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Isoforms Recommended:	LIMK1

Results for "

LIMK1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	LIM Kinase (LIMK) (30) AAK1 (1) Apoptosis (1) Aurora Kinase (1) Bcr-Abl (1) CaMK (1) Caspase (1) CDK (2) Cyclin G-associated Kinase (GAK) (1) Ephrin Receptor (1) Ferroptosis (2) FGFR (1) MAP3K (2) MAP4K (1) MAPKAPK2 (MK2) (1) MMP (1) p38 MAPK (1) PAK (2) PKA (2) PROTACs (2) Reactive Oxygen Species (ROS) (1) Reverse Transcriptase (1) Ribosomal S6 Kinase (RSK) (1) ROCK (3) Salt-inducible Kinase (SIK) (2) Small Interfering RNA (siRNA) (3) Src (1) ULK (2)
By Research Areas:	Cancer (20) Cardiovascular Disease (1) Endocrinology (2) Infection (1) Metabolic Disease (2) Neurological Disease (5)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: LIM Kinase (LIMK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18305

BMS-5 5 Publications Verification LIMKi 3	LIM Kinase (LIMK)	Cancer
BMS-5 (LIMKi 3) is a potent *LIMK* inhibitor with IC₅₀s of 7 nM and 8 nM for *LIMK1* and *LIMK2*, respectively.

HY-18832

AWL-II-38.3	Ephrin Receptor	Cancer
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf ^[1] ^[1] .

HY-128062

LIMK1 inhibitor BMS-4	LIM Kinase (LIMK)	Cancer
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells ^[1] .

HY-18304

BMS-3 3 Publications Verification	LIM Kinase (LIMK)	Cancer
BMS-3 is a potent *LIMK* inhibitor with IC₅₀s of 5 nM and 6 nM for *LIMK1* and *LIMK2*, respectively.

HY-136848

SM1-71	MAP3K Src FGFR Ribosomal S6 Kinase (RSK) LIM Kinase (LIMK)	Cancer
SM1-71 (compound 5) is a potent *TAK1* inhibitor, with a K_i of 160 nM, it also can covalently inhibit MKNK2, *MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1* and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines ^[1] .

HY-122630

TH-257 1 Publications Verification	LIM Kinase (LIMK)	Cancer
TH-257 is a potent inhibitor of *LIMK1* and *LIMK2* with IC₅₀ values of 84 nM and 39 nM for *LIMK1* and *LIMK2, respectively, and it can be used as a chemical probe for LIMK1* and *LIMK2*. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM ^[1].

HY-19353

SR7826 1 Publications Verification	LIM Kinase (LIMK)	Neurological Disease Cancer
SR7826 is a class of bis-aryl urea derived potent, selective and orally active LIM kinase (LIMK) inhibitor with an IC₅₀ of 43 nM for *LIMK1. SR7826 is >100-fold more selective for LIMK1* than ROCK and JNK kinases ^[1].

HY-12659

LX7101 3 Publications Verification	LIM Kinase (LIMK) ROCK PKA	Endocrinology
LX7101 is a potent LIM-kinase, ROCK and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 has the potential for ocular hypertension and associated glaucoma research ^[1] .

HY-120097

R-10015	LIM Kinase (LIMK) Reverse Transcriptase	Infection
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC₅₀ of 38 nM for human LIMK1 ^[1].

HY-148061

DB1113	PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)	Cancer
DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity ^[1].

HY-14227

LIMK-IN-1	LIM Kinase (LIMK) ROCK	Others
LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC₅₀s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research ^[1].

HY-170781

MDI-114215	LIM Kinase (LIMK)	Metabolic Disease
MDI-114215 (compound 85) is an allosteric *LIMK1/2* dual inhibitor with good in vivo tolerance. MDI-114215 can inhibit cofilin phosphorylation in mouse brain region-induced pluripotent stem cells (iPSCs), which can be used for Fragile X Syndrome (FXS) research ^[1].

HY-W070753

LIMK1 inhibitor 2 WAY-248134	LIM Kinase (LIMK)	Cancer
LIMK1 inhibitor 2 (compound 41) is a *LIMK1* inhibitor with the IC₅₀ of 9 μM ^[1].

