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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3858 Results for "
Lys-
" in MedChemExpress (MCE) Product Catalog:
Products (3858)
3858 Results for "Lys-" in MCE Product Catalog:
268
268 Publications Verification
Referencia número: HY-P0175
No. CAS: 1236188-16-1
Synonyms: 740YPDGFR; PDGFR 740Y-P
135
135 Cited Publications
Referencia número: HY-P1410A
Target:
Áreas de investigación:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
135
135 Cited Publications
Referencia número: HY-P1410
No. CAS: 1209500-46-8
Target:
Áreas de investigación:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
72
72 Cited Publications
Synonyms: Exenatide
Target:
Áreas de investigación:
Exendin‑4 (Exenatide) is an orally active, blood-brain barrier-permeable glucagon-like peptide-1 receptor (GLP‑1 receptor) agonist that resists degradation mediated by dipeptidyl peptidase IV. Exendin‑4 mediates multiple glucose-regulating effects, including stimulation of glucose-dependent insulin secretion, inhibition of glucagon production, increase in β-cell mass, delay of gastric emptying, reduction of food intake, improvement of peripheral insulin sensitivity, and restoration of normal islet structure. Exendin‑4 inhibits oxidative stress, alleviates inflammatory responses, and reduces neuronal apoptosis. Exendin‑4 reduces the aggregation level of mutant huntingtin, improves motor function, prolongs survival time, and regulates the expression levels of leptin and ghrelin. Exendin‑4 can be used in research related to type 2 diabetes, acute ischemic stroke, and Huntington's disease .
72
72 Cited Publications
Synonyms: Exenatide acetate
Target:
Áreas de investigación:
Exendin-4 acetate (Exenatide acetate) is an orally active, blood-brain barrier-permeable glucagon-like peptide-1 receptor (GLP‑1 receptor) agonist that resists degradation mediated by dipeptidyl peptidase IV. Exendin-4 acetate mediates multiple glucose-regulating effects, including stimulation of glucose-dependent insulin secretion, inhibition of glucagon production, increase in β-cell mass, delay of gastric emptying, reduction of food intake, improvement of peripheral insulin sensitivity, and restoration of normal islet structure. Exendin-4 acetate inhibits oxidative stress, alleviates inflammatory responses, and reduces neuronal apoptosis. Exendin-4 acetate reduces the aggregation level of mutant huntingtin, improves motor function, prolongs survival time, and regulates the expression levels of leptin and ghrelin. Exendin-4 acetate can be used in research related to type 2 diabetes, acute ischemic stroke, and Huntington's disease .
51
51 Cited Publications
Referencia número: HY-P0128
No. CAS: 131602-53-4
Synonyms: Amyloid beta-peptide (25-35); Aβ25-35; β-Amyloid peptide (25-35)
Target:
Áreas de investigación:
51
51 Cited Publications
Referencia número: HY-P0128A
No. CAS: 131602-53-4
Synonyms: Amyloid beta-peptide (25-35), HFIP-treated; Aβ25-35, HFIP-treated; β-Amyloid peptide (25-35), HFIP-treated
Target:
Áreas de investigación:
46
Target:
Exendin (9-39) amide (Avexitide) is a competitive GLP-1R antagonist. Exendin (9-39) amide blocks the Semaglutide (HY-114118)-induced increase in insulin secretion and also attenuates the hypoglycemic effect of Semaglutide. Exendin (9-39) amide abolishes the islet-protective effect of Liraglutide. Exendin (9-39) amide can be used in research on type 2 diabetes and type 1 diabetes .
46
46 Cited Publications
Referencia número: HY-P0264A
No. CAS: 2051593-46-3
Synonyms: Avexitide acetate
Target:
Áreas de investigación:
Exendin (9-39) amide acetate (Avexitide acetate) is a competitive GLP-1R antagonist. Exendin (9-39) amide acetate blocks the Semaglutide (HY-114118)-induced increase in insulin secretion and also attenuates the hypoglycemic effect of Semaglutide. Exendin (9-39) amide acetate abolishes the islet-protective effect of Liraglutide. Exendin (9-39) amide acetate can be used in research on type 2 diabetes and type 1 diabetes .
45
45 Cited Publications
Referencia número: HY-P0151
No. CAS: 213546-53-3
Target:
Áreas de investigación:
37
Target:
35
35 Cited Publications
Referencia número: HY-P0319
No. CAS: 402750-12-3
Target:
Áreas de investigación:
35
35 Cited Publications
Referencia número: HY-P0319A
Target:
Áreas de investigación:
34
34
Áreas de investigación:
32
32 Cited Publications
Referencia número: HY-P0023
No. CAS: 161552-03-0
32
32 Cited Publications
Referencia número: HY-P0023A
No. CAS: 500577-51-5
27
27 Cited Publications
Referencia número: HY-P0223
No. CAS: 98849-88-8
Target:
Áreas de investigación:
27
27 Cited Publications
Referencia número: HY-P0223A
Target:
Áreas de investigación:
27
Target:
Áreas de investigación:
β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
