotides

Targets Recommended: KLF

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16291

APTO-253 Maximum Cited Publications 21 Publications Verification LOR-253; LT-253	c-Myc KLF Apoptosis	Inflammation/Immunology Cancer
APTO-253 (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through induction of the Krüppel-like factor 4 (KLF4) tumor suppressor . APTO-253 has antiarthritic activity .

HY-12302

Kenpaullone 10+ Cited Publications 9-Bromopaullone; NSC-664704	CDK GSK-3	Cancer
Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC₅₀s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC₅₀s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of *KLF4*, reduces self-renewal of breast cancer stem cells and cell motility in vitro.

HY-RS16607

Klf4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Klf4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Klf4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Klf4 Mouse Pre-designed siRNA Set A Klf4 Mouse Pre-designed siRNA Set A

HY-RS07341

KLF4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KLF4 Human Pre-designed siRNA Set A contains three designed siRNAs for KLF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KLF4 Human Pre-designed siRNA Set A KLF4 Human Pre-designed siRNA Set A

HY-RS23041

Klf4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Klf4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Klf4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Klf4 Rat Pre-designed siRNA Set A Klf4 Rat Pre-designed siRNA Set A

HY-174592

*Human KLF4* mRNA**	mRNA	Cancer
Human kruppel like factor 4 (KLF4) mRNA encodes a protein that belongs to the Kruppel family of transcription factors. KLF4 protein is thought to regulate the expression of key transcription factors during embryonic development and play an important role in maintaining embryonic stem cells, and in preventing their differentiation. In addition it is also required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface.

HY-131923

DAPM	Notch	Cancer
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .

HY-16291A

APTO-253 hydrochloride LOR-253 hydrochloride; LT-253 hydrochloride	c-Myc	Inflammation/Immunology
APTO-253?(LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253?hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4?(KLF4)?tumor suppressor. APTO-253?hydrochloride exhibits antiarthritic activity .

HY-121917

Ro 31-7837	c-Myc Apoptosis	Inflammation/Immunology
APTO-253 (LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4 (KLF4) tumor suppressor. APTO-253 hydrochloride exhibits antiarthritic activity.

HY-W072962

WX2-43	Histone Methyltransferase PAK Bcl-2 Family KLF	Cancer
WX2-43 is a *PRMT5-KLF4* inhibitor (K_d of 11.0 nM). WX2-43 binds to the region between amino acids L400-M500 on PRMT5. WX2-43 efficiently intercepts the interaction between KLF4 and PRMT5, and blocks KLF4 methylation. WX2-43 decreases p21 levels and increases Bax levels. WX2-43 suppresses triple negative breast tumor progression. WX2-43 can be used in the research of triple-negative breast cancer and colorectal cancer .

Cat. No.	Product Name

HY-L039

Reprogramming Compound Library	3,086 compounds
Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells. MCE Reprogramming Compound Library contains a unique collection of 3,086 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Reprogramming Compound Library

3,086 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 3,086 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Cat. No.	Product Name	Target	Research Area

HY-131923

DAPM	Notch	Cancer
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .

Host:	Mouse (4) Rabbit (4)
Reactivity:	Human (8) Rat (5) Mouse (6)
Application:	IHC-P (6) ICC/IF (4) IP (1) IHC-F (2) WB (6) FC (2) ELISA (3)
Isotype:	IgG (4) IgG1 (2) IgG2b (2)
Conjugation:	Non-conjugated (8)
Clonality:	Monoclonal (4) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83840

	KLF4 Antibody (YA3537) EZF; GKLF; KLF4	IHC-P, ELISA	Human
	KLF4 Antibody (YA3537) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KLF4.

HY-P83840A

	KLF4 Antibody (YA3537)(PBS only) EZF; GKLF; KLF4	IHC-P, ELISA	Human
	KLF4 Antibody (YA3537) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KLF4.

HY-P80201

	KLF4 Antibody (YA321)	WB, ICC/IF, IHC-P	Human, Mouse
	KLF4 Antibody (YA321) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLF4.

HY-P86625

	KLF4 Antibody (YA6317) KLF4; EZF; GKLF; Krueppel-like factor 4; Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	KLF4 Antibody (YA6317) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLF4.

HY-P86666

	KLF4 Antibody (YA6358) Endothelial Kruppel like zinc finger protein; EZF; GKLF; KLF; Kruppel like factor 4(Epithelial zinc finger protein EZF)(Gut enriched Krueppel like factor); Kruppel like factor 4(gut); Krueppel-like factor 4; EZF; GKLF; KLF 4; KLF-4; Krueppel like factor 4; KLF4_HUMAN.	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse, Rat
	KLF4 Antibody (YA6358) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLF4.

HY-P86666A

	KLF4 Antibody (YA6358)(PBS only) Endothelial Kruppel like zinc finger protein; EZF; GKLF; KLF; Kruppel like factor 4(Epithelial zinc finger protein EZF)(Gut enriched Krueppel like factor); Kruppel like factor 4(gut); Krueppel-like factor 4; EZF; GKLF; KLF 4; KLF-4; Krueppel like factor 4; KLF4_HUMAN.	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse, Rat
	KLF4 Antibody (YA6358) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLF4.

HY-P80735

	KLF4 Antibody (YA716) Endothelial Kruppel like zinc finger protein; Epithelial zinc finger protein EZF; EZF; GKLF; Gut-enriched krueppel-like factor; KLF; KLF4; KLF4_HUMAN; Krueppel-like factor 4; Kruppel like factor 4; Epithelial zinc finger protein EZF; Gut enriched Krueppel	WB	Human, Mouse, Rat
	KLF4 Antibody (YA716) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KLF4.

HY-P80735A

	KLF4 Antibody (YA716)(PBS only) Endothelial Kruppel like zinc finger protein; Epithelial zinc finger protein EZF; EZF; GKLF; Gut-enriched krueppel-like factor; KLF; KLF4; KLF4_HUMAN; Krueppel-like factor 4; Kruppel like factor 4; Epithelial zinc finger protein EZF; Gut enriched Krueppel	WB	Human, Mouse, Rat
	KLF4 Antibody (YA716) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KLF4.

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Cat. No.	Product Name		Classification

HY-RS16607

Klf4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Klf4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Klf4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07341

KLF4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KLF4 Human Pre-designed siRNA Set A contains three designed siRNAs for KLF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23041

Klf4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Klf4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Klf4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174592

*Human KLF4* mRNA**		mRNA Transcription Factors
Human kruppel like factor 4 (KLF4) mRNA encodes a protein that belongs to the Kruppel family of transcription factors. KLF4 protein is thought to regulate the expression of key transcription factors during embryonic development and play an important role in maintaining embryonic stem cells, and in preventing their differentiation. In addition it is also required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface.

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