HY-151539

TH470	LIM Kinase (LIMK)	Neurological Disease
TH470 is a highly selective *LIMK1/2* (LIM kinase1/2) inhibitor (LIMK1 IC₅₀=9.8 nM; LIMK2 IC₅₀=13 nM), and can be used in orphan disease research ^[1].

HY-120025

CRT0105950	LIM Kinase (LIMK)	Cancer
CRT0105950 is a potent *LIMK* inhibitor, with IC₅₀s of 0.3 nM and 1 nM for *LIMK1* and *LIMK2* respectively. CRT0105950 can be used for the research of cancer ^[1].

HY-148063

DB0614	PROTACs AAK1 Aurora Kinase CaMK CDK Ferroptosis Salt-inducible Kinase (SIK) LIM Kinase (LIMK) ULK	Metabolic Disease
DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity ^[1] .(Blue: Thalidomide-4-OH (HY-103596), Black: linker, Pink: FLT3-IN-17 (HY-148070))

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

HY-RS07662

LIMK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) LIM Kinase (LIMK)	Others
LIMK1 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LIMK1 Human Pre-designed siRNA Set A LIMK1 Human Pre-designed siRNA Set A

HY-RS07663

Limk1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) LIM Kinase (LIMK)	Others
Limk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Limk1 Mouse Pre-designed siRNA Set A Limk1 Mouse Pre-designed siRNA Set A

HY-169605

LIMK1 inhibitor 1	LIM Kinase (LIMK)	Cancer
LIMK1 inhibitor 1 (compound 24) is a LIMK1 inhibitor. LIMK1 inhibitor 1 can be used in anti-cancer research ^[1].

HY-RS07664

Limk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) LIM Kinase (LIMK)	Others
Limk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Limk1 Rat Pre-designed siRNA Set A Limk1 Rat Pre-designed siRNA Set A

HY-174229

SM311	LIM Kinase (LIMK)	Neurological Disease Cancer
SM311 (Compound 10), a chemical probe, is a potent selective irreversible *LIMK1* inhibitor (EC₅₀=0.045 μM, >30-fold selective over *LIMK2*). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion ^[1].

HY-123345

CRT 0105446	LIM Kinase (LIMK)	Cancer
CRT 0105446 (compound 22d) is a *LIMK1* inhibitor, with an IC₅₀ of 8 nM ^[1].

HY-135843

TH-263	LIM Kinase (LIMK)	Cancer
TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257 ^[1].

HY-175656

MDI-117740	LIM Kinase (LIMK)	Neurological Disease Cancer
MDI-117740 is a dual *LIMK1/2* inhibitor. MDI-117740 shows effective cellular target engagement with *LIMK1* (pIC₅₀ = 6.73) and LIMK2 (pIC₅₀ = 7.18) in HEK293 cells. MDI-117740 exerts significant anti-migratory activity in MDA-MB-231 cells. MDI-117740 can be used for the study of cancers and neurodegenerative disorders ^[1].

HY-N10868

8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide	LIM Kinase (LIMK)	Cancer
8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has *anti-LIMK1* activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility ^[1].

HY-168908

LIJTF500025	LIM Kinase (LIMK)	Cancer
LIJTF500025, a chemical probe, is a potent and selective *LIMK* inhibitor, with pIC₅₀ values of 6.77 and 7.03 for LIMK1 and LIMK2, respectively, as determined by NanoBRET. LIJTF500025 can be used for the research of cancer ^[1].

HY-159897

PAK4-IN-5	PAK LIM Kinase (LIMK) Apoptosis Reactive Oxygen Species (ROS)	Cancer
PAK4-IN-5 (Compound 12i) is a PAK4 inhibitor (IC₅₀: 7.68 nM for PAK4, 1872.01 nM for PAK1). PAK4-IN-5 binds to PAK4 stably via multiple interactions. PAK4-IN-5 inhibits the proliferation and the migratory potential of MDA-MB-231 cells by inhibiting the phosphorylation of PAK4 and LIMK1. PAK4-IN-5 arrests cell cycle in the G0/G1 phase, induces apoptosis and ROS production. LD₅₀: >500 mg/kg for mice (p.o.) ^[1].

HY-12659B

LX7101 monohydrochloride	LIM Kinase (LIMK) ROCK PKA	Endocrinology
LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research ^[1] .

HY-125444

TH251	LIM Kinase (LIMK)	Neurological Disease Cancer
TH251 is a *LIMK1* and *LIMK2* inhibitor with IC₅₀s of 52 nM and 47 nM against LIMK1 and LIMK2, respectively. TH251 binds to inactive αC-out and DFG-out LIMK1 conformations, inhibits unphosphorylated LIMK1 and LIMK2 enzymatic activity, and exhibits unchanged potency despite PAK-mediated phosphorylation of either kinase. TH251 can be used for the research of cancers, glaucoma, and CNS diseases ^[1] .

HY-111103

CZh226	PAK LIM Kinase (LIMK) MMP	Cancer
CZh226 is a selective PAK4 inhibitor with an IC₅₀ of 0.0111 μM and a K_i of 0.009 μM. CZh226 functionally inhibits PAK4 activity and reduces the phosphorylation level of downstream signaling molecules. CZh226 inhibits the migration and invasion of tumor cells. CZh226 is applicable to lung cancer-related research ^[1].

HY-182103

ZAK-IN-2	MAP3K Caspase p38 MAPK	Cardiovascular Disease
ZAK-IN-2 (Compound 8) is a selective, covalent ZAK inhibitor with an IC₅₀ of 11.5 nM. ZAK-IN-2 forms a covalent bond with Cys22 in the P-loop of ZAK to inhibit its kinase activity. ZAK-IN-2 inhibits the phosphorylation of the downstream target p38. ZAK-IN-2 blocks Doxorubicin (HY-15142A)-induced cleavage of Caspase 3. ZAK-IN-2 is applicable to research related to myocardial hypertrophy ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide	Terpenoids Sesquiterpenes Chloranthaceae Plants Source Classification	LIM Kinase (LIMK)
8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has *anti-LIMK1* activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility ^[1].

Recombinant Proteins Recommended:

LIMK1

Species:	Human (3)
Tag:	His (2) Tag Free (1) GST (1)
Source:	sf9 insect cells (1) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705847

	LIMK1 Protein, Human (sf9, His-GST) LIMK1; LIM domain kinase 1; LIMK-1	Human	sf9 insect cells

HY-P701792

	LIMK1 Protein, Human (D460N, sf9) LIMK1; LIM domain kinase 1; LIMK-1	Human	Sf9 insect cells
	The LIMK1 protein is an important serine/threonine protein kinase that controls actin dynamics downstream of Rho GTPases. Activation of ROCK1, PAK1, and PAK4 phosphorylates LIMK1, allowing it to phosphorylate and inhibit actin depolymerizing factors, including cofilin-1/CFL1 and destrin/DSTN. LIMK1 Protein, Human (D460N, sf9) is the recombinant human-derived LIMK1 protein, expressed by sf9 insect cells , with tag free.

HY-P701793

	LIMK1 Protein, Human (D460N, sf9, His) LIMK1; LIM domain kinase 1; LIMK-1	Human	Sf9 insect cells
	The LIMK1 protein is an important serine/threonine protein kinase that controls actin dynamics downstream of Rho GTPases. Activation of ROCK1, PAK1, and PAK4 phosphorylates LIMK1, allowing it to phosphorylate and inhibit actin depolymerizing factors, including cofilin-1/CFL1 and destrin/DSTN. LIMK1 Protein, Human (D460N, sf9, His) is the recombinant human-derived LIMK1 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

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Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (2) Mouse (3) Monkey (1)
Application:	IHC-P (1) ICC/IF (1) WB (3) FC (1) ELISA (1)
Isotype:	IgG (2) IgG1 (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81941

	LIM Kinase 1 Antibody (YA1686) LIMK1; LIMK; LIM domain kinase 1; LIMK-1	WB	Human, Mouse
	LIM Kinase 1 Antibody (YA1686) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LIM Kinase 1.

HY-P85864

	LIM Kinase 1+2 Antibody (YA5556) LIM domain kinase 1; LIMK-1;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	LIM Kinase 1+2 Antibody (YA5556) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LIM Kinase 1+2.

HY-P810393

	LIM Kinase 1 Antibody (YA9710) EC 2.7.1.37, LIM domain containing protein kinase, LIM domain kinase 1, LIM kinase, LIM motif containing protein kinase, LIMK 1, LIMK, LIMK-1, LIMK1, LIMK1_HUMAN	WB, IHC-P, FC	Human, Mouse, Rat, Monkey
	LIM Kinase 1 Antibody (YA9710) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to LIM Kinase 1